Experimental Xenotransplantation in Rodents — III: Total Lymphoid Irradiation, Cyclosporine, and Monoclonal Antibodies

  • D. A. Steinbruchel
  • B. Nielsen
  • E. Kemp


A treatment strategy including total body irradiation (TBI) or total lymphoid irradiation (TLI) in combination with cyclosporine (CsA) would seem to be a promising method for prolonging xenograft survival in the rodent [1-6]. The most impressive resuhs have been reported by Knechtle et al. where graft survival after TLI + CsA treatment was prolonged for more than 100 days in a Syrian hamster-to-Lewis rat model [7, 8]. Several attempts by other groups, however, to reproduce these results have not been successful [4,5,9].


Graft Survival Graft Rejection Total Lymphoid Irradiation Flow Cytometric Evaluation Xenograft Survival 
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© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • D. A. Steinbruchel
  • B. Nielsen
  • E. Kemp

There are no affiliations available

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