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Thin-Layer Chromatography pp 1–4Cite as

History of the Development of Thin-Layer Chromatography

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Abstract

It is remarkable that although the principle of thin-layer chromatography was described as early as 25 years ago, this method has become accepted as indispensable only during the last 3 years. A short summary of the development of thin-layer chromatography is, therefore, not only interesting in itself, but also will help towards an understanding of the technique. The first publication in the field dates back to the period when Tswett’s column chromatography was enjoying a great success. It was at this time that constant efforts were being made to achieve “micro-chromatography” by reducing the diameter of the column to 1 mm. The inherent difficulties were summed up by Zechmeister [74] in 1938 as follows: “The main problem in ‘micro-chromatography’ is not the development of the right apparatus (i.e. for column chromatography), but the accurate identification of adsorbed substances.” This problem was solved by the change-over from the “closed” to the “open” column, to the thin separating layer, in fact. This method, published some years ago, demonstrated the simplicity of the process and its wide applicability [56].

Keywords

  • Cellulose Fiber
  • Chromatographic Adsorption
  • Partition Chromatography
  • Adsorbed Substance
  • Loose Layer

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  1. Egon Stahl
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  1. Institute for Pharmacognosy, University of the Saar, Stadtwald, Saarbrücken 15, Germany

    Egon Stahl

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Stahl, E. (1965). History of the Development of Thin-Layer Chromatography. In: Stahl, E. (eds) Thin-Layer Chromatography. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-01031-0_1

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