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Nichtsaure antipyretische Analgetika

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Analgetika Antinozizeptiva Adjuvanzien

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Zusammenfassung

Nichtsaure antipyretische Analgetika lassen sich in folgende 2 Gruppen einteilen:

  1. 2.1

    Nichtsaure Pyrazolone

  2. 2.2

    Anilinderivate

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18 Literatur

  • Ajgaonkar VS, Marathe SN, Virani AR (1988) Dipyrone versus Paracetamol: a double-blind study in typhoid fever. J Intern Med Res 16: 225–230

    CAS  Google Scholar 

  • Asmardi G, Jamali G (1985) Pharmacokinetics of dipyrone in man; role of the administration route. Eur J Drug Metab Pharmacokin 10(2): 121–125

    Article  CAS  Google Scholar 

  • Benoist JM (1988) Analgésiques non morphiniques. Pharmacologie clinique. Bases de la thérapeutique (Giroud JP, Mathé G, Meyniel G, eds.), Expansion scientifique Francaise (Paris), pp 864–897

    Google Scholar 

  • Carlsson KH, Helmreich J, Jurna J (1986) Activation of inhibition from the periaqueductal grey matter mediates central analgesic effect of metamizol (Dipyrone). Pain 27: 373–390

    Article  PubMed  CAS  Google Scholar 

  • Cohen JL (1986) Pharmacokinetic changes in aging. Am J Med 80(S 5A): 31–38

    Article  PubMed  CAS  Google Scholar 

  • Forth A (1985) Spasmolytische Effekte von Pyrazolonen. In: Brune K, Lanz R (eds) 100 Jahre Pyrazolone. Urban & Schwarzenberg, München

    Google Scholar 

  • Haupt E, Hoppe FU, Bamberg E (1989) Zur Frage der Wechselwirkungen von Analgetika und oralen Antidiabetika: Metamizol-Glibenclamid. Medwelt 40: 681–683

    Google Scholar 

  • Hempel V (1988) Metamizol—praktische Anwendung. Schmerz 2: 170–172

    Article  PubMed  CAS  Google Scholar 

  • Koch-Weser J, Greenblatt DJ, Scilers EM et al. (1982) Drug disposition in old age. N Engl J Med 306: 1081–1088

    Article  Google Scholar 

  • Kramer MS, Lane DA, Hutchinson TA (1987) Analgesic use, blood dyscrasias, and case-control pharmacoepidemiology: a critique of the IAAAS. J Chron Dis 40: 1073–1081

    Article  PubMed  CAS  Google Scholar 

  • Levy M, Flusser D, Zylber-Katz E et al. (1984) Plasma kinetics of dipyrone metabolites in rapid and slow acetylators. Eu J Clin Pharmacol 27: 453–458

    Article  CAS  Google Scholar 

  • Neddermann E, Rohdewald P (1988) Dose-dependent pharmacokinetics of metabolites of Dipyrone in saliva. Euro J Drug Metab Pharmacokinet 13: 105–111

    Article  CAS  Google Scholar 

  • Ovtcharov R, Pola W, eds., (1978) Dipyrone. Symposium Moscow Proceedings, F.K. Schattauer

    Google Scholar 

  • Patel CV, Koppikar MG, Patel MS (1980) A double-blind comparison of dipyrone in the treatment of post-operative pain. Curr Med Res Opin 6: 624–629

    Article  PubMed  CAS  Google Scholar 

  • Rohdewald P, Nedermann E (1988) Dosisabhängigkeit der analgetischen Wirkung von Metamizol. Anaesthesist 37: 150–155

    PubMed  CAS  Google Scholar 

  • Rohdewald R, Granitzki HW, Neddermann E (1988) Comparison of the Analgesic Efficacy of Metamizole and Tramadol in Experimental Pain. Pharmacology 37: 209–217

    Article  PubMed  CAS  Google Scholar 

  • Schroth HJ (1989) Direkte spasmolytische Wirkung des Metamizols auf die glatte Muskulatur der abführenden Harn-und Gallenwege.Therapiewoche 39: 1522–1525

    Google Scholar 

  • Schroth HJ, Garth H, Rupp S et al. (1986) Wirkung von Metamizol auf die Harnwegs-Motilität. Fortschr Med 104,18: 378–382

    PubMed  CAS  Google Scholar 

  • Schroth HJ, Garth H, Rupp S et al. (1987) Wirkung von Metamizol auf die Kontraktilität der Gallenblase. Fortschr Med 105,7: 136–138

