• K. Rother
  • G. O. Till


It was on the basis of heat “inactivation” of serum that complement was discovered in 1889 as a bactericidal entity, separate from a heat stable factor now known to have been an antibody. Subsequently, in 1901, a hemolytic indicator system was established by Bordet and Gengou [1] which has up to the present time provided the basis for defining complement lytic activity.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bordet J, Gengou O (1901) Sur l’existences de substance sensibilisations. Ann Inst Past 15:290Google Scholar
  2. 2.
    Brand E (1907) Über das Verhalten der Komplemente bei der Dialyse. Berl Klin Wschr 44:1075Google Scholar
  3. 3.
    Doerr, R (1947) Das Komplement. In: Die Immunitätsforschung. Ergebnisse und Probleme in Einzeldarstellungen. Band II. Springer, WienGoogle Scholar
  4. 4.
    Ehrlich P, Morgenroth J (1900) Über Hämolysine. Dritte Mitteilung. Berl Klin Wschr 37:453Google Scholar
  5. 5.
    Ehrlich P, Morgenroth J (1900) Über Hämolysine. Vierte Mitteilung. Berl Klin Wschr 37:681Google Scholar
  6. 6.
    Lay W, Nussenzweig V (1968) Complement dependent receptor sites for antigen-antibody complexes on macrophages, polymorphonuclear leukocytes and lymphocytes. Fed Proc 27:621Google Scholar
  7. 7.
    Mayer MM (1958) Studies on the mechanism of hemolysis by antibody and complement. Prog Allergy 5:215PubMedGoogle Scholar
  8. 8.
    Müller-Eberhard HJ (1962) Mechanism of cell and tissue damage produced by immune reactions. IInd International symposium on immunopathology, Brook Lodge, Mi Schwabe, Basel, pp 23–26Google Scholar
  9. 9.
    Rother U, Rother K (1961) Über einen angeborenen Komplement-Defekt bei Kaninchen. Z Immun Forsch Exp Ther 121:224Google Scholar
  10. 10.
    Rother U, Rother K (eds) (1987) Complement deficiencies in animals and men. Prog Allergy 39Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • K. Rother
  • G. O. Till

There are no affiliations available

Personalised recommendations