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Calcium Metabolism and Its Relationship to Blood Pressure in Humans

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Cellular Aspects of Hypertension

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Abstract

Essential hypertension (EHT) is a condition carrying increased risk of vascular morbidity and death. Whether the blood pressure per se or hither to unidentified factors associated with EHT are the cause of this morbidity is not well understood, neither are the mechanisms behind the development of hypertension yet known. Let us imagine how this group of subjects at risk for vascular disease might have been identified if the invention of the calcium atomic absorption technique, the ionized calcium analyzer, and the parathyroid hormone assay had preceded the invention of the sphygmomanometer — and furthermore had been at least as easy to employ in the screening of populations.

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References

  1. Hvarfner A, Ljunghall S, Mörlin C, Wide L, Bergström R (1986) Indices of mineral metabolism in relation to blood pressure in a sample of a healthy population. Acta Med Scand 219: 461–468

    Article  PubMed  CAS  Google Scholar 

  2. Hvarfner A, Bergström R, Mörlin C, Wide L, Ljunghall S (1987) Relationships between calcium metabolic indices and blood pressure in patients with essential hypertension as compared with a healthy population. J Hypertens 5: 451–456

    Article  PubMed  CAS  Google Scholar 

  3. Hvarfner A, Larsson R, Mörlin C, Rastad J, Wide L, Akerström G, Ljunghall S (1988) Cytosolic free calcium in platelets: relationship to blood pressure and indices of systemic calcium metabolism. J Hypertens 6: 71–77

    Article  PubMed  CAS  Google Scholar 

  4. Hvarfner A, Mörlin C, Wide L, Ljunghall S (1989) Interactions between indices of calcium metabolism and blood pressure during an intravenous calcium infusion in humans. J Hum Hypertens 3: 211–220

    PubMed  CAS  Google Scholar 

  5. Hvarfner A, Bergström R, Mörlin C, Theodorsson E, Ljunghall S (1988) The calcitonin gene related peptide ( CGRP) response to intravenous calcium is related to blood pressure. Acta Physiol Scand 132: 439–440

    Google Scholar 

  6. Hvarfner A, Bergström R, Lithell H, Mörlin C, Wide L, Ljunghall S (1988) Changes in calcium metabolic indices during long-term treatment of patients with essential hypertension. Clin Sci 75: 543, 549

    Google Scholar 

  7. Hvarfner A, Mörlin C, Präntare H, Wide L, Ljunghall S (1990) Calcium metabolic indices, vascular retinopathy and plasma renin activity in essential hypertension. Am J Hypertens 3(12) (in press)

    Google Scholar 

  8. Hallam TJ, Sanchez A, Rink TJ (1984) Stimulus-response coupling in human platelets. Biochem J 218: 819–827

    PubMed  CAS  Google Scholar 

  9. Hallam TJ, Thompson NT, Scrutton MC, Rink TJ (1984) The role of cytoplasmic free calcium in the response of quin2-loaded human platelets of vasopressin. Biochem J 221: 897–901

    PubMed  CAS  Google Scholar 

  10. Hallam TJ, Daniel JL, Kendrick-Jones J, Rink TJ (1985) Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets. Biochem J 232: 373–377

    PubMed  CAS  Google Scholar 

  11. Lindner A, Keuny M, Meacham Ai (1987) Effects of a circulating factor in patients with essential hypertension on intracellular free calcium in normal platelets. N Engl J Med 316: 509–513

    Article  PubMed  CAS  Google Scholar 

  12. Niedermann R, Pollard TD (1975) Human platelet myosin. II In vitro assembly and structure of myosin filaments. J Cell Biol 67: 72–79

    Google Scholar 

  13. Erne P, Bolli P, Bürgiesser E, Bühler FR (1984) Correclation of platelet calcium with blood pressure effect of antihypertensive therapy. N Engl J Med 310: 1084–1088

    Article  PubMed  CAS  Google Scholar 

  14. Webb RC, Bohr DF (1978) Mechanism of membrane stabilization by calcium in vascular smooth muscle. Am J Physiol 235: 227–232

