Experimental Xenotransplantation in Rodents — I: Plasma Exchange and Splenectomy

  • R. Reding


A variety of microsurgical transplantation models that are available in rodents for organ ahografting [1] have been used in xenograft research, particularly with rats as recipients of organs from size-matched xenogeneic donors. Among the 1687 species classified as rodents in the zoological taxonomy, only four have been used for xenotransplantation — the hamster, rat and mouse belong to the same suborder (Myomorpha), whereas the guinea pig (Hystricomorpha) is more distantly related [2]. Theoretically, a rough prediction of xenograft survival time can be made according to disparity in the zoological system — the more distantly related the donor and the recipient, the more aggressively and rapidly wdl the xenograft rejection process occur.


Graft Survival Species Combination Hyperacute Rejection Total Lymphoid Irradiation Humoral Rejection 
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© Springer-Verlag Berlin Heidelberg 1991

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  • R. Reding

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