Radiation Techniques for the Treatment of Retinoblastoma and Orbital Tumors

  • Winfried E. Alberti
  • Jan Schipper
  • Robert H. Sagerman
Part of the Medical Radiology book series (MEDRAD)


External beam radiation therapy has been used successfully to treat primary and metastatic neoplasms of the globe and orbit. Depending upon tumor location and extent, adequate treatment with sparing of the lens can be accomplished but requires meticulous technique. Many field arrangements have been described for unilateral and bilateral disease. Isodose distributions for several of the more commonly employed techniques are presented for direct comparison. Particle beam techniques and plaque isodose distributions are discussed in Chaps. 6 and 7, and 4, 5, 35, 36, and 37, respectively (this volume).


Anterior Border Lateral Field Orbital Tumor Lateral Beam Lateral Soft Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Alberti W, Halama J, Wannenmacher M (1987) Tumoren im Kopfbereich. Tumoren des Auges und der Orbita. In: Scherer E (ed) Strahlentherapie. Radiologische Onkologie. Springer, Berlin Heidelberg New York, pp 412–453Google Scholar
  2. Armstrong DI (1974) The use of 4–6 MeV electrons for the conservative treatment of retinoblastoma. Br J Radiol 47:326–269PubMedCrossRefGoogle Scholar
  3. Bagshaw MA, Kaplan HS (1966) Supervoltage linear accelerator radiation therapy. Radiology 86:242–246PubMedGoogle Scholar
  4. Bedford MA, Bedotto C, McFaul PA (1971) Retinoblastoma, a study of 139 cases. Br J Ophthalmol 55:19–27PubMedCrossRefGoogle Scholar
  5. Donaldson SS, Egbert PR (1989) Retinoblastoma. In: Pizzo PA, Poplack DG (eds) Principles and practice of pediatric oncology. JB Lippincott, PhiladelphiaGoogle Scholar
  6. Griem ML, Ernest JT, Rozenfeld ML et al. (1986) Eye lens protection in the treatment of retinoblastoma with high-energy electrons. Radiology 90:351–352Google Scholar
  7. Harnett AN, Hungerford IL, Lambert GD et al. (1987) Improved external beam radiotherapy for the treatment of retinoblastoma. Br J Radiol 60:753–760PubMedCrossRefGoogle Scholar
  8. Haye C, Schlienger P, Calle R et al. (1985) Traitement conservateur des tumeurs de la rétine a l’Institut Curie. Bull Cancer (Paris) 73:87–98Google Scholar
  9. Hilgartner HL (1903) Report of a case of double glioma treated by x-rays. Texas Medical J 18:322Google Scholar
  10. Hultberg S, Walstam R, Asard PE (1965) Two special applications of high-energy electron beams. Acta Radiol Ther 3:287–295Google Scholar
  11. Kärcher KH, Heckenthaler W, Binder W, Dimopoulos J, Seitz W (1971) Indikation zur Strahlentherapie in der Ophthalmologie. Strahlentherapie 142:381–389PubMedGoogle Scholar
  12. Martin HE, Reese AB (1936) Treatment of retinal gliomas by the fractionated or divided dose principle of roentgen radiation, a preliminary report. Arch Ophthalmol 16:733–761CrossRefGoogle Scholar
  13. McCormick B, Ellsworth R, Abramson D et al. (1988) Radiation therapy for retinoblastoma: comparison of results with lens-sparing versus lateral beam techniques. Int J Radiat Oncol Biol Phys 15:567–574PubMedCrossRefGoogle Scholar
  14. McFaul PA, Bedford MA (1970) Ocular complications after therapeutic irradiation. Br J Ophthalmol 54:237–247CrossRefGoogle Scholar
  15. Messmer EP, Sauerwein W, Heinrich T et al. (1990) New and recurrent tumor foci following local treatment as well as external beam radiation in eyes of patients with hereditary retinoblastoma. Graefes Arch Clin Exp Ophthalmol 228:426–431PubMedCrossRefGoogle Scholar
  16. Moore RF (1930) Choroidal sarcoma treated by the intraocular insertion of radon seeds. Br J Ophthalmol 14:145–152PubMedCrossRefGoogle Scholar
  17. Reese AB, Hyman GA, Tapley ND, Forrest AW (1985) The treatment of retionoblastoma by x-ray and triethylene melanine. Arch Ophthalmol 60:897–906CrossRefGoogle Scholar
  18. Schipper J (1980) Retinoblastoma. A medical and experimental study. Thesis, UtrechtGoogle Scholar
  19. Schipper J (1983) An accurate and simple method for megavoltage irradiation therapy of retinoblastoma. Radiother Oncol 1:31–41PubMedCrossRefGoogle Scholar
  20. Schipper J, Tan KEWP, van Peperzeel A (1985) Treatment of retinoblastoma by precision megavoltage radiation therapy. Radiother Oncol 3:117–132PubMedCrossRefGoogle Scholar
  21. Skeggs DBL, Williams IG (1966) The treatment of advanced retinoblastoma by means of external irradiation combined with chemotherapy. Clin Radiol 17:169–172PubMedCrossRefGoogle Scholar
  22. Stallard HB (1933) Radient energy as (a) a pathogenic, (b) a therapeutic agent in ophthalmic disorders. Br J Ophthalmol, Monograph Supplement 6Google Scholar
  23. Stallard HB (1936) Glioma retinae treated by radon seeds. Br Med J II:962–964CrossRefGoogle Scholar
  24. Weiss DR, Cassady JR, Petersen R (1975) Retinoblastoma: a modification in radiation therapy technique. Radiology 114:705–708PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Winfried E. Alberti
    • 1
  • Jan Schipper
    • 2
  • Robert H. Sagerman
    • 3
  1. 1.Clinic for Radiation Therapy and Nuclear MedicineAlfried Krupp HospitalEssen 1Germany
  2. 2.Arnhem Radiotherapeutic InstituteArnhemThe Netherlands
  3. 3.Radiation Oncology Division, Health Science CenterState University of New YorkSyracuseUSA

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