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Epigenetics pp 125–139Cite as

Epigenetics—New Aspects of Chemicals Policy

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Abstract

Epigenetics is the study of the natural processes that regulate the differentiation of cells and tissues, and are of significance in the development of organisms. This means it is able to offer a specific perspective on how various factors and stressors in the environment control gene activity. For instance, chemicals such as hormonally active ‘endocrine disruptors’ leave behind traces in the epigenetic code that not only trigger illnesses, but can also be passed on from generation to generation. These epigenetic mechanisms of action are not taken sufficiently into consideration in the use and regulation of chemicals. Although the evaluation of hormone disrupting effects due to endocrine disruptors is covered by various product-specific European regulations, neither an unambiguous regulatory definition nor specific toxicological testing strategies have been in place to date. As a result of this, the protective measures provided for in the existing legislation remain vague. It has not been possible up until now for the state to monitor the use of these substances in everyday products. How society deals with the consequences of the influence epigenetic mechanisms have due to anthropogenically conditioned changes in the environment constitutes an interdisciplinary challenge for the academic community, policymakers and ethicists. The European Parliament has adopted a resolution on the protection of public health from endocrine disruptors in which it demands precautionary action because risks to the environment and human health cannot be ruled out. This means epigenetics has arrived as a topic on the current political agenda in the context of the impact assessment and regulation of substances with epigenetic mechanisms of action.

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References

  • Austrian Federal Ministry of Agriculture, Forestry, Environment and Water Management, and Environment Agency Austria. (2012). Epigenetik in der Risikoabschätzung: ExpertInnen-Workshop: “Berücksichtigung von epigenetischen Effekten in der Risikoabschätzung”. http://www.umweltbundesamt.at/umweltsituation/gentechnik/gentechnik_termine/epigenetik/. Last accessed May 8, 2016.

  • Commission Directive 2011/8/EU of 28 January 2011 amending Directive 2002/72/EC as regards the restriction of use of Bisphenol A in plastic infant feeding bottles: OJ L 26/11, January 29, 2011.

    Google Scholar 

  • Commission of the European Communities: Communication from the Commission on the precautionary principle, COM. (2000). 1 final, Brussels, February 2, 2000.

    Google Scholar 

  • Commission Regulation (EU) No. 10/2011 of 14 January 2011 on plastic materials and articles intended to come into contact with food: OJ L 12/1, January 15, 2011.

    Google Scholar 

  • Diamanti-Kandarakis, E., Bourguignon, J. P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., et al. (2009). Endocrine-disrupting chemicals: An Endocrine Society scientific statement. Endocrine Reviews, 30(4), 293–342.

    Article  Google Scholar 

  • European Food Safety Authority (EFSA). (2006). Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to 2,2-BIS(4-HYDROXYPHENYL)PROPANE. EFSA Journal, 428, 1–75.

    Google Scholar 

  • European Food Safety Authority (EFSA). (2010). Scientific opinion on Bisphenol A: Evaluation of a study investigating its neurodevelopmental toxicity, review of recent scientific literature on its toxicity and advice on the Danish risk assessment of Bisphenol A. EFSA Journal, 8(9), 1829–1945.

    Article  Google Scholar 

  • European Food Safety Authority (EFSA). (2013). Scientific opinion on the hazard assessment of endocrine disruptors: Scientific criteria for identification of endocrine disruptors and appropriateness of existing test methods for assessing effects mediated by these substances on human health and the environment. EFSA Journal, 11(3), 3132.

    Article  Google Scholar 

  • European Parliament. (2013). Resolution: Protection of public health from endocrine disruptors, 2012/2066(INI), March 14, 2013 (P7_TA(2013)0091).

    Google Scholar 

  • Feinberg, A. P. (2007). Phenotypic plasticity and the epigenetics of human disease. Nature, 447(7143), 433–440.

    Article  Google Scholar 

  • German Federal Environment Agency (UBA). (2009). In K. Becker, H. Pick-Fuß, A. Conrad, C. Zigelski, M. Kolossa-Gehring, T. Göen, & A. Seidel (Eds.), Kinder-Umwelt-Survey (KUS) 2003/06, Human-Biomonitoring-Untersuchungen auf Phthalat- und Phenanthrenmetabolite sowie Bisphenol A, Funding Code 01 EH 0202. Umwelt und Gesundheit 4/2009.