    PubMed  CAS  Google Scholar 

  • Stevenson IH (1983) Drugs for the elderly. In: Lemburger L, Reidenberg MM (eds) Proc 2nd World Conference on Clinical Pharmacology and Therapeutics, Bethesda. Am Soc Pharmacol Exp Ther, pp 64–73

    Google Scholar 

  • The International Agranulocytosis and Aplastic Anemia Study (1987) Reply. J Chron Dis 40: 1083–1085

    Article  Google Scholar 

  • The International Agranulocytosis and Aplastic Anemia Study (1986) Risks of agranulocytosis and aplastic anemia: a first report of their relation to drug use with special reference to analgesics. JAMA 256: 1749–1757

    Article  Google Scholar 

  • Travers AF (1991) A fatality after antipyrine administration. Clin Pharmacol Ther 49: 695–696

    Article  PubMed  CAS  Google Scholar 

  • Vlahov V, Badian M, Verho M et al. (1990) Pharmacokinetics of metamizol metabolites in healthy subjects after a single oral dose of metamizol sodium. Eur J Clin Pharmacol 38: 61–65

    Article  PubMed  CAS  Google Scholar 

  • von Bülow H (1988) Die analgetische Wirkung von Tilidin im Vergleich zu Metamizol Tropfen bei posttraumatischen Schmerzen im Kindesalter. Therapiewoche 38: 1232–1234

    Google Scholar 

  • Weithmann KU, Alpermann HG (1985) Biochemical and pharmacological effects of dipyrone and its metabolites in model systems related to arachidonic acid cascade. Arzneimittel Forschung 35: 947–952

    PubMed  CAS  Google Scholar 

  • Zylber-Katz E, Granit L, Stessman J et al. (1989) Effect of age on the pharmacokinetics of dipyrone. Eur J Clin Pharmacol 36: 513–516

    Article  PubMed  CAS  Google Scholar 

18.2 Ergänzende Literatur

18 Literatur

18 Literatur

  • Abbadie C, Besson JM (1994) Chronic treatments with aspirin or acetaminophen reduce both the development of polyarthritis and Fos-like immunoreactivity in rat lumbar spinal cord. Pain 57: 45–54

    Article  PubMed  CAS  Google Scholar 

  • Beaver WT, MacMillan D (1980) Methodological considerations in the evaluation of analgesic combinations: acetaminophen (paracetamol) and hydrocodone in postpartum pain. Br J Pharmacol 10: 2155–2235

    Google Scholar 

  • Beaver WT (1984) Combination analgesics. Am J Med 10: 38–53

    Google Scholar 

  • Benoist JM (1988) Utilisation des analgésiques „périphériques“. Douleur Anaig 1: 35–45

    Article  Google Scholar 

  • Björkman R, Hallman KM, Hedner J et al. (1994) Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P. Pain 57: 259–264

    Article  PubMed  Google Scholar 

  • Carlsson KH, Jurna I (1987) Central analgesic effect of paracetamol manifested by depression of nociceptive activity in thalamic neurones of the rat. Neurosci Lett 77: 339–343

    Article  PubMed  CAS  Google Scholar 

  • Carlsson KH, Monzel W, Jurna I (1988) Depression by morphine and the non-opioid analgesic agents, metamizol (dipyrone), lysine acetylsalicylate, and paracetamol of activity in rat thalamus neurones evoked by electrical stimulation of nociceptive afferents. Pain 32: 313–326

    Article  PubMed  CAS  Google Scholar 

  • Cheung L, Potts RG, Meyer KC (1994) Acetaminophen treatment nomogram. Correspondence. N Engl J Med 330: 1907–1908

    Article  PubMed  CAS  Google Scholar 

  • Clissold SP (1986) Paracetamol and phenacetin. Drugs 32(84): 46–59

    Article  PubMed  Google Scholar 

  • Committee on infectious Diseases (1982) Aspirin and Reye’s syndrome. Pediatrics 69:310

    Google Scholar 

  • Delaney JC (1976) The diagnosis of aspirin idiosyncrasy by analgesic challenge. Clin Allergy 6:177, zit. in: Szczeklik 1992 (s. Aspirin)

    Google Scholar 

  • Ellis M, Haydik I, Gillman S et al. (1988) Immediate adverse reactions to acetaminophen. J Allergy Clin Immunol 81; 180: A348

