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Production of Amyloid β Protein from Normal and Mutated Amyloid β Protein Precursors

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Amyloid Protein Precursor in Development, Aging and Alzheimer’s Disease

Part of the book series: Research and Perspectives in Alzheimer’s Disease ((ALZHEIMER))

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Abstract

In patients with Alzheimer’s disease (AD), large numbers of senile plaques are found throughout the neuropil of the cerebral neocortex and hippocampus. These senile plaques, which are present in small numbers in the brains of aged mammals and normal elderly individuals, are observed in large numbers only in AD and thus represent a change that is quite specific for this disorder. “Classic” senile plaques consist of a spherical cluster of abnormal neurites surrounding an extracellular amyloid core composed of 5–10 nm fibrils that can be visualized on light microscopy by staining with Congo Red or Thioflavin S (Terry 1985). In most cases of AD, amyloid fibrils are also found in the walls of cerebral vessels (Glenner 1983).

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Author information

Authors and Affiliations

  1. Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OH, 44106, USA

    T. E. Golde

Authors
  1. T. E. Golde
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  2. X.-D. Cai
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  3. T.-T. Cheung
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  4. M. Shoji
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  5. S. G. Younkin
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Editor information

Editors and Affiliations

  1. Department of Pathology, The University of Melbourne and The Mental Health Research Institute of Victoria, Parkville, Victoria, 3025, Australia

    C. L. Masters M.D.

  2. Center for Molecular Biology, University of Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany

    K. Beyreuther Ph.D.

  3. Hôpital Neurologique, 59, Bld Pinel, 69003, Lyon, France

    M. Trillet Prof.

  4. Fondation IPSEN, 24, rue Erlanger, 75781, Paris, France

    Y. Christen Ph.D.

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© 1994 Springer-Verlag Berlin Heidelberg

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Golde, T.E., Cai, XD., Cheung, TT., Shoji, M., Younkin, S.G. (1994). Production of Amyloid β Protein from Normal and Mutated Amyloid β Protein Precursors. In: Masters, C.L., Beyreuther, K., Trillet, M., Christen, Y. (eds) Amyloid Protein Precursor in Development, Aging and Alzheimer’s Disease. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-01135-5_4

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  • DOI: https://doi.org/10.1007/978-3-662-01135-5_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-01137-9

  • Online ISBN: 978-3-662-01135-5

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