Abstract
At present, it seems to be generally agreed that proteins play a major part in the growth, differentiation and dedifferentiation of a cell. Nevertheless, it is still not known what determines the differentiation of a cell in a specific direction, and what controls the normal growth of the cell, although some protein factors regulating mammalian cell growth are now well established. Furthermore, we do not know why the cell dedifferentiates. It is almost generally accepted that proteins bring it about, and that proteins play a key role in all of the biological processes, physiological as well as pathological, including cell dedifferentiation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bhat N R, Arimoto K, Warecka K, Brunngraber E G (1986) Expression of a2-glycoprotein by glial precursor cells: an immunocytochemical study with glial cultures. Dev Brain Res 29: 31–36
Brunngraber E G, Susz J P, Warecka K (1974) Electrophoretic analysis of human brain-specific proteins obtained by affinity chromatography. J Neurochem 22: 181–182
Brunngraber E G, Susz J P, Javaid J, Aro A, Warecka K (1975) Binding of Concanavalin A to the brain specific proteins obtained from human white matter by affinity chromatography. J Neurochem 24: (805–806)
Elias SB (1987) Oligodendrocyte development and the natural history of multiple sclerosis. new hypothesis for the pathogenesis of the disease. Arch Neurol 44: 1294–1299
Ghandour M S, Langley O K, Gombos G, Vincendon G, Warecka K (1982) Cellular localization of the brain specific a2-glycoprotein in rat cerebellum: an immunohistochemical study. Neuroscience 7: 231–237
Lange U (1976) Gehirnspezifische Proteine bei Mäusemutanten “Jimpy” und anderen Mammalia. Thesis, Medical College of Lübeck
Langley O K, Ghandour M S, Vincendon G, Gombos G, Warecka K (1982) Immunoelectron microscopy of a2-glycoprotein. J Neuroimmunol 2: 131–143
Rose S P R (1967) Preparation of enriched fractions from cerebral cortex containing isolated, metabolically active neuronal and glial cells. Biochem J 102: 33–43
Strache J (1983) Das Vorkommen von gehirnspezifischem Alpha2-Glykoprotein in Hirnen verstorbener Patienten, die an Multipler Sklerose gelitten haben. Thesis, Medical College of Lübeck
Vogel H M (1971) Die Lokalisation des gehirnspezifischem Alpha2-Glykoproteins in Gehirnzellen. Thesis, Medical College of Lübeck
von Schweinitz und Krain J C (1976) Das Vorkommen von gehirnspezifischem Alpha2-Glykoprotein in Hirntumoren. Thesis, Medical College of Lübeck
Warecka K (1975) Immunological differential diagnosis of human brain tumors. J Neunil Sci 26: 511–516
Warecka K (1980) Onto-and phylogenesis, maturation and genetic differences of glia specific glycoprotein. In: Baumann N (ed) Neurological mutations affecting myelination. Elsevier/North-Holland, Amsterdam (INSERM symposium no 14 )
Warecka K, Bauer H (1967) Studies on “brain-specific” proteins in aqueous extracts of brain tissue. J Neurochem 14: 783–787
Warecka K, Müller D (1969) The appearance of human “brain-specific” glycoprotein in ontogenesis. J Neurol Sci 8: 329–345
Warecka K, Möller H J, Vogel H M, Tripatzis I (1972) Human brain-specific alpha2-glycoprotein: purification by affinity chromatography and detection of a new component; localization in nervous cells. J Neurochem 19: 719–725
Weber K, Osborn M (1969) The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. J Biol Chem 244: 4406–4412
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Warecka, K. (1990). Neurogenesis and Pathogenesis of Glia: Immunological Studies. In: Deecke, L., Eccles, J.C., Mountcastle, V.B. (eds) From Neuron to Action. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02601-4_73
Download citation
DOI: https://doi.org/10.1007/978-3-662-02601-4_73
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-02603-8
Online ISBN: 978-3-662-02601-4
eBook Packages: Springer Book Archive