Zusammenfassung
Die Kinetik der Opioide hängt ab von der Verabreichungsform.
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Literatur
Beachte, daß evtl. einzelne Literaturstellen im Buchteil A oder in entsprechenden Wirkstoffprofilen zu finden sind.
Abajian JC, Mellish PWI, Brolone AE et al.(1984) Spinal anesthesia for the high risk infant. Anesth Analg; 63: 359–362
Abbott WO, Pendergrass EP (1936) Intubation studies of the human small intestine. V. The motor effects of single clinical doses of morphine sulphate in normal subjects. Am J Roentgen 35: 289–299
Abboud TK, Dror A, Mosaad P et al. (1988) Minidose intrathecal morphine for the relief of post-ces-arean section pain: Safety, efficacy and ventilatory responses to carbon dioxide. Anesth Analg 67: 137–143
Abboud TK, Lee K, Zhu J et al. (1990) Prophylactic oral naltrexone with intrathecal morphine in ces-arean section: Effects of adverse reactions and analgesia. Anesth Analg 71: 367–370
Abboud TK, Zhu J, Gangolly J et al. (1991) Transnasal butorphanol: a new method for pain relief in post-cesarean section pain. Anesthesiology 35: 14–18
Abid A, Benhamou D, Labaille T (1990) Analgésie postopératoire après césarienne: buprénorphine sublinguale versus morphine sous-cutanée. Ann F Anesth Réan 9: 275–279
Abouleish E (1988) Apnoe associated with the intrathecal administration of morphine in obstetrics. A case report. Br J Anaesth 60: 592–594
Ackermann WE, Juneja MM, Kaczorowski DM et al. (1989) A comparison of the incidence of pruritus following epidural opioid administration in the parturient. Can J Anaesth 36: 388–391
Adams JU, Holtzman SC (1990) Pharmacologic characterization of the sensitization to the rate-decreasing effects of naltexone induced by acute opioid pretreatment in rats. J Pharmacol Exp Ther 253/2: 483–489
Adams AP, Pybus DA (1978) Delayed respiratory depression after use of fentanyl during anaesthesia. Br Med J 1: 278–279
Adams JU, Paronis CA, Holtzman SG (1990) Assessment of relative intrinsic activity of mu-opioid analgesics in vivo by using beta-funaltrexamine. J Pharmacol Exp Ther 255/3: 1027–1032
Adler TK, Fujimoto JM, Way EL et al. (1955) The metabolic fate of codeine in man. J Pharmacol 114: 251–262
Adriani J (1970) The pharmacology of anaesthetic drugs. Charles C Thomas, 5th ed, 1970: 118
Aguwa CN, Olusanya OA (1978) Analgesic prescribing for severe pain studied. Drug Intell Clin Pharm 12: 556
Aimone LD, Yaksh TL (1989) Opioid modulation of capsaicin-evoked release of substance P from rat spinal cord in vivo. Peptides 10: 1127–1131
Aitkenhead AR, Robinson S (1990) Influence of morphine and pethidine on the incidence of anasto-motic dehiscence after colonic surgery. Br J Anaesth Suppl.: 230–231
Akerman B, Arweström E, Post C (1988) Local anesthetics potentiate spinal morphine antinociception. Anesth Analg 67: 943–948
Akil H, Liebeskind JC (1975) Monoaminergic mechanisms of stimulation-produced analgesia. Brain Res 94: 279–296
Akil H, Watson ST, Young E et al. (1984) Endogenous opioids: biology and function. Annu Rev Neu-rosci 7: 233–255
Aldrete JA, Roman-de-Jesus JC, Russell LJ et al. (1987) Intranasal ketamine as induction in children: preliminary report. Anesthesiology 67: A514
Alguacil LF, Alamo C, Santos A et al. (1987) Yohimbine reduces morphine tolerance in guinea-pig ileum. Life Sci 40: 155–160
Ali J, Khan TA (1979) The comparative effects of muscle transection and median upper abdominal incisions on postoperative pulmonary function. Surg Gynecol Obst 148: 863–866
Ali J, Weisel RD, Layug AB et al. (1974) Consequences of postoperative alterations in respiratory mechanics. Am J Surg 128: 376–382
Ali NMK (1986) Hyperalgesic response in a patient receiving high concentrations of spinal morphine. Anesthesiology 65: 449
Allen CR, Murphy MA, Meek WJ (1945) The action of morphine in slowing the heart rate of unconditioned dog. Anesthesiology 6: 149–153
Ammer H, Schulz R (1993) Alterations in the expression of G-Proteins and regulation of adenylate cyclase in human neuroblastoma SH-sysy cells chronically exposed to low-efficacy mu-opioids. Bio-chem J 295: 263–271
Andersen R, Krogh K (1976) Pain as a major cause of postoperative nausea. Can Soc J 23: 366–369
Andrée RA (1980) Sudden death following naloxone administration. Anesth Analg 59: 782–784
Angell J (1982) The quality of mercy. N Engl J Med 306: 98–99
Appelmans N, Carroll JA, Rance MJ et al. (1986) Sodium ions increase the binding fo the antagonist peptide ICI 174864 to the δ-opiate receptor. Neuropept 7: 129–143
Archer S (1993) Chemistry of nonpeptide opioids. In: Herz (ed) A Opioids I. Springer, Berlin Heidelberg New York Tokyo, p 251
Arkinstall B, Goughinour B, Stewart J et al. (1986) Double-blind crossover comparison between sustained release morphine tablets and oral morphine solution in patients with severe pain: A preliminary report. In: Band P, Stewart J, Towson T (eds) Advances in the management of chronic pain. Purdue Frederick, Toronto, pp 51–56
Arturson G (1990) Possible involvement of arachidonic acid metabolites in thermal trauma. In: Dole-cek R, Brizio-Molteni L, Molteni A, Traber D (eds) Endocrinology of thermal trauma. Lea & Febiger, London, pp 238–250
Arunasalam K, Davenport HT, Painter S et al. (1983) Ventilatory response to morphine in young and old subjects. Anaesthesia 38: 529–533
Asbury AJ (1986) Pupil response to alfentanil and fentanyl. A study in patients anaesthetized with halothane. Anaesthesia 41: 717–720
Ashton N, Balment RJ, Blackburn TP (1990) Kappa opioid receptor agonists modulate the renal excretion of water and electrolytes in anaesthetized rats. Br J Pharm 99: 181–185
Askitopoulou H, Whitwam JG, Al-Khudhairi D et al. (1985) Acute tolerance to fentanyl during anesthesia in dogs. Anesthesiology 63: 255–261
Atkinson RL (1982) Naloxone decreases food intake in obese humans. J Clin Endocrin Metab 55: 196–198
Atkinson RL, Berke LK, Drake CR et al. (1985) Effects of long-term therapy with naltrexone in obese humans. Int J Obes 9: 347–353
Atweh SF, Kuhar MJ (1977) Autoradiographic localization of opiate receptors in rat brain. II. The brain stem. Brain Res 129: 1–12
Au J, Walker WS, Scott DHT (1991) Withdrawal syndrome after propofol. Letter. Anaesthesia 45: 741–742
Aungst BJ, Husscin MA (1992) Sustained propranolol delivery and increased oral bioavailability in dogs given a propranolol laurate salt. Pharmaceut Res 9: 1507–1509
Ausems ME, Hug CC jr, De Lange S (1983) Variable rate infusion of alfentanil as a supplement to nitrous oxide anesthesia for general surgery. Anesth Analg 62: 982–986
Ausems JM, Stanski DR, Hug CC jr (1985) An evaluation of the accuracy of pharmacokinetic data for the computer assisted infusion of alfentanil. Br J Anaesth 57: 1217–1225
Ausems ME, Vuyk J, Hug CC jr et al. (1988) Comparison of a computer-assisted infusion versus intermittent bolus administration of alfentanil as a supplement to nitrous oxide for lower abdominal surgery. Anesthesiology 68: 851–861
Austin KL, Stapleton JV, Mather LE (1980) Multiple intramuscular injections: a major source of variability in analgesic response to meperidine. Pain 8: 47–51
Ayesta FJ, Ableitner A, Emmett Oglesby MW et al. (1992) Paradoxical effect of chronic fentanyl treatment on naltrexone-induced supersensitivity and up-regulation. J Pharmacol Exp Ther 260: 168–174
Azar I, Patel AK, Phau CQ (1981) Cardiovascular responses following naloxone administration during enflurane anesthesia. Anesth Analg 60: 237–238
Azar I, Turndorf H (1979) Severe hypertension and multiple atrial premature contractions following naloxone administration. Anesth Analg 58: 524–525
Baghdoyan HA, Spotts JL, Snyder SG (1993) Simultaneous pontine and basal forebrain microinjections of carbachol suppresses REM sleep. J Neuroscience 13: 227–240
Bailey PL, Wilbrink J, Zwanikken P et al. (1985) Anesthetic induction with fentanyl. Anesth Analg 64: 48–53
Bailey PL, Clark NJ, Pace NL et al. (1987) Antagonism of postoperative opioid-induced respiratory depression: nalbuphine versus naloxone. Anesth Analg 66: 1109–1114
Bailey PL, Pace N, Ashburn M et al. (1990) Frequent hypoxemia and apnea after sedation with mida-zolam and fentanyl. Anesthesiology 73: 826–830
Ballantyne JC, Loach AB, Carr DB (1988) Itching after epidural and spinal opiates. Pain 33: 149–160
Barash P, Kopriva C, Giles R et al. (1980) Global ventricular function and intubation: Radionuclear profiles. Anesthesiology 53: S109
Barber A (1993) Mu-and kappa-opioid receptor agonists produce peripheral inhibition of neurogenic plasma extravasation in the rat skin. Eur J Pharmacol 236: 113–120
Barnwell SG, Laudanski T, Story MJ et al. (1992) Improved oral bioavailability of propranolol in healthy human volunteers using a liver bypass drug delivery system containing oleic acid. Int J Pharmacol 88: 423–432
Barrie HJ (1941) Meningitis following spinal anesthesia. Lancet I: 242–243
Bartlett EE, Hutaserani O (1961) Xylocaine for the relief of postoperativ pain. Anesth Analg 40: 296–300
Baskoff JD, Watson RL, Muldoon SM (1980) Respiratory arrest after intrathecal morphine. Anesth Rev 7: 12–15
Bauer AJ, Szurszewski JH (1991) Effect of opioid peptides on circular muscle of canine duodenum. J Physiol 434: 409–422
Bauer AJ, Sarr MG, Szurszewski JH (1991) Opioids inhibit neuromuscular transmission in circular muscle of human and baboon jejunum. Gastroenterology 101: 970–976
Beaver WT, Wallenstein SL, Houde RW et al. (1967) A clinical comparison of the analgesic effects of methadone and morphine administered intramusculary, and of orally and parenterally administered methadone. Clin Pharm Ther 8: 415
Becker LD, Paulson BA, Miller RD et al. (1976) Biphasis respiratory depression after fentanyl-droperi-dol or fentanyl alone used to supplement nitrous oxide anesthesia. Anesthesiology 44: 291–296
Behar M, Olshwang D, Magora F et al. (1979) Epidural morphine in treatmentof pain. Lancet I: 527–529
Bell MD, Murray GR, Mishra P et al. (1985) Buccal morphine — a new routine for analgesia? Lancet I: 71–73
Bellville JW (1964) Pentazocine vs morphine. JAMA 189: 332
Bellville JW, Seed JC (1960) The effects of drugs on the respiratory response to carbon dioxide. Anesthesiology 21: 727
Benedetti C, Premuda L (1990) The history of opium and ist derivatives. In: Benedetti C, Chapman CR, Giron G (eds) Advances in pain research and therapy, vol 14. Raven, New York, pp 1–35
Bennett MJ, Anderson LK, McMillan JC et al. (1986) Anaphylactic reaction during anesthesia associated with positive intradermal skin test to fentanyl. Can Anaesth Soc J 33: 75–78
Bennett RL, Batenhorst RL, Bivins BA et al. (1982) Patient-controlled analgesia: a new concept of postoperative pain relief. Ann Surg 195: 700–705
Benthuysen JL, Smith NT, Sanford TJ et al. (1986) Physiology of alfentanil-induced rigidity. Anesthesiology 64: 440–446
Benzer A, Haussler R (1992) Increase in cerebrospinal fluid pressure in normocapnic volunteers in response to nalbuphine. Eur J Clin Pharm 43: 193–195
Bentley JB, Borel JD, Nenad RE et al. (1982) Age and fentanyl pharmacokinetics. Anesth Analg 61: 968–971
Benzer A, Gottardis M, Russegger et al. (1992) Fentanyl increases cerebrospinal fluid pressure in normocapnic volunteers. Eur J Anaesth 9: 473–477
Bergh GS, Layne JA (1940) A demonstration of the independent contraction of the sphincter of the commone bile duct in human subjects. Am J Physiol 128: 690–694
Berkowitz BA (1976) The relationship of pharmacokinetics to pharmacological activity: morphine, methadone and naloxone. Clin Pharmacokin 1: 219–230
Berkowitz BA, Ngai SH, Yang JC et al. (1975) The dispositions of morphine in surgical patients. Clin Pharmacol Ther 17: 629–635
Berman RS, Eisele JH (1978) Bacteremia, spinal anesthesia, and development of meningitis. Anesthesiology 48: 376–377
Bernard C (1869) Thérapeutique médicale: des effets physiologiques de la morphine et de leur combinaison avec ceux du chloroforme. (Keine Verlagsangabe)
Bernard J, Hommerol J, Passuti N et al. (1991) Postoperative analgesia by intravenous donidine. Anesthesiology 75: 577–582
Bernards CM (1993) Flux of morphine, fentanyl, and alfentanil through rabbit arteries in vivo. Anesthesiology 78: 1126–1131
Bernards CM, Hill HF (1991) The spinal nerve root sleeve is not a preferred route for redistribution of drugs from the epidural space to the spinal cord. Anesthesiology 75: 827–832
Bernards CM, Hillf HF (1990) Morphine and alfentanil permeability through the spinal dura, arachnoid and pia mater of dogs and monkeys. Anesthesiology 73: 1214–1219
Bernards CM, Hill HF (1992) Physical and chemical properties of drug molecules governing their diffusion through the spinal méninges. Anesthesiology 77: 750–756
Besse D, Lombard MC, Zajac JM et al. (1990) Pre-and postsynaptic distribution of mu, delta and kappa opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord. Brain Res 521: 15–22
Beubler E, Badhri P (1990) Comparison of the antisecretory effects of loperamide and loperamide oxide in the jejunum and the colon of rats in-vivo. J Pharm Pharmacol 42: 689–692
Beubler E, Lembeck F (1979) Inhibition of stimulated fluid secretion in the rat small and large intestine by opiate agonists. Naunyn Schmiedebergs Arch Pharmacol 306: 113–118
Beubler E, Lembeck F (1980) Inhibition by morphine of prostaglandin E1-stimulated secretion and cyclic adenosine 3′,5′-monophosphate formation in the rat jejunum in vivo. Br J Pharmacol 68: 513–518
Beubler E, Badhri P, Schirgi-Degen A (1993) Antisecretory activities of orally administered loperamide and loperamide oxide on intestinal secretion in rats. J Pharm Pharmacol 45: 803–806
Beyer C, Roberts LA, Kornizaruk BR (1985) Hyperalgesia induced by altered glycinergic activity at the spinal cord. Life Sci 237: 875–882
Bidwai AV, Stanley TH, Bloomer et al. (1975) Effects of anesthetic doses of morphine on renal function in the dog. Anesth Analg 54: 357–360
Bijlsma JW, Van den Brink BR (1992) Estrogens and rheumatoid arthritis. Am J Rep Immunol 28: 231–234
Bircher B, Sharifi S (1991) Drug dosage in patients with liver disease. In: Mclntyre N, Benhamou JP, Bircher J, Rizzetto M, Rodes J (eds) Oxford textbook of clinical hepatology, vol 2. Oxford Univ Press, Oxford, pp 1388–1400
Björkqvist SE (1975) Clonidine in alcohol withdrawal. Acta Psych Scand 52: 256–263
Bloor BC, Flacke WE (1982) Reduction in halothane anesthetic requirement by clonidine, an alpha-adrenergic agonist. Anaesth Analg 61: 741–745
Boas RA, Villiger JW (1985) Clinical actions of fentanyl and buprenorphine: the significance of receptor binding. Br J Anaesth 57: 192–196
Boas RA, Covino BG, Shahnarian A (1982) Analgesic responses to i.v. lignocaine. Br J Anaesth 54: 501–5
Bodnar RJ, Williams CL, Lee SJ et al. (1988) Role of mu-1-opiate receptors in supraspinal opiate analgesia: a microinjection study. Brain Res 447: 25–34
Bodo RC, Co Tui FW, Benaglia HE (1937) Studies on the mechanism of morphine hyperglycemia. The role of sympathetic nervous system with special reference to the sympathetic supply to the liver. J Pharmacol Exp Ther 62: 88–105
Bohne P, Fuxe K, Agnati L et al. (1978) Cardiovascular effects of morphine and opioid peptides following intracisternal administration in chloraloseanesthetized rats. Eur J Pharmacol 48: 319–324
Bond A, Seijas D, Dawing S et al. (1994) Systemic absorption and abuse liability of snorted flunitraze-pam. Addiction 89: 821–830
Bonica JJ, Ventafridda V (1990) Pain Control with anticancer modalities. In: Bonica JJ (ed) The management of pain, 2nd edn. Lea & Febiger, Philadelphia, p 429
Bonnet F, Boico O, Rostaing S et al. (1990) Clonidine induced analgesia in postoperative patients: epidural versus intramuscular administration. Anesthesiology 72: 423–427
Booker PD, Bryson THL, Beddard J (1980) Obstetric pain relief using epidural morphine. Anaesthesia 37: 377–379
Boos G, Sloan P, Thirlwell M et al. (1987) Steady-state pharmacokinetics of sustained release morphine tablets (MS contin) and morphine sulfate solution (MSS). Proc Am Soc Clin Oncol 6: 44
Borgbjerg FM, Nielsen K, Franks J (1994) Pain stimulates respiration and attenuates respiratory depression following i.v. morphine. Scand ASP 1994: 13
Borgeat A, Saiah M, Rifat K (1991) Does propofol relieve epidural or subarachnoid morphine-induced pruritus? Letter. Reg Anesth 16: 245
Borgeat A, Wilder-Smith OHG, Saiah M et al. (1992) Subhypnotic doses of propofol relieve pruritus induced by epidural and intrathecal morphine. Anesthesiology 76: 510–512
Bornschein RL, Crockett RS, Smith RP (1977) Diurnal variations in the analgesic effectiveness of morphine in mice. Pharmacol Biochem Behavior 6: 621–626
Borsook D (1994) Opioids and neurotrophic effects. Curr Opin Anaesthesiology 7: 352–357
Boudoulas H, Lewis RP, Rittgers SE et al. (1979) Increased diastolic time: A possible important factor in the beneficial effect of propranolol in patients with coronary artery disease. J Cardiovasc Pharmacol 1: 503–513
Bouhassira D, Villanueva L, Le Bars D (1992) Effects of systemic morphine on diffuse noxious inhibitory controls: role of the periaqueductal grey. Eur J Pharmacol 216: 149–152
Boulard G, Arnauld E, Guerin J et al. (1982) Hormone antidiurétique, ACTH et prolactine plasmatique au cours de l’administration de fentanyl chez l’homme. Agressologie 23: 43–46
Bourke DL, Furman WR (1993) Improved postoperative analgesia with morphine added to axillary block solutions. J Clin Anesth 5: 114–117
Bovill JG, Sebel PS (1980) Pharmacokinetics of high-dose fentanyl: A study in patients undergoing cardiac surgery. Br J Anaesth 1980; 52: 795–801
Bovill JG, Sebel PS, Blackburn CL et al. (1981) The pharmacokinetics of alfentanil. Anesthesiology 55: A174
Bovill JG, Sebel PS, Wauqier A, Rog P (1981) Effects of high-dose fentanyl anesthesia on the electroencephalogram. Anesthesiology 55: 203–211
Bovill JG, Sebel PS, Wauqier A et al. (1983) Influence of high-dose alfentanil on the electroencephalogram: Correlation with plasma concentrations. Br J Anaesth 55 (SuppL): 199–209
Bowdle TA (1990) Opioid antagonists and agonist-antagonist combinations. In: ASA Annual Refresher Course Lectures, October 19–23 (Las Vegas), 125: 1–7
Bower S (1981) Plasma protein binding of fentanyl. J Pharm Pharmacol 33: 507–513
Bower S, Hull CJ (1983) Comparative pharmacokinetics of fentanyl and alfentanil. Br J Anaesth 54: 871–877
Boysen K, Hertel S, Chraemmer-Jorgensen B et al. (1988) Buprenorphine antagonism of ventilatory depression following fentanyl anaesthesia. Anesthesiology 32: 490–492
Brase DA, Ward CR, Bey PS et al. (1991) Antagonism of the morphine-induced locomotor activation of mice by fructose: comparison with othe opiates and sugars, and sugar effects on brain morphine. Life Sci 49(10): 727–734
Brashear R, Cornog J, Forney R (1973) Cardiovascular effects of heroin in the dog. Anesth Analg 52: 323–327
Brenneis C, Michaud M, Bruera E et al. (1986) Local toxicity during subcutaneous infusion of narcotics: a prospective study. In: 6th WC on the Care of the Terminally 111 (Proc., Montreal, September)
Brodin E, Gazelius B, Panopoulos P et al. (1983) Morphine inhibits substance P release from peripheral sensory nerve endings. Acta Physiol Scand 117: 567–570
Bromage PR, Camporesi EM, Durant PAC et al. (1982) Rostral spread of epidural morphine. Anesthesiology 56: 431–436
Bromm B, Forth W, Richter E et al. (1992) Effects of acetaminophen and antipyrine on non-inflammatory pain and EEG activity. Pain 50: 213–221
Brownridge P (1986) Shivering related to epidural blockade with bupivacaince in labour, and the influence of epidural pethidine. Anaesth Intensive Care 14: 412–417
Bruera E, Brenneis C, Michaud M et al. (1987) Continuous subcutaneous infusion of narcotics using a portable disposable device in patients with advanced cancer. Cancer Treat Rep 71: 635–637
Bruera E, Brenneis C, MacDonald RN (1987) Continuous infusion of narcotics for the treatment of cancer pain. Cancer Treat Rep 71: 953–957
Bruera E, Brenneis C, Michaud M et al. (1988) Patient-controlled subcutaneous hydromorphone versus continuous subcutaneous infusion for the treatment of cancer pain. J Natl Cancer Inst 80: 1152–1154
Bruera E, Brenneis C, Michaud M et al. (1988) Use of the subcutaneous route of the administration of narcotics in patients with cancer pain. Cancer 62: 407–411
Bruera E, Macmillan K, Pither J et al. (1990) Effects of morphine on the dyspnea of terminal cancer patients. J Pain Sympt Man 5: 341–344
Bruera E, Macmillan K, Selmser P et al. (1990) Decreased local toxicity with subcutaneous diamorphine (heroin): a preliminary report. Pain 43(1): 91–94
Bruera E, de Stoutz N, Velasco-Leiva A et al. (1993) Effects of oxygen on dyspnoea in hypoxaemic terminal-cancer patients. Lancet 342: 13–14
Bruni JF, Van Vugt D, Mashall S et al. (1977) Effects of naloxone, morphine, methionine enkephalin on serum prolactin, luteinizing hormones, follicle stimulating hormones, thyroid stimulating hormone and growth hormone. Life Sci 21: 461–466
Brunk SF, Delle M (1974) Morphine metabolism in man. Clin Pharmacol Ther 16: 51–57
Bullingham RES, McQuay HJ, Moore RA et al. (1980) Buprenorphine kinetics. Clin Pharm Ther 28: 667–672
Bullingham RES, McQuay HJ, Dwyer D et al. (1981) Sublingual buprenorphine used postopera-tively: clinical observations and preliminary pharmacokinetic analysis. Br J Clin Pharmacol 12: 117–122
Bullingham RES, O’Sullivan G, McQuay HJ et al. (1983) Perineural injection of morphine fails to relieve postoperative pain in humans. Anesth Analg 62: 164–167
Bullingham RES, McQuay HJ, Moore RA (1984) Studies on the peripheral action of opioids in postoperative pain in man. Acta Anaesthesiol Belg 35 SuppL: 285–290
Bunegin L, Albin MS, Ernst PS et al. (1989) Cerebrovascular responses to sufentanil citrate in primates with and without intracranial hypertension. J Neurosurg Anesth 2: 138–139
Burks TF (1973) Mediation by 5-hydroxytryptamine of morphine stimulant actions in dog intestine. J Pharmacol Exp Ther 185: 530–539
Burks TF (1976) Gastrointestinal pharmacology. Ann Rev Pharmacol 16: 15–31
Burks TF (1980) Central sites of gastrointestinal drugs. Gastroenterology 74: 322–324
Burks TF, Long JP (1967) Release of intestinal 5-hydroxytryptamine by morphine and related agents. J Pharmacol Exp Ther 158: 264–271
Butel B (1995) L’opium. Histoire d’une fascination. Perrin, Paris.