    Google Scholar 

  • Ferrari RA, Ward SJ, Zobre CM et al. (1990) Estimation of the in vivo effect of cyclooxgenase inhibitors on prostaglandin E2 levels in mous brain. Eur J Pharmacol 179: 25–34

    Article  PubMed  CAS  Google Scholar 

  • Flower RJ, Vane JR (1972) Inhibition of prostaglandin synthetase in brain explains the antipyretic activity of paracetamol (4 acetamidophenol). Nature 240: 410–411

    Article  PubMed  CAS  Google Scholar 

  • Forrest JAH, Clements JA, Prescott LF (1982) Clinical pharmacokinetics of paracetamol. Clin Pharmacokin 7: 93–107

    Article  CAS  Google Scholar 

  • Fowler PD (1987) Aspirin, paracetamol and non steroidal anti-inflammatory drugs. A comparative review of side effects. Med Toxicol 2: 338–366

    CAS  Google Scholar 

  • Gaudreault P, Guay J, Nicol O et al. (1988) Pharmacokinetics and clinical efficacy of intrarectal solution of acetaminophen. Can J Anaesth 35: 149–152

    Article  PubMed  CAS  Google Scholar 

  • Gazzard BG, Ford-Hutchinson AW, Smith MJ et al. (1973) The binding of paracetamol to plasma proteins of man and pigs. J Pharm Pharmacol 25: 964–967

    Article  PubMed  CAS  Google Scholar 

  • Goujon C, Keravel Y (1990) Analgesic efficacy of a paracetamol-codeine combination after discectomy. Pain 5(S): 155

    Article  Google Scholar 

  • Hunskaar S, Fasmer OB, Hole K (1985) Acetylsalicylic acid, paracetamol and morphine inhibit behavioural responses to intrathecally administered substance P or capsaicin. Life Sci 37: 1835–1841

    Article  PubMed  CAS  Google Scholar 

  • Jorup-Ronstrom C, Beermann B et al. (1986) Reduction of paracetamol and aspirin metabolism during viral hepatitis. Clin Pharmacokin 11: 250–256

    Article  CAS  Google Scholar 

  • Lauterburg BH, Velez ME (1988) Glutathione deficiency in alcoholics: risk factor for paracetamol hepatoxicity. Gut 29: 1153–1157

    Article  PubMed  CAS  Google Scholar 

  • Lands WEM (1981) Actions of anti-inflammatory drugs. Trends Pharmacol Sci 2: 78–80

    Article  CAS  Google Scholar 

  • Lechat P, Kisch R (1989) Le Paracétamol. Thérapie 44(N°5)

    Google Scholar 

  • Licht H, Seeff LB, Zimmermann HJ (1980) Apparent potentiation of acetaminophen hepatoxicity by alcohol. Ann Intern Med 92:511

    PubMed  CAS  Google Scholar 

  • Lokken P, Skjelbred P (1980) Analgesic and antiinflammatory effects of paracetamol evaluated by bilateral oral surgery. Br J Clin Pharmacol 10: 235–260

    Google Scholar 

  • Lökken P, Skoglund LA (1995) Anti-inflammatory efficacy of treatments with aspirin and acetaminophen. Letter to the Editor. Pain 60: 231–232

    Google Scholar 

  • Maddrey WC (1987) Hepatic effects of acetaminophen. Enhanced toxicity in alcoholics. J Clin Gastroenterol 9: 180–185

    Article  PubMed  CAS  Google Scholar 

  • McQueen DS, Iggo A, Birrell GI et al. (1991) Effects of paracetamol and aspirin on neural activity of joint mechanonociceptors in adjuvant arthritis. Br J Pharmacol 104: 178–182

    PubMed  CAS  Google Scholar 

  • Nahata MC, Powell DA, Dunel DE (1984) Acetaminophen accumulation in pediatrie patients after repeated therapeutic doses. Eur J Clin Pharmacol 27: 57–59

    PubMed  CAS  Google Scholar 

  • Peterson RG, Rumack BH (1978) Pharmacokinetics of acetaminophen in children. Pediatris 62: 877–879

    CAS  Google Scholar 

  • Pezzano M, Richard C, Lampl E et al. (1988) Toxicité hépatique et rénale du paracétamol chez l’alcoolique chronique. Presse Méd 17: 21–24

