Abstract
Twenty-six patients were treated by daily intravenous or intramuscular injections of L-asparaginase (Bayer A) in doses of 200 IU/kg body weight or, in three cases, 1000 IU/kg. Treatment usually lasted for a period of 28 days. Twenty patients (14 children and 6 adults) had acute leukemia and the remaining patients had different types of solid tumors. Among the children with leukemia eight achieved complete remission and three partial remission. Of the remaining three children two died within 2 weeks without signs of remission and one failed to respond to 4 weeks of treatment. All adults with leukemia and all patients with solid tumors also failed to respond.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Oettgen, H. F., Old, E. A., Boyse, E. A., Campbell, H. A., Philips, F. S., Clarson, B. D., Talal, L., Leeper, R. D., Schwarz, M. K., Kim, J. H.: Inhibition of Leukemias in Man by L-Asparaginase. Cancer Rec. 27, 2619 (1967).
Fawcett, J. K., Scott, J. E.: A rapid and precise method for the determination of Urea. J. clin. Path. 13, 156 (1960).
Wide, L., Porath, J.: Radioimmunoassay of proteins with the use of Sephadex-coupled antibodies. Biochin. biophys. Acta (Amst.) 130, 257 (1966).
Porath, J. — Axén, R., Porath, J.: Radioimmunosorbent assay for proteins. Chemical couplings of antibodies to insoluble dextran. Immunochemistry 4, 381 (1967).
Porath, J. Axén, R., Porath, J. — Bennich, H., Johansson, S. G. O.: Diagnosis of allergy by an in-vitro test for allergen antibodies. Lancet II, 1105 (1967).
Porath, J. Axén, R., Porath, J. Bennich, H., Johansson, S. G. O. — Radioimmunoassays employing immunosorbents. Acta endocr. Supplement 142, 207 (1969).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1970 Springer-Verlag Berlin • Heidelberg
About this chapter
Cite this chapter
Dohlwitz, A. et al. (1970). Studies on Antibody Formation in Patients Treated with L-Asparaginase. In: Grundmann, E., Oettgen, H.F. (eds) Experimental and Clinical Effects of L-Asparaginase. Recent Results in Cancer Research, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-99984-0_25
Download citation
DOI: https://doi.org/10.1007/978-3-642-99984-0_25
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-99986-4
Online ISBN: 978-3-642-99984-0
eBook Packages: Springer Book Archive