Abstract
Sebum is the fuel of the acne flame. It is not only comedogenic in its own right but provides the substrate for the growth of Propionibacterium acnes. Any drug that reduces sebum secretion by 30% or more will have a therapeutic beneficial effect.
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References
Fanta D (1980) Quantity and quality of sebum production. In: Fanta D: Hormone therapy of acne. Clinical and experimental principles. Springer, Wien, pp 4–12
Fanta D (1990) Cyproterone acetate in acne. J Dermatol Treat (Suppl 3) 1:19–22
Goodfellow A, Alaghband-Zadeh J, Carter G, Cream JJ, Holland S, Scully J, Wise P (1984) Oral spironolactone improves acne vulgaris and reduces sebum excretion. Br J Dermatol 111:209–214
Hammerstein J (1980) Possibilities and limits of endocrine therapy. In: Hammerstein J, Lachnit-Fixson U, Neumann F, Plewig G (eds) Androge-nization in women — acne, seborrhea, androgenic alopecia and hirsutism. Excerpta Media, Amsterdam, pp 221–238
Lucky AW (1983) Endocrine aspects of acne. Pedi-atr Clin North Am 30:495–499
Lucky AW (1988) The paradox of androgens and balding: where are we now? J Invest Dermatol 91:99–100
Lucky AW (1985) Topical antiandrogens. What use in dermatology? Arch Dermatol 121:55–56
Lucky AW, McGuire J, Rosenfield RL, Lucky PA, Rich BH (1983) Plasma androgens in women with acne vulgaris. J Invest Dermatol 81:70–74
Lucky AW, Rosenfield RL, McGuire J, Rudy S, Helke J (1986) Adrenal androgen hyperresponsive-ness to adrenocorticotropin on women with acne and/or hirsutism: adrenal enzyme defects and exaggerated adrenarche. J Clin Endocrinol Metab 62:840–848
Muhlemann MF, Carter GD, Cream JJ, Wise P (1986) Oral spironolactone: an effective treatment for acne vulgaris in women. Br J Dermatol 115:227–232
Pochi PE (1983) Hormonal therapy of acne. Dermatol Clin 1:377–384
Pocchi PE, Langcope C (1989) 5 α-androstane-3 α-, 17 β-diol glucuronide blood levels and sebum secretion in acne and normal subjects. I: Marks R, Plewig G (eds) Acne and related disorders. Dunitz, London, pp 67–69
Redmond GP, Bergfeld WP (1990) Treatment of androgenic disorders in women: acne, hirsutism, and alopecia. Cleve Clin J Med 57:428–432
Redmond GP, Gidwani GP, Gupta MK, Bedocs NM, Parker R, Skibinski C, Bergfeld W (1990) Tratment of androgenic disorders with dexam-ethasone: dose-response relationship for suppression of dehydroepiandrosterone sulfate. J Am Acad Dermatol 22:91–93
Rich BH, Rosenfield RL, Lucky AW, Heike JC, Otto P (1981) Adrenarche: changing adrenal response to adrenocorticotropin. J Clin Endocrinol Metab 52:1129–1136
Rosenfeld RL, Rich BH, Lucky AW (1982) Adrenarche as a cause of benign pseudopuberty in boys. J Pediatr 101:1005–1009
Schindler AE (1987) Antriandrogen therapy for signs of androgenization: an overview. In: Schindler AE (ed) Antiandrogen-estrogen therapy for signs of androgenization. De Gruyter, Berlin, pp 15–20
Shaw JC (1991) Spironolactone in dermatologic therapy. J Am Acad Dermatol 24:236–243
Vexiau P, Husson C, Chivot M, Brerault JL, Fiet J, Julien R, Vilette JM, Hardy N, Cathelineau G (1990) Androgen excess in women with acne alone compared with women with acne and/or hirsutism. J Invest Dermatol 94:279–283
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© 1993 Springer-Verlag Berlin Heidelberg
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Plewig, G., Kligman, A.M. (1993). Antiandrogens and Aldosterone Antagonists. In: ACNE and ROSACEA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97234-8_85
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DOI: https://doi.org/10.1007/978-3-642-97234-8_85
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