Abstract
A monocyte-derived steroid-induced factor has been shown previously to induce dispersive locomotion in human neutrophils and to lower adhesion to an albumin-coated glass surface. In this paper we show that this factor inhibits adhesion of neutrophils to bovine aorta and human endothelial cells by an undetermined mechanism. It induces unique changes in neutrophil shape with a characteristic monopolar pattern of F-actin distribution, which may correlate with the dispersive locomotion observed in the absence of a concentration gradient. This factor also inhibits N-formyl-methionyl-leucyl-phenylalanine-induced chemotaxis of neutrophils in a modified Boyden chamber assay. The reduction of adhesion and the inhibition of chemotaxis by the factor in vitro indicate a possible in vivo anti-inflammatory role.
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Young, J.D., MacLean, A.G., Lawrence, A.J., Stevenson, R.D., Chettibi, S. (1998). Relationship of Human Neutrophil Morphology and Actin Distribution to Dispersive Locomotion caused by a steroid induced factor. In: EBO — Experimental Biology Online Annual 1996/97. EBO — Experimental Biology Online Annual, vol 1996/1997. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-00932-1_17
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DOI: https://doi.org/10.1007/978-3-662-00932-1_17
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