Butsch WL, McGowan JM (1936) Clinical studies on the influence of certain drugs related to biliary pain and to the variations in intrabiliary pressure. Surg Gynecol Obstet 63: 451–456
Calderone G, Léglise M, Giampietro M et al. (1986) Antropometric, body composition, biological maturation and growth prediction in young female gymnasts of high agonistic level. J Sports Med 26: 263–273
Calvey TN, Milne IA, Williams NE (1983) Effect of antacid on the plasma concentration of phenoperi-dine. Br J Anaesth 55: 535–539
Camann WR, Hurley RH, Gilbertson LI et al. (1991) Epidural nalbuphine for analgesia following caesarean delivery; dose-response and effect of local anaesthetic choice. Can J Anaesth 38: 728–732
Camann WR, Loferski BL, Fanciullo GJ et al. (1992) Does epidural administration of butorphanol offer any clinical advantage over the intravenous route? Anesthesiology 76: 216–220
Campbell CF, Mason JB, Weiler JM (1983) Continuous cubcutaneous infusion of morphine for the pain of terminal malignancy. Ann Intern Med 98: 51–52
Campos AE, Luján M, Lopez E et al. (1983) Circadian variation in the lethal effect of morphine in the mouse. Proc West Pharmacol Soc 26: 101–103
Caplan RA, Ready LB, Olsson GL et al. (1986) Transdermal delivery of fentanyl for postoperative control. Anesthesiology 65: A196
Cardan E (1984) Herpes simplex after spinal morphine. Letter. Anaesthesia 39: 1031
Cardena HL, Ross DH (1976) Calcium depletion of synaptosomes after morphine treatment. Br J Pharmacol 57: 521–526
Cardenas HL, Ross DH (1975) Morphine induced depletion of calcium in discrete regions of rat brain. J Neurochem 24: 487–493
Carp H, Bailey S (1992) The association between meningitis and durai puncture in bacteremic rats. Anesthesiology 76: 739–742
Carr DJJ, Kim CH, DeCosta BR et al. (1989) Opioid receptors on cells of the immune systems: evidence for δ-and ϰ-selective opioid agonists. J Endocrin 122: 161
Carr DJJ, DeCosta BR, Radesca L et al. (1991) Functional assessment and partial characterization of [3H](+)-pentazocine binding sites on cells of the immune system. J Neuroimmuno 35: 153
Carr DJJ, Mayo S, Woolley TW et al. (1992) Immunoregulatory properties of (+)-pentazocine and sigma ligands. Immunology 77/4: 527–531
Carter BD, Medzihradsky F (1993) Receptor mechanisms of opioid tolerance in SH-SY5Y human neural cells. Mol Pharmacol 43: 465–473
Cassuto J, Wallin G, Höggström S et al. (1985) Inhibition of postoperative pain by continuous low-dose intravenous infusion of lidocaine. Anesth Analg 64: 971–974
Cassuto J, Nellgard P, Stage L et al. (1990) Amide local anaesthetics reduce albumin extravasation in burn injuries. Anesthesiology 72: 302–307
Cavazzuti M, Porro CA, Barbieri A et al. (1991) Brain and spinal cord metabolic activity during pro-pofol anaesthesia. Br J Anaesth 66: 490–495
Celesia GC, Jasper HH (1966) Acetylcholine released from cerebral cortex in relation to state of activation. Neurology 16: 1053–1063
Chabal C, Russell LC, Burchiel KJ (1989) The effect of intravenous lidocaine, tocainide, and mexiletine on spontaneously active fibers originating in rat sciatic neuromas. Pain 38: 333–338
Chabal C, Jacobson L, Mariano A et al. (1992) The use of oral mexiteline for the treatment of pain after peripheral nerve injury. Anesthesiology 76: 513–517
Chambers FA, McCarroll M, MacSullivan R (1994) Polyarthralgia and amenorhoea as a complication of intrathecally infused morphine and Dilaud in the treatment of chronic benign back pain. Correspondence. Br J Anaesth 72(6): 734
Chang HM, Berde CB, Holz IV et al. (1989) Sufentanil, morphine. met-enkephalin and k-agonist (U-50488) inhibit substance P release from primary sensory neurons: a model for presynaptic spinal opioid actions. Anesthesiology 70: 672–677
Chang J, Fish KJ (1985) Acute respiratory arrest and rigidity after anesthesia with sufentanil: A case report. Anesthesiology 63: 710–711
Chan K, Kendall MJ, Mitchard M et al. (1975) The effect of aging on plasma pethidine concentrations. Br J Clin Pharm 2: 297–302
Chapman CR, Benedetti C (1977) Analgesia following transcutaneous electrical stimulation and its partial reversal by a narcotic antagonist. Life Sci 21: 1645–1648
Chapman V, Dickenson AH (1992) The combination of NMD A antagonism and morphine produces profound antinociception in the rat dorsal horn. Brain Res 573: 321–323
Chapman WP, Rowlands EN, Jones CM (1950) Multiple-balloon kymographif recording of the comparative action of demerol, morphine and placebos in the motility of the upper small intestine in man. N Engl J Med 243: 171–177
Charman WNA, Stella VJ (1986) Estimating the maximal potential for intestinal lymphatic transport of liphilic molecules. Int J Pharmaceut 34: 175–178
Chavkin C, Goldstein A (1982) Reduction in opiate receptor reserve in morphine-tolerant guinea pig ilea. Life Sci 31: 1687–1690
Chavkin A, Goldstein A (1984) Opioid receptor reserve in normal and morphine-tolerant guinea pig ileum myenteric plexus. Proc Natl Ac Sci USA 81: 7253–7257
Chen Y, Mestek A, Liu J et al. (1993) Molecular cloning and functional expression of a β-opioid receptor from rat brain. Mol Pharmac 44: 8–12
Cheng P, Decena J, Wu D et al. (1991) The effects of selective mu-1, opiate receptor blockade on breathing patterns in the fetal lamb. Ped Res 30: 202–206
Cherry DA (1987) Drug delivery systems for epidural administration of opioids. Anesthesiology 85(S): 54–59
Chestnut DH (1991) Editorial views: epidural anesthesia and instrumental vaginal delivery. Anesthesiology 74: 805–808
Chestnut DH (1992) Editorial views: spinal anesthesia in the febrile patient. Anesthesiology 76: 667–669
Childers SR (1993) Opioid receptor-coupled second messenger systems. In: Herz A (ed) Opioids I. Springer, Berlin Heidelberg New York Tokyo, pp 189–216
Chmielewski DH, Brewton ES (1987) Comparative bio availability of multiple doses of sustained release morphine tablets (Roxanol SR q 12 h) and immediate release morphine solution (q 4 h). Proc Am Soc Clin Oncol 6: 375
Choonara I, Laurence A, Michalkiewicz A et al. (1992) Morphine metabolism in neonates and infants. Br J Clin Pharmacol 34: 434–437
Chou DT, Wang SC (1975) Studies on the localization of central cough mechanisms. Sites of action of antitussive drugs. J Pharmacol Exp Ther 194: 499–505
Christensen V (1980) Respiratory depression after extradural morphine. Br J Anaesth 52: 841
Christian CM, Waller JL, Moldenhauer OC (1983) Postoperative rigidity following fentanyl anesthesia. Anesthesiology 58: 275–277
Chrousos GP (1992) Regulation and dysregulation of the hypothalamic-pituitary-adrenal axis. Endo-crinol Metab Clin North Am 21: 833–853
Chrubasik J, Meynadier J, Scherpereel P (1985) Somatostatin versus morphine in epidural treatment after major abdominal operations. Anesthesiology 63: A237
Chrubasik J, Geller E, Niv D (1987) Morphin inhalation versus intravenous infusion of pain treatment after abdominal surgery. Anesth Analg 66: S 29
Chrubasik J, Wust H, Griedrich G et al. (1988) Absorption and bioavailability of nebulized morphine. Br J Anaesth 61: 228
Chrubasik J, Friedrich G, Geller E (1988) Absorption and bioavailability of morphine offered via inhalation. Reg Anesth 67: S 266
Chugani HT, Ackerman RF, Chugani DC et al. (1984) Opioid-induced epileptogenic phenomena: anatomical, behavioral, and electroenephalographic features. Ann Neurol 15: 361–368
Cicero TJ, Bell RD, Wiest WG et al. (1975) Function of the male sex organs in heroin and methadone users. N Engl J Med 292: 882–887
Ciaessens AL, Malina RM, Lefevre JL et al. (1989) Growth and pubertal development of young female gymnasts and swimmers: a correlation with parental data. Int J Sports Med 10: 87–91
Clark JA, Liu L, Price M et al. (1989) Kappa opiate receptor multiplicity: evidence for two U50,488-sen-sitive K-1-subtypes and a novel K-3-subtype. J Pharmacol Exp Ther 251: 461–468
Cleeland CS (1984) The impact of pain on the patient with cancer. Cancer 54: 2635–2641
Cleeland CS (1987) Barriers to the management of the hospice patient. Oncology 1 Suppl: 19–26
Cohen F (1980) Postsurgical pain relief: patient’s status and nurses’medication choices. Pain 9: 265–274
Cohen RA, Coffman JD (1981) Effect of morphine on limb capacitance and resistance vessels. Clin Sci 60: 5–9
Cold GE, Jensen FT, Malmros R (1977) The cerebrovascular C02, reactivity during the acute phase of brain injury. Anesthesiology 21: 222–231
Collier HOJ (1968) Supersensitivity and dependence. Nature 220: 228–231
Collier HOJ, Roy AC (1974) Morphine-like drugs inhibit stimulation by E prostaglandins of cyclic AMP formation by rat brain homogenate. Nature 248: 24–26
Colpaer FC, Niemegeers CJ, Janssen PAJ et al. (1980) The effects of prior fentanyl administration and of pain on fentanyl analgesia: Tolerance to and enhancement of narcotic analgesia. J Pharmacol Exp Ther 213: 418–424
Comstock M, Carter J, Moyers J et al. (1981) Rigidity and hypercarbia associated with high-dose fentanyl. Anesth Analg 60: 362–363
Conahan TJ, Ominsky AJ, Wollman H et al. (1973) A prospective random comparison of halothane and morphine for open-heart anesthesia: one year’s experience. Anesthesiology 38: 528–535
Coombs DW, Saunders RL, Lachanie D et al. (1985) Intrathecal morphine tolerance: use of intrathecal clonidine, DADLE, and intraventricular morphine. Anesthesiology 62: 358–363
Corssen G, Domino EF, Sweet RB (1964) Neuroleptanalgesia and anesthesia. Anesth Analg 43: 748–762
Cousins MJ, Mather LE (1984) Intrathecal and epidural administration of opioids. Anesthesiology 61: 276–310
Couturier M (1990) La douleur: Place des antalgiques. Ed. de l’Interligne, Paris
Cowan A (1993) Effects of opioids on the spontaneous behavior of animals. In: Herz A (ed) Opioids I, chap 46. Springer, Berlin Heidelberg New York Tokyo, pp 393–428
Coyle N, Mauskop A, Maggard J et al. (1986) Continuous subcutaneous infusions of opiates in cancer patients with pain-Oncol Nurs Forum 13: 53–57
Craig DB (1981) Postoperative recovery of pulmonary function. Anesth Analg 60: 46–52
Crain SM, Shen KF (1990) Opioid can evoke direct receptor-mediated excitatory effects on sensory neurons. Trends Pharm Scie 11: 77–81
Crain SM, Shen KF (1992) After chronic opioid exposure sensory neurones become supersensitive to the excitatory effects of opioid agonists and antagonists as occurs after elevation of GM1 ganglio-side. Brain Res 575: 13–24
Crone L-AL, Conly JM, Storgard JM et al. (1990) Herpes labialis in parturients receiving epidural morphine following cesarean section: Anesthesiology 73: 208–213
Cuillerier DJ, Mannimen PH, Gelb AW (1990) Alfentanil, sufentanil and fentanyl: effect on cerebral perfusion pressure. Anesth Analg 70: S 75
Cusan L, Dupont A, Kledzik GS et al. (1977) Potent prolactin and growth hormone releasing activity of more analogues of met-enkephalin. Nature 268: 544–546
Dahl J, Joranson D, Engber D et al. (1988) The cancer pain problem: Wisconsin’s response. A report on the Wisconsin Cancer Pain Initiative. In: J Pain Symp Manag 3(S): 1–20
Dahl JB, Rosenberg J, Hansen BL et al. (1992) Differential analgesic effect of low-dose epidural morphine and morphine-bupivacaine at rest and during mobilization after major abdominal surgery. Anesth Analg 74: 362–365
Dahlström B, Bolme P, Feychting J (1979) Morphine kinetics in children. Clin Pharm Ther 26: 354–365
Dahlström B, Tamsen A, Paalzow L et al. (1982) Patient-controlled analgesic therapy, part IV: phar-macokinetics and analgesic plasma concentrations of morphine. Clin Pharmacokin 7: 266–279
Dalton B (1972) Anaesthesia and coronary heart disease. J Irish Coll Physician Surg 2: 36–40
Daniel EE, Sutherland WH, Bogoch A (1959) Effects of morphine and other drugs on motility of the terminal ileum. Gastroenterology 36: 510–523
Daniel H et al. (1988) Cascin als Mittel gegen Diarrhoe. Forschungsarbeiten an der Universität Giessen. Deutscher Forschungsdienst/Berichte aus der Wissenschaft 35(42): 9–11
Darby JM, Yonas H, Marion DW et al. (1988) „Inverse steal“ induced by hyperventilation in head injury. Neurosurg 23: 84–88
Dashwood M, Feldberg W (1978) A pressor response to naloxone. Evidence for release of endogenous opioid peptides. J Physiol 281: 30–31P
Daskalopoulos NT, Laubie M, Schmitt H (1975) Localization of the central sympatho-inhibitory effect of a narcotic analgesic agent, fentanyl, in cats. Eur J Pharmacol 33: 91–97
Daugaard JJ, Dahl JB, Christensen CB (1989) Concentrations of morphine in the cerebrospinal fluid after femoral perineural morphine administration. Anesth Analg 68: 413
Daunderer M (1991) Drogenhandbuch. Ecomed, Landsberg
Davies GG, From R (1988) A blinded study using nalbuphine for prevention of pruritus induced by epidural fentanyl. Anesthesiology 69: 763–765
Davis TP, Gillespie TJ, Shook J et al. (1991) Changes in opioid receptor selectivity following processing of peptide E: effect on gut motility. Gastroenterology 100: 1603–1615
Daykin AP, Bowen DJ, Saunders A et al. (1986) Respiratory depression after morphine in the elderly. Anaesthesia 41: 910–914
De Bodo RC (1944) The antidiuretic action of morphine, and its mechanism. J Pharmacol Exp Ther 82: 74–85
De Boer AB, Moolenar F, de Leede LGJ et al. (1982) Rectal drug administration: Clinical pharmacokine-tic considerations. Clin Pharmacokin 7: 285–311
De Boer AB, De Leede LGJ, Breimer DD (1984) Drug absorption by sublingual and rectal routes. Br J Anaesth 56: 69–82
De Castro J, Viars P (1968) Anesthésie analgésique séquentielle. Arch Med 23: 121
Dejgaard A, Petersen P, Kastrup J (1988) Mexiletina for treatment of chronic painful diabetic neuropathy. Lancet 29: 9–11
De Jong RH, Nace RA (1968) Nerve impulse conduction during intravenous lidocaine injection. Anesthesiology 29: 22–28
De Lange S, De Bruijn N, Stanley TH (1981) Alfentanil oxygen anesthesia. Comparison of continuous infusion and frequent bolus techniques for coronary surgery. Anesthesiology 55: A42
De Leon-Casarola OA, Lema MJ (1992) Epidural sufentanil for acute pain control in a patient with extreme opioid dependency. Anesthesiology 76: 853–856
De Leon-Casarola OA, Myers DP, Donaparthi S et al. (1991) Postoperative epidural analgesia for chronic cancer patients taking oral narcotics. Anesthesiology 75: A655
Delia Bella D, Casacci F, Sassi A (1978) Opiate receptors: different ligand affinity in various brain regions. Adv Biochem Psychopharm 18: 271–277
De Marchi S, Cecchin E, Villalta D et al. (1992) Relief of pruritus and decreases in plasma histamine concentrations during erythropoietin therapy in patients with uremia. N Engl J Med 326: 969–974
Denavit-Saubie M, Champagnat J, Zieglgänsberger W (1978) Effects of opiates and methionine-enke-phalin on pontine and bulbar respiratory neurons of the cat. Brain Res 155: 55–67
De Ponti F, Malagelada JR, Azpirozz F et al. (1990) Variations in gastric tone associated with duodenal motor events after activation of central emetic mechanisms in the dog. J Gastroin Mot 2: 1–11
Derbyshire D, Smith G (1986) Observations on the use of sustained release morphine tablets for postoperative analgesia. In: Band P, Stewart J, Towson T (eds) Advances in the management of chronic pain. Purdue Frederick, Toronto, pp 113–118
DeSilva RA, Verrier RL, Lown B (1978) Protective effect of the vagotonic action of morphine sulfate on ventricular vulnerability. Cardiovasc Res 12: 167–172
Deutsch S, Bastron RD, Pierce EC et al. (1969) The effects of anaesthesia with thiopentone, nitrous oxide, narcotics and neuromuscular blocking drugs on renal function in normal man. Br J Anaesth 41: 807–815
De Chiro G (1964) Movement of the cerebrospinal fluid in human beings. Nature 204: 290–291
Diament ML, Palmer KNV (1966) Postoperative changes in gas tensions of arterial blood and in venti-latory function. Lancet II: 180–187
Dickenson AH (1990) A cure for wind-up: NMDA receptor antagonists as potential analgesics. Trends Pharmacol Scie 11: 307–309
Dierking GW, Ostergaard HT, Dissing CK et al. (1994) Analgesic effect of intra-articular morphine after arthroscopy meniscectomy. Anaesthesia 49: 627–629
Dionne RA, Campbell RA, Cooper SA et al. (1983) Suppression of postoperative pain by preoperative administration of ibuprofen in comparison to placebo, acetaminophen, and acetaminophen plus codeine. J Clin Pharmacol 23: 37–4
Doorley BM, Knight VV, Spaulding TC (1988) Development of acute tolerance to the cardiorespiratory effects of alfentanil after subsequent bolus injections in conscious dogs. Life Sci 43: 365–372
Dosaka-Akita K, Tortella FC, Holaday JW et al. (1993) The kappa opioid agonist U-50,488H antagonizes respiratory effects of mu opioid receptor agonists in conscious rats. J Pharmacol Exp Ther 264: 631–637
Douglas MJ, McMorland GH (1987) Possible association of herpes simplex type I reactivation with epi-dural morphine administration. Letter. Can J Anaesth 34: 426–427
Doze VA, Chen BX, Maze M (1989) Dexmedetomidine produces a hypnotic-anesthetic action in rats via activation of central α-2-adrenoceptors. Anesthesiology 71: 75–79
Dray A, Metsch R (1984) Inhibition of urinary bladder contractions by a spinal action of morphine and other opioids. J Pharmacol Exp Ther 231: 254–260
Drayer BP, Rosenbaum AE (1978) Studies of the third circulation. Amipaque CT cisternography and ventriculography J Neurosurg 48: 946–956
Drew JH, Dripps RD, Comroe JH (1946) Clinical studies on morphine. II. The effect of morphine upon the circulation of man and upon the circulatory and respiratory responses to tilting. Anesthesiology 7: 44–61
Drexel H, Lang AH, Spiegel RW et al. (1985) Pumpengesteuerte kontinuierliche subkutane Opiat-Infusion zur Behandlung schwerster Schmerzen. Dtsch Med Wochenschr 110: 1063–1067
Dripps RD, Vandam LD (1954) Long-term follow-up of patients who received 10,098 spinal anesthetics. JAMA 156: 1486–1491
Dubach UC, Rosner B, Stürmer T (1991) An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968-1987). N Engl J Med 324: 155–160
Dubi A (1959) Zur Bedeutung pontiner Atmungssubstrate für den Husten. Helv Physiol Pharm Acta 17: 166–174
Dubinsky B, Crew MC, Melgar MD et al. (1975) Correlation of analgesia with levels of tilidine and a biologically active metabolite in rat plasma and brain. Biochem Pharmacol 24: 277–281
Duffin J, Hung S (1985) Respiratory rhythm generation. Can Anaesth Soc J 32: 124–137
Dundee JW (1979) The ideal intravenous anaesthetics. In: Feldmann and Scurr (eds) Current topics in anaesthesia, part 1: Intravenous anaesthetic agents. Arnold, London
Duthie DJR, McLaren JD, Nimmo WS (1986) Pharmacokinetics of fentanyl during constant rate IV infusion for the relief of pain after surgery. Br J Anaesth 58: 950–956
Eckenhoff JE, Oech SR (1960) The effects of narcotics and antagonists upon respiration and circulation in man. A review. Clin Pharmacol Ther 1: 483–524
Edge WG, Cooper GM, Morgan M (1979) Analgesic effects of sublingual buprenorphine. Anaesthesia 34: 463–467
Edmonds-Seal J, Prys-Roberts C (1970) Pharmacology of drugs used in NLA. Br J Anaesth 42: 207–216
Eger EI II, Saidman LJ (1965) Hazards of nitrous oxide anesthesia in bowel obstruction and pneumothorax. Anesthesiology 26: 61
Eger EI II, Saidman LJ, Brandstater B (1965) Minimum alveolar anesthetic concentration: a standard of anesthetic potency. Anesthesiology 26: 756–763
Eimerl D, Magora F, Shir Y et al. (1986) Patient-controlled analgesia with epidural methadone by-means of an external infusion pump. Schmerz-Pain-Douleur 4: 156–160
Ekbom G, Schulte WJ, Condon RE et al. (1980) Effect of narcotic analgesics on bowel motility in subhuman primates. J Surg Reg 28: 293–296
El Allaf M, Chapelle JP, El Allaf D et al. (1986) Differentiating muscle damage from myocardial injury by means of the serum creatinine kinase (CK) isoenzyme MB mass measurement/total CK activity ratio. Clin Chem 32: 291–295
El-Ganzouri AR, Ivankovich AD, Braverman B et al. (1985) Monoamine oxidase inhibitors: should they be discontinued preoperatively? Anesth Analg 64: 592–596
Elliott K, Minami N, Kolesnikov Y et al. (1994) The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids. Pain 56: 69–75
Engelman E. Lipszyc M, Gilbart E et al. (1989) Effects of clonidine on anesthetic drug requirements and hemodynamic response during aortic surgery. Anesthesiology 71: 178–187
Ennis C, Wyllie MG (1984) Evidence for functionally distinct μ receptors modulating acetylcholine release. Neuropeptides 5: 109–112
Eriksen J, Jensen NH, Kamp-Jensen M et al. (1989) The systemic availability of buprenorphine administered by nasal spray. J Pharm Pharmacol 41: 803–805
Eriksson PS, Carlsson B, Isaksson OGP et al. (1992) Altered amounts of G-protein mRNA and cAMP accumulated after long-term opioid receptor stimulation of neurons in primary culture from the rat cerebral cortex. Brain Res 14: 317–325
Esplugues JV, Barrachina MD, Esplugues J (1992) Modulation by peripheral opioids of basal distension-stimulated gastric acid secretion in the rat. Br J Pharmacol 106: 33–38
Etches R, Sandier A, Daley M (1989) Respiratory depression and spinal opioids. Review. Can J Anaesth 36: 165–185
Evans CJ, Keith DE, Morrison H et al. (1992) Cloning of a delta opioid receptor by functional expression. Science 258: 1952–1995
Eyster JAE, Meek WJ (1952) Cardiac irregularities in morphine poisoning in the dog. Heart 4: 542