    Google Scholar 

  15. Orlov SN, Postnov YV (1982) Ca+2 binding and membrane fluidity in essential and renal hypertension. Clin Sci 63: 281–284

    PubMed  CAS  Google Scholar 

  16. Robinson BF (1984) Altered calcium handing as a cause of primary hypertension. J Hypertens 2: 543–460

    Article  Google Scholar 

  17. Sprenger KGB (1985) Alteration of cellular calcium metabolism as primary cause of hypertension. Clin Physiol Biochem 3: 208–220

    PubMed  CAS  Google Scholar 

  18. Marone C, Beretta-Piccolo C, Weidmann P (1980) Acute hypercalcemic hypertension in man: role of hemodynamics, catecholamines and renin. Kidney Int 20: 92–96

    Article  Google Scholar 

  19. Berl T, Levi M, Ellis M, Chaimovitz C (1985) Mechanism of acute hypercalcemic hypertension in the conscious rat. Hypertension 7: 923–930

    Article  PubMed  CAS  Google Scholar 

  20. Lau K, Eby B (1985) The role of calcium in genetic hypertension. Hypertension 7: 657–667

    Article  PubMed  CAS  Google Scholar 

  21. Rosenthal FD, Roy S (1972) Hypertension and hyperparathyroidism. Br Med J 4:396–397

    Google Scholar 

  22. Hulter HN, Melby JC, Peterson JC, Cooke CR (1986) Chronic continuous PTH infusion results in hypertension in normal subjects. J Clin Hypertens 4: 360–370

    Google Scholar 

  23. Borle AB, Uchikawa T (1978) Effects of parathyroid hormone on the distribution and transport of calcium of cultured kidney cells. Endocrinology 102: 1725–1732

    Article  PubMed  CAS  Google Scholar 

  24. Marcus C, Orner FB (1980) Parathyroid hormone as a calcium ionophore in bone cells: tests of specificity. Calcif Tissue Int 5: 159

    Google Scholar 

  25. Hruska KA, Goligorsky M, Scolbe J, Tsutsumi M, Westbrook S, Moskowitz D (1986) Effects of parathyroid hormone on cytosolic calcium in renal proximal tubular primary cultures. Am J Physiol 251: F188 - F198

    PubMed  CAS  Google Scholar 

  26. Dolson GM, Hise MK, Weinman ED (1985) Relationship among parathyroid hormone, cAMP and calcium on proximal tubule sodium transport. Am J Physiol 249: F409 - F416

    PubMed  CAS  Google Scholar 

  27. Nickols GA, Netz MA, Cline WH (1986) Endothelium-independent linkage of parathyroid hormone receptors of rat vascular tissue with increased adenosine 3’-5’monophosphate and relaxation of vascular smooth muscle. Endocrinology 119: 349–356

    Article  PubMed  CAS  Google Scholar 

  28. Dowe JP, Joshua IG (1987) In vivo arteriolar dilation in response to parathyroid hormone fragments. Peptides 8: 443–448

    Article  PubMed  CAS  Google Scholar 

  29. Shoback DM, Thatcher J, Leombruno R, Brown EM (1984) Relationship between parathyroid hormone secretion and cytosolic calcium concentration in dispersed bovine parathyroid cells. Proc Natl Acad Sci USA 81: 3113–3117

    Article  PubMed  CAS  Google Scholar 

  30. Larsson R, Wallfelt C, Abrahamsson H, Gylfe E, Ljunghall S, Rastad J, Rorsman P, Wide L, Akerström G (1984) Defective regulation of the cytosolic Ca-+ activity in parathyroid cells from patients with hyperparathyroidism. Biosci Rep 4: 909–915

    Article  PubMed  CAS  Google Scholar 

  31. Gennari C, Nami R, Bianchini C, Aversa AM (1985) Blood pressure effects of acute hypercalcemia in normal subjects and thyroparathyroidectomized patients. Miner Electrolyte Metab 11: 369–373

