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Cytomegalovirus infection does not increase the risk of vanishing bile duct syndrome after liver transplantation

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Transplant International

Abstract

Cytomegalovirus (CMV) infection and HLA-DR sharing have been reported to be associated with the development of vanishing bile duct syndrome (VBDS) after liver transplantation. We retrospectively analyzed the importance of these risk factors for VBDS in 126 consecutive recipients of a first transplant. In contrast to previous studies, CMV was monitored strictly using the antigenemia assay, a quantitative marker of the viral load. Patient and graft survival were comparable in patients with and without CMV infection. The incidence of VBDS was low, regardless of the CMV infection status or degree of HLA-DR sharing. Improvements in the early diagnosis and treatment of CMV infection may have eliminated its negative influence on graft survival.

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Author information

Authors and Affiliations

  1. Department of Clinical Immunology, University Hospital Groningen, P.O. Box 30.001, NL-9700 RB, Groningen, The Netherlands

    A. P. van den Berg & T. H. The

  2. Department of Gastroenterology and Hepatology, University Hospital, P.O. Box 30.001, NL-9700 RB, Groningen, The Netherlands

    I. J. Klompmaker & E. B. Haagsma

  3. Department of Transplantation Immunology, University Hospital, P.O. Box 30.001, NL-9700 RB, Groningen, The Netherlands

    B. G. Hepkema & S. P. Lems

  4. Department of Pathology, University Hospital, P.O. Box 30.001, NL-9700 RB, Groningen, The Netherlands

    A. S. H. Gouw

  5. Department of Hepatobiliary and Pancreatic Surgery, University Hospital, P.O. Box 30.001, NL-9700 RB, Groningen, The Netherlands

    M. J. H. Slooff

Authors
  1. A. P. van den Berg
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  2. I. J. Klompmaker
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  3. B. G. Hepkema
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  4. A. S. H. Gouw
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  5. E. B. Haagsma
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  6. S. P. Lems
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  7. T. H. The
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  8. M. J. H. Slooff
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Editor information

Editors and Affiliations

  1. Vienna, Austria

    Ferdinand Mühlbacher

  2. Department of Surgery, University Hospital, P.Debyelaan 25, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands

    G. Kootstra

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© 1996 Springer-Verlag Berlin Heidelberg

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van den Berg, A.P. et al. (1996). Cytomegalovirus infection does not increase the risk of vanishing bile duct syndrome after liver transplantation. In: Mühlbacher, F., et al. Transplant International . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-00818-8_42

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  • DOI: https://doi.org/10.1007/978-3-662-00818-8_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61024-3

  • Online ISBN: 978-3-662-00818-8

  • eBook Packages: Springer Book Archive

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