Faden AI, Holaday JW (1979) Opiate antagonists: A role in the treatment of hypovolemic shock. Science 205: 317–318
Fakuda K, Kato S, Mori K et al. (1993) Primary structures and expression from cDNAs of rat opioid receptor δ and μ-subtypes. FEBS Lett 327: 311–314
Farley HF, Joyce N, Long B et al. (1986) Will that IM needle reach the muscle? Am J Nurs 86: 1327–1331
Fasano M, Waldvogel HH (1982) Peridural administration of morphine, with or without adrenalin, for postoperative analgesia. Acta Anaesth Belg 33: 195–202
Fasano M, Waldvogel HH, Muller CA (1979) Prophylaxie de l’iléus paralytique après chirurgie du côlon par blocage sympathique péridural continu. Helv Chir Acta 46: 245–248
Feld LH, Champeau MW, Van Steennis CA et al. (1989) Preanesthetic medication in children: a comparison of oral transmucosal fentanyl citrate versus placebo. Anesthesiology 71: 374–377
Feldman HR (1987) Practice makes perfect but research makes a difference. Nursing 17(March): 47
Fell D, Chmielewski A, Smith G (1982) Postoperative analgesia with controlled-release morphine sulphate: comparison with intramuscular morphine. BMJ 285: 92–94
Fennessy MR, Ortiz A (1968) The behavioural and cardiovascular actions of intravenously administered morphine in the conscious dog. Eur J Pharmacol 3: 177–185
Fennessy MR, Rattray JF (1971) Cardiovascular effects of intravenous morphine in the anesthetized rat. Eur J Pharmacol 14: 1–8
Ferguson-Segall M, Flynn JJ, Walker J et al. (1982) Increased immunoreactivte dynorphin and leu-enkephalin in posterior pituitary of obese mice (ob/ob) and supersensitivity to drugs that act at x receptor. Life Sci 31: 233–236
Ferrante FM, Ostheimer GW, Covino BG (eds) (1990) Patient controlled analgesia, 2nd edn. Blackwell, Oxford
Ferrante FM, Chan VWS, Arthur GR et al. (1991) Interpleural analgesia after thoracotomy. Anesth Analg 72: 105–109
Fields HL, Emson PC, Leigh BK et al. (1980) Multiple opiate receptor sites on primary afferent fibres. Nature 284: 351–353
Finer B (1970) Studies of the variability in expiratory efforts before and after cholecystectomy. Anesthe-siology 38: S8–S67
Fink BR (1961) The stimulant effects of wakefulness on respiration: clinical aspects. Br J Anaesth 33: 97–101
Finn JW, Large S, Krebs L et al. (1987) Cross-over of sustained release morphine sulfate (Roxanol SR) in advanced cancer. Proc Am Soc Clin Oncol 6: 261
Fish DJ, Rosen SM (1990) Epidural opioids as a cause of vertical nystagmus. Correspondence. Anesthe-siology 73: 785–786
Flacke JW, Flacke WE, William GD (1977) Acute pulmonary edema following naloxone reversal of high dose morphine anesthesia. Anesthesiology 47: 376–378
Flacke J, Bloor B, Kripke B et al. (1985) Comparison of morphine, meperidine, fentanyl, and sufentanil in balanced anesthesia. Anesth Analg 64: 897–910
Fletcher JE, Thomas TA, Hill RGB (1980) Beta-endorphin and parturition. Lancet i (Feb 9): 310
Flórez J, McCarthy LE, Borison HL (1968) A comparative study in the cat of the respiratory effects of morphine injected intravenously and into the cerebrospinal fluid. J Pharmacol Exp Ther 163: 448–455
Floréz J, Hurlé MA, Mediavilla A (1982) Respiratory responses to opiates applied to the medullary ventral surface. Life Sci 31: 2189–2192
Foldes FF, Swerlow M, Siker ES (1984) Narcotics and narcotic antagonists. Thomas, Springfield, PP 3–9
Foley KM (1985) The treatment of cancer pain. N Engl J Med 313: 84–95
Follette JW, Farley WJ (1993) Anesthesiologist addicted to propofol. Anesthesiology 77(4): 817–818
Foote RW, Maurer R (1982) Autoradiographic localization of opiate k-receptors in the guinea pig brain. Eur J Pharmacol 85: 99–103
Ford TG, Whitelaw WA, Rosenal TW et al. (1983) Diaphragma functions after upper abdominal surgery in humans. Am Rev Respir Dis 127: 431–436
Ford GT, Grant DA, Riedeout KS et al. (1988) Inhibition of breathing associated with gallbladder stimulation in dogs. J Appl Phys 65: 72–79
Fox LS (1982) Pain management in the terminally ill cancer patient: an investigation of nurses’attitudes, knowledge, and clinical practice. Milit Med 147: 455–460
Frager RJ, Booyi HDJ, Braak GJJ et al. (1983) Pharmacokinetics of the infusion of alfentanil in man. Br J Anaesth 55: 1077–1081
Frank RM (1980) Pain management and the appropriate use of analgesics. Cancer Nurs 3: 155–157
Frantzides C, Cowles V, Salaymeh B et al. (1992) Morphine effects on human colonic myoelectric activity in the postoperative period. Am J Surg 163: 144–149
Fraser HM, Chapman V, Dickenson AH (1992) Spinal local anaesthetic actions on afferent evoked re-sponses and wind-up of nociceptive neurones in the rat spinal cord: combination with morphine produces marked potentiation of antinociception. Pain 49: 33–41
Frederickson RCA, Burgis V, Edwars JD (1977) Hyperalgesia induced by naloxone follows diurnal rhythm in responsivity to painful stimuli. Science 198: 756–758
Freund F, Martin W, Wong K et al. (1973) Abdominal muscle rigidity induced by morphine and nitrous oxide. Anesthesiology 38: 358–362
Freye E (1974) Cardiovascular effects of high doses of fentanyl, meperidine, and naloxone in dogs. Anesth Analg 53: 40–47
Freye E (1991) Opioide in der Medizin. Springer, Berlin Heidelberg New York Tokyo, S 23
Freye E, Kuschinsky K (1976) Effects of fentanyl and droperidol on the dopamine metabolism of the rat striatum. Pharm 14: 1–7
Freye E, Härtung E, Schenk SG (1983) Bremazocine an opioid that induces sedation and analgesia without respiratory depression. Anesth Analg 62: 483–488
Friderichs E, Felgenhauer F, Jongschaap P et al. (1978) Pharmakologische Untersuchungen zur Analgésie, Abhängigkeits-und Toleranzentwicklung von Tramadol, einem stark wirkenden Analgeti-kum. Arzneim Forsch Drug Res 28(I): 122–134
Friesen RH, Lockhart CH (1992) Oral transmucosal fentanyl citrate for preanesthetic medication of pédiatrie day surgery with and without droperidol as a prophylactic anti-emetic. Anesthesiology 76: 46–51
Fuller RW, Karlsson JA, Choudry NB et al. (1988) Effect of inhaled and systemic opiates on responses to inhaled capsaicin in humans. J Apppl Physiol 65: 1125
Gal TJ, Di Fazio CA, Moscicki J (1982) Analgesic and respiratory depressant acitivity of nalbuphine: a comparison with morphine. Anesthesiology 57: 367–374
Gallegos KV, Browne CH, Veit FW et al. (1988) Addiction in anesthesiologists: drug access and patterns of substance abuse. QRB 14: 116–122
Galt RHM (1977) The opiate anomalies — another possible explanation. J Pharm Pharmacol 29: 711–714
Gamse R, Holzer P, Lembeck F (1979) Indirect evidence for presynaptic location of opiate receptors on chemosensitive primary sensory neurons. Naunyn Schmiedebergs Arch Pharmacol 308: 281–285
Gardocki CF, Yelnosky J (1964) A study of some of the pharmacologic actions of fentanyl citrate. Tox Appl Pharm 6: 48–62
Garfield JM, Gugino L (1987) Central effects of local anesthetic agents. In: Strichartz GR (ed) Local anesthetics. Springer, Berlin Heidelberg New York Tokyo, pp 253–284
Garrett JM, Sauer WG, Moertel CG (1967) Colonic motility in ulcerative colitis after opiate administration. Gastroenterol 53: 93–100
Gates M, Tschudi G (1956) Synthesis of morphine. J Am Chem Soc 78: 1380
Gauchy C, Agid Y, Glowinski J et al. (1973) Acute effects of morphine on dopamine synthesis and release and tyrosine metabolism in the rat striatum. Eur J Pharmacol 22: 311–319
Gefke K, Andersen LW, Friesel F (1983) Lidocaine given intravenously as a suppressant of cough and laryngospasm in connections with extubation after tonsillectomy. Anesthesiology 27: 111–112
George R (1971) Hypothalamus: Anterior pituitary gland. In: Clouet D (ed) Narcotic drugs, Biochem. Pharmacol. Plenum, New York, pp 283–299
Georgis SD, Hoyt JL, Sokoll MD (1971) Effects of Innovar and Innovar plus nitrous oxide on muscle tone and the H-reflex. Anesth Analg 50: 743–747
Geschwinde TH (1985) Rauschdrogen. Springer, Berlin Heidelberg New York Tokyo
Getto CJ, Fullerton DJ, Carlson IH (1988) Plasma immunoreactive B-endorphin response to glucose ingestion in human obesity. Appetite 5: 329–334
Giacomini KM, Giacomini JC, Gibson TP et al. (1980) Propoxyphene and norpropoxyphene plasma concentrations after oral propoxyphene in cirrhotic patients with and without surgically constructed portocaval shunt. Clin Pharmacol Ther 28: 414–417
Giardino L, Calza L, Montanini V et al. (1990) Functional plasticity of opioid peptides: Daily rhythms in opiate receptors. In: Benedetti C, Chapman CR, Giron G (eds) Advances in pain and therapy, vol 14. Raven, New York, p 101
Giarman NJ, Condouris GA (1954) The antidiuretic action of morphine and some of its analogs. Arch Int Pharmacodyn 97: 28–33
Giarman NJ, Mattie LR (1953) Studies on the antidiuretic action of morphine. Science 117: 225–226
Gierarts R, Navalgund A, Vaes L et al. (1987) Increased incidence of itching and herpes simplex in patients given epidural morphine after cesarean section. Anesth Analg 66: 1321–1324
Giles TD, Burch GE (1970) Anesthesia, dogs and cardiovascular data. Am Heart J 79: 141–142
Giugliano D (1992) Opioid peptides and obesity. Eur J Neurol 1(2): 90–96
Givens JR, Kurtz BR, Kitabchi AE et al. (1987) Reduction of hyperinsulinemia and insulin resistance by opiate receptor blockade in the polycystic ovary syndrome with acanthosis nigricans. J Clin Endocrin Metab 64: 377–382
Givens JR, Wiedemann E, Andersen RN et al. (1980) Beta-endorphin and Beta-lipotropin plasma levels in hirsute women: correlation with body weight. J Clin Endocrinol Metab 50: 975–976
Glass PSA, Doherty M, Jacobs JR et al. (1993) Plasma concentration of fentanyil with 70 % nitrous oxide, to prevent movement at skin incision. Anesthesiology 78: 842–847
Glynn CJ, Mather LE (1982) Clinical pharmacokinetics applied to patients with intractable pain: Studies with pethidine. Pain 13: 237–246
Glynn CJ, Mather LE, Cousins MJ et al. (1979) Spinal narcotics and respiratory depression. Lancet I: 356–357
Go VLW, Yaksh TL (1987) Release of substance p from the cat spinal cord. J Physiol 391: 141–167
Gold MS (1993) Opiate addiction and the locus coeruleus: the clinical utility of clonidine, naltrexone, methadone, and buprenorphine. Psychiat Clin N Am 16: 61–73
Gold MS, Redmond DE, Kleber HD (1978) Clonidine blocks acute opiate withdrawal symptoms. Lancet 16: 599
Gold MS, Redmond DE, Kleber HD (1978) Clonidine in opiate withdrawal. Lancet 29: 929
Gold MS, Pottash AC, Sweeney DR et al. (1980) Opiate withdrawal using clonidine. A safe, effective and rapid non-opiate treatment. JAMA 243: 343–346
Goldberg AH (1973) Myocardial depression by fentanyl and morphine. Anesthesiology 38: 600–602
Goldberg AH, Padget CH (1969) Comparative effects of morphine and fentanyl on isolated heart muscle. Anesth Analg 48: 978–982
Goldberg M, Ishak S, Garcia C et al. (1985) Postoperative rigidity following sufentanil administration. Anesthesiology 63: 199–201
Goldstein A (1974) Opiate receptors. Life Sci 14: 615–623
Goldstein A, James IF (1984) Multiple opioid receptors: criteria for identification and classification. Trends Pharmacol Sci 5: 503–505
Goldstein A, Lowney LI, Pal BK (1971) Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain. Proc Natl Acad Sci USA 68: 1742–1745
Goldstein SR, Matsumoto RR, Thompson TL et al. (1989) Motor effects of two sigma ligands mediated by nigrostratial dopamine neurons. Synapse 4: 254–258
Goldstein-Dresner MC, Davis PJ, Kretchman E et al. (1991) Double-blind comparison of oral transmu-cosal fentanyl citrate with oral meperidine, diazepam, and atropine as preanesthetic medication in children with congenital heart disease. Anesthesiology 74: 28–33
Goltz D (1974) Studien zur altorientalischen und griechischen Heilkunde. Therapie-Arzneiberatung-Rezeptstruktur. In: Beihefte zu Sudhoffs Archiv, Bd 16. Steiner, Wiesbaden
Gordh T jr (1988) Epidural clonidine for treatment of postoperative pain after thoracotomy: a double blind placebo-controlled study. Anesthesiology 32: 702–709
Gordh T jr, Post C, Olsson Y (1986) Evaluation of the toxicity of subarachnoid clonidine, guanfacine and substance P-antagonist on rat spinal cord and nerve roots: light and electron microscopic observations after chronic intrathecal administration. Anesth Analg 65: 1303–1311
Gostomzyk JG, Heller WD (1987) Betäubungsmittelverschreibung in der ärztlichen Praxis. Münch Med Wochenschr 129: 213–215
Gouarderes C, Cros J, Quirion R (1985) Autoradiographic localization of mu, delta and kappa opioid receptor binding sites in rat and guinea-pig spinal cord. Neuropeptides 6: 331–342
Gourlay GK, Cherry DA, Cousins MJ (1985) Cephalead migration of morphine in CSF following lumbar epidural administration in patients with cancer pain. Pain 23: 317
Gourlay GK, Cherry DA, Plummer JL et al. (1987) The influence of drug polarity on the absorption of opioid drugs into CSF and subsequent cephalad migration following lumbar epidural administration: Application to morphine and pethidine. Pain 31: 297–305
Gourlay GK, Murray TM, Plummer L et al. (1989) Pharmacokinetics of fentanyl in lumbar and cervical CSF following lumbar epidural and intravenous administration. Pain 38: 253–259
Grabinski PY, Kaiko RF, Rogers AG et al. (1983) Plasma levels and analgesia following deltoid and gluteal injections of methadone and morphine. J Clin Pharmacol 23: 48–55
Gradison S, Guidotti A (1977) Stimulation of food intake by muscimol and β-endorphin. Neuropharm 16: 533–536
Graubard DJ, Robertazzi R, Petersen MC (1948) One year’s experience with intravenous procaine. Anesth Analg 27: 222–226
Grauer SM, Tao R, Auerbach SB (1992) Morphine induces an increase in extracellular serotonin in the rat diencephalon. Brain Res 599: 277–282
Gravenstein JS, Kory WP, Marks RG (1983) Drug abuse by anesthesia personnel. Anesth Analg 62: 467–472
Greaves MW (1992) Itching — research has barely scratched the surface. N Engl J Med 326(15): 1016–1017
Green JF, Jackman AP, Krohn KA (1978) Mechanism of morphine-induced shifts on blood volume betreen extracorporeal reservoir and the systemic circulation of the dog under conditions of constant blood flow and vena caval pressures. Circ Res 42: 479–486
Green JF, Jackman AP, Parsons G (1978) The effects of morphine on the mechanical properties of the systemic circulation in the dog. Circ Res 42: 474–478
Greene NM (1969) Physiology of spinal anesthesia. 3rd edn. Williams & Wilkins, Baltimore, (chap 1: „Distribution of local anesthetics in spinal fluid; uptake, elimination“)
Greene NM (1983) Uptake and elimination of local anesthetics during spinal anesthesia. Anesth Analg 62: 1013–1024
Greene NM (1985) Distribution of local anesthetic solutions within the subarachnoid space. Anesth Analg 64: 715–730
Greenstein AJ, Kaynan A, Singer A et al. (1972) A comparative study of pentazocine and meperidine on the biliary passage pressure. Am J Gastroenterol 58: 417–427
Grewe R, Mondon A (1948) Synthesis in the phenanthrene series: VI. Synthesis of morphinan. Chem Ber 81: 279–286
Grove LH (1973) Backache, headache and bladder dysfunction after delivery. Br J Anaesth 45: 1147–1149
Gruber CM, Robinson PI (1929) Studies on the influence of morphine, papaverine and quinidine upon the heart. J Pharmacol Exp Ther 37: 429–449
Grundy HF (1971) Cardiovascular effects of morphine, pethidine, diamorphine and nalorphine on the cat and rabbit. Br J Pharmacol 42: 159–178
Guillemin R (1977) Endorphins, brain peptides that act like opiates. N Engl J Med 296: 116–118
Gundlach AL, Largent BL, Snyder SH (1986) Autoradiographic localization of σ-receptor binding sites in guinea pig and rat central nervous system with (+)-3H-3-(3-hydroxphenyl)-N-(1-propyl)-piperi-dine. J Neurosci 6: 1757–1770
Gustafsson LL (1990) Systemic and local distribution of opioids after spinal administration: Implications for their clinical use. In: Rawal N, Coombs DW (eds) Spinal narcotics. Kluwer, Boston, PP 33–42
Gustafsson LL, Schildt B, Jacobsen K (1982) Adverse effects of extradural and intrathecal opiates; report of a nationwide study in Sweden. Br J Anaesth 54: 479–486
Gutner LB, Gould WJ, Batterman RC (1952) The effect of potent analgesics upon vestibular function. J Clin Invest 31: 259–266
Guy G, Rhodes A (1986) Effects of food on the absorption of morphine from MST Continus tablets. In: Band P, Stewart J, Towson T (eds) Advances in the management of chronic pain. Purdue Frederick, Toronto, pp 131–134
Gwirtz K (1990) Intraspinal narcotics in the management of postoperative pain. Anesthesiol Rev 17: 16–28
Haas H (1955) Zentrale Analgetika. Dtsch Apotheker Ztg 48: 1143–1148
Hamilton RC, Dundee JW, Clarke RSJ et al. (1967) Studies of drugs given before anaesthesia. XIII: Pen-tazocine and other opiate antagonists. Br J Anaesth 39: 647–656
Hamilton WK, Cullen SC (1953) Effect of levalorphan tartrate upon opiate induced respiratory depression. Anesthesiology 14: 550–554
Hanks GW, Rose NM, Aherne GW et al. (1980) Controlled-release morphine tablets: A double-blind trial in dental surgery patients. Br J Anaesth 53: 1259–1264
Hanks GW, Twycross RG, Lloyd JW (1981) Unexpected complications of successful nerve block. Morphine induced respiratory depression precipitated by removal of severe pain. Anaesthesia 36: 37–39
Hanks GW, Hoskin PJ, Aherne GW et al. (1987) Explanation for potency of repeated oral doses of morphine? Lancet II: 723–725
Hanning CD, Vickers AP, Smith G et al. (1988) The morphine hydrogel suppository. A new sustained release rectal preparation. Br J Anaesth 61: 221–227
Harmer M, Rosen M, Vickers MD, eds. (1985): Patient controlled analgesia. Blackwell, Oxford
Harris A (1992) Cytotoxic therapy induced vomiting is mediated via enkephalin pathways. Lancet I: 714–716
Harrison DM, Sinatra R, Morgese L et al. (1988) Epidural narcotic and patient-controlled analgesia for post-cesarean section pain relief. Anesthesiology 68: 454–457
Hasbrouck JD (1970) Morphine anesthesia for open-heart surgery. Ann Thor Surg 10: 364–369
Hassan AHS, Ableitner A, Stein C et al. (1993) Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerves and increases their densitiy in the inflamed tissue. Neuroscience 55: 185–195
Havemann U, Kuschinsky K (1981) Further characterization of opioid receptors in the striatum mediating muscular rigidity in rats. Naunyn Schmiedebergs Arch Pharmacol 317: 321–325
Health and Public Policy Committee (1983) Am Coll Phys Penn: Drug therapy for severe, chronic pain in terminal illness. Ann Int Med 99: 870–873
Heard SO, Edwards WT, Ferrary D et al. (1992) Analgesic effect of intraarticular morphine after arth-roscopic knee surgery: a randomized, double-blind study. Anesth Analg 74: 822–826
Heel RC, Brogden RN, Speight TM et al. (1979) Buprenorphine: A review of its pharmacological properties and therapeutic efficacy. Drugs 17: 81–100
Heilmann K (1977) Therapeutische Systeme. Enke, Stuttgart
Helmers JHJH, Noorduin H, Peer A van et al. (1989) Comparison of intravenous and intranasal sufen-tanil adsorption and sedation. Can J Anaesth 36: 494–497
Henderson JM, Brodsky DA, Fisher DM et al. (1988) Preinduction of anesthesia in pédiatric patients with nasally administered sufentanil. Anesthesiology 68: 671–675
Henney RP, Vasko JS, Brawley RK et al. (1966) The effects of morphine on the resistance and capacitance vessels of the peripheral circulation. Am Heart J 72: 242–250
Herz A, Teschemacher HJ (1971) Activities and sites of antinociceptive action of morphine-like analgesics and kinetics of distribution following intravenous intracerebral and intraventricular application. Adv Drug Res 6: 79–119
Heyman JS, Vaught JL, Mosberg HL et al. (1989) Modulation of mu-mediated antinociception by delta agonists in the mouse: selective potentiation of morphine and normorphine by (D-Pen-2,D-Pen-5)enkephalin. Eur J Pharmactol 165: 1–10
Higgins MJ, Asbury AJ, Brodie M (1991) Inhaled nebulised fentanyl for postoperative analgesia. Anaesthesia 46: 973–976
Hilgenberg JC (1981) Intraoperative awareness during high dose fentanyl-oxygen anesthesia. Anesthesiology 54: 341–343
Hill AB, Nahrwold ML, De Rosayro AM et al. (1981) Prevention of rigidity during fentanyl-oxygen induction. Anesthesiology 1980; 53: S68 und Anesthesiology 55: 452–454
Hill RG, Hughes J (1984) Endogenous opioid peptides-biological and clinical significance. In: Nimmo WS, Smith G (eds) Opioid agonist/antagonist drugs in clinical practice. Excerpta Medica, Genf
Hjortsjö CN, Lund C, Mogensen T (1986) Epidural morphine improves pain relief and maintains sensory analgesia during continuous epidural bupivacaine after abdominal surgery. Anesth Analg 65: 1033–1036
Hochstetter von AHC (1954) Über die intraglutaeale Injektion, ihre Komplikationen und deren Verhütung. Schweiz Med Wochenschr 84: 1226–1227
Hochstetter AHC von(1955) Über Probleme und Technik der intraglutaealen Injektion. 1. Teil. Schweiz Med Wochenschr 85: 1138–1144
Hochstetter AHC von(1955) Über Probleme und Technik der intraglutaealen Injektion. 2. Teil Schweiz Med Wochenschr 86: 69–76
Hochstetter AHC von (1956) Wie lassen sich aseptische „Spritzenschäden“ bei intraglutaealer Injektion sicher vermeiden? Schweiz Ärzteztg (Huber, Bern), N° 18
Hochstetter AHC von (1969) Eine sichere Technik der intramuskulären Injektion in den Oberschenkel: Lateraler-Vastus-Injektion. Schweiz Med Wochenschr 99: 266–269
Hochstetter AHC von, Rechenberg HK von, Schmidt R (1958) Die intraglutaeale Injektion. Thieme
