Abstract
The importance of sodium and the key role of the kidneys in the pathogenesis of hypertension is widely recognized. Excessive dietary salt may not play an etiologic role in all individuals with essential hypertension, but the majority of patients with this disease, especially those with low-renin essential hypertension, respond to reduced dietary sodium and/or natriuretic drugs. Despite these well-established observations, the relationship between sodium and hypertension is still vigorously debated because the precise pathogenic mechanisms are not known.
Supported by a research grant from the National Institutes of Health (AR-32276).
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References
Ashida T, Blaustein MP (1987) Regulation of cell calcium and contractility in arterial smooth muscle: the role of Na/Ca exchange. J Physiol (Lond) 392: 617–635
Blackburn H, Prineas R (1983) Diet and hypertension: anthropology, epidemiology and public health implications. Prog Biochem Pharmacol 19: 31–79
Blaustein MP (1977) Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. Am J Physiol 232 (1): C165–C173
Blaustein MP (1989) Sodium/calcium exchange in cardiac, smooth and skeletal muscle: key to the control of contractility. Curr Top Membr Transport 34: 289–330
Blaustein MP, Hamlyn JM (1984) Sodium transport inhibition, cell calcium, and hypertension: the natriuretic hormone/Na-Ca exchange/hypertension hypothesis. Am J Med 77: 45–59
Bova S, Blaustein MP, Harris DW, Ludens JH, DuCharme DW, Hamlyn JM (1990) Effects of an endogenous digitalis-like factor ( EDLF) on heart and aorta (abstract). Hypertension 16: 316–317
Bova S, Goldman WF, Yuan X -J, Blaustein MP (1990) Influence of the Na+ gradient on Cat+ transients and contraction in vascular smooth muscle. AM J Physiol 259: H409–H423
Curtis JJ, Luke RG, Dustan HP, Kashgarian M, Whelchel JD, Jones P, Diethelm AG (1983) Remission of essential hypertension after renal transplantation. N Engl J Med 309: 1009–1015
Dahl LK, Knudsen KD, Iwai J (1969) Humoral transmission of hypertension: evidence from parabiosis. Circ Res 24 [Suppl I]:I-21-I-33
DeWardener HE, Mills IH, Clapham WF, Hayter CJ (1961) Studies on the efferent mechanism of the sodium diuresis which follows the administration of intravenous saline in the dog. Clin Sci 21: 249–258
Fujimura A, Ebara A, Yaoka O (1984) The effect of long term digoxin administration on blood pressure of rat. Jpn J Hypertens 7 (1): 49
Goldman WF, Blaustein MP (1988) Stimulation-induced regional alteration of Cat+ levels in single arterial smooth muscle cells. J Cardiovasc Pharmacol 12 [Suppl 5]: S13–S19
Guidi E, Bianchi G, Rivolta E, Ponticelli C, Quarto di Palo F, Minetti L, Polli E (1985) Hypertension in man with a kidney transplant: role of familial vs. other factors. Nephron 41: 14–21
Guyton AC, Coleman TG, Cowley AW, Scheel KW, Manning RD, Norman RA (1977) Arterial pressure regulation: overriding dominance of the kidneys in longterm regulation and in hypertension. Am J Med 52: 584–594
Hamlyn JM (1989) Increased levels of a humoral digitalis-Like factor in deoxycorticosterone acetate-induced hypertension in the pig. J Endocrinol 122: 409–420
Hamlyn JM, Blaustein MP (1986) Sodium chloride, extracellular fluid volume, and blood pressure regulation. Am J Physiol 251: F563–F575
Hamlyn JM, Ringel R, Schaeffer J, Levinson PD, Hamilton BP, Kowarski AA, Blaustein MP (1982) A circulating inhibitor of ( Na+K)-ATPase associated with essential hypertension. Nature 300: 650–652
Hamlyn JM, Harris DW, Ludens JH (1989) Digitalis-like activity in human plasma. Purification, affinity, and mechanism. J Biol Chem 264: 7395–7404
Hamlyn JM, Harris DW, Resau J, Ludens JH (1990) Digitalis-like activity in human and bovine adrenals. FASEB J 4: A295 (abstract)
Kurtz TW, Al-Bander HA, Morris RC Jr (1987) “Salt-sensitive” essential hypertension in men: is the sodium ion alone important? N Engl J Med 317:1043–1048
Magyar K, Nguyen TT, Török TL, Toth PT (1987) [3H]noradrenaline release from rabbit pulmonary artery: sodium-pump-dependent sodium-calcium exchange. J Physiol (Lond) 393: 29–42
Matthews WR, Harris DW, DuCharme DW, Lutzke BS, Mandel F, Clark MA, Ludens JH, Hamlyn JM (1990) Endogenous digitalis-like factor (EDLF). III, Mass spectral characterization (abstract) Hypertension 16: 316
Morgan T, Carney S, Myers J (1979) Sodium and hypertension. A review of the role of sodium in pathogenesis and the action of diuretic drugs. Pharmacol Ther 9: 395–418
Reuter H, Blaustein MP, Haeusler G (1973) Na-Ca exchange and tension development in arterial smooth muscle. Philos Trans R Soc Lond [Biol] 265: 87–94
Skrabal F, Herholz H, Neumayr M, Hamberger L, Ledochowski M, Sporer H, Hortnagl H, Schwarz S, Schonitzer D (1984) Salt sensitivity in humans is linked to enhance sympathetic responsiveness and to enhanced proximal tubular reabsortion. Hypertension 6: 152–158
Weder AB (1986) Red cell lithium-sodium countertransport and renal lithium clearance in hypertension. N Engl J Med 314: 198–201
Weinberger MH (1987) Sodium chloride and blood pressure. N Engl J Med 317: 1084–1086
Woolfson RG, Hilton PJ, Poston L (1990) The effects of ouabain and low sodium on the contractility of human subcutaneous resistance vessels. Hypertension 15: 583–590
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© 1991 Springer-Verlag Berlin • Heidelberg
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Blaustein, M.P. (1991). Pathogenesis of Essential Hypertension: The Sodium Pump Inhibitor (Natriuretic Hormone) — Sodium/Calcium Exchange — Hypertension Hypothesis. In: Bruschi, G., Borghetti, A. (eds) Cellular Aspects of Hypertension. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-00983-3_10
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DOI: https://doi.org/10.1007/978-3-662-00983-3_10
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