Advertisement

Histopathology of Cardiac Xenograft Rejection

  • A. G. Rose

Abstract

Widespread acceptance of cardiac transplantation as the treatment for endstage heart failure has placed ever increasing demands upon human organ donation. Despite increased public acceptance of organ donation, human sources of transplanted hearts continue to be insufficient to meet the demand. Whilst formidable problems, particularly that of hyperacute rejection, stand in the way of cross-species organ transplantation, the pressing paucity of human donor hearts has led to renewed interest in xenotransplantation and, consequently, in finding a means of preventing hyperacute rejection.

Keywords

Cardiac Allograft Hyperacute Rejection Total Lymphoid Irradiation Cardiac Allograft Rejection Vascular Rejection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Rose, A.G., Uys, C.J. Pathology of acute rejection. In: D.K.C. Cooper and D. Novitzky (eds.) The Transplantation and Replacement of Thoracic Organs. Kluwer; Dordrecht, Boston, London, 1990, p. 115.CrossRefGoogle Scholar
  2. 2.
    Rose, A.G., Uys, C.J. Pathology of graft atherosclerosis (chronic rejection). In: D.K.C. Cooper and D. Novitzky (eds.) The Transplantation and Replacement of Thoracic Organs. Kluwer; Dordrecht, Boston, London, 1990, p. 161.CrossRefGoogle Scholar
  3. 3.
    Hardy, J.D., Chavez, C.M., Kurrus, F.E., Neely, W.A., Webb, W.R., Eraslan, S. Turner, M.D., Fabian, L.W., Labecki, J.D. Heart transplantadon in man: development studies and report of a case. J. Amer. Med. Assoc. 188,1132, 1964.CrossRefGoogle Scholar
  4. 4.
    Barnard, C.N., Wolpowitz, A., Losman, J.G. Heterotopic cardiac transplantation with a xenograft for assistance of the left heart in cardiogenic shock after cardiopulmonary bypass. 5. Afr. Med. J. 52,1035, 1977.Google Scholar
  5. 5.
    Bailey, L.L., Nelsen-Cannarella, S.L., Concepcion, W., Jolley, W.B. Baboon-to-human cardiac xenotransplantation in a neonate. J. Amer. Med. Assoc. 254,3321, 1985.Google Scholar
  6. 6.
    Forbes, R.D.C., Guttmann, R.D., Kuramochi, T., Klassen, J., Knaack, J. Non-essendal role of neutrophils as mediators of hyperacute cardiac allograft rejection in the rat. Lab. Invest. 34,229,1916.Google Scholar
  7. 7.
    Forbes, R.D.C., Kuramochi, T., Guttmann, R.D., Klassen, J., Knaack, J.A. A controlled sequendal morphologic study of hyperacute rejection in the rat. Lab. Invest. 33, 280, 1975.PubMedGoogle Scholar
  8. 8.
    Forbes, R.D.C., Guttmann, R.D. Mechanisms of humoral mediated cardiac allograft rejection in vivo: controlled comparative morphological studies utilizing inbred rat models. J. Heart Transplant. 1,196, 1982.Google Scholar
  9. 9.
    Sharma, H.M., Rosenweig, J., Chatterjee, S., Moore, S., De Champlain, M.L. Platelets in hyperacute rejection of heterotopic cardiac allografts in presensitized dogs. Am. J. Pathol. 70,155, 1973.PubMedGoogle Scholar
  10. 10.
    Caves, P.K., Dong, E., Morris, R.E. Hyperacute rejection of orthotopic cardiac allografts in dogs following solubilized antigen pre-treatment. Transplantation. 16, 252, 1973.PubMedCrossRefGoogle Scholar
  11. 11.