Hoffman PE (1974) Clinical evaluation of xylazine as a chemical restraining agent, sedative and analgesic in horses. J Am Vet Med Ass 164: 42–45
Holley FO, Van Steenis C (1986) Transdermal administration of fentanyl for postoperative analgesia. Anesthesiology 65: A548
Hollt V (1983) Multiple endogenous opioid peptides. Trends Neurosci 4: 24–26
Hohnes B, Ward A (1985) Meptazinol — a review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs 30: 285–312
Homesley HD, Welander C, Muss H et al. (1986) Dosage range study of morphine sulfate controlled-release. Am J Clin Oncol 9: 449–453
Hoos A, Rust M (1990) Schmerztherapie und Depression bei Karzinompatienten. Fortschr Med 24: 462–466
Hopton DS, Torrance HB (1967) Action of various analgesic drugs on the human common bile duct. Gut 8: 296–300
Hornstein W von, Gralow I, Lawin P (1989) Kontinuierliche subkutane Morphingabe mittels eines externen tragbaren Infusorsystems bei inkurablen Kopf-Hals-Tumoren: Pilotstudie. Anaesthesist 38 (Suppl. ZAK Innsbruck, Abstract FV 29.8, S 562)
Horrobin DF, Manku MS (1973) Roles of prostaglandins suggested by the prostaglandin agonist/ antagonist actions of local anaesthetic, antiarrhytmic,anti-malarial,tricyclic antidepressant and methylxanthine compounds,effects on membranes and on nucleic acid function. Med Hypotheses 3: 71–86
Hoskin PJ, Hanks GW (1991) Opioid agonist-antagonist drugs in acute and chronic pain states. Review Article. Drugs 41/3: 326–344
Hoskin PJ, Hanks GW, Aherne GW et al. (1989) The bioavailability and pharmacokinetics of morphine after intravenous, oral and buccal administration in healthy volunteers. Br J Clin Pharmacol 27: 499–505
Howard R, Sears T (1990) The effects of opiates on the respiratory activity of thoracic motoneurones in the anaesthetized and decerebrate rabbit. J Physiol 437: 181–199
Hsu HO, Hickey RF, Forbes AF (1979) Morphine decreases peripheral vascular resistance and increases capacitance in man. Anesthesiology 59: 98–102
Hug CC jr (1988) Pharmacology of narcotics as anesthetic agents. In: Refresher Course Lectures, 9th WCA, May 22–28, Washington, S 541: 1–5
Hug CC jr, Longnecker DE (1986) Narcotics and narcotic antagonists. In: Smith NT, Corbascio AN (eds) Drug interactions in anaesthesia, 2nd edn. Lea & Febiger, Philadelphia, pp 321–339
Hug CC jr, Aldrete JA, Sampson JF et al. (1979) Morphine anesthesia in patients with liver failure. Anesthesiology 51: 30
Hug CC jr, Murphy MR, Sampson JF et al. (1981) Biotransformation of morphine and fentanyl in an-hepatic dogs. Anesthesiology 55: A261
Hughes J (1975) Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine. Brain Res 88: 295–308
Hughes MA, Glass PSA, Jacobs JR (1992) Context-sensitive half-time in multicompartment pharma-cokinetic models for intravenous anesthetic drugs. Anesthesiology 76: 334–341
Hull CJ (1985) Editorial: Receptor binding and its significance. Br J Anaesth 57: 192
Hung OR, Hall RI (1993) Specific opioids and their clinical applications. Curr Op Anaesth 6: 678–682
Hunter JC, Leighton KG, Meecham KG et al. (1990) CI-977, a novel and selective agonist for the K-opioid receptor. Br J Pharmacol 101: 183–189
Husscin AA (1989) Mechanism of nasal adsorption of drugs. Prog Clin Biol Res 292: 261–272
Hylden JLK, Thomas DA, Iadarola MJ et al. (1991) Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: possible involvement of noradrenergic mechanisms. Eur J Pharmacol 194: 135–143
Iglesias V, Alguacil LF, Alamo C et al. (1992) Effects of Yohimbine on morphine analgesia and physical dependence in the rat. Eur J Pharmacol 211: 35–38
Inturrisi CE, Umans JG (1983) Pethidine and its active metabolites, norpethidine. In: Bullingham RES (ed) Opiate analgesia. Clinics in anaesthesiology. Saunders, London, p 123
Inturrisi CE, Schmitz M, Shin S et al. (1983) Evidence from opiate bindung studies that heroin acts through its metabolites. Life Sci 33: 773
Irwin K, Mibandumba N, Mbuyi K et al. (1993) More on vaginal inflammation in africa. N Engl J Med 328: 888–889
Itzhak Y, Stein I, Zhang SH et al. (1990) Binding of σ-ligands do C57GL/6 mous breain membranes: effects of monoamine oxidase inhibitors and subcellular distribution studies suggest the existence of σ subtypes. J Pharmacol Exp Ther 257: 141–148
Jacobs HK, Rao TLK, Kumer P et al. (1980) Transmural coronary blood flows and myocardial metabolism with high dose fentanyl. Anesthesiology 53: S65
Jacobsen J, Flachs H, Dich-Nielsen JO et al. (1988) Comparative plasma concentration profiles after IV, IM and rectal administration of pethidine in children. Br J Anaesth 60: 623–626
Jacobson L (1984) Intrathecal and extradural narcotics. In: Benedetti C (ed) Advances in pain research and therapy. Raven, New York, pp 199–236
Jaffe RS, Moldenhauer CC, Hug CC jr et al. (1988) Nalbuphine antagonism of fentanyl-induced venti-latory depression: a randomized trial. Anesthesiology 68: 254–260
Jakovlev V, Sofia RD, Achterrath-Tuckermann U et al. (1985) Untersuchungen zur pharmakologischen Wirkung von Flupirtin, einem strukturell neuartigen Analgetikum. Arzneimittel-Forschung Drug Res 35(1): 28–81
Janik J, Callahan P, Rabii J (1993) Morphine induced analgesia is attenuated in post-partum lactating rats. Life Sci 52: 271–279
Janssen PAJ (1962) A review of the chemical features associated with strong morphine-like activity. Br J Anaesth 34: 260–268
Janssen PAJ (1964) Zur Chemie morphinartiger Körper. Anaesthesist 11: 1–7
Janssen PAJ (1981) Potent, new analgesics, tailor-made for different purposes. Janssen Research News 2: 2–15
Jasinsky DR (1984) Opioid receptors and classification. In: Nimmo WS, Smith G (eds) Opioid agonist/antagonist drugs in clinical practice. Excerpta Medica, Genf
Jeanrenaud B (1985) A hypothesis on the aetiology of obesity: dysfunction of the central nervous system. Diabetol 28: 502–513
Jewitt DE, Maurer GJ, Hubner PJB (1970) Increased pulmonary arterial pressures after pentazocine in μocardial infarction. BMJ 1: 795–796
Jewitt DE, Maurer BJ, Sonnenblick EJ et al. (1971) Pentazocine: Effect on ventricular muscle and hemo-dynamic changes in ischaemic heart disease. Circulation 44 (Suppl II): 118
Jian Q, Takemori AE, Sultana PS (1991) Differential antagonism of opioid delta antinociception by (D-ala2,leu5,cys6) Enkephalin and Naltrindole 5′-Isothiocyanate: evidence for delta receptor subtypes. J Pharmacol Exp Ther 257: 1069–1075
Jobes DR, Kennell EM, Bitner R et al. (1975) Effects of morphine-nitrous oxide anesthesia on cerebral autoregulation. Anesthesiology 42: 30–34
Jobes DR, Kennell EM, Bush GL et al. (1977) Cerebral blood flow and metabolism during morphine-nitrous oxide anesthesia in man. Anesthesiology 47: 16–18
Johnson DS, Finley RS (1992) Pain management of acute and chronic pain syndromes. Am Druggist 6: 70, 72, 74, 76, 78, 80, 82-84
Johnson MD, Sevarino FB, Lema MJ (1989) Cessation of shivering and hypothermia associated with epidural sufentanil. Anesth Analg 68: 70–71
Johnson N, Houghten R, Pasternak W (1982) Binding of 3H-β-endorphin in rat brain. Life Sci 31: 1318–1384
Johnson SM, Fleming WW (1989) Mechanisms of cellular adaptive sensitivity changes: applications to opioid tolerance and dependence. Pharmacol Rev 41: 435–488
Johnstone RE, Jobes DR, Kennell EM et al. (1974) Reversal of morphine anesthesia with naloxone. Anesthesiology 41: 361–367
Jones RM, Fiddian-Green R, Knight PR (1980) Narcotic induced choledochoduodenal sphincter spasm reversed by glucagon. Anesth Analg 59: 946–947
Jones RM, Detmer M, Hille AB et al. (1981) Incidence of choledochoduodenal sphincter spasm during fentanyl-supplemented anesthesia. Anesth Analg 60: 638–640
Jönsson A, Cassuto J, Hanson B (1991) Inhibition of burn pain by intravenous lignocaine infusion. Lancet 338: 151–152
Jonsson T, Christensen CB, Jordernung H et al. (1988) The bioavailability of rectally administered morphine. Pharm Toxicol 62: 203–205
Joranson DE et al. (1987) Wisconsins initiative for improving cancer pain management: progress report. J Pain Symptom Man 2: 11–113
Jordan C, Lehane JR, Robson PJ et al. (1979) A comparison of the respiratory effects of meptazinol, pentazocine and morphine. Br J Anaesth 51: 497–502
Joris JL, Dubner R, Haregreaves KM (1987) Opioid analgesia at peripheral sites: a target for opioids released during stress and inflammation. Anesth Analg 66: 1277–1281
Joshi GP, McCarroll SM, Brady OH et al. (1993) Intra-articular morphine for pain relief after anterior cruciate ligament repair. Br J Anaesth 70: 87–88
Joris JL, Dubner R, Hargreaves KM (1987) Opioid analgesia peripheral sites: a target for opioids released during stress and inflammation? Anesth Analg 66/12: 1277–1281
Julien CH G, Bonardet A, Alloua D et al. (1982) Perturbation fonctionelle prolongée de la sécrétion de prolactine après chirurgie sous neuroleptanalgésie. Can Anaesth Soc 29: 468–472
Jurna I, Brune K (1990) Central effect of the non-steroid and anti-inflammatory agents indomethacin, ibuprofen, and diclofenac, determined in C fibre-evokde acticity in single neurones of the rat thalamus. Pain 41: 71–80
Kadikani H, Rurutani Y, Takahashi H et al. (1982) Cloning and sequence analysis of cDNA for porcine B-neo-endorphin-dynorphin precursor. Nature 298: 345–349
Kafer E, Brown J, Scott D et al. (1983) Biphasic depression of ventilatory responses to CO2 following epidural morphine. Anesthesiology 58: 418–427
Kaiko R, Horodniak J, Saverese J et al. (1987) Bioequivalency of controlled release morphine (MS Con-tin), 15, 160, and 100 mg vs. the 30 mg tablet. 12th ACO, Oncol Nurs Forum 14: 112
Kaiser KG, Bainton CR (1987) Treatment of intrathecal morphine overdose by aspiration of cerebro-spinal fluid. Anesth Analg 66: 475–477
Kanner RF, Foley KM (1981) Patterns of narcotic use in a cancer pain clinic. Ann NY Acad Sci 362: 161
Karl HW, Keifer AT, Rosenberger JL et al. (1992) Comparison of the safety of intranasal midazolam or sufentanil for preinduction of anesthesia in pédiatrie patients. Anesthesiology 76: 209–215
Kase Y, Wakita Y, Kito G et al. (1970) Centrally induced coughs in the cat. Life Sci 9: 49–59
Kaufman RD, Agleh KA, Belville JW (1979) Relative potencies and duration of action with respect to respiratory depression of intravenous meperidine, fentanyl and alphaprodine in man. J Pharmacol Exp Ther 208: 73–79
Kaukinen L, Kaukinen S, Eerola R et al. (1981) The antagonistic effect of pentazocine on fentanyl induced respiratory depression compared with nalorphine and naloxone. Ann Clin Res 13: 396–401
Kauppila T, Kemppainen P, Tanila H et al. (1991) Effect oft systemic medetomidine, an α2-adrenocep-tor agonist, on experimental pain in humans. Anesthesiology 74: 3–8
Kay B (1990) Opiatagonist-Antagonisten: Allgemeine Pharmakologie. In: Lehmann KA (Hrsg) Der postoperative Schmerz. Springer, erlin Heidelberg New York Tokyo, S 190–200
Kay B, Roily G (1977) Duration of action of analgesic supplement to anaesthesia. Acta Anaesth Belg 28: 25–32
Kay DC, Eisenstein RB, Jasinski DR (1969) Morphine effects on human REM state, waking state, and NREM sleep. Psychopharmac 14: 404–416
Kayaalp SO, Kaymakcalan S (1966) A comparative study of the effects of morphine in unanesthetized and anesthetized cats. Br J Pharmacol 26: 196–204
Kayser V, Besson JM, Guilbaud G (1987) Paradoxical hyperalgesic effect of exceedingly low doses of systemic morphine in an animal model of persistent pain (Freunds adjuvant-induced arthritic rats). Brain Res 414: 155–157
Kayser V, Gobeaux D, Lombard MC et al. (1990) Potent and long lasting antinociceptive effects after injection of low doses of a mu-opioid receptor agonist, fentanyl, into the brachial plexus sheath of the rat. Pain 42: 215–225
Keats A (1985) The effect of drugs on respiration in man. Annu Rev Pharmacol Toxicol 25: 41–65
Keen MF (1986) Comparison of intramuscular injection techniques to reduce site discomfort and 1 esions. Nursing Res 35: 207–210
Keeri-Szanto M (1979) Drugs or drums: what relieves postoperative pain? Pain 6: 217–262
Keifer JC, Baghdoyan HA, Lydic R (1992) Sleep disruption and increased apnoeas after pontine micro-injection of morphine. Anesthesiology 77: 973–982
Keller R, Waldvogel HH, Herzog H (1975) Neurolept analgesia for bronchoscopic examinations. Chest 67(3): 315–319
Kendig JJ, Savola MT, Maze M (1989) Effects of a sedative/analgesic adrenergic agonist, dexmedeto-midine, in the spinal cord of newborn rats. Anesthesiology 71: A579
Kennedy BL, West TC (1967) Effects of morphine on electrically-induced release of autonomic mediators in the rabbit sinoatrial node. J Pharmacol Exp Ther 157: 149
Kentor ML, Schwalb AJ, Lieberman RW (1980) Rapid high dose fentanyl induction for CABG. Anesthesiology 53: S 95
Kerr ME, Brycua J (1993) Hyperventilation in the head-injured patient: an effective treatment modality? Heart Lung 22: 516–521
Kety SS, Schmidt CF (1948) Effects of blood arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral consumption of normal young men. J Clin Invest 27: 484–492
Khoury GF, Chen AC, Garland DE et al. Intraarticular morphine, bupivacaine, and morphine/bupiva-caine for pain control after knee videoartrhoscopy. Anesthesiology 77: 263–266
Kiefer BL, Befort K, Gaveriaux-Ruff C et al. (1992) The δ-opioid receptor: isolation of a cDNA by expression cloning and pharmacologie characterization. Proc Natl Acad Sci USA 89: 12048–12052
Kihara T, Kaneto H (1986) Important role of adrenergic function in the development of analgesic tolerance to morphine in mice. Jpn J Pharmacol 42: 419–423
Kirby H, Heaton KW, Burton JL (1974) Pruritic effect of bile salts. BMJ IV: 693
Kisin I, Markiewicz W, Birkhahn J (1979) Effect of large doses of morphine on experimental μlocardial ischemia in cats. Isr J Med 15: 588–591
Kissin I, Brown PT, Bradley EL jr (1991) Magnitude of acute tolerance to opioids is not related to their potency. Anesthesiology 75: 813–816
Kistner JR, Miller ED, Lake CL et al. (1979) Indices of myocardial oxygenation during coronary-artery revascularization in man with morphine versus halothane anesthesia. Anesthesiology 50: 324–330
Klepper ID, Rosen M, Vickers MD et al. (1986) Respiratory function following nalbuphine and morphine in anaesthetized man. Br J Anaesth 58: 625–629
Klotz U, McHorse TS, Wilkinson GR et al. (1974) The effect of cirrhosis on the disposition and elimination of meperidine in man. Clin Pharmacol Ther 16: 667–675
Knapp RJ, Hawkins KN, Lui GK et al. (1990) Multiple opioid receptors and novel ligands. In: Benedetti C, Chapman CR, Giron G (eds) Advances in pain research and therapy, vol 14. Raven, New York, pp 45–85
Koehntop D, Rodman J, Brundage D et al. (1986) Pharmacokinetics of fentanyl in neonates. Anesth Analg 65: 227–232
Kofke WA, Garman RH, Tom CW et al. (1992) Alfentanil-induced hypermetabolism, scizure, and histo-pathology in rat brain. Anesth Analg 75: 953–964
Kogan JH, Nestler AJ, Aghajanian GK (1992) Elevated basal firing rates and enhanced responses to 8-Br-cAMP in locus coeruleus neurones in brain slices from opiate-dependent rats. Eur J Pharmacol 211: 47–53
Kolesnikov YA, Ferkany J, Pasternak GW (1993) Blockade of mu and kappa1 opioid analgesic tolerance by NPC17742, a novel NMDA antagonist. Life Sci 53: 1489–1494
Kolesnikov YA, Pick CG, Ciszewska G et al. (1993) Blockade of tolerance to morphine but not to opioids by a nitric oxide synthase inhibitor. Proc Natl Acad Sci USA 90: 5162–5166
Kongsgaard UE, Pettersen B, Bjorgo S et al. (1993) Myoclonic contractions associated with intrathecal infusion of high-dose morphine. 7th World Congress Pain Abstract 594, Poster 247
Kopacz DJ, Slover RB (1990) Accidental epidural cephalozin injection: safeguards for patient-controlled analgesia. Anesthesiology 72: 944–947
Koren G, Butt W, Chinyanga H et al. (1985) Postoperative morphine infusion in newborn infants: assessment of disposition characteristics and safety. J Ped 107: 963–967
Korinek AM, Languille M, Bonnet F et al. (1985) Effect of postoperative extradural morphine on ADH secretion. Br J Anaesth 57: 407–411
Kossmann B, Hecht M, Bowdler I et al. (1985) Therapie von Karzinomschmerzen: Vergleich einer wäβ-rigen Morphinlösung mit MST-Tabletten. Schmerz-Pain-Douleur 4: 143–151
Kosterlitz HW, Lord JAH (1971) The morphine receptor in the guinea pig ileum. A. Antagonist of nor-morphine, phenoperidine, fentanyl and etorphine. B. Methadone. C. Antagonists with very long duration of action. Com Prob Drug Depend; 33rd Ann Scie Meeting, Toronto
Kosterlitz HW, Paterson SJ, Robson CE (1981) Characterisation of the kappa-subtype of the opioid receptor in the guinea pig brain. Br J Pharmacol 73: 939
Kosterlitz HW, Paterson SJ (1990) Opioid receptors and mechanisms of opioid analgesia. In: Benedetti C, Chapman CR, Giron G (eds) Advances in pain research and therapy, vol 14. Raven, New York, PP 37–43
Krames ES, Wilkie DJ, Gershow J (1986) Intrathecal D-Ala2-D-Leu5-enkephalin (DADL) restores analgesia in a patient analgetically tolerant to intrathecal morphine sulfate. Pain 24: 205–209
Krause L, Shuster S (1983) Mechanism of action of antipruritic drugs. BJM 287: 1199–1200
Kraushaar OF, Bradbury JT, Wang YK et al. (1949) Morphins suppression of urinary output in pregnant and nonpregnant women. Am J Obstet Gynecol 57: 302–311
Krieger DT (1983) Brain peptides: where and what? Science 222: 975
Krishna G, Paradise RR (1974) Effect of morphine on isolated human atrial muscle. Anesthesiology 40: 147–151
Kromer W, Beubler E (1993) Dual opioid modulation of chloride/water secretion in the guinea-pig colon in vitro and the rat jejunum in vivo. J Auton Pharmacol 13: 315–321
Kruger-Theimer E (1968) Continuous intravenous infusion and multicompartment accumulation. Eur J Pharmacol 4: 317
Kruszewski A, Lang S, Johnson J (1979) Effects of positioning on discomfort from intramuscular injections in the dorsogluteal site. Nursing Res 28: 103–105
Kryger MH, Roth T, Dement WC (1989) Principles and practice of sleep medicine. Saunders, Philadelphia
Kubicki ST, Stölzel R, Orten J et al. (1970) Exzitatorische und inhibitorische Phänomene am Zentralnervensystem verursacht durch Fentanyl. In: Henschel WF (ed) Neue klinische Aspekte der Neuro-leptanalgesie. Schattauer, Stuttgart, S 21–30
Kuhar MJ, Pasternak GW (eds) (1984) Analgesics: Neurochemical behavioural, and clinical perspectives. Raven, New York
Kuhar MJ, Pert CB, Snyder SH (1973) Regional distribution of opiate receptor binding in monkey and human brain. Nature 245: 447–450
Kuhnert BR, Kuhnert PM, Tu AL et al. (1979) Meperidine and normeperidine levels following meperi-dine administration in labor. II. Fetus and neonate. Am J Obstet Gynec 133: 909–914
Kupferburg HJ, Way EL (1963) Pharmacologic basis for the increased sensitivity of the newborn rat to morphine. J Pharmacol Exp Ther 141: 105–112
Kurose H, Seino Y, Shima M et al.(1987) Intranasal absorption of salmon calcitonin. Calcif Tiss Int 41: 249–251
Kuschinsky K, Hornykiewicz (1972) Morphine katalepsy in the rat: relation to striatal dopamine metabolism. Eur J Pharmacol 19: 119
Kutter E, Herz A, Teschemacher HJ et al. (1970) Structure-activity correlations of morphine-like analgesics based on efficiencies following intravenous and intraventricular application. J Med Chem 13: 801–805
Kyriakides M, Silverstorne T, Jeffcoate W et al. (1980) Effect of naloxone on hyperphagia in Prader-Willis syndrome. Lancet I: 876–877
Laatikainen TJ (1991) Corticotropin-releasing hormone and opioid peptides in reproduction and stress. Ann Med 23: 489–496
Laduron PM (1984) Criteria for receptor sites in binding studies. Biochem Pharm 33: 833–839
Laduron PM (1984) Axonal transport of opiate receptors in capsaicin-sensitive neurons. Brain Res 294: 157–160
Lake CL, Duckworth EN, Di Fazio CA et al. (1982) Cardiovascular effects of nalbuphine in patients with coronary or valvular heart disease. Anesthesiology 57: 498–503
Lal S, Savidge RS, Chabra GP (1969) Cardiovascular and respiratory effects of morphine and pentazo-cine in patients with myocardial infarction. Lancet 1: 379–381
Lamb SA, Hosobuchi Y (1990) Intrathecal morphine sulfate for chronic benign pain delivered by implanted pump delivery systems. IASP Meeting, Adelaide (Australia), p 120
Langer SZ (1980) Presynaptic regulation of the release of catecholamines. Pharmacol Rev 32: 337–362
Lappas DG, Geha D, Fischer JE et al. (1975) Filling pressures of the heart and pulmonary circulation of the patient with coronary artery disease after large intravenous doses of morphine. Anesthesiology 42: 153–159
Lappas DG, Buckely MJ, Laver MB et aL (1975) Left ventricular circulation following addition of nitrous oxide to morphine during coronary artery surgery. Anesthesiology 43: 61–69
Lappas DG, Fahmy NR, Slater EE et al. (1980) Catecholamines, renin and cardiovascular responses to fentanyl-diazepam anesthesia. Anesthesiology 53: S 14
Larochelle P, Ogilvie RI (1975) Effect of drugs on effective vascular compliance in acute heart failure. Can J Physiol Pharmacol 53: 850–858
Larson CP, Mazze RI, Cooperman LH et al. (1974) Effects of anesthetics on cerebral, renal, and splanchnic circulations: recent developments. Anesthesiology 41: 169–181
Lassagna L, Beecher HL (1954) The optimum dose of morphine. Am Med Ass J 156: 230
Lassen NA, Christensen MS (1976) Physiology of cerebral blood flow. Br J Anaesth 48: 719–734