    Google Scholar 

  • Gies, A., & Soto, A. M. (2013). Bisphenol A: Contested science, divergent safety evaluations. In European Environment Agency (EEA) (Eds.), Late lessons from early warnings: Science, precaution, innovation, chap. 10 (pp. 247–71). http://www.eea.europa.eu/publications/late-lessons-2. Last accessed May 8, 2016.

  • Jirtle, R. L., & Skinner, M. K. (2007). Environmental epigenomics and disease susceptibility. Nature Reviews Genetics, 8, 253–262.

    Article  Google Scholar 

  • Lang, I. A., Galloway, T. S., Scarlett, A., Henley, W. E., Depledge, M., Wallace, R. B., et al. (2008). Association of urinary Bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA, 300(11), 1303–1310.

    Article  Google Scholar 

  • Leranth, C., Hajszan, T., Szigeti-Buck, K., Bober, J., & MacLusky, N. J. (2008). Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates. Proceedings of the National Academy of Sciences of the United States of America, 105(37), 14187–14191.

    Article  Google Scholar 

  • National Research Council (NRC). (1983). Risk assessment in the federal government: Managing the process. Washington, DC: The National Academies Press.

    Google Scholar 

  • Newbold, R., Jefferson, W. N., & Padilla-Banks, E. (2009). Prenatal exposure to Bisphenol A at environmentally relevant doses adversely affects the murine female reproductive tract later in life. Environmental Health Perspectives, 117(6), 879–885.

    Article  Google Scholar 

  • Nilsson, E., Larsen, G., Manikkam, M., Guerrero-Bosagna, C., Savenkova, M. I., & Skinner, M. K. (2012). Environmentally induced epigenetic transgenerational inheritance of ovarian disease. PLoS ONE, 7(5), e36129.

    Article  Google Scholar 

  • Owen, C. M., & Segars, J. H, Jr. (2009). Imprinting disorders and assisted reproductive technology. Seminars in Reproductive Medicine, 27(5), 417–428.

    Article  Google Scholar 

  • Porta, M., & Lee, D.-H. (2012). Review of the science linking chemical exposures to the human risk of obesity and diabetes. Chem Trust report. http://www.chemtrust.org.uk/wp-content/uploads/CHEM-Trust-Obesity-Diabetes-Full-Report.pdf. Last accessed May 8, 2016.

  • Regulation (EC) 1107/2009 of the European Parliament and the Council of 21 October 2009 concerning the placing of plant protection products on the market and repealing Council Directives 79/117/EEC and 91/414/EEC, OJ L 309/1, November 24, 2009.

    Google Scholar 

  • Regulation (EC) 1223/2009 of the European Parliament and the Council of 30 November 2009 on cosmetic products, OJ L 342/59, December 22, 2009.

    Google Scholar 

  • Regulation (EC) 1272/2008 of the European Parliament and the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures (CLP), amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No. 1907/2006, OJL 353, December 31, 2008.

    Google Scholar 

  • Regulation (EC) 1907/2006 of the European Parliament and the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), OJ L 396/1, December 30, 2006.

    Google Scholar 

  • Regulation (EC) 1935/2004 of the European Parliament and the Council of 27 October 2004 on materials and articles intended to come into contact with food and repealing Directives 80/590/EEC and 89/109/EEC, OJ L 338/4, November 13, 2004.

    Google Scholar 

  • Regulation (EU) 528/2012 of the European Parliament and the Council of 22 May 2012 concerning the making available on the market and use of biocidal products, OJ L 167/1, June 27, 2012.

    Google Scholar 

  • Rothstein, M. A., Cai, Y., & Marchant, G. E. (2009). The ghost in our genes: Legal and ethical implications of epigenetics. Health Matrix Clevel, 19(1), 1–62.

    Google Scholar 

  • Schug, T. T., Janesick, A., Blumberg, B., & Heindel, J. (2011). Endocrine disrupting chemicals and disease susceptibility. Journal of Steroid Biochemistry and Molecular Biology, 127, 204–215.

