Studies on the Control of Asparagine Biosynthesis in Mammalian Tissues

  • M. K. PattersonJr.
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 33)


Among certain malignant tissues, sensitivity to L-asparaginase (ASNase)1 appears to be related to the nutritional requirement and biosynthesis of L-asparagine (ASN) [7, 9, 14]. With other malignant or normal tissues the relationship is not clear. From the early studies of the in vivo effects of ASNase by Kidd [10] and the in vitro nutritional requirements for ASN by McCoy et al. [11] and others [3, 15], it became apparent that under certain injection regimes or culturing conditions nutritional variants could be derived from the parent population. These variants no longer required ASN for growth and were resistant to ASNase. A similar phenomenon now appears to prevail following the clinical use of ASNase on human malignancies. A second anomoly existed in normal tissues. Those normal tissues tested showed no requirement for ASN and a resistance to ASNase, but only limited L-asparagine synthetase (ASN SYN) [4, 8, 17, 20].


Mammalian Tissue Asparagine Synthetase Cellular Parameter Nutritional Variant Relative Specific Activity 
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Copyright information

© Springer-Verlag Berlin • Heidelberg 1970

Authors and Affiliations

  • M. K. PattersonJr.
    • 1
  1. 1.Biomedical DivisionThe Samuel Roberts Noble Foundation, Inc.ArdmoreUSA

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