    Guttmann, R.D. Genetics of acute rejection of rat cardiac allografts and a model of hyperacute rejection. Transplantation. 17,383, 1974.PubMedCrossRefGoogle Scholar
  12. 12.
    Kuwahara, O., Kondo, Y, Kuramochi, T, Grogan, J.B., Cockreh, J.V., Hardy, J.D. Organ specificity in hyperacute rejection of canine heart and kidney allografts. Ann. Surg. 180,72, 1974.PubMedCrossRefGoogle Scholar
  13. 13.
    Cattell, v., Jamieson, S.W. Hyperacute rejecdon of guinea-pig to rat cardiac xenografts. I. Morphology. J. Pathol. 115,183, 1975.Google Scholar
  14. 14.
    Corry, R.J., Kelly, S.E. Survival of cardiac xenografts. Effect of antithymocyte serum and enhancing heteroserum. Arch. Surg. 110,1143, 1975.PubMedCrossRefGoogle Scholar
  15. 15.
    Jamieson, S.W. Modification of the hyperacute reaction in the rat by sulphinylpyrazone. Thromb. Diath. Haemorrh. 30,349, 1975.Google Scholar
  16. 16.
    Whittum, J.A., Lindquist, R.R. Mechanism of cardiac allograft rejection in the inbred rat: the effect of complement depletion by cobra venom factor on hyperacute cardiac allograft rejection. Transplantation. 24,226, 1977.PubMedCrossRefGoogle Scholar
  17. 17.
    Forbes, R.D., Guttmann, R.D., Bazin, H. Hyperacute rejection of cardiac allografts in a rat strain with a hereditary platelet function defect. Lab. Invest. 37,158, 1977.PubMedGoogle Scholar
  18. 18.
    Guttmann, R.D. In vitro correlates of rejection. I. Suppressive effect and specificity in mixed lymphocyte interaction of alloantiserum producing hyperacute rejection. Transplant. Proc. 9,755, 1977.PubMedGoogle Scholar
  19. 19.
    Forbes, R.D., Guttmann, R.D., Kuramochi, T. Controlled studies of the pathogenesis of hyperacute cardiac allograft rejection in actively immunized recipients. Transplant. Proc. 9,301, 1977.PubMedGoogle Scholar
  20. 20.
    Forbes, R.D., Guttmann, R.D., Pinto-Blonde, M. A passive transfer model of hyperacute rat cardiac allograft rejection. Lab. Invest. 41, 348, 1979.PubMedGoogle Scholar
  21. 21.
    Guttmann, R.D., Bazin, H. Lack of significance of allograft differences in hyperacute rejection of rat cardiac allografts. Transplantation. 28,155, 1979.PubMedCrossRefGoogle Scholar
  22. 22.
    Coleman, D.A., Eichwald, E.J. Hyperacute rejection of allografted murine hearts and the white graft reaction. Transplantation. 26,355, 1978.PubMedCrossRefGoogle Scholar
  23. 23.
    O’Regan, C.C., Robitaille, P., Pinto-Blonde, M., Chartrand, C. Delayed rejection of cardiac xenografts in C6-deficient rabbits. Immunology. 38,245, 1979.PubMedGoogle Scholar
  24. 24.
    Lexer, G., Cooper, D.K.C., Rose, A.G., Wicomb, W.N., Rees, J., Keraan, M., du Toit, E. Hyperacute rejection in a discordant (pig-to-baboon) cardiac xenograft model. J. Heart Transplant. 5,411, 1986.PubMedGoogle Scholar
  25. 25.
    Lexer, G., Cooper, D.K.C, Wicomb, W.N., Rose, A.G., Rees, J., Keraan, M., Reichart, B., du Toit, E. Cardiac transplantation using discordant xenografts in a non-human primate model. Transplant. Proc. 19,1153, 1987.PubMedGoogle Scholar
  26. 26.
    Cooper, D.K.C., Lexer, G., Rose, A.G., Rees, J., Keraan, M., du Toit, E., Oriol, R. Cardiac allograft survival in ABO blood group incompatible baboons. Transplant. Proc. 19,1036, 1987.PubMedGoogle Scholar
  27. 27.
