Verhandlungen pp 342-344 | Cite as

Electron microscopy of ribonuclease crystals

  • I. M. Dawson
  • D. H. Watson


The aim of this work was to extend to a low molecular weight protein, the electron microscope observations already made by Wyckoff (7), Hall (4), Dawson (3) and others on some of the higher molecular weight proteins. It was hoped to obtain information from direct examination of the material at high resolution, which would confirm and possibly supplement information gained from X-ray structural analysis of the protein. Ribonuclease was selected since a great deal is known about its structure from the work of Carlisle et al. (1, 2) and of Mafdoff et al. (5, 6).


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  1. 1.
    CARLISLE, C H, and H. ScouLOUDI: Proc. roy. Soc. A 207, 496 (1951).ADSCrossRefGoogle Scholar
  2. 2.
    CARLISLE, C H, H. ScouLOUDI and M. SPIER: Proc. roy. Soc. B 141, 85 (1953).CrossRefGoogle Scholar
  3. 3.
    DAWSON, I. M.: Nature (Lond.) 168, 241 (1951).ADSCrossRefGoogle Scholar
  4. 4.
    HALL, C. E.: J. biol. Chem. 185, 45 (1950).Google Scholar
  5. 5.
    MACDOFF, B. S., and F. H. C. CRICK: Acta crystallogr. (Copenh.) 8, 461 (1955).CrossRefGoogle Scholar
  6. 6.
    MACDOFF, B. S., F. H. C. CRICK and V. LUZZATI: Acta crystallogr. (Copenh.) 9, 156 (1956).CrossRefGoogle Scholar
  7. 7.
    WYCKOFF, R. W. G.: Electron Microscopy, p. 72. New York: Interscience Publ. 1949.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1960

Authors and Affiliations

  • I. M. Dawson
    • 1
  • D. H. Watson
    • 1
  1. 1.Department of ChemistryThe UniversityGlasgow W. 2.Scotland

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