Abstract
The vasodilative action of prostaglandin El (PGE1) on the systemic and pulmonary circulation was investigated in swine models of orthotopic liver transplantation. In the PGE1-treated group (n = 8), PGE1 (0.05 μg/kg per minute) was intravenously infused from the onset of the anhepatic stage to 30 min after revascularization. During the anhepatic stage, PGE1 decreased systemic vascular resistance without a corresponding hypotension, so cardiac output was maintained at a higher level. In the control group (n = 8), pulmonary vascular resistance increased to 3 times the anhepatic value during reperfusion, accompanied by a decline in cardiac output with a 28% decrease in blood pressure. In the PGE1-treated group, on the other hand, pulmonary vascular resistance was maintained within the normal range without any associated decrease in cardiac output. The blood pressure decreased slightly by 12%. In conclusion, in this model, PGE1, increased cardiac output without hypotension during the anhepatic stage and also prevented postreperfusion pulmonary hypertension and the subsequent systemic hypotension.
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© 1996 Springer-Verlag Berlin Heidelberg
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Oishi, M., Tanaka, N., Orita, K. (1996). Beneficial effects of prostaglandin E1 on hemodynamic changes during liver transplantation in pigs. In: Mühlbacher, F., et al. Transplant International . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-00818-8_26
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DOI: https://doi.org/10.1007/978-3-662-00818-8_26
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-61024-3
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