    Cooper, D.K.C., Human, P.A., Reichart, B. Prolongation of cardiac xenograft (vervet monkey-to-baboon) function by a combination of total lymphoid irradiation and immunosuppressive drug therapy. Transplant. Proc. 19,4441, 1987.PubMedGoogle Scholar
  28. 28.
    Cooper, D.K.C., Human, P.A., Rose, A.G. Is ABO compatibility essential in xenografting between closely related species? Transplant. Proc. 19,4437, 1987.PubMedGoogle Scholar
  29. 29.
    Reemtsma, K., Pierson, R.N., Marboe, C.C., Michler, R.E., Smith, C.R., Rose, E.A., Fenogho, J.J. Will atherosclerosis limit clinical xenografting? Transplant. Proc. 19,108, 1987.PubMedGoogle Scholar
  30. 30.
    Cooper, D.K.C, Human, P.A., Lexer, G., Rose, A.G., Rees, J., Keraan, M., du Toit, E.A Effects of cyclosporine and antibody adsorption on pig cardiac xenograft survival in the baboon. J. Heart Transplant. 7,238, 1988.PubMedGoogle Scholar
  31. 31.
    Cooper, D.K.C, Rose, A.G., Lexer, G., Keraan, M., Rees, J., du Toit, E., Oriol, R. Cardiac allotransplantation across major blood group barriers in the baboon. J. Med. Primatol. 17,333, 1988.PubMedGoogle Scholar
  32. 32.
    Reichenspurner, H., Human, P.A., Boehm, D.M., Rose, A.G., May, R., Cooper, D.K.C., Zilla, P., Reichart, B. Optimalization of immunosuppression after xenogeneic heart transplantation in primates./. Heart Transplant. 8,200, 1989.Google Scholar
  33. 33.
    Cooper, D.K.C., Human, P.A., Rose, A.G., Rees, J., Keraan, M., Reichart, B., du Toit, E., Oriol, R. The role of ABO blood group compatibility in heart transplantation between closely related animal species. 7. Thorac. Cardiovasc. Surg. 97,447, 1989.Google Scholar
  34. 34.
    Rose, A.G., Cooper, D.K.C., Human, P.A., Reichenspurner, H., Reichart, B. Histopathology of hyperacute rejection of the heart - experimental and clinical observations in allografts and xenografts. J. Heart Transplant. In press.Google Scholar
  35. 35.
    Forbes, R.D., Pinto-Blonde, M., Guttmann, R.D. The effect of anticomplementary cobra venom factor on hyperacute rat cardiac allograft rejection. Lab. Invest. 39, 463, 1978.PubMedGoogle Scholar
  36. 36.
    Reichenspurner, H., Human, P.A., Rose, A.G., Reichart, B., Cooper, D.K.C. Effect of pharmacologic immunosuppression on donor heart survival in a closely related nonhuman primate xenograft model. Transplant. Proc. 22,1086, 1990.PubMedGoogle Scholar
  37. 37.
    Knopf, W.D., Gravanis, M.B. Cardiac transplantation. In: Cardiovascular Pathophysiology, M.B. Gravanis (Ed.), New York, McGraw Hill, 1987, p. 298.Google Scholar
  38. 38.
    Trento, A., Hardesty, R.L., Griffith, B.P., Zerbe, T., Kormos, R.L., Bahnson, H.T. Role of the antibody to vascular endothehal cells in hyperacute rejection in patients undergoing cardiac transplantation. J. Thorac. Cardiovasc. Surg. 95,37, 1988.PubMedGoogle Scholar
  39. 39.
    Hammond, E.H., Yoweh, R.L., Numoda, S., Menlove, R.L., Renlund, D.G., Bristow, M.R., Gay, W.R. JR., Jones, K.W., O’Connell, J.B. Vascular (humoral) rejection in heart transplantation: pathologic observations and clinical implications. J. Heart Transplant. 8, 430, 1989.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • A. G. Rose

There are no affiliations available

Personalised recommendations