Central Pontine and Extrapontine Myelinolysis
Central pontine myelinolysis (CPM) is a demyelinative disorder affecting mainly the ventral part of the pons. In some cases CPM is accompanied by extrapontine myelinolysis (EPM, together CPM/EPM). CPM/EPM is not a primary disease but develops rather against a background of other, usually severe conditions, apparently as a complication of the main disease. It occurs mostly in alcoholics but has also been reported in association with diabetic ketoacidosis, psychogenic excessive water drinking, inappropriate antidiuretic hormone secretion, malnutrition, and chronic debilitating diseases. It is probable that the underlying cause of myelinolysis in all these disorders is a derangement of serum sodium concentration, particularly a rapid correction of hyponatremia.
KeywordsSerum Sodium Diabetic Ketoacidosis Thiamine Deficiency Serum Sodium Concentration Centrum Semiovale
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