Zusammenfassung
In diesem Kapitel werden Wirkungen gestagener Steroide abgehandelt, die diese Substanzen neben ihren eigentlichen sexual-spezifischen Effekten haben können, die also unspezifischer Natur sind. Besonders wichtig und als mögliche Nebenwirkungen in Frage kommend sind die Beeinflussung des Mineralstoffwechsels durch Progesteron, die anaesthetische Wirkung sowie die Hemmung der ACTH-Sekretion durch bestimmte Gestagene, die eine inhärente Corticoidwirkung besitzen. Alle übrigen ,sonstigen Wirkungen‘, abgesehen auch von den sexual-spezifischen Effekten bei Amphibien und Fischen, sind relativ uncharakteristisch. Der Bericht darüber kann daher nur als Nachschlagwerk aufgefaßt werden, wobei auf Vollständigkeit Wert gelegt wurde. Da es sich außer bei den genannten Ausnahmen überwiegend um uncharakteristische Wirkungen handelt, sind die berichteten Ergebnisse häufig widersprüchlich. Der Grund dafür liegt außerdem in den erheblichen zeitlichen und räumlichen Distanzen und dem sicherlich verschiedenen Tiermaterial. In den meisten Fällen wurden die bei den Versuchen angewandten Lösungsmittel nicht angegeben, die bekanntlich weit stärkere Effekte haben können als die gelösten Gestagene selbst. Außerdem sind zur Herstellung einer wäßrigen Lösung von Progesteron z.B. Mengen an Lösungsvermittler erforderlich, die etwa das 15fache des Progesterons selbst betragen. Auf diese Fakten hinzuweisen erscheint auch im Hinblick auf die hohen Dosen notwendig, die die Autoren häufig zur Erzielung unspezifischer pharmakologischer Effekte anwenden mußten.
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Kramer, M., Damrosch, L., Klink, G. (1968). Sonstige Wirkungen von Gestagenen. In: Damrosch, L., et al. Die Gestagene. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 22 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-99941-3_5
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