Urinary Tract

Abstract

In contrast to the liver, the kidneys are rarely the primary target of a pathological event after bone marrow transplantation. GVHD (acute or chronic) does not visibly affect the kidney and a specific disease entity related to radio-chemotherapy damage such as radiation nephritis has not been observed. However, it is likely that a subclinical degree of tubular damage occurs during the conditioning regimen. Renal impairment is predominantly secondary to circulatory disturbances associated with veno-occlusive disease, septicemia or hypovolemic shock. Further some of the drugs frequently used posttransplant can injure the tubular system. The severity of renal impairment can range from mild prerenal insufficiency to acute oliguric (or anuric) renal failure.