    PubMed  CAS  Google Scholar 

  32. Zawada ET Jr, Johansson M, McClung D, TreWee J, MacKenzie T (1987) Systemic and renal hemodynamic consequences of manipulation of serum calcium and/or parathyroid hormone in the intact conscious mongrel dog. J Am Coll Nutr 6: 131–138

    PubMed  CAS  Google Scholar 

  33. Franco-Cereceda A, Gennari C, Nami R, Agnusdei D, Pernow J, Lundberg JM, Fischer AJ (1987) Cardiovascular effects of calcitonin gene-related peptides I and II in man. Circ Res 60: 393–397

    Article  PubMed  CAS  Google Scholar 

  34. Struthers AD, Brown MJ, MacDonald DWR, Beacham JL, Stevenson JC, Morris HR, Maclntyre I (1986) Human calcitonin gene-related pepide: a potent endogenous vasodilator in man. Clin Sci 70: 389–393

    PubMed  CAS  Google Scholar 

  35. Singer P, Gödicke W, Voigt S, Hajdu I, Weiss M (1985) Postprandial hyperinsulinemia in patients with mild essential hhpertension. Hypertension 7: 182–186

    Article  PubMed  CAS  Google Scholar 

  36. Ladenson JH, Shyong JC (1977) Influence of fatty acids on the binding of calcium to human serum albumin. Clin Chim Acta 75: 293–302

    Article  PubMed  CAS  Google Scholar 

  37. Wortsmann J, Traycoff RB (1980) Biological activity of protein-bound calcium in serum. Am J Physiol 238 (1): E104 - E107

    Google Scholar 

  38. Zaloga GP, Willey S, Tomasic P, Chernow B (1987) Free fatty acids alter calcium binding: a cause for misinterpretation of serum calcium values and hypocalcemia in critical illness. J Clin Endocrinol Metab 64: 1010–1014

    Article  PubMed  CAS  Google Scholar 

  39. Deacon SP (1978) The effects of atenolol and propranolol upon lipolysis. Br J Clin Pharmacol 5: 123–125

    Article  PubMed  CAS  Google Scholar 

  40. Day JL, Metcalfe J, Simpson CN (1982) Adrenergic mechanisms in control of plasma lipid concentrations. Br Med J 284: 1145–1148

    Article  CAS  Google Scholar 

  41. Norberg K-A, Persson B, Granberg P-O (1975) Adrenergic innervation of the human parathyroid gland. Acta Chir Scand 141: 319–322

    PubMed  CAS  Google Scholar 

  42. Brown EM, Hurwitz S, Aurbach GD (1977) Beta-adrenergic stimulation of cyclic AMP content and parathyroid hormone release from isolated parathyroid cells. Endocrinology 100: 1696–1702

    Article  PubMed  CAS  Google Scholar 

  43. Hanley DA, Taktsuki K, Birnbaumer ME, Schneider AB, Sherwood LM (1980) In vitro perfusion for the study of parathyroid hormone secretion: effects of extra-cellular calcium concentration and ß-adrenergic regulation on bovine parathyroid hormone secretion in vitro. Calcif Tissue Int 32: 19–27

    Article  PubMed  CAS  Google Scholar 

  44. Fischer JA, Blum JW, Binswanger U (1973) Acute parathyroid hormone response to epinephrine in vivo. J Clin Invest 52: 2434–2440

    Article  PubMed  CAS  Google Scholar 

  45. Mayer GP, Hust JG, Barto JA, Keaton JA, Moore MP (1979) Effect of epinephrine on parathyroid hormone secretion in calves. Endocrinology 104: 1181–1187

    Article  PubMed  CAS  Google Scholar 

  46. Kukreja SC, Williams GA, Vora NM, Hargis GK (1981) Normal responsiveness of serum parathyroid hormone to ß-adrenergic blockade in patients with secondary hyperparathyroidism. Horm Metab Res 13: 233–235