    PubMed  CAS  Google Scholar 

  • Pharma-Flash (1994) Médicaments de référence (Dayer P, ed.). 21(2-5): 135–136

    Google Scholar 

  • Prescott LF, Critchley JAJH (1983) The treatment of acetaminophen poisoning. Annu Rev Pharmacol Toxicol 23: 87–101

    Article  PubMed  CAS  Google Scholar 

  • Rawlins MD, Henderson DB, Hijab AR (1977) Pharmacokinetics of paracetamol (acetaminophen) after intravenous and oral administration. Eur J Clin Pharmacol 11: 283–286

    Article  PubMed  CAS  Google Scholar 

  • Rumack BH (1986) Acetaminophen overdose in children and adolescents. Ped Clin North Am 33: 691–701

    CAS  Google Scholar 

  • Rumack BH, Peterson RC, Koch GG et al. (1981) Acetaminophen overdose: 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med 141: 380–385

    Article  PubMed  CAS  Google Scholar 

  • Seeff LB, Cuccherini BA, Zimmermann HJ et al. (1986) Acetaminophen hepatoxicity in alcoholics: a therapeutic misadventure. Ann Intern Med 104: 399–404

    PubMed  CAS  Google Scholar 

  • Smilkstein MJ; Knapp GL, Kulig KW et al. (1988) Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. N Engl J Med 319: 1557–1562

    Article  PubMed  CAS  Google Scholar 

  • Strieker BH, Meyboom RHB, Lindquist M (1985) Acute hypersensitivity reactions to paracetamol. BMJ 291: 938–939

    Google Scholar 

  • Temple AR: Pediatrie dosing of acetaminophen. Pediatr Pharmacol 3: 321–327

    Google Scholar 

  • Tjölsen A, Lund A, Erge OG et al. (1991) Antinociceptive effect of paracetamol in rats is partly dependent on the spinal serotoninergic system. Eur J Pharmacol 193: 193–201

    Article  PubMed  Google Scholar 

  • Vinegar R, Truax FF, Selph JL (1976) Quantitative comparison of the analgesic and anti-inflammatory activities of aspirin, phenacetin and acetaminophen in rodents. Eur J Pharmacol 37: 23–30

    Article  PubMed  CAS  Google Scholar 

  • Von Meyring J (1893) Beiträge zur Kenntnis der Antipyretica. Therap Med Schrift 7: 577

    Google Scholar 

18.2 Ergänzende Literatur

18 Literatur

  • Brodie BB, Axelrod J (1948) The fate of acetanilide in man. J Pharmacol Exp Ther 94: 29–38

    PubMed  CAS  Google Scholar 

  • Brodie BB, Axelrod J (1948) The fate of acetophenetidin (phenacetin) in man and methods for the estimation of acetophenetidin and its metabolites in biological material. J Pharmacol Exp Ther 97: 58–67

    Google Scholar 

  • Dubach UC, Rosner B, Stürmer T (1991) An epidemiologic study of abuse of analgesic drugs-effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968-1987). N Engl J Med 324: 155–160

    Article  PubMed  CAS  Google Scholar 

  • Dubach UC (1967) Urinary estimation of p-aminophenol as a routine test for detection of phenacetin intake. Geriat Med Mon 12: 380–384

    Google Scholar 

  • Raaflaub J, Dubach UC (1975) On the pharmacokinetics of phenacetin in man. Eur J Clin Pharmacol 8: 261–265

    Article  PubMed  CAS  Google Scholar 

  • Sandier DP, Smith JC, Weinberg CR et al. (1989) Analgesic use and chronic renal disease. N Engl J Med 320: 1238–1243

    Article  Google Scholar 

  • Stolley PD (1991) The risks of phenacetin use. N Engl J Med 324(3): 191–193

    Article  PubMed  CAS  Google Scholar 

18.2 Ergänzende Literatur

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  1. La Forestière, F-74500, St. Paul en Chablais, Frankreich

    Dr. med. Herman Hans Waldvogel

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  1. Dr. med. Herman Hans Waldvogel
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© 1996 Springer-Verlag Berlin Heidelberg

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Waldvogel, H.H. (1996). Nichtsaure antipyretische Analgetika. In: Analgetika Antinozizeptiva Adjuvanzien. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97649-0_18

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  • DOI: https://doi.org/10.1007/978-3-642-97649-0_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-97650-6

  • Online ISBN: 978-3-642-97649-0

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