Lassner J, Norman J (1985) Future work on patient-controlled analgesia: summary of open discussion. in: Harmer M, Rosen M, Vickers MD (eds) Patient-controlled analgesia. Blackwell, Oxford, pp 191–194
Latasch L, Christ R (1986) Opiatrezeptoren. Anaesthesist 35: 55–65
Latasch L, Probst S, Dudziak R (1984) Reversal by nalbuphine of respiratory depression caused by fentanyl. Anesth Analg 63: 814–816
Latimer RG, Dickman M, Day WC et al. (1971) Ventilatory patterns and pulmonary complications after upper abdominal surgery determined by preoperative and postoperative computerized spiro-metry and blood gas analysis. Am J Surg 122: 622–632
Laubie M, Schmitt H, Drouillat M (1977) Central sites and mechanisms of the hypotensive and brady-cardic effects of the narcotic analgesic agent fentanyl. Naunyn Schmiedebergs Arch Pharmacol 296: 255–261
Laubie M, Schmitt H, Vincent M et al. (1977) Central cardiovascular effects of morphinomimetic peptides in dogs. Eur J Pharmacol 46: 67–71
Laubie M, Schmitt H, Vincent M (1979) Vagal bradycardia produced by microinjections of morphine-like drugs into the nucleus ambiguus in anaesthetized dogs. Eur J Pharmacol 59: 287–291
Laugner B, Müller A, Thiebaut JB (1985) Analgesia with an implanted device for repetitive intrathecal injections of MSG. Ann F Anesth Rean 4: 511–520
Laurent SC, Nolan JP, Pozo LJ et al. (1994) Addition of morphine to intra-articular bupivacaine does not improve analgesia after day-case arthroscopy. Br J Anaesth 72: 170–173
Lauterburg BH, Taswell HF, Pineda AA et al. (1980) Treatment of pruritus of cholestasis by plasma perfusion through USP-charcoal-coated glass beads. Lancet II: 53–55
Law PY, Griffin MT, Loh HH (1984) Mechanisms of multiple cellular adaptation process in clonal cell lines during chronic opiate treatment. In: Sharp CW (ed) NIDA Res Prog: Mechanisms of tolerance dependence, Monograph N° 54. US Government Printing Offiice, Washington/DC, pp 119–135
Lawhead RG, Blaxall HS, Bylund DB (1992): α2Ais the predominant α2-adrenergic receptor subtype in human spinal cord. Anesthesiology 77: 983–991
Lawrence AJ, Joshi J, Michalkiewicx A et al. (1992) Evidence for analgesia mediated by peripheral opioid receptors in inflamed synovial tissue. Eur J Clin Pharmacol 43: 351–355
Le Bars D, Willer JC, De Broucker T (1992) Morphine blocks descending pain inhibitory controls in humans. Pain 48: 13–20
Leander JD (1983) Further study of kappa opioids on increased urination. J Pharmacol Ther 227: 35–41
Lee NM, Smith AP (1984) Possible regulatory function of dynorphin and its clinical implications. Trends Pharmacol Sci 5: 108–110
Lehmann KA (1983) „On demand Analgésie“. Dtsch Med Wochenschr 108: 647–650
Lehmann KA (1990) On-demand-Analgesic In: Lehmann KA (Hrsg) Der postoperative Schmerz Springer, Berlin Heidelberg New York Tokyo, S 237–265
Lehmann KA, Neubauer ML, Daub D et al. (1983) Co2-Antwortkurve als Maß für eine opiatbedingte Atemdepression. Untersuchungen mit Fentanyl. Anaesthesist 32: 242–258
Lehmann KA, Gerhard A, Horrichs-Haermeyer G et al. (1991) Postoperative patient-controlled analgesia with sufentanil: Analgesic efficacy and minimum effective concentrations. Anesthesiology 35: 221–226
Leiman BC, Watford A, Rawal N et al. (1987) The effects of oral transmucosal fentanyl citrate preme-dication on gastric volume and acidity in children. Anesthesiology 67: A489
Leith S, Wheatley RG, Jackson IJB et al. (1994) Extradural infusion analgesia for postoperative pain relief. Br J Anaesth 73: 552–558
Leong Way E, Kemp JW, Young JM et al. (1960) The pharmacologic effects of heroin in relationship to its rate of biotransformation. J Pharmacol Exp Ther 129: 144–154
Lesley RM, Tso S, Holbutt TE (1982) Differential appearance of opiate receptor subtypes in neonatal rat brain. Life Sci 31: 1393–1396
Leslie ST (1981) Continus controlled release preparations. Br J Clin Pract 10: 5–10
Leslie ST (1986) The Contin controlled delivery system: dosing considerations. J Allerg Clin Immunol 78: 768–773
Leslie ST, Rhodes A, Black MP (1980) Controlled release morphine sulfate tablets-A study in normal volunteers. Br J Clin Pharmacol 9: 532–534
Levine JD, Fields HL, Basbaum AI (1993) Peptides and the primary nociceptor. J Neurosci 13: 2273–2286
Levitsky S, Mullin EM, Sloane RE et al. (1971) Experimental evaluation of pentazocine: Effect on myo-cardial contractility and peripherel vascular resistance. Am Heart J 81: 381–386
Levy JH, Rockoff MA (1982) Anaphylaxis to meperidine. Anesth Analg 61: 301–303
Lewis JW (1985) Buprenorphine. Drug Alcohol Depend 14: 363–372
Leysen JE, Laduron PM, Niemegeerts CJE (1978) Receptor binding binding properties in vitro and in vivo of new long acting narcotic analgesics. In: Ree J van, Terenius R (eds) Characteristics and functions of opioids. Elsevier, Amsterdam, pp 479–482
Leysen JE, Gommeren W, Niemegeers CJE (1983) [3]H-sufentanil: a superior ligand for mu-opiate receptors: binding properties and a regional distribution in rat brain and spinal cord. Eur J Pharmacol 87: 209–225
Leysen JE, Tollenaere JP, Koch MHJ et al. (1977) Differentiation of opiate and neurolept receptor binding in rat brain. Eur J Pharmacol 43: 447–453
Li LY, Zhang ZM, Su YF et al. (1993) Pharmacological mechanisms of opioid analgesics. Clin Neuro-pharm 16: 1–18
Lind HG, Marcus MA, Mears Slashburn MA et al. (1991) Oral transmucosal fentanyl citrate for analgesia and sedation in the emergency department. Ann Emerg Med 20: 1117–1120
Lindblom V, Lindstrom P (1984) Analgesic effect of tocainide in neuralgia. Acta Neurol Scand 69: 216–217
Lindell P, Hedenstierna G (1976) Ventilatory efficiency after different incisions for cholecystectomy. Acta Chir Scand 142: 561–565
Ling GSF, Spiegel K, Lockhart SH et al. (1985) Separation of opioid analgesia from respiratory depression: evidence for different receptor mechanisms. J Pharmacol Exp Ther 232: 149–155
Livingston EH, Passaro EP (1990) Postoperative ileus. Dig Dis 35: 121–132
Liu WS, Bidwai AV, Stanley TH et al. (1976) Cardiovascular dynamics after large doses of fentanyl and fentanyl plus N2O in the dog. Anesth Analg 55: 168–172
Lloyd-Thomas AR (1990) Pain management in paediatric patients. Br J Anaesth 64: 85–104
Lo SL, Colemann RR (1987) Exceptionally high narcotic analgesic requirements in a terminally ill cancer patient. Clin Pharm 5: 282
Locke KW, Little JA, Fielding S (1987) The effects of mu-and kappa-opioid receptor agonists on sciatic nerve stimulation-evoked potentials in the rat. Ann Meet Soc Neuroscience A13/3, part 3, 1590, Abstract N° 440.9
Lockeridge O, Mottershaw-Jackson N. Eckerson HW et al. (1980) Hydrolysis of diacetyl morphine (heroin) by human serum cholinesterase. J Pharmacol Exp Ther 215: 1–8
Loeschcke HH (1965) A concept of the role of intracranial chemosensitivity in respiratory control. In: Brookes McCC, Kao FF, Lloyd BB (eds) Cerebrospinal fluid and the regulation of ventilation. Black-well, Oxford
Loeschcke HH, Sweel A, Kough RH et al. (1953) The of effect of morphine and of meperidine (dolan-tin, demerol) upon the respiratory response of normal men to low concentrations of inspired carbon dioxide. J Pharmacol Exp Ther 108: 376–382
London SW (1987) Respiratory depression after single epidural injection of local anaesthetic and morphine. Anesth Analg 66: 797–770
Lord JAH, Waterfield AA, Hughes J et al. (1977) Endogenous opioid peptides: multiple agonists and receptors. Nature 267: 495–499
Lowenstein E (1971) Morphine „anesthesia“ — a perspective. Anesthesiology 35: 563–565
Lowenstein E, Philbin DM (1981) Narcotic „anesthesia“ in the eighties. Anesthesiology 55: 195–197
Lowenstein E, Hallowell P, Levine FH et al. (1969) Cardiovascular response to large doses of intravenous morphine in man. N Engl J Med 281: 1389–1393
Lowenstein E, Whiting RB, Bittar DA et al. (1972) Local and neurally mediated effect of morphine on skeletal muscle vascular resistance. J Pharmacol Exp Ther 180: 359–367
Lucas JJ, Mellstrom B, Colado MI et al. (1993) Molecular mechanism in pain: serotonin 1A receptor agonists trigger transactivation by c-fos of the prodynorphin gene in spinal cord neurons. Neuron 10: 599–611
Lundberg N, Kjallquist A, Bien C (1959) Reduction of increased intracranial pressure by hyperventila-tion: a therapeutic aid in neurological surgery. Acta Psychiat Neurol Scand 34 (Suppl 139): 5–64
Lunn JK, Stanley TH, Eisele J et al. (1979) High dose fentanyl anesthesia for coronary artery surgery: Plasma fentanyl concentrations and influence of nitrous oxide on cardiovascular responses. Anesth Analg 58: 390–395
Lydic R, Keifer JC, Baghdoyan HA et al. (1993) Microdialysis of the pontine reticular formation reveals inhibition of acetylcholine release by morphine. Anesthesiology 79: 1003–1012
Lynn AM, Slattery JT (1987) Morphine pharmacokinetics in early infancy. Anesthesiology 66: 136–139
Lynn RK, Olsen GD, Leger RM et al. (1976) The secretion of methadone and its major metabolite in the gastric juice of humans. Drug Metab Dis 4: 504
Macdonal R (1991) Editorial I: Aspirin and extradural blocks. Br J Anaesth 66: 1–3
Madej TH, Strunin L (1987) Comparison of epidural fentanyl with sufentanil. Anaesthesia 42: 1156–1161
Magnan J, Paterson SJ, Tavani A et al. (1982) The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties. Naunyn Schmiedebergs Arch Pharmacol 319: 197–205
Malcolm R, O’Neil PM, Sexauer JD et al. (1985) A controlled trial of naltrexone in obese humans. Int J Obes 9: 347–353
Maldonado R, Koob GF (1993) Destruction of the locus coeruleus decreases physical signs of opiate withdrawal. Brain Res 605: 128–138
Maloney CM, Kesner RK, Klein G et al. (1989) The rectal administration of MS Contin-R: Clinical implications of use in end stage cancer. Am J Hosp Care 1: 34–35
Manara AR, Shelly MP, Quinn KG et al. (1989) Pharmacokinetics of morphine following administration by the buccal route. Br J Anaesth 62: 498–502
Manara AR, Bodenham AR, Park GR (1990) Analgesic efficacy of perioperative buccal morphine. Br J Anaesth 64: 551–555
Markovitz BP, Duhaime AC, Sutton L et al. (1992) Effects of alfentanil on intracranial pressure in children undergoing ventriculoperitoneal shunt revision. Anesthesiology 76: 71–76
Marks RM, Sachar EJ (1973) Undertreatment of medical inpatients with narcotic analgesics. Ann I ntern Med 78: 173–181
Marks RJ, Derrington MC, Hewlett AM (1985) Peripheral actions of narcotics. Anaesthesia 40: 85
Marshall EK, Rosenfeld M (1936) Depression of respiration by oxygen. J Pharmacol Exp Ther 57: 437–457
Marshall H, Porteous C, McMillan I et al. (1985) Relief of pain by infusion of morphine after operation: does tolerance develop. BMJ 291: 19–21
Martin WR (1967) Opioid antagonists. Pharmacol Rev 19: 463–521
Martin WR (1979) History and development of mixed opioid agonists, partial agonists and antagonists. Br J Clin Pharmacol 7 (Suppl. 3): 273S–279S
Martin WR (1983) Pharmacology of opioids. Pharmacol Rev 35: 283–323
Martin WR, Eades CG (1961) Demonstration of tolerance and physical dependence in the dog following a short-term infusion of morphine. J Pharmacol Exp Ther 133: 262–270
Martin WR, Jasinsi DR (1969) Physiological parameters of morphine dependence in man-Tolerance, early abstinence, protracted abstinence. J Psychiatr Res 7: 9–17
Martin WR, Takemorie AE (1987) Modification of the development of acute opiate tolerance by increased dopamine receptor sensitivity. J Pharmacol Exp Ther 241(1): 48–55
Martin WR, Eades CG, Thompson JA et al. (1976) The effect of morphine-and nalorphine like drugs in the non dependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther 197: 517–532
Maruta T, Swanson DW, Finlayson RE (1979) Drug abuse and dependency in patients with chronic pain. Mayo Clin Proc 54: 241–244
Marx W, Shah N, Long C et al. (1989) Sufentanil, alfentanil, and fentanyl: impact on cerebrospinal fluid pressure in patients with brain tumors. J Neurosurg Anesth 1: 3–7
Mason JS, Heber D (1982) Endogenous opiates modulate insulin secretion in flushing noninsulin-dependent diabetics. J Clin Endocrin Metab 54: 693–697
Masters N, Heao G, Wedley J et al. (1988) Inhaled nebulised morphine und diamorphine: useful in general practice? Pract 232/1: 910
Mather LE (1987) Opioid kinetics in relation to their effects. Anaesth Intensive Care 15: 15–22
Mather LE, Owen H (1988) The scientific basis of patient-controlled analgesia. Anaesth Intensive Care 16: 427–447
Mather LE, Tucker GT, Pflug AE et al. (1975) Meperidine kinetics in man. Clin Pharmacol Ther 17: 21–30
Matsumoto RR, Hemstreet MK, Lai NL et al. (1990) Drug specifity of pharmacological dystonia. Pharmacol Biochem Behav 36: 151–155
Matthews NC, Corser G (1988) Epidural fentanyl for shaking in obstetrics. Anaesthesia 43: 783–785
Matthiessen von H, Grote B, Kiwit J et al. (1987) Therapie tumorbedingter Schmerzen: Verordnungsund Dosierungshinweise. Sonderdruck Dtsch Ärztebl-Ärztl Mitt 39: 3–7
Mauskop A, Coyle N, Foley KM (1987) Continuous subcutaneous infusion (CSI) of narcotic analgesics (NA) in cancer patients with pain. Pain (Suppl 4): S 342
Maves TJ, Gebhart GF (1991) Analgesic synergy between intrathecal opioids and local anesthetics. Anesth Analg 73: 365–366
Maves TJ, Gebhart GF (1992) Antinociceptive synergy between intrathecal morphine and lidocaine during visceral and somatic nociception in the rat. Anesthesiology 76: 91–99
Max MB, Inturrisi CE, Kaiko RF et al. (1985) Epidural and intrathecal opiates: cerebrospinal fluid and plasma profiles in patients with chronic pain. Clin Pharmacol Ther 38: 631
Mayer DJ, Price DD (1976) Central nervous system mechanisms of analgesia. Pain 2: 379–404
Mayer DJ, Wolfe TL, Akil H et al. (1971) Analgesia from electrical stimulation in the brainstem of the rat. Science 174: 1351
Maze M (1981) Clinical implications of membrane receptor function in anesthesia. Anesthesiology 51: 160–171
Maze M, Tranquilli W (1991) Alpha-2 adrenoceptor agonists: defining the role in clinical anesthesia. Anesthesiology 74: 581–605
McCaffery M, Beebe A (1989) Pain. Clinical Manual for Nursing Practice, Mosby (Toronto)
McCammon RL, Viegas OJ, Stoelting RK et al. (1978) Naloxone reversal of choledochoduodenal spin-cter spasm associated with narcotic administration. Anesthesiology 48: 437–439
McConville GJ, Norman AB, Fogelson MH (1994) Sequential use of opioid antagonists and agonists in Tourette’s syndrome. Lancet (8897): 601
McCrea FD, Meek WJ (1926) The action of morphine in slowing the pulse. J Pharmacol Exp Ther 28: 361–366
McDermott R, Stanley TH (1974) The cardiovascular effects of low concentrations of nitrous oxide during anaesthesia. Anesthesiology 41: 89
McGaugh JL, Introini-Collison IB, Castellano C (1993) Involvement of opioid peptides in learning and memory. In: Opioids I (Herz A, ed.), Springer, Ch 47: 429–447
McGilliard KL, Takemori AE (1978) Antagonism by naloxone of narcotic-induced respiratory depression and analgesia. J Pharmacol Exp Ther 207: 494–503
McGivney WT, Crooks GM (1984) The care of patients with severe chronic pain in terminal illness. JAMA 251: 1182–1188
McQuay HJ, Moore RA, Paterson GMC et al. (1979) Plasma fentanyl concentrations and clinical observations during and after operation. Br J Anaesth 51: 741
McQuay HJ, Bullingham RES, Moore RA (1981) Acute tolerance in man. Life Sci 27: 2513–2516
McRorie TI, Lynn AN, Nespeca MK et al. (1992) The maturation of morphine clearance and metabolism. Am J Dis Child 146: 972–976
Melzack R, Mount BM, Gordon JM (1979) The Brompton mixture vs. morphine solution given orally: effects on pain. Can Med Ass J 120: 435–439
Menk EJ, Baumgarten RK, Kingsley CP et al. (1990) Success of reentry into anesthesiology training programs by residents with a history of substance abuse. JAMA 263: 3060–3062
Mergens PA (1991) Muscle rigidity after narcotics: pharmacologic concepts. In: Faust RJ (ed) Anesthesiology review, chap 48. Churchill Livingstone, pp 102–103
Miaskowski C, Taiwo O, Levine JD (1990) Kappa and delta agonists synergize to produce potent analgesia. Brain Res 509: 165–168
Michaelis LL, Hickey PR, Clark TA (1974) Ventricular irritability associated with the use of naloxone hydrochloride. Ann Thor Surg 18: 608–614
Milde LN, Milde JH, Gallagher WJ (1990) Effects of sufentanil on cerebral circulation and metabolism in dogs. Anesth Analg 70: 138–146
Millan MJ (1986) Multiple opioid systems and pain. Pain 27: 303–347
Millan MJ (1990) K-Opioid receptors and analgesia. Trends Pharmacol Sci 11: 70–76
Millan MJ, Czlonkowski A, Morris B et al. (1988) Inflammation of the hind limb as a model of unilateral, localized pain: influence on multiple opioid systems in the spinal cord of the rat. Pain 35: 299–312
Millan MJ, Czlonkowski A, Lipkowski A et al. (1989) Kappa-opioid receptor-mediated antinociception in the rat. II. Supraspinal in addition to spinal sites of action. J Pharmacol Exp Ther 251: 342–350
Miller RL, Forsyth RP, Melmon KL (1972) Morphine-induced redistribution of cardiac output in the unanesthetized monkey. Pharmacol 7: 138–148
Miralles FS, Lopez-Soriano F, Perez D et al. (1986) Subarachnoid administration of calcitonin produces postoperative analgesia. Anesthesiology 65: A199
Miser AW, Davis DM, Hughes CS et al. (1983) Continuous subcutaneous infusion of morphine in c hildren with cancer. Am J Dis Child 137: 383–385
Misra AL (1978) Metabolism of opiates. In: Adler MW, Manara L, Samanin R (eds) Factors affecting the action of narcotics. Raven, New York, pp 297–343
Misra AL, Pontani RB, Vadlamani NL (1987) Stereospecific potentiation of opiate analgesie by cocaine: predominant role of noradrenalin. Pain 28/1: 129–138
Mitchard M (1977) Drug distribution in the elderly. In: Crooks J, Stevenson IH (eds) Drugs and the elderly. Macmillan, London
Moore RA, Bullingham RES, McQuay HJ et al. (1982) Durai permeability to narcotics: in vitro determination and application to extradural administration. Br J Anaesth 54: 1117–1128
Moore RA, Bullingham RES, McQuay HJ et al. (1984) Spinal fluid kinetics of morphine and heroin. Clin Pharmacol Ther 35: 40–45
Morgan JP (1985–1986) American opiophobia: customary underutilization of opioid analgesics. Adv Alcohol Subst Abuse 5: 163–173
Mori K (1987) The EEG and awareness during anaesthesia. Anaesthesia 42: 1153–1155
Morley JE, Levine AS (1980) Stress-induced eating is mediated through endogenous opiates. Science 209: 1259–1261
Morley JE, Levine AS (1981) Dynorphin-(1-13) induces spontaneous feeding in rats. Life Sci 29: 1902–1903
Morley JE, Levine AS (1982) The role of endogenous opiates as regulators of appetite. Am J Clin Nutr 35: 757–761
Morrison JC, Wiser WL, Rosser SI et al. (1973) Metabolites of meperidine related to fetal depression. Am J Obstet Gynecol 115: 1132–1137
Morrison JC, Whybrew WD, Rosser SI et al. (1976) Metabolites of meperidine in the fetal and maternal serum. Am J Obstet Gynecol 126: 997–1002
Moss E, Powell D, Gibson RM et al. (1978) Effects of fentanyl on intracranial pressure and cerebral perfusion pressure during hypocapnia. Br J Anaesth 50: 779–784
Motsch J, Gräber E, Ludwig K (1990) Addition of clonidine enhances analgesia from epidural morphine: a double blind study. Anesthesiology 73: 1067–1073
Moulin DE, Inturrisi CE, Foley KM (1986) Epidural and intrathecal opioids: cerebrospinal fluid and plasma pharmacokinetics in cancer pain patient. Adv Pain Res Ther 8: 369–383
Moulin DE, Kreeft JH, Murray-Parsons N et al. (1991) Comparison of continuous subcutaneous and intravenous hydromorphone infusions for the management of cancer pain. Lancet 337: 465–468
Mount BM (1980) Narcotic Analgesics. In: Twycross RG, Ventafridda V (eds) The continuing care of terminal cancer patients. Pergamon, New York, pp 97–116
Mulder AM, Schoffelmeer ANM (1993) Multiple opioid receptors and presynaptic modulation of neurotransmitter release in the brain. In: Herz A (ed) Opioids, chap 7. Springer, Berlin Heidelberg New York Tokyo, pp 125–144
Müller-Lissner SA, Blum L (1981) Effects of specific gravity and eating on gastric emptying of slow-release capsules. N Engl J Med 304: 1365
Mummaneni N, Rao TLK, Montoya A (1980) Awareness and recall with high-dose fentanyl-oxygen anesthesia. Anesth Analg 59: 948–949
Muranishi S (1991) Drug targeting towards the lympathics. Adv Drug Res 21: 1–38
Murphy MR, Hug CC (1982) Dose-dependent pharmacokinetics of fentanyl. Anesthesiology 57: A347
Murphy P, Salomon J, Roseman DL (1980) Narcotic anesthetic drugs: their effect on biliary dynamics. Arch Surg 115: 710–711
Nadasdi M, Zsoter TT (1969) The effect of meperidine on the peripheral circulation. Clin Pharmacol Ther 10: 239–243
Nagashima H, Karamanian A, Malovany R et al. (1976) Respiratory and circulatory effects of intravenous butorphanol and morphine. Clin Pharmacol Ther 19: 738–745
Neal EA, Meffin PJ, Gregory PB et al. (1979) Enhanced bioavailability and decreased clearance of analgesics in patients with cirrhosis. Gastroenterology 77: 96–102
Neely J (1969) The effects of analgesic drugs on gastrointestinal motility in man. Br J Surg 56: 925–929
Negri L, Potenza RL, Melchiori P (1991) Evidence for two subtypes of delta opioid receptors in rat brain. Eur J Pharmacol 196: 335–336
Neidhart P, Burgener MC, Schwieger I et al. (1989) Chest wall rigidity during fentanyl-and midazolam-fentanyl induction: ventilatory and haemodynamic effects. Acta Anaesth Scand 33: 1–5
Neil A (1990) Tolerance and Dependence. In: Benedetti C, Chapman CR, Giron G (eds) Advances in pain research and therapy, vol 14. Raven, New York, pp 121–142