    Article  PubMed  CAS  Google Scholar 

  47. Farrington K, Hamzeh J, Varghese Z, Moorhead JF (1980) Effects of oral propranolol on parathyroid hormone secretion in chronic renal failure. Br Med J 281: 1320

    Article  PubMed  CAS  Google Scholar 

  48. Coevoet B, Desplan C, Sebert JL, Makdassi R, Andrejak M, Gheerbrant JD, Tolani M, Calmette C, Moukthar MS, Fournier A (1980) Effect of propranolol and metoprolol on parathyroid hormone and calcitonin secretion in uraemic patients. Br Med J 280: 1344–1346

    Article  PubMed  CAS  Google Scholar 

  49. McCarron DA, Muther RS, Plant SB, Krutzik S (1982) Ionized calcium and the in vivo response of normal and hyperplastic parathyroid glands to ß-adrenergic agents. Nephron 32: 149–154

    Article  PubMed  CAS  Google Scholar 

  50. Ljunghall S, Rudberg C, Akerström G, Wide L (1982) Effects of ß-adrenergic blockade on serum parathyroid hormone in normal subjects and patients with primary hyperparathyroidism. Acta Med Scand 211: 27–30

    Article  PubMed  CAS  Google Scholar 

  51. Epstein S, Heath III H, Bell NH (1983) Lack of influence of isoproterenol, propranolol, and dopamine on immunoreactive parathyroid hormone and calcitonin in normal man. Calci Tissue Int 35: 32–36

    Article  CAS  Google Scholar 

  52. Andersen T, McNair P, Fogh-Andersen N, Nielsen IT, Hyldstrup L, Transböl I (1986) Increased parathyroid hormone as a consequence of changed complex binding of plasma calcium in morbid obesity. Metabolism 35: 147–151

    Article  PubMed  CAS  Google Scholar 

  53. Modan M, Halkin H, Almog S, Lusky A, Eshkol A, Shefi M, Shitrit A, Fuchs Z (1985) Hyperinsulinemia–a link between hypertension, obesity and glucose intolerance. J Clin Invest 75: 809–817

    Article  PubMed  CAS  Google Scholar 

  54. Pollare T, Lithell H, Berne C (1990) Insulin resistance is a characteristic feature of primary hypertension independently of obesity. Metabolism 39: 167–174

    Article  PubMed  CAS  Google Scholar 

  55. DeFronzo RA, Cooke CR, Andres R, Faloona GR, Davis PJ (1975) The effect on insulin on renal handling of sodium, potassium, calcium and phosphate in man. J Clin Invest 55: 845–855

    Article  PubMed  CAS  Google Scholar 

  56. Muldowney FP, Freaney R, Moloney MF (1982) Importance of dietary sodium in the hypercalciuria syndrome. Kidney Int 22: 292–296

    Article  PubMed  CAS  Google Scholar 

  57. deWardener HE (1978) The control of sodium excretion. Am J Physiol 235: F163 - F173

    CAS  Google Scholar 

  58. Blaustein MP, Hamlyn JM (1984) Sodium transport inhibition, cell calcium and hypertension. Am J Med 77: 45–49

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, University Hospital, S-75185, Uppsala, Sweden

    A. Hvarfner

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  1. A. Hvarfner
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  1. Istituto di Clinica Medica e Nefrologia, Facolta di Medicina e Chirurgia, Università degli Studi di Parma, Via A. Gramsci, 14, I-43100, Parma, Italy

    Giacomo Bruschi  & Alberico Borghetti  & 

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© 1991 Springer-Verlag Berlin • Heidelberg

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Hvarfner, A. (1991). Calcium Metabolism and Its Relationship to Blood Pressure in Humans. In: Bruschi, G., Borghetti, A. (eds) Cellular Aspects of Hypertension. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-00983-3_11

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  • DOI: https://doi.org/10.1007/978-3-662-00983-3_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-00985-7

  • Online ISBN: 978-3-662-00983-3

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