    Article  Google Scholar 

  • Skinner, M. K. (2011). Role of epigenetics in developmental biology and transgenerational inheritance. Birth Defects Res C Embryo Today, 93, 51–55.

    Article  Google Scholar 

  • Skinner, M. K., Manikkam, M., & Guerrero-Bosagna, C. (2010). Epigenetic transgenerational action of environmental factors in disease etiology. Trends in Endocrinology and Metabolism, 21, 214–222.

    Article  Google Scholar 

  • Stöger, R. (2008). The thrifty epigenotype: An acquired and heritable predisposition for obesity and diabetes? BioEssays, 30, 156–166.

    Article  Google Scholar 

  • Susiarjo, M., Hassold, T. J., Freeman, E., & Hunt, P. A. (2007). Bisphenol A exposure in utero disrupts early oogenesis in the mouse. PLoS Genetics, 3(1), e5.

    Article  Google Scholar 

  • Svenska Dagbladet. (2013). Vi tar strid i EU om förbud mot bisfenol, February 1, 2013. http://www.svd.se/opinion/brannpunkt/vi-tar-strid-i-eu-om-forbud-mot-bisfenol_7878460.svd. Last accessed May 8, 2016.

  • Tang, W., Levin, L., Talaska, G., Yun, C., Herbstman, Y. J., Tang, D., et al. (2012). Maternal exposure to polycyclic aromatic hydrocarbons and 5’-CpG methylation of interferon-[gamma] in cord white blood cells. Environmental Health Perspectives, 120(8), 1195–1200.

    Article  Google Scholar 

  • The 2013 Berlaymont Declaration on Endocrine Disrupters. (2013). http://www.brunel.ac.uk/__data/assets/pdf_file/0005/300200/The_Berlaymont_Declaration_on_Endocrine_Disrupters.pdf. Last accessed May 8, 2016.

  • Treaty of Lisbon amending the Treaty on European Union and the Treaty establishing the European Community, OJ C 306/01 (2007), consolidated versions of the Treaties published in OJ C 326/01 (2012).

    Google Scholar 

  • Weinhold, B. (2012). More chemicals show epigenetic effects across generations. Environmental Health Perspectives, 120, 228.

    Article  Google Scholar 

  • World Health Organization International Programme on Chemical Safety (WHO/IPCS). (2002). Global assessment of the state-of-the-science of endocrine disruptors. http://www.who.int/ipcs/publications/new_issues/endocrine_disruptors/en/. Last accessed May 8, 2016.

  • World Health Organization and United Nations Environment Programme (WHO/UNEP). (2013). In Å. Bergman, J. J. Heindel, S. Jobling, K. A. Kidd, & R. T. Zoeller (Eds.), State of the science of endocrine disrupting chemicals. Geneva: WHO/UNEP. http://www.who.int/ceh/publications/endocrine/en/index.html. Last accessed May 8, 2016.

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Authors and Affiliations

  1. KIT—The Research University in the Helmholtz Association, Institute for Technology Assessment and Systems Analysis (ITAS), Karlstraße 11, 76133, Karlsruhe, Germany

    Jutta Jahnel

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  1. Jutta Jahnel
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Correspondence to Jutta Jahnel .

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Editors and Affiliations

  1. Inst.Technikfolgenab. u. Systemanalyse, Karlsruher Institut für Technologie Inst.Technikfolgenab. u. Systemanalyse, Karlsruhe, Baden-Württemberg, Germany

    Reinhard Heil

  2. Karlsruher Institut für Technologie , Karlsruhe, Germany

    Stefanie B. Seitz

  3. Inst.Technikfolgenab. u. Systemanalyse, Karlsruher Institut für Technologie , Karlsruhe, Baden-Württemberg, Germany

    Harald König

  4. Müden, Germany

    Jürgen Robienski

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Jahnel, J. (2017). Epigenetics—New Aspects of Chemicals Policy. In: Heil, R., Seitz, S., König, H., Robienski, J. (eds) Epigenetics. Technikzukünfte, Wissenschaft und Gesellschaft / Futures of Technology, Science and Society. Springer VS, Wiesbaden. https://doi.org/10.1007/978-3-658-14460-9_10

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