Nelson PS, Streisand JB, Mulder S et al. (1987) Premedications in children: a comparison of oral trans-mucosal fentanyl citrate (fentanyl lollipop) and oral solution of meperidine, diazepam and atropine. Anesthesiology 67: A490
Nickel B (1987) The antinociceptive activity of flupirtin: a structurally new analgesic. Postgr Med J 63(S 3): 19–28
Nickel B, Aledter A (1987) Comparative physical dependence studies in rats with flupirtin and opiate receptor stimulating analgesics. Postgr Med J 63(S 3): 41–43
Nickel B, Jakovlev V, Szelenyi I (1990) Einfluß von Flupirtin, verschiedener Analgetika und Muskel-relaxanzien auf den Skelettmuskeltonus wacher Ratter. Arzn-Forschung Drug Res 40/II: 909–911
Nimmo WS (1982) Gastrointestinal function following surgery. Reg Anesth 7: S 105
Nimmo WS, Todd JG (1985) Fentanyl by constant rate IV infusion for postoperative analgesia. Br J Anaesth 57: 250–254
Nimmo WS, Heading RC, Wilson J et al. (1975) Inhibition of gastric emptying and drug absorption by narcotic analgesics. Br J Clin Pharmacol 2: 509–513
Nishi M, Takeshima H, Fukuda K et al. (1993) cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for ϰ-subtype-selecetive ligands. FEBS Lett 330: 77–80
Nishino K, Su YF, Wong CS et al. (1990) Dissociation of μ opioid tolerance from receptor down-regulation in rat spinal cord. J Pharmacol Exp Ther 253: 67–72
Nishitateno K, Ngai SH, Finck AD et al. (1979) Pharmacokinetics of morphine: concentrations in the serum and brain of the dog during hyperventilation. Anesthesiology 50: 520–523
Noda M, Furutani Y, Takahashi H et al. (1982) Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin. Nature 295: 202–206
Noda M, Teranishi Y, Takahashi H et al. (1982) Isolation and structural organization of the human preproenkephalin gene. Nature 297: 431–434
Nordberg G, Hedner T, Meilstrand T et al. (1984) Pharmacokinetic aspects of intrathecal morphine analgesia. Anesthesiology 60: 448–454
Norman J (1985) Terminology used in patient-controlled analgesia. In: Harmer M, Rosen M, Vickers MD (eds) Patient controlled analgesia. Blackwell, Oxford, pp 1–6
North RA (1993) Opioid actions on membrane ion channels. In: Herz A (ed) Opioids. Springer, Berlin Heidelberg New York Tokyo, pp 773–797
Novack GD, Bullock JL, Eisele JH (1978) Fentanyl: cumulative effects and development of short-term tolerance. Neuropharm 17: 77–82
Novick DM, Kreek MJ, Fanizza AM et al. (1981) Methadone disposition in patients with chronic liver disease. Clin Pharmacol Ther 30: 353–362
Nudelmann I (1987) Nasal delivery: a revolution in drug delivery. Proc Robert S First, Drug Del Conf 1987, Pharmaceutical Technology, Eugene (Oregon): Astor Publishing Corp., pp 43–48
Oldendorf WH, Hyman S, Braun L et al. (1972) Blood-brain barrier: penetration of morphine, codeine, heroin and methadone after carotid injection. Science 178: 984–986
Olinas MC, Onali P (1992) Characterization of opioid receptors mediating stimulation of adenylate cyclase in rat olfactory bulb. Molecul Pharmacol 42: 109–115
Oliver RM (1986) Bronchospasm and heroin inhalation. Lancet I: 915
Olkkola KT, Maunuksela EL, Korpela R et al. (1988) Kinetics and dynamics of postoperative intravenous morphine in children. Clin Pharmacol Ther 44: 128–136
Onofrio BM, Yaksh TL (1983) Intrathecal δ-receptor ligand produces analgesia in man. Lancet 1: 122–124
Orwoll ES, Kenall JW (1980) Beta-endorphin and adrenocorticotropin in extrapituitary sites: gastrointestinal tract. Endocrin 107: 438–442
Osci-Gyimah P, Archer S (1981) Some 14-ß substituted analogues of N-(cyclo-propylmethyl)normor-phine. J Med Chem 24: 212–215
Ostheimer GW, Shanahan EA, Guyton RA et al. (1975) Effects of fentanyl and droperidol on canince left ventricular performance. Anesthesiology 42: 288–291
Owen H, Mather LE, Rowley K (1988) The development and clinical use of patient-controlled analgesia. Anaesth Intensive Care 16: 437–447
Owen JA, Sitar DS, Berger L et al. (1983) Age-related morphine kinetics. Clin Pharmacol Ther 34: 364–368
Pagliaro AM (1986) Preparation, administration, and monitoring of medications. In: Pagliaro AM, Pagliaro LA (eds) Pharmacologic aspects of nursing. Mosby, St. Louis, pp 30–67
Painter NS, Truelove SC (1964) The intraluminal pressure patters in diverticulosis of the colon. Part II: the effects of morphine. Gut 5: 207–213
Painter NS, Truelove SC (1964) The intraluminal pressure patterns in diverticulosis of the colon. Part IV: the effect of pethidine and probanthine. Gut 5: 369–373
Papper S, Papper EM (1964) The effects of pre-anesthetic, anesthetic, and postoperative drugs on renal function. Clin Pharmacol Ther 5: 205–215
Papper S, Saxon L, Burg MB et al. (1957) The effect of morphine sulfate upon the renal excretion of ater and solute in man. J Lab Clin Med 50: 692–704
Parikh RK, Rymaszeweski, Scott NB (1995) Prolonged postoperative analgesia for arthrolysis of the elbow joint. Br J Anaesth 74: 469–471
Parker RK, Holtmann B, White PF (1991) Patient controlled analgesia: Does a concurrent opioid infusion improve pain management after surgery? JAMA 266: 1947–1952
Parolaro D, Sala M, Gori E (1977) Effect of intracerebroventricular administration of morphine upon intestinal motility in rat and its antagonism with naloxone. Eur J Pharmacol 46: 329–338
Paronis CA, Holtzman SG (1991) Increased analgesic potency of my agonists after continuous naloxone infusion in rats. J Pharmacol Exp Ther 259/2: 582–589
Paronis CA; Holtzman SG (1991) Analgesic cross-tolerance between mu-opioids with different intrinsic activities. Abstract. Pharmacologist 33/3: 137, A 1
Parsons CG, Herz A (1990) Peripheral opioid receptors mediating antinociception in inflammation. Evidence for activation by enkephalin-like opioid peptides after cold water swim stress. J Pharmacol Exp Ther 255: 795–802
Parsons CG, Czlonkowski A, Stein A et al. (1990) Peripheral opioid receptors mediating antinociception. Activation by endogenous opioids and role of the pituitary-adrenal axis. Pain 41: 81–93
Pasternak GW, Wood PL (1986) Multiple mu receptors. Life Sci 38: 1889–1898
Pasternak GW, Zhang AZ, Tecolt L (1980) Developmental differences between high and low affinity opiate binding sites: their relationships to analgesia and respiratory depression. Life Sci 27: 1185–1190
Pasternak GW, Adler BA, Rodriguez J (1985) Characterization of the opioid receptor binding and animal pharmacology of meptazinol. Postgr Med J 61(S2): 5–12
Patwardhan RV, Johnson RF, Hoyumpa A jr et al. (1981) Normal metabolism of morphine in cirrhosis. Gastroenterology 81: 1006–1011
Paul D, Bodnar RJ, Gistrak MA et al. (1989) Different mu receptor subtypes mediate spinal and supra-spinal analgesia. Eur J Pharmacol 168: 307–314
Payne R (1987) Role of epidural and intrathecal narcotics and peptides in the management of cancer pain. Med Clin North Am 71: 313–327
Peck SL, Johnston RB, Horrowitz LD (1985) Reduced neutrophil Superoxide anion release after prolonged infusion of lidocaine. J Pharmacol Exp Ther 235: 418–422
Peden CJ, Prys-Roberts C (1992) Dexmedetomidine-a powerful new adjunct to anaesthesia? Editorial II. Br J Anaesth 68: 123–125
Pelligrino DA, Reigler FX, Albrecht RF (1989) Ventilatory effects of fourth cerebroventricular infusions of morphine-6-or morphine-3-glucuronide in the awake dog. Anesthesiology 71: 936–940
Penn RD, Paice JA (1987) Chronic intrathecal morphine for intractable pain. J Neurosurg 67: 182–186
Pennant JH, Wallace D (1991) Intrathecal morphine and reactivation of oral herpes simplex. Anesthesiology 75: 167
Penning JP, Yaksh TL (1992) Interaction of intrathecal morphine with bupivacaine and lidocaine in the rat. Anesthesiology 77: 1186–1200
Penning JP, Samson B, Baxter AD (1988) Reversal of epidural morphine-induced respiratory depression and pruritus with nalbuphine. Can J Anaesth 35: 599–604
Pere P (1993) Effect of continuous interscalene brachial plexus with 0.125 % bupivacaine plus fentanyl on diaphragmatic motility and ventilatory function. Reg Anaesth 18: 93–97
Perriss BW, Latham BV, Wilson IH (1990) Analgesia following extradural and IM pethidine in post-cesarean section patients. Br J Anaesth 64: 355–357
Perry S, Heidrich G (1982) Management of pain during debridement: a survey of US burn units. Pain 13: 267–280
Pert CB, Snyder SH (1973) Opiate receptor: demonstration in nervous tissue. Science 179: 1011–1014
Pert CB, Snyder SH (1974) Opiate receptor binding of agonists and antagonists affected differentially by sodium. Mol Pharmacol 10: 868–879
Petrow M, Falay S (1983) Postoperative Morphinanalgesie nach axillärer Plexus-brachialis-Blockade. Anaesthesist 32 (AV 17.8): 258–259
Pfeiffer A, Pasi A, Mehraein P et al. (1982) Opiate receptor binding sites in human brain. Brain Res 248: 87–96
Pfeiffer A, Brantl V, Herz A et al. (1986) Psychomimesis mediated by kappa opiate receptors. Science 233: 774–776
Philbin DM, Coggins CH (1978) Plasma antidiuretic hormone levels in cardiac surgical patients during morphine and halothane anesthesia. Anesthesiology 49: 95–98
Philbin DM, Wilson NE, Sokoloski J et al. (1976) Radioimmunoassay of antidiuretic hormone during morphine anaesthesia. Can Anaesth Soc J 23: 290–295
Philbin DM, Moss J, Rosow CE et al. (1981) The use of H1 and H2 histamine antagonists with morphine anesthesia: A double blind study. Anesthesiology 55: 292–296
Phillips OC, Ebner H, Nelson AT et al. (1969) Neurologic complications following spinal anesthesia with lidocaine: A prospective review of 10,440 cases. Anesthesiology 30: 284–289
Pichard-Léandri E, Gauvain-Piquard A (1989) La douleur chez l’enfant. Medsi/McGraw, Paris
Pickard JD, Czosnyka M (1993) Management of raised intracranial pressure. J Neurol Neurosurg Psych 56: 845–858
Plezia PM, Linford J, Kramer TH et al. (1986) Transdermal therapeutic system (fentanyl) for postoperative pain. An efficacy, toxicity and pharmacokinetic trial. Anesthesiology 65: S210
Plourde G, Boylan JF (1991) The auditory steady state response during sufentanil anaesthesia. Br J Ana-esth 66: 683–691
Pohl M, Lombard MC, Bourgoin S et al. (1989) Opioid control for the in vitro release fo calcitonin gene-related peptide from primary afferent fibers projecting in the rat cervical cord. Neuropeptides 14: 151–159
Polak JM, Sullivan SN, Boom SR et al. (1977) Enkephalin-like immunoreactivity in the human gastrointestinal tract. Lancet I: 972–974
Poleka ML, Okkola KT, Koivisto M et al. (1992) Pharmacokinetics and pharmacodynamics of intravenous meperidine in neonates and infants. Clin Pharmacol Ther 52: 342–349
Pond SM, Tong T, Benowitz NL et al. (1981) Presystemic metabolism of meperidine to normeperidine in normal and cirrhotic subjects. Clin Pharmacol Ther 30: 183–188
Pontiroli AE, Alberetto M, Pozza G (1985) Intranasal calcitonin and plasma calcium concentrations in normal subjects. BMJ 290: 1390–1391
Pontiroli AE, Calderara A, Pozza G (1989) Intranasal drug delivery: potential advantages and limitations from a clinical pharmacokinetic perspective. Clin Pharmacokinet 17: 299–307
Porreca F, Filla A, Burks T (1982) Spinal cord-mediated effects on the gastrointestinal transit in mice. Eur J Pharmacol 86: 135–136
Porreca F, Heyman JS, Mosberg HI et al. (1987) Role of mu and delta receptors in the supraspinal and spinal analgesic effects of (D-Pen2,D-Pen5) enkephalin in the mouse. J Pharmacol Exp Ther 241: 393–400
Porter J, Jick H (1980) Addiction rare in patients treated with narcotics. Letter. N Engl J Med 302: 123
Portoghese PS, Lipkowski AW, Takemori AE (1987) Binaltorphimine and nor-binalthorphomine, potent and selective ϰ-opioid receptor antagonists. Life Sci 40: 1287–1292
Porthoghese PS, Nagase H, Lipkowski AW et al. (1988) Binalthorphimine-related bivalent ligands and their ϰ-opioid receptor antagonist activity. J Med Chem 31: 836–841
Pounder DR, Steward DJ (1992) Postoperative analgesia: opioid infusions in infants and children. Can J Anaesth 39: 969–974
Poznansky MJ, Juliano RL (1984) Biological approaches to the controlled delivery of drugs: a critical review. Pharmacol Rev 36: 277–33
Pray LG (1941) Lumbar puncture as a factor in the pathogenesis of meningitis. Am J Dis Child 62: 295–308
Priano LL, Vanter SF (1981) Generalized cardiovascular and regional hemodynamics of meperidine in conscious dogs. Anesth Analg 60: 649–654
Proudfit HK, Anderson EG (1975) Morphine analgesia: blockage by raphe magnus lesions. Brain Res 98: 612–618
Prys-Robert C, Sear JW (1984) Non-barbiturate intravenous anesthetics and continuous infusion anesthesia. In: Prys-Robert C, Hug CC jr (eds) Pharmacokinetics of anesthesia. Blackwell, St. Louis, p 128
Przewlocki R, Machelska H, Przewlocki B (1993) Inhibition of nitric oxide synthase enhances morphine antinociception in the rat spinal cord. Life Sci 53: 1–5
Puerto BA, Wong KC, Puerto AX et al. (1979) Epinephrine induced dysrhythmias: comparison during anaesthesia with narcotics and with halogenated inhalation agents in dogs. Can Anaesth Soc J 26: 263–268
Purcell-Jones G, Dormon F, Sumner E (1987) The use of opioids in neonates. Anaesthesia 42: 1316–1320
Putensen-Himmer G, Putensen C, Lammer H et al. (1992) Comparison of postoperative respiratory function after laparascopy or open laparatomiy for cholecystectomie. Anesthesiology 77: 675–680
Quiding H, Olsson GL, Boreus LO et al. (1992) Infants and young children metabolise codeine to morphine. A study after single and repeated rectal administration. Br J Clin Pharmacol 33: 45–49
Radnay PA, Brodman E, Mankikar D et al. (1980) The effect of equi-analgesic doses of fentanyl, morphine, meperidine, and pentazocine on common bile duct pressure. Anaesthesist 29: 26–29
Raja SN, Dickstein RE, Johnson CA (1992) Comparison of postoperative analgesic effect of intraarti-cular bupivacaine and morphine following arthroscopic knee surgery. Anesthesiology 77: 1143–1147
Rance MJ (1983) Multiple opiate receptors: their occurence and significance. In: Bullingham RES (ed) Clinics in anesthesiology, vol I(I): Opiate analgesia. Saunders, London
Randall T (1993) Morphine receptor cloned-improved analgesics, addiction therapy expected. JAMA 270: 1165–1166
Rasmussen K, Beitner-Johnson DB, Krystal JH et al. (1990) Opiate withdrawal and the locus coeruleus: behavioral, electrophysiological and biochemical correlates. J Neurosci 10: 2308–2317
Ravnborg M, Hensen FM, Jensen NH et al. (1987) Pupillary diameter and ventilatory CO2 sensitivity after epidural morphine and buprenorphine. Anesth Analg 66: 847–851
Rawal J, Mollefors K, Axelsson K et al. (1983) An experimental study of urodynamic effects of epidural morphine and of naloxone reversal. Anesth Analg 62: 641
Rawal N, Sjostrand UH (1986) Clinical application of epidural and intrathecal opioids for pain management. Int Anesth Clin 24: 43–57
Rawal N, Tandon B (1985) Epidural and intrathecal morphine in intensive care units. Intensive Care Med 11: 129–133
Rawal N, Arnér S, Gustafsson L et al. (1987) Present state of extradural and intrathecal opioid analgesia in Sweden. Br J Anaesth 59: 791–799
Rawal N, Nuutinen L, Raj PR et al. (1991) Behavioral and histopathologic effects following intrathecal administration of butorphanol, sufentanil, and nalbuphine in sheep. Anesthesiology 75: 1025–1034
Rees HA, Muir AL, MacDonald HR et al. (1967) Circulatory effects of pethidine in patients with acute myocardial infarction. Lancet II: 863–866
Reitan JA, Stengert KB, Wymore MC et al. (1978) Central vagal control of fentanyl induced bradycar-dia during halothane anesthesia. Anesth Analg 57: 31–36
Reves JG, Kissin I, Fournier I et al. (1984) Additive negative inotropic effect of a combination of diaze-pam and fentanyl. Anesth Analg 63: 97–100
Rifat K (1972) Pentazocine in sequential analgesic anaesthesia. Br J Anaesth 44: 175–182
Rimbäck G, Cassuto J, Wallin G et al. (1988) Inhibition of peritonitis by amide local anesthetics. Anesthesiology 69: 881–886
Roberts SP, Petts HV (1990) Meningitis after obstetric spinal anesthesia. Anaesthesia 45: 376–377
Robins LN, Davis DH, Goodwin DW (1974) Drugs used by U.S. army enlisted men in Vietnam: A follow-up on their return home. Am J Epidemiol 99: 148–156
Rogers KJ, Thornton JA (1969) The interaction between monoamine oxidase inhibitors and narcotic analgesics in mice. Br J Pharmacol 36: 470–480
Rogers NF, El-Fakahany EE (1986) Morphine-induced opioid receptor down-regulation detected in intact adult brain cells. Eur J Pharmacol 42: 221–230
Roizen FM, Horrigan RW, Fragen BM (1981) Anesthetic doses blocking adrenergic (stress) and cardiovascular responses to incision-MAC BAR. Anesthesiology 54: 390–398
Romagnoli A, Keats AS (1980) Ceiling effect for respiratory depression by nalbuphine. Clin Pharmacol Ther 27: 478–485
Römer DM, Büscher H, Hill RC et al. (1980) Bremazocine: a potent, long acting opioid kappa-agonist. Life Sci 27: 971–978
Rorie DK, Muldoon SM, Tyce GM (1981) Effect of fentanyl on adrenergic function in canine coronary arteries. Anesth Analg 60: 21–27
Rosenbaum JS, Holford NHG, Sadée W (1985) In vivo receptor binding of opioid drugs at the mu site. J Pharmacol Exp Ther 233(3): 735–740
Rosow CE (1985) Newer synthetic opioid analgesics. In: (Smith G, Covino BG (eds) Acute pain. Butter-worths. London, pp 68–103
Rosow CE, Moss J, Philbin DM et al. (1980) Histamine in human plasma following administration of morphine or fentanyl. 7th WCA (Amsterdam), A579
Rosow CE, Moss J, Philbin DM et al. (1982) Histamine release during morphine and fentanyl anesthesia. Anesthesiology 56: 93–96
Rosow CE, Philbin DM, Keegan CR et al. (1984) Hemodynamic and histamine release during induction with sufentanil or fentanyl. Anesthesiology 60: 489–491
Rossier J (1982) Opiod peptides have found their roots. Nature 298: 221–222
Rothman RB, Jacobson AE, Rice KC et al. (1987) Autoradiographic evidence for two classes of mu opioid binding sites in rat brain using (125-l) FK 33824. Peptides 8: 1015–1021
Rothman RB, France CP, Bykov V et al. (1989) Pharmacological activities of optically pure enantiomers of the kappa opioid agonist U520,488 and its cis diastereomer: evidence for three kappa receptor subtypes. Eur J Pharmacol 167: 345–353
Rothman RB, Holaday JW, Porreca F (1993) Allosteric coupling among opioid receptors: evidence for an opioid receptor complex. In: Herz A (ed) Opioids I chap 10. Springer, Berlin Heidelberg New York Tokyo, S 217–237
Rowlingson JC, Di Fazio CA, Foster J et al. (1980) Lidocaine as an analgesic for experimental pain. Anesthesiology 52: 20–25
Roy CS, Sherrington CS (1890) On the regulation of the blood-supply of the brain. J Physiol 11: 5–108
Roy SB, Singh I, Bhatia MH et al. (1965) Effects of morphine on pulmonary blood volume in convalescents from high altitude edema. Br Heart J 27: 876
Roze C, Chariot J, de la Tour J et al. (1978) Methadone blockade of 2-deoxy-glucose-induced pancreatic secretion in man. Gastroenterol 74: 215–220
Russell RD, Leslie JB, Su YF et al. (1987) Continuous intrathecal opioid analgesia: tolerance and cross-tolerance of δμ and δ opioid receptors. J Pharmacol Exp Ther 240: 150–158
Rutter PC, Murphy F, Dudley HAF (1980) Morphine: controlled trial of different methods of administration for postoperative pain relief. Br Med J 280: 12–13
Sabbe MB, Grafe MR, Mjanger E et al. (1994) Spinal delivery of sufentanil, alfentanil, and morphine in dogs. Anesthesiology 81: 899–920
Sacchetti G, Roncoroni L, Mandelli V et al. (1976) Effect of analgesic agents on emptying of the gallbladder in man. Eur J Clin Pharm 10: 127–131
Salik JO, Siegel CI, Mendeloff AI (1973) Biliary duodenal dynamics in man. Radiology 106: 1–11
Samuel IO, Clarke RS, Dundee JW (1977) Some circulatory and respiratory effects of morphine in patients without pre-existing cardiac disease. Br J Anaesth 49: 927–933
Samuel IO, Unni VKN, Dundee JW (1977) Peripheral vascular effects of morphine patients without preexisting cardiac disease. Br J Anaesth 49: 935–939
Samuel IO, Morrison JD, Dundee JW (1980) Central haemodynamic and forearm vascular effects of morphine in patients after open heart surgery. Br J Anaesth 52: 1237–1246
Sanchez V, Arthur GR, Strichartz GR (1987) Fundamental properties of local anesthetics: I. The dependence of lidocaine’s ionization and octanol: buffer partitioning on solvent and temperature. Anesth Analg 66: 159–165
Sandier A, Chovyz P, Whiting W (1986) Respiratory depression following epidural morphine: a clinical study. Can Anaesth Soc J 33: 549–559
Sandyk R (1985) Sensory symptoms in Parkinson’s disease and the opioid system. Med Hypothesis 16: 361–364
Sassajima M (1970) Analgesic effects of morphine-3-monoglucuronide. Keio Gaku 47: 421–526
Sato Y, Sato S, Baba Y et al. (1994) Prolongation of epidural anesthesia using biodegradable copolymer in the rabbit. Anesthesiology 81(3A): A387
Satoh M, Takagi H (1971) Enhancement by morphine of the central descending inhibitory influence on spinal sensory transmission. Eur J Pharmacol 14: 60
Satz N, Mäder C, Ott A et al. (1988) Erfolgreiche Schmerzbehandlung durch kontinuierliche subkutane Morphininjektion. Schw Rundschau Med (Praxis) 77: 630–633
Savarese J, Kaiko R, Thomas G et al. (1986) Correlation of onset and frequency of side effects with Cmax of a single dose of controlled morphine sulfate. J Clin Pharmacol 26: 558–561
