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Metabolism of Organophosphorus Anticholinesterase Agents

  • Chapter
Cholinesterases and Anticholinesterase Agents

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 15))

Abstract

The growth of the chemical industry has brought a large number of new compounds into common use. Technological developments are sometimes attended by toxicological problems, the study of which in certain cases has led to significant advances in biochemical knowledge. An example of this has been provided by the development of a group of organic derivatives of phosphoric acid, some of which are among the most poisonous substances known. Many of these compounds, originally developed as pesticides, are also useful tools in physiology and biochemistry and may provide new drugs for medicine. A number of organophosphorus compounds have been considered as potential chemical warfare agents, and other related substances are finding new uses in chemical industries Balls and Jansen (1953) have pointed out that any extensively toxic substance is to be suspected a priori of being an inhibitor of some vitally important enzyme system, and the physiological process characteristic of a number of organophosphorus compounds was found to be the inhibition of cholinesterases (ChE’s).

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  1. L. A. Mounter
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Editors and Affiliations

  1. Department of Pharmacology, Schools of Medicine, University of Pennsylvania, Philadelphia 4, Pa., USA

    George B. Koelle Ph.D., M.D. (Professor and Chairman) (Professor and Chairman)

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Mounter, L.A. (1963). Metabolism of Organophosphorus Anticholinesterase Agents. In: Koelle, G.B. (eds) Cholinesterases and Anticholinesterase Agents. Handbook of Experimental Pharmacology, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-99875-1_10

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  • DOI: https://doi.org/10.1007/978-3-642-99875-1_10

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