Säwe J (1986) Morphine and its 3-and 6-glucuronides in plasma and urine during chronic oral administration in cancer patients. In: Foley KM, Inturrisi CE (eds) Advances in pain research and therapy, vol 8. Raven, New York, pp 45–55
Scarry E (1985) The body is pain: the making and unmaking of the world. Oxford, New York
Schaeffler P, Pichard E, Ramboatiana R et al. (1986) Bacterial meningitis due to infection of a lumbar drug release system in patients with cancer pain. Pain 25: 75–77
Schäfer M, Carter L, Stein C (1994) Interleukin-1 ß and Corticotropin-releasing factor inhibit pain by releasing opioids from immune celles in inflamed tissue. Proc Nat Acad Scie (USA) 91: 4219–4223
Scheinin B, Asantila R, Orko R (1987) The effect of bupivacaine and morphine on pain and bowel function after colonic surgery. Acta Anaesthesiol Scand 31: 161–164
Scheinin B, Lindgren L, Randell T et al. (1992) Dexmedetomidine attenuates sympthoadrenal responses to trachéal intubation and reduces the need for thiopentone and peroperative fentanyl. Br J Anaesth 68: 126–131
Schmidt CF, Livingston AE (1933) The action of morphine on the mammalian circulation. J Pharmacol Exp Ther 47: 411–441
Schmucker P, van Ackern K, Franke N et al. (1980) Hemodynamic and respiratory effects of pentazo-cine. Studies on surgical cardiac patients. Anaesthesist 29: 475–480
Schnapp M, Mays KS, North WC (1981) Intravenous 2-chloroprocaine in treatment of chronic pain. Anesth Analg 60: 844–845
Schoenfield LJ, Sjovall J, Perman E (1967) Bile acids on the skin of patients with pruritic hepatobiliary disease. Nature 213: 93
Schoon W, Erdmann H, Kleeberg UR (1987) Die kontinuierliche subkutane Opioidinfusion in der onkologischen Schmerztherapie. Med Klin 82: 805–811
Schrock TR, Devene CW, Dunphy JE (1973) Factors contributing to colonic anastomosis. Ann Surg 177: 513–518
Schulte-Steinberg H, Weninger E, Jokisch D et al. (1995) Intraperitoneal versus interpleural morphine or bupivacaine for pain after laparoscopic cholecystectomy. Anesthesiology 82: 634–640
Schweichel E, Schmidt E, Schneider E et al. (1979) Circulatory pattern and duration of action of nalo-xone in dogs with and without opioid pretreatment. Anesthesiology 23: 336–343
Scott DB, Hibbard BM (1990) Serious non-fatal complications associated with extradural block in obstetric practice. Br J Anaesth 64: 537–541
Scott JC, Panganis KV, Stanski DR (1985) EEG quantification of narcotic effect. The comparative phar-macodynamics of fentanyl and alfentanil. Anesthesiology 62: 234–241
Scott JC, Stanski DR (1987) Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation. J Pharmacol Exp 240: 159–166
Scott JC, Cooke JE, Stanski DR (1991) Elektroencephalographic quantitation of opioid effect: comparative pharmacodynamics of fentanyl and sufentanil. Anesthesiology 74: 34–42
Scott JS (1970) Obstetric analgesia: a consideration of labour pain and a patient controlled technique for its relief with meperidine. Am J Obst Gyn 106: 959–978
Scott PA, Fischer HBJ (1982) Spinal opiate analgesia and facial pruritus: a neural theory. Postgr Med J 58: 531–535
Sebel PS, Bovill JG, Wauquier A et al. (1981) Effects of high-dose fentanyl anesthesia on the electroencephalogram. Anesthesiology 55: 203–211
Sechzer PH (1968) Objective measurement of pain. Anesthesiology 29: 209–210
Sechzer PH (1971) Studies in pain with the analgesic-demand system. Anesth Analg 50: 1–10
Sechzer PH (1990) Patient-controlled analgesia (PCA): a retrospective. Anesthesiology 72: 735
Sederber J, Stanley TH, Reddy P et al. (1981) Hemodynamic effects of butorphanol-oxygen anesthesia in dogs. Anesth Analg 60: 715–719
Seed JC, Wallenstein SL, Houde RW et al. (1958) A comparison of the analgesic and respiratory effects of dihydrocodeine and morphine in man. Arch Int Pharmacodyn 116: 358
Semple P, Jackson IJB (1991) Postoperative pain control. A survey of current practice. Anaesthesia 46: 1074–1076
Sevarino FB, McFarlane C, Sinatra RS (1991) Epidural fentanyl does not influence PCA requirements in the post-cesarean patient. Can J Anaesth 38: 450–453
Severinghaus JW, Mitchell RA (1962) Ondine’s curse: failure of respiratory center automaticity while awake. Clin Res 10: 22
Shafer A, White PF, Schüttler J et al. (1983) Use of fentanyl infusion in the intensive care unit: Tolerance to its effects? Anesthesiology 59: 245–248
Shanker KB, Palkar NV, Nishkala R (1985) Paraplegia following epidural analgesia. Anaesthesia 40: 45–47
Sharma S, Nirenberg M, Klee W (1975) Morphine receptors as regulators of adenylate cyclase activity. Proc Natl Acad Sci (USA) 72: 590–594
Shaw JE, Urquhart J (1981) Transdermal drug administration: a nuisance becomes an opportunity. Br J Med 282: 875–876
Sheehan AP, Sauerbier GA (1986) Continuous subcutaneous infusion of morphine. Oncol Nurs Forum 13: 92
Sheehan MJ, Hayes AG, Tyers MB (1988) Lack of evidence for e-opioid receptors in the rat vas deferens. Eur J Pharmacol 154: 237–245
Sheehan PB, Zomow MH (1992) The effects of fentanyl and sufentanil on intracranial pressure and cerebral blood flow in rabbits with an acute cryogenic brain injury. J Neurosurg Anesth 4: 261–267
Shen KF, Crain SM (1992) Chronic selective activation of excitatory opioid receptor functions in sensory neurons results in opioid’ dependence’ without tolerance. Brain Res 597: 74–83
Short CE, Greenwald W, Bendick F (1970) Oxygen, carbon dioxide, and pH responses in arterial blood or dogs given analgesics, neuroleptanalgesic and ataractic agents. J Am Vet Med Ass 156(10): 1406–1410
Sides CA (1987) Hypertension during anaesthesia with monoamine oxydase inhibitors. Anaesthesia 42: 633–635
Silverstein JH, Silva DA, Iberti TJ (1993) Opioid addiction in anesthesiology. Review Article. Anesthe-siology 79: 354–375
Simantov R, Snowman AM, Snyder SH (1976) A morphine-like factor „enkephalin“ in rat brain: sub-cellular localization. Brain Res 107: 650–655
Simon EJ, Gioannini TL (1993) Opioid receptor multiciplicity: isolation, purification, and chemical characterization of binding sites. In: Herz A (ed) Opioids I, chap 1. Springer, erlin Heidelberg New York Tokyo, pp 3–26
Simon EJ, Hileer JM, Edelman I (1973) Stereospecific binding of the potent narcotic analgésie [3H] etor-phine to rat-brain homogenate. Proc Nat Acad Sci (USA) 70: 1947–1449
Simpson KH, Tring IC, Ellis FR (1989) An investigation of premedication with morphine given by the buccal or intramuscular route. Br J Clin Pharm 27: 377–380
Sjöberg M, Appelgren L, Einarsson S et al. (1991) Long-term intrathecal morphine and bupivacaine in refractory cancer pain. I. Results from the first series of 52 patients. Anesthesiology 35: 30–43
Sjöberg M, Nitescu P, Appelgren L et al. (1994) Long-term intrathecal morphine and bupivacaine in patients with refractory cancer pain. Anesthesiology 80: 284–297
Sjöström S, Tamsen A, Persson M et al. (1987) Pharmacokinetics of intrathecal morphine and meperi-dine in humans. Anesthesiology 67: 889–895
Slattery PJ, Mark A, Couch RAC (1986) Analgesic and gastrointestinal effects of nalbuphine — a comparison with pethidine. Anaesth Intensive Care 14: 121–125
Smart D, Smith G, Lambert DG (1993) Opioid receptor stimulation of inositol (1,4,5) triphosphate formation via a pertussis toxin-sensitive G protein. J Neurochem 62: 1009–1014
Smith AL, Wollman H (1972) Cerebral blood flow and metabolism: Effects of anesthetic drugs and techniques. Anesthesiology 36: 303–314
Smith AO, Law PY, Loh HH (1988) Role of opiate receptors in narcotic tolerance/dependence. In: The Opiate Receptors (Pasternak, ed.), Humana (Clifton) pp 441–485
Smith NT, Dec-Silver H, Sanford TJ et al. (1984) EEGs during high-dose fentanyl-, sufentanil-, or morphine-oxygen anesthesia. Anesth Analg 63: 386–393
Smith NT, Benthuysen JL, Bickford RG et al. (1989) Seizures during opioid anesthetic induction — are they opioid induced rigidity? Anesthesiology 71: 852–862
Smith TC (1971) Pharmacology of respiratory depression. Int Anesth Clin 19: 752–756
Snead OC III, Bearden LF (1982) The epileptogenic spectrum of opiate agonists. Neuropharm 21: 1137–1144
Snyder SH (1977) Opiate receptors and internal opiates. Scie Am 236: 44–56
Snyder SH (1977) Opiate receptors in the brain. N Engl Med J 296: 266–271
Sofuoglo M, Portoghese S, Takemori AE (1991) Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. J Pharmacol Exp Ther 257: 676–680
Sokoll MD, Hoyt JL, Georgis SD (1972) Studies in muscle rigidity, nitrous oxide and narcotic analgesic agents. Anesth Analg 51: 16–20
Sorge J (1987) Medikamentöse Schmerztherapie bei Tumorpatienten. Niedersächs Ärztebl 22 (Sonderdruck vom 20.11.)
Sorge J, Zenz M (1989) Schmerzpatienten unterversorgt-Verschreibung von Betäubungsmitteln: Vorurteile und Hindernisse. Dtsch Ärztebl 86: 1583–1586
Sorge J, Lehmkuhl C, Lohse K et al. (1990) Langzeittherapie von Tumorschmerzen mit Morphin-retard-Tabletten. Med Klin 9: 523–528
Spaulding T, Fielding S, Venafro J et al. (1979) Antinociceptive activity of clonidine and its potentia-tion of morphine analgesia. Eur J Pharmacol 58: 19–25
Sperry RJ, Bailey PL, Reichman MV et al. (1992) Fentanyl and sufentanil increase intracranial pressure in head injury patients. Anesthesiology 77: 416–420
Spiegel K, Pasternak GW: Meptazinol (1984) A novel μ-1 selective opioid analgesic. J Pharmacol Exp Ther 228: 414–419
Spiegel K, Kourides IA, Pasternak GW (1982) Prolactin and growth hormone release by morphine in the rat: different receptor mechanism. Science 217: 745–747
Spiegelman WG, Saunders L, Mazze RI (1984) Addiction and anesthesiology. Anesthesiology 60: 335–341
Sriwatanakul K, Weis OF, Alloza JL et al. (1983) Analysis of narcotic analgesic usage in the treatment of postoperative pain. JAMA 250: 926–929
St. Marie B, Henrickson K (1988) Intraspinal narcotic infusions for terminal cancer pain. J Intraven Nurs 11: 161–163
Stacey BR, Watkins WD (1994) Mechanisms and modulators of opioid analgesia. Curr Opin Anaesth 7: 343–346
Stager JM, Robertshae D, Miescher E (1990) Delayed menarche in swimmers in relation to age at the onset of training and athletic performance. Med Scie Sport Exerc 22: 546–558
Stahl KD, van Bever W, Janssen P et al. (1977) Receptor affinity and pharmacological potency of a s eries of narcotic analgesics, anti-diarrheal and neuroleptic drugs. Eur J Pharmacol 46: 199–205
Stanfa LC, Sullivan AF, Dickenson AH (1992) Alterations in neuronal excitability and the potency of spinal mu, delta and kappa opioids after carrageenan-induced inflammation. Pain 50: 345–354
Stanley TH (1988) New routes of administration and new delivery systems of anesthetics. Editorial. Anesthesiology 68: 665–667
Stanley TH (1990) Opioids: Practical operating room considerations. In: ASA Annual Refresher Course Lectures, Oct 19–23, 124: 1–7
Stanley TH, Gray NG, Stanford W et al. (1973) The effects of high-dose morphine on fluid and blood requirements in open-heart operations. Anesthesiology 38: 536–541
Stanley TH, Gray NH, Bidway AV et al. (1974) The effect of high dose morphine and morphine plus nitrous oxide on urinary output in man. Can Anaesth Soc J 21: 379–384
Stanley TH, Isern-Amaral L et al. (1975) The effects of morphine anesthesia on urine norepinephrine during and after coronary artery surgery. Can Anesth Soc J 22: 478
Stanley TH, Bennett GM, Loeser EA et al. (1976) Cardiovascular effects of diazepam and droperidol uring morphine anesthesia. Anesthesiology 44: 255–258
Stanley TH, Hague B, Mock DL et al. (1989) Oral transmucosal fentanyl citrate (lozenge) premedica-tion in human volunteers. Anesth Analg 69: 21–27
Stanski DR, Hug CC jr (1982) Alfentanil-akinetically predictable narcotic analgesic. Editorial. Anesthesiology 57: 435–437
Stanski DR, Greenblatt DJ, Lowenstein E (1978) Kinetics of intravenous and intramuscular morphine. Clin Pharm Ther 24: 52–59
Staritz M, Poralla T, Manns M et al. (1986) Effect of modern analgesic drugs (Tramadol, pentazocine, and buprenorphine) on the bile duct spincter in man. Gut 27: 567–569
Stein C: Peripheal mechanisms of opioid analgesia. In: Opioids II (Herz A, ed.), Springer, Ch 34: 91–103
Stein C, Millan MJ, Shippenberg TS et al. (1988) Peripheral effect of fentanyl upon nociception in inflamed tissue of the rat. Neurosci Lett 84: 225–228
Stein C, Gramsch C, Herz A (1990) Intrinsic mechanisms of antinociception in inflammation: local opioid receptors and b-endorphin. J Neurosci 10: 1292–1298
Stein C, Hassan AHS, Przewlocki R et al. (1990) Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation. Proc Natl Acad Sci (USA) 87: 5935–5939
Stein C, Comisel K, Haimerl E et al. (1991) Analgesic effect of intraarticular morphine after arthrosco-pic knee surgery. N Engl J Med 325(16): 1123–1126
Stein EA (1976) Morphine effects on the cardiovascular system of awake freely behaving rats. Arch Int Pharmacodyn 223: 54–63
Steinhaus JE, Gaskin LP (1963) A study of intravenous lidocaine as a suppressant of cough reflex. Anesthesiology 24: 285–2
Steriade M, McCarley RW (1990) Brainstem control of wakefulness and sleep. Plenum, New York, pp 1–499
Sternbach HA, Annetto W, Pottash ALC et al. (1988) Anorexic effect of naloxone in man. Lancet I: 388–389
Stevens CW, Yaksh TL (1989) Magnitude of opioid dependence after continuous infusion of mu-and δ-selective opioids in the rat. Eur J Pharmacol 166: 467–472
Stevens CW, Yaksh TL (1989) Time course characteristics of tolerance development to continuously infused spinal antinociceptive agents in rat spinal cord. J Pharmacol Exp Ther 251: 216–233
Stevens CW, Yaksh TL (1992) Studies of morphine and D-ala2-D-Leu5-enkephalin (DADLE) cross-tolerance after continuous intrathecal infusions in the rat. Anesthesiology 76: 596–603
Stevens RA, Sharrock NE (1991) Nystagmus following epidural morphine (letter). Anesthesiology 74: 390–391
Stewart PE, Hammond DL (1993) Evidence for delta opioid receptor subtypes in rat spinal cord: studies with intrathecal Naltriben, cyclic [D-Pen2, D-Pen5] enkephalin and δ Ala2, Glu4delorphin. J Pharmacol Exp Ther 266: 820–828
Stillman MJ, Moulin DE, Foley KM (1987) Paradoxical pain following high dose spinal morphine. Pain 4: 389
Stix G (1994) Lollipop, lollipop: a candied sedative with a kick arouses oppositions from doctors. Sci Am 270: 113
Stoeckel H, Hengstmann JH, Schüttler J (1979) Pharmacokinetics of fentanyl as a possible explanation for recurrence of respiratory depression. Br J Anaesth 51: 741–744
Stoelting RK, Gibbs PS (1973) Hemodynamic effects of morphine and morphine-nitrous oxide in valvular heart disease and coronary artery disease. Anesthesiology 38: 45–52
Strauer BE (1972) Contractile responses to morphine, piritramide, meperidine, and fentanyl: A comparative study of effects on the isolated ventricular myocardium. Anesthesiology 37: 304–310
Strauer BE (1973) Myocardial depression by fentanyl and morphine. Anesthesiology 38: 602–604
Streisand JB, Hague B, Van Vreeswijk H et al. (1987) Oral transmucosal fentanyl premedication in children. Anesth Analg 66: 170
Streisand JB, Varvel JR, Stanski DR et al. (1991) Absorption and bioavailability of oral transmucosal fentanyl citrate. Anesthesiology 75: 223–229
Streisand JB, Bailey PL, LeMaire L et al. (1993) Fentanyl-induced rigidity and unconsciousness in human volunteers. Incidence, duration, and plasma concentrations. Anesthesiology 78: 629–634
Striebel HW, Gottschalk B, Krämer J (1992) Intranasal fentanyl titration for postoperative pain management. Anesthesiology 75: A671
Striebel WH, Pommering J, Rieger A et al. (1993) Intranasal fentanyl for postoperativer pain management in an unselected population. Br J Anaesth 70 (Suppl 1): 108 (A 209)
Striebel WH, Wessel A, Rieger A et al. (1993) Intranasal fentanyl for breakthrough cancer pain or incident pain. Br J Anaesth 70 (Suppl 1): 109 (A 210)
Su TP, London ED, Jaffe JH (1988) Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems. Science 240: 219
Suarez-Roca H, Maixner W (1992) Morphine produces a multiphasic effect on the release of substance P from rat trigeminal nucleus slices by activating different opioid receptors subtypes. Brain Res 579: 195–203
Suarez-Roca H, Abdullah L, Zunga J et al. (1992) Multiphasic effect of morphine on the release of substance P from rat trigeminal nucleus slices. Brain Res 579: 187–194
Sugioka K, Davis DR (1960) Hyperventilation with oxygen: possible cause of cerebral hypoxia. Anesthesiology 21: 135–143
Sukin RTS, Eghbali M, Oliver D et al. (1988) Characterization and visualization of rat guinea pig brain kappa opioid receptors: evidence for kappa1 and kappa2 opioid receptors. Proc Natl Acad Sci (USA) 85: 4061–4065
Sullivan AF, Kalso EA, McQuay HJ et al. (1992) Evidence for the involvement of the μ but not δ receptor subtype in the synergistic interaction between opioid and α2 adrenergic antinociception in the rat spinal cord. Neurosci Lett 139: 65–68
Sullivan DL, Wong KC (1973) The effects of morphine on the isolated heart during normothermia and hypothermia. Anesthesiology 38: 550–556
Swenzen GO, Whitwam JG (1986) Selective tolerance of group III and IV somatosympathetic reflexes to the effects of alfentanil. Neuropharmacol 25: 1379–1385
Szelenyi I, Nickel B (1987) Putative site(s) and mechanism(s) of action of flupirtin, a novel analgesic compound. Postgr Med J 63(S3): 57–60
Szeto HH, Inturrisi CE, Houde R et al. (1977) Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure or cancer. Ann Int Med 86: 738–741
Takemori AE, Begonia YH, Naeseth JS et al. (1988) Nor-binalthorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays. J Pharmacol Ther 246: 255–258
Takeshita H, Michenfelder JD, Theye RA (1972) The effects of N-allylnormorphine on canince cerebral metabolism and circulation. Anesthesiology 37: 605–612
Talbott GD, Gallegos KV, Wilson PO et al. (1987) The medical association of Georgia’s impaired physicians program: Review of the first 1000 physicians. Analysis of specialty. JAMA 257: 2927–2930
Tamsen A (1987) Epidural Morphine: A review of current pharmacological and clinical studies. Astra Alab AG, Pain Control, Sweden
Tamsen A, Gordh T (1984) Epidural donidine produces analgesia. Lancet II: 231–232
Tanberg D, Abercrombie D (1982) Treatment of heroin overdose with endotracheal naloxone. Ann Emerg 11: 443
Tanelian DL, Brose WG (1991) Neuropathic pain can be relieved by drugs that are use-dependent sodium channel blockers: Lidocaine, carbamazepine and mexiletine. Anesthesiology 74: 949–951
Tanelian DL, Maclver MB (1991) Analgesic concentrations of lidocaine supress tonic A-δ and C fiber discharges produced by acute injury. Anesthesiology 74: 934–936
Tang R, Shimomura SK, Rotblatt M (1980) Meperidine-induced scizures in sickle cell patients. Hosp Formul 86: 764–772
Taub DD, Eisenstein TK, Geller EB et al. (1991) Immunomodulatory activity of μ-and ϰ-selective opioid agonists. Proc Nat Ac Sci (USA) 88: 360
Tejwani GA, Rattan AK, McDonald JS (1992) Role of spinal opioid receptors in the antinociceptive interactions between intrathecal morphine and bupivacaine. Anesth Analg 74: 726–734
Tenen SS (1968) Antagonism of the analgesic effect of morphine and other drugs by p-chloro-phenylalanine, a serotonin depletor. Psychopharm 12: 278–285
Terasaki T, Pardridge WM, Denson DD (1986) Differential effect of plasma protein binding of bupiva-cain on its in vivo transfer into the brain and salivary gland of rats. J Pharmacol Exp Ther 239: 724–729
Terenius L (1973) Characteristics of the „receptor“ for narcotic analgesics in synaptic plasma membrane fraction from rat brain. Acta Pharmacol Toxicol 33: 377–384
Terenius L, Wahlström A (1975) Search for an endogenous ligand for the opiate receptor. Acta Physiol Scand 94: 74–81
Teuchmann JK, Kania BF (1970) The effects of etorphine, fentanyl and morphine on noradrenaline and dopamine concentrations in the striatum of rat. Acta Physiol (Pol) 28/2: 107–112
Thamsborg G, Storm TL, Brinch E et al. (1990) The effect of different doses of nasal salmon calcitonin on plasma cyclic AMP and serum ionized calcium. Calcif Tiss Int 46: 5–8
Thirlwell MP, Boos GJ, Hollingsworth ML (1990) Clinical pharmacokinetics of oral controlled release morphine: An overview. In: Benedetti C, Chapman CR (eds) Advances in pain research and therapy, vol 14. Raven, New York, pp 275–284
Thompson DA, Welle SL, Lüivivat U et al. (1982) Opiate receptor blockade in man reduces 2-deo-xyglucose-induced food intake but not hunger, thirst and hypothermia. Life Sci 31: 847–852
Thompson RC, Mansour A, Akil H et al. (1993) Cloning and pharmacological characterization of a rat μ opioid receptor. Neuron 11: 903–913
Thorén P, Önerg B (1981) Studies on the endoanesthetic effects of lidocaine and benzonatate on on-medullated nerve endings in the left ventricle. Acta Physiol Scand 111: 51–58
Thoren SE, Sundberg A, Wattwil M et al. (1989) Effects if bupivacaine and epidural morphine on bowel function and pain after hysterectomy. Acta Anaesthesiol Scand 33: 181–185
Thoren SE, Wattwil M, Näslund I (1992) Postoperative morphine but not epidural bupivacaine, delays gastric emptying on the first day after cholecystectomy. Reg Anesth 17: 35–42
Thorpe DH (1984) Opiate structure and activity: a guide to understanding the receptor. Anesth Analg 63: 143–151
Tigerstedt I, Turunen M, Tammisto T et al. (1981) The effect of buprenorphine and oxycodone on the intracholedochal passage pressure. Anesthesiology 25: 99–102
Timmis AD, Rothman MT, Henderson MA et al. (1980) Haemodynamic effects of intravenous morphine in patients with acute myocardial infarction complicated by severe left ventricular failure. Br Med J 5: 980–982
Tiseo PJ, Inturrisi CE (1993) Attenuation and reversal of morphine tolerance by the competitive N-Methyl-D-Aspartate receptor antagonist, LY274614. J Pharmacol Exp Ther 264: 1090–1096
Tive L, Ginsberg K, Pick CG et al. (1992) Kappa (3) receptors and levorphanol-induced analgesia. Neuropharm 31/9: 851–856
Tommasino C, Maekawa T, Shapiro HM (1984) Fentanyl-induced scizures activate subcortical brain metabolism. Anesthesiology 60: 283–290
Trendelenburg P (1917) Physiologische und pharmakologische Versuche über die Dünndarmperistal-tik. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol 81: 55–129
Trotter JM, Scott R, Macbeth FR et al. (1981) Problems of the oncology outpatient: role of the liaison health visitor. Br Med J 282: 122–124
Tseng LF (1982) Tolerance and cross-tolerance to morphine after chronic spinal D-ala2-D-Leu5-enke-phalin infusion. Life Sci 31: 987–992
Tseng LF (1983) Partial cross-tolerance to D-ala-2-D-Leu-5-enkephalin after chronic spinal morphin infusion. Life Sci 32: 2545–2550
Tsung JS, Tsung SS (1986) Creatine kinase isoenzymes in extracts of various human skeletal muscles. Clin Chem 32: 1568–1570
Tuckett RP, Martin HA (1989) Are there different classes of polymodal nociceptor limits for pain and itch? Skin Pharmacol 2: 217–218
Tuffier MT (1899) C. r. Soc. Bio. (Paris) 51: 222, zit. in Macintosh RR (1953) Lumbaipunktion und Spinalanästhesie. Schwabe, Basel, S 16
Tung AS, Yaksh TL (1982) In vivo evidence for multiple opiate receptors mediating analgesia in the rat spinal cord. Brain Res 247: 75–83
Tung AS, Tenicela R, Winter PM (1980) Opiate withdrawal syndrome following intrathecal administration of morphine. Anesthesiology 53: 340
Twitchell WA, Rane SG (1993) Opioid peptide modulation of CA2+-dependent K+ and voltage-activated CA2+currents in bovine adrenal chromafin cells. Neuron 10: 701–709
Twycross RG (1982) Controlling pain in cancer patients. Mod Med 8: 2
Twycross RG (1982) Ethical and clinical aspects of pain treatment in cancer patients. Anesthesiology 74(S): 83–90
Twycross RG, Lack SA (1983) Symptom control in far advanced cancer: pain relief. Pitman, London
Twycross RG, Lack SA (1984) Oral morphine in advanced cancer. Beaconsfield England
Umans JG, Inturrisi CE (1981) Pharmadynamics of subcutaneously administered diacetylmorphine, 6-acetylmorphine and morphine in mice. J Pharmacol Exp Ther 218/2: 409–415
Urquar J (1982) Rate-controlled dosage. Drugs 23: 207–226
Urquart ML, Klapp K, White PF (1988) Patient-controlled analgesia: a comparison of intravenous versus subcutaneous hydromorphone. Anesthesiology 69: 428–432
Urthaler F, Isobe JH, Gilmour KE et al. (1973) Morphine and autonomic control of the sinus node. Chest 64: 203–212
Urthaler F, Isobe JH, James TN (1975) Direct and vagally mediated chronotropic effects of morphine studied by selective perfusion of the sinus node of awake dogs. Chest 68: 222–228
Usubiaga JE (1975) Neurological complications following epidural analgesia. Int Anaesth Clin 13: 19–50
Vadas EB, Hoscin EA (1978) Alteration of the erythrocyte ultrastructure and blood viscosity by morphine. Can J Physiol Pharm 56: 245–251
Van Dercar DH, Martinez AP, De Lisser EA (1991) Sleep apnea syndromes: a potential contraindication for patient-controlled analgesia. Anesthesiology 1991; 74: 623–624
Van Hoogdalen EJ, De Boer AG, Breimer DD (1991) Pharmacokinetics of rectal drug administration. Part I. General considerations and clinical applications of centrally acting drugs. Clin Pharmacokin 21: 11–26
Vargish T, Beamer KC, Daly T et al. (1987) Myocardial opiate receptor actitivity is stereospecific, independent of muscarinic receptor antagonism, and may play a role in depressing cardiac function. Surgery 102: 171–177
Vasko JS, Henney RP, Oldham HN et al. (1966) Mechanisms of action of morphine in the treatment of experimental pulmonary edema. Am J Cardiol 18: 876–883
Vasko JS, Henney RP, Brawley RK et al. (1966) Effects of morphine on ventricular function and myocardial force. Am J Physiol 210: 329–334
Vassalle M (1961) Role of catecholamine release in morphine hyperglycemia. Am J Physiol 200: 530–534
Vater M, Smith G, Aherne G et al. (1983) Pharmacokinetics and analgesic effect of slow-release oral morphine in balanced anesthesia: Studies in children. Drug Metab Rev 14: 887–891
Vaught J, Rothman RB, Westfall TC (1982) Mu and delta receptors: their role in analgesia and in the differential effects of opioid peptides on analgesia. Life Sci 30: 1443–1455
Vaupel DB (1983) Naltrexone fails to antagonize the sigma effects fo PCP and SKF 10,047 in the dog. Eur J Pharmacol 92: 269–274
Vedrenne JB, Estève M, Guillaume A (1991) Prévention par la naloxone des effects secondaires de l’analgésie péridurale par morphine pour douleur cancéreuse. Ann F Anesth Réanim 10: 98–103
Ventafredda V, Spoldi E, Caraceni A et al. (1986) The importance of continuous subcutaneous morphine administration for cancer pain control. Pain Clinic 1: 47–55
Vereby K, Volavka J, Mule SJ et al. (1976) Naltrexone: disposition, metabolism, and effects after acute and chronic dosing. Clin Pharm Ther 20: 315–328
Vertommen JD, Vandermeulen E, Van Aken H et al. (1991) The effects of the addition of sufentanil to 0.125 % bupivacaine on the quality of analgesia during labor and on the incidence of instrumental deliveries. Anesthesiology 74: 809–814
Vettor R, Martini C, Manno M et al. (1985) Effects of naloxone-induced opiate receptor blockade on insulin secretion in obesity. Horm Metab Res 17: 374–375
Vettor R, Martini C, Macor C et al. (1989) Beta-endorphin in relation to obesity. J Endocrinol Invest 12(S4): 81–86
Viel EJ, Eledjam JJ, De la Coussaye JE et al. (1989) Brachial plexus block with opioids for postoperative pain relief: Comparison between buprenorphine and morphine. Reg Anesth 14: 274–278
Vismara LA, Leaman DM, Zelis R (1976) The effects of morphine on venous tone in patients with acute pulmonary edema. Circulation 54: 335–337
Volterra A, Restani P, Brunello N et al. (1986) Interaction of β-casomorphins with multiple opioid receptors: in vitro and in vivo studies in the newborn rat brain. Dev Brain 30: 25–30
von Essen EJ, Bovill JG, Ploeger EJ et al. (1988) Intrathecal morphine and clonidine for control of intractable cancer pain: a case report. Acta Anaesth Belg 39: 109–112
Vree TB, Verwey-Van Wissen CPWGM (1992) Pharmacokinetics and metabolism of codeine in humans. Biopharm Drug Disp 13: 445–460
Wagemans MFM, Bakker EN, Zuurmond WWA et al. (1994) High dose morphine solutions intrathe-cally decreases the pH of cerebrospina fluid. Anesthesiology 81(3A): A932
Wagner GA (1922) Zur Behandlung des Ileus mit Lumbaianästhesie. Arch Gynäk 177: 336
Wagner JG (1974) A safe method for rapidly achieving plasma concentration plateaus. Clin Pharmacol Ther 16: 691
Wahba WM, Don HF, Craig DB (1975) Post-operative epidural analgesia: Effects on lung volumes. Can Anaesth Soc J 22: 519–527
Wajima Z, Nakajima Y, Kim C et al. (1995) I.v. compared with brachial plexus infusion of butorphanol for postoperative analgesia. Br J Anaesth 74: 392–395
Walbergh EJ, Will RJ, Eckhert J (1991) Plasma concentrations of midazolam in children following intranasal administration. Anesthesiology 74: 233–235
Waldvogel HH (1983) L’Anesthésie obstétricale a la Clinique de Montchoisi Lausanne 1972–1982. Rév Méd Suisse Romande 103: 841–849
Waldvogel HH (1983) Transdermales Scopolamin gegen postoperatives Erbrechen: Eine neue Prämedikationsformel? Anaesth Intensivther Notfallmed 18: 258–260
Waldvogel HH, Fasano M (1983) Extradural administration of lofentanyl for balanced postoperative analgesia. Anaesthesist (S)32: 256–257
Walker JM, Matsumoto RR, Bowen WD et al. (1988) Evidence for a role of haloperidol-sensitive sigma ‘opiate’ receptors in the motor effects of antipsychotic drug. Neurol 38: 961–965
Walker JM, Bowen WD, Walker FO et al. (1990) Sigma receptors: biology and function. Pharmacol Rev 42: 355–402
Walker JM, Bowen WD, Goldstein SR et al. (1992) Autoradiographic distribution of [3H](+)-pentazo-cine and [3H]1, 3-di-o-tolylguanidine (DTG) binding sites in guinea pig brain: a comparative study. Brain Res 58: 33–38
Wallenstein MC (1979) Biphasic effects of morphine on cardiovascular system of the cat. Eur J Pharmacol 59: 253–260
Walsh TD (1984) Oral morphine in chronic cancer pain. Pain 18: 1
Wals TD (1984) Opiates and respiratory function in advanced cancer. Cancer Res 89: 115–117
Walsh D (1993) Dyspnoea in advanced cancer. Commentary. Lancet 342: 450–451
Walsh TD, Saunders CM (1984) The treatment of pain in advanced cancer. Rec Results Cancer Res 89: 201–211
Walts LF, Kaufman RD, Moreland JR et al. (1985) Total hip arthroplasty. An investigation of factors related to postoperative urinary retention. Clin Ortho Rel Res 194: 280–282
Wang JK, Nauss LE, Thomas JE (1979) Pain relief by intrathecally applied morphine in man. Anesthe-siology 50: 149–151
Ward CF (1993) Substance abuse: now, and for some time to come. Editorial. Anesthesiology 77: 619–622
Ward CF, Ward GC, Saidman LJ (1983) Drug abuse in anesthesia training programs: A survey. 1970 through 1980. JAMA 250: 922–925
Ward JW, McGrath RL, Weil JV (1972) Effects of morphine on the peripheral vascular response to sympathetic stimulation. Am J Cardiol 29: 656–666
Ward SJ, Takemori AE (1983) Relative involvement of receptor subtypes in opioid-induced inhibition of gastrointestinal transit in mice. J Pharmacol Exp Ther 224: 359–363
Ward SJ, Loprect D, James D et al. (1986) Effects of mu and delta selective opioid agonists in the guinea pig ileum preparation: differentiation into peptide and non peptide classes using β-FNA. J Pharmacol Exp Ther 283: 625–636
Watkins LR, Wiertelak EP, Grisel JE et al. (1992) Parallel activation of multiple spinal opiate systems appears to mediate’ non-opiate’ stress-induced analgesia. Brain Res 594: 99–108
Watson J, Moore A, McQuay H et al. (1984) Plasma morphine concentrations and analgesic effects of lumbar extradural morphine and heroin. Anesth Analg 63: 629–634
Watson SJ, Khachaturian H, Akil H et al. (1982) Comparison of the distribution of dynorphin system and enkephalin system in the brain. Science 218: 1134–1136
Way EL, Kemp JW, Grasetti DR (1960) The pharmacologic effects of heroin in relationship to its rate of biotransformation. J Pharmacol Exp Ther 129: 144–154
Weber E, Sonders M, Quarum M et al. (1986) 1, 3-di(2-[5-3 H]tolyl)guanidine: a selective ligand that labels σ receptors for psychotomimetic opiates and antipsychotic drugs. Proc Nat Ac Sci (USA) 83: 8784–8788
Weil JV, McCullough RE, Kline JS et al. (1975) Diminished ventilatory response to hypoxia and hyper-capnia after morphine in normal man. N Engl J Med 292: 1103–1106
Weinberg DS, Inturrisi CE, Reidenberg B et al. (1988) Sublingual absorption of selected opioid analgesics. Clin Pharmacol Ther 44: 335–342
Weinger MB, Segal IS, Maze M (1989) Dexmedetomidine, acting through central α-2-adrenoceptors, prevents opiate-induced muscle rigidity in the rat. Anesthesiology 71: 242–249
Weinstabl C, Mayer N, Richling B et al. (1991) Effect of sufentanil on intracranial pressure in neuro-surgical patients. Anaesthesia 46: 837–840
Weinstabl C, Mayer N, Spiess CK (1992) Sufentanil decreases cerebral blood flow velocity in patients with elevated intracranial pressure. Eur J Anaesth 9: 481–484
Weiss OF, Sriwatanakul K, Alloza JL et al.(1983) Attitudes of patients, housestaff and nurses towards postoperative analgesic care. Anesth Analg 62: 70–74
Weissman DE, Haddox DJ (1989) Opioid pseudoaddiction — an iatrogenic syndrome. Clinical note. Pain 36: 363–366
Weitzman RE, Fisher DA, Minck S et al. (1977) Beta-endorphin stimulates resecretion of arginine vasopressin „in vivo“. Endocrinology 101: 1643–1645
Wells D, Davies G, Wagner D (1987) Accidental injection of epidural methohexital. Anesthesiology 67: 846–848
Weite M, Haimerl E, Groh J et al. (1992) Effect of interpleural morphine on postoperative pain and pulmonary function after thoracotomy. Br J Anaesth 69: 637–639
Werner C, Hoffman WE, Baughman VL et al. (1991) Effects of sufentanil on cerebral blood flow, cerebral flow velocity and metabolism in dogs. Anesth Analg 72: 177–181
Werz MA, MacDonald RL (1982) Opiate alkaloids antagonize postsynaptic glycine and GABA responses: correlation with convulsant action. Brain Res 236: 107–119
Werz MA, MacDonald RL (1983) Opioid peptides with differential affinity of mu and delta receptors decrease sensory neuron calcium-dependent action potentials. J Pharmacol Exp Ther 227: 394–402
Wesche DL, Frederickson RCA (1981) The role of the pituitary in the diurnal variation in tolerance to painful stimuli and brain enkephalin levels. Life Sci 29: 2199–2205
Westerling D, Andersson KE (1984) Rectal administration of morphine hydrogel: Absorption and bio-availability in women. Anesthesiology 28: 540–543
White DG, Story MJ, Barnwell SG (1991) An experimental animal model for studying the effects of a novel lymphatic drug delivery system for propranolol. Int J Pharm 69: 169–174
White PF (1988) Use of patient controlled analgesia for management of acute pain. JAMA 259: 243–247
WHO (1989) WHO expert committee on drug dependence. WHO, Genf (Technical Report Series 775)
WHO (1990) Cancer pain relief and palliative care. Report of a WHO expert Committee. WHO, Genf (Technical Report Series 804)
Wiesenfeld-Hallin Z, Lindblom U (1985) The effect of systemic tocainide, lidocaine and bupivaicaine on nociception in the rat. Pain 23: 357–360
Wilder A (1950) Sites and mechanisms of action of morphine and related drugs in the central nervous system. Pharmacol Rev 2: 435–506
Wilcox GL (1993) Spinal mediators of nociceptive neurotransmission and hyperalgesia: relationships among synaptic plasticity, analgesic tolerance, and blood flow. J Am Pain Soc 2: 265–275
Willer JC (1985) Studies on pain: effects of morphine on a spinal nociceptive flexion reflex and related pain sensation in man. Brain Res 331: 105–114
Williams A, Olufemi R (1993) More on vaginal inflammation in africa. N Engl J Med 328: 888
Wilton NCT, Leigh J, Rosen DR et al. (1988) Intranasal midazolam premedication in pre-school children. Anesth Anaig 67: S 266
Wilton NCT, Leigh J, Rosen DR et al. (1988) Preanesthetic sedation of preschool children using intranasal midazolam. Anesthesiology 69: 972–975
Winter CA, Gaffney CE, Flataker L (1954) The effect of N-allylnormorphine upon the antidiuretic action of morphine. J Pharmacol Exp Ther 11: 360–364
Wirz-Justice A (1987) Circadian rhythms in mammalian neurotransmitter receptors. Prog Neurobiol 29: 219–259
Wolfe SA, Kulsakdinum C jr, Battaglia G et al. (1988) Initial identification and characterization of sigma receptors on human peripheral blood leucocytes. J Pharmacol Exp Ther 247: 1114
Wollerman M, Benyhe S, Simon J (1993) The kappa opioid receptor: evidence for the different subtypes. Life Sci 52: 599–611
Wong KC (1983) Narcotics are not expected to produce unconsciousness and amnesia. Anesth Analg 62: 625–626
Wong KC, Martin WE, Hornbein TF et al. (1973) The cardiovascular effects of morphine sulfate with oxygen and with nitrous oxide in man. Anesthesiology 38: 542–549
Wong SC (1963) Emetic and anti-emetic drugs. In: Root WD, Hafmonn FG (eds) Physiological pharmacology. Academic Press, New York, pp 255–328
Wong CS, Su YF, Chang KJ (1992) Intrathecal pertussis toxin treatment attenuates opioid antinoci-ception and reduces high-affinity state of opioid receptors. Anesthesiology 77: 691–699
Wong CS, Su YF, Watkins WD et al. (1992) Continuous intrathecal opioid treatment abolishes the regulatory effects of magnesium and guanine nucleotides on mu opioid receptor bindung in rat spinal membranes. J Pharmacol Exp Ther 262: 317–326
Wood AJT, Moir DC, Campbell C (1974) Medicines, evaluation and monitoring. Group: Central nervous effects of pentazocine. Br Med J 1: 305–307
Wood J (1855) New Methods of treating neuralgia by the direct application of opiates to the painful points. Edinburg Med Surg J 82: 265–281
Wood M (1990) Opioid Agonists and Antagonists, In: Drugs and Anesthesia (Wood M, Wood AJJ, eds), 2nd ed., Williams & Wilkins, ch 7: 129–178
Woodside BC, Lee BA, Rochford J (1994) Suckling-induced changes in responsivity to the hypoalgesic effect of morphine. Pain 59: 209–217
Woolf CJ, Thompson SWN (1991) The induction and maintenance of central sensitization is dependent on NMDA receptor activation: implications for the treatment of post-injury pain supersensitivity. Pain 44: 293–301
Woolf CJ, Wiesenfeld-Hallin Z (1985) The systemic administration of local anaesthetics produces a selective depression of C-afferent fibre evoked activity in the spinal cord. Pain 23: 361–374
Worsley MH, Macleod AD, Brodie MJ et al. (1990) Inhaled fentanyl as a method of analgesia. Anaesthesia 45: 449–451
Wu XZ, Bell JA, Spivak CE et al. (1991) Electrophysiology and binding studies on intact NCB-20C cells suggest presence of a low affinity sigma receptor. J Pharmacol Exp Ther 257: 351–359
Xu H, Ni Q, Jacobson AE et al. (1991) Preliminary ligand binding data for subtypes of the delta opioid receptor in rat brain membranes. Life Sci 49: 141–146
Xu JY, Tseng LF (1993) Increase of nitric oxide by L-Arginine potentiates β-endorphin, but not μ1 δ or ϰ or opioid induced antinociception in the mouse. Eur J Pharmacol 236: 137–142
Xu Q, Takahashi M, Kaneto H (1992) Dependency on the brain function of arginine vasopressin system of the development to and recovery from analgesic tolerance to morphine. Brain Res 577: 189–193
Yaksh TL (1988) Substance P release from knee joint afferent terminals: modulation by opioids. Brain Res 458: 319–324
Yaksh TL, Noueihed R (1985) The physiology and pharmacology of spinal opiates. Annu Rev Pharmacol Toxicol 25: 433–462
Yaksh TL, Harty GJ, Onofrio BM (1986) High doses of spinal morphine produce a nonopiate receptor mediated hyperesthesia: Clinical and theoretic implications. Anesthesiology 64: 590–597
Yamamoto T, Shimoyama N, Mizuguchi T (1993) The effects of morphine, MK-801, an NMDA antagonist, and CP-96,345, an NKi antagonist, on the hyperesthesia evoked by carageenan injection in the rat paw. Anesthesiology 78: 124–133
Yasuda K, Raynor K, Kong H et al. (1993) Cloning and functioning comparison of γ and δ opioid receptor from mous brain. Proc Nat Acad Scie (USA) 90: 6736–6740
Yee MK, Evans WD, Facey PE et al. (1991) Gastric emptying and small bowel transit in male volunteers after i.m. ketorolac and morphine. Br J Anaesth 67: 426–431
Yeh SY, Mitchell CL (1972) Effect of monoamine oxidase inhibitors on formation of morphine glucu-ronide. Biochem Pharm 21: 571–578
Yost CS (1993) G-Proteins: basic characteristics and clinical potential for the practice of anesthesia. Anesth Analg 77: 822–834
Young IH, Daviskas E, Keena VA (1989) Effect of low dose nebulised morphine on exercise endurance in patients with chronic lung disease. Thorax 44: 387
Young ML, Smith DA, Greenburg J et al. (1984) Effects of sufentanil on regional cerebral glucose utilization in rats. Anesthesiology 61: 564–568
Young WS, Wamsley JK, Zarbin MA et al. (1980) Opioid receptors undergo axonal flow. Science 210: 76–77
Yudioka H, Bogod DR, Rosen M (1987) Recovery of bowel motility after surgery. Br J Anaesth 59: 581–584
Zaffaroni A (1971) New approaches to drug administration 31st Int Cong Pharm Scie, Washington, Abstract Seite 19–20
Zelis R, Mansour EJ, Capone RJ (1974) The cardiovascular effects of morphine. The peripheral capacitance and resistance vessels in human subjects. J Clin Invest 54: 1247–1258
Zelis R, Flaim SF, Eisele JH (1977) Effects of morphine on reflex arteriolar constriction induced in man by hypercapnia. Clin Pharmacol Ther 22: 172–178
Zenz M, Strumpf M, Tryba M et al.(1989) Retardiertes Morphin zur Langzeittherapie schwerer Tumorschmerzen. Dtsch Med Wschr 114: 43–47
Zieglgänsberger W, Bayerl H(1976) The mechanism of inhibition of neuronal activity by opiates in the spinal cord of cat. Brain Res 115: 111–128
Zimpfer M, Kotai E, Mayer N et al. (1983) Einfluß von Morphin auf die Kreislaufkontrolle bei akuter progressiver Hämorrhagie. Anaesthesist 32: 259–264
Zlotkin SH, Fettes IM, Stalling VA (1986) The effect of naltrexone, an oral β-endorphin antagonist, in children with the Prader-Willi syndrome. J Clin Endrocrinol Metab 63: 1229–1232
Zola M, McLeod C (1983) Comparative effects and analgesic efficacy of the agonist-antagonist opioids. Drug Int Clin Pharm 17: 411
Zukin SR, Zukin RS (1979) Specific 3H-Phencyclidine binding in rat central nervous system. Proc Nat Acad Scie (USA) 76: 182–191
Zurick AM, Urzua J, Yared JP et al. (1982) Comparison of hemodynamic and hormonal effects of large single-dose fentanyl anesthesia and halothane/nitrous oxide anesthesia for coronary artery surgery. Anesth Analg 61: 521–526
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Waldvogel, H.H. (1996). Allgemeine Kinetik zentraler Schmerzmittel — mit besonderer Berücksichtigung der Opioide. In: Analgetika Antinozizeptiva Adjuvanzien. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97649-0_9
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