Urinary System pp 369-375 | Cite as

Urologic Syndrome, Mouse

  • Alison M. Bendele
  • William W. Carlton
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Murine urologic syndrome is an obstructive uropathy which affects male mice of various strains. The clinical signs and gross alterations are variable since the disease occurs as either an acute or a chronic condition. Mice with the acute form are found dead with no prior signs of illness. At necropsy, the urinary bladder is markedly distended with clear, yellow urine, which is culturally negative for bacteria. White, firm proteinaceous plugs resembling vesicular gland secretions are often present in the neck of the bladder and proximal urethra.


Obstructive uropathy urogenital syndrome 


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  1. Babcock VI, Southam CM (1965) Obstructive uropathy in laboratory mice. Proc Soc Exp Biol Med 120: 580–581PubMedGoogle Scholar
  2. Green RW, Scott RC (1975) Lower urinary tract disease. In: Ettinger SJ (ed) Textbook of veterinary internal medicine, vol 2. WB Saunders, Philadelphia, Chap 54, pp 1541–1577Google Scholar
  3. Hong CC, Ediger RD (1978a) Preputial gland abscess in mice. Lab Anim Sci 28: 153–156PubMedGoogle Scholar
  4. Hong CC, Ediger RD (1978b) Self-mutilation of the penis in C57BL/6N mice. Lab Anim 12: 55–57PubMedCrossRefGoogle Scholar
  5. Rapp JP (1962) Terminal formation of urethral plugs in male mice. Proc Soc Exp Biol Med 111: 243–245PubMedGoogle Scholar
  6. Silverstein E, Sokoloff L, Mickelsen O, Jay GE Jr (1961) Primary polydipsia and hydronephrosis in an inbred strain of mice. Am J Pathol 38: 143–159PubMedGoogle Scholar
  7. Sokoloff L, Barile MF (1962) Obstructive genitourinary disease in male STR/1N mice. Am J Pathol 41: 233–246PubMedGoogle Scholar
  8. Tuffery AA (1966) Urogenital lesions in laboratory mice. J Pathol Bacteriol 91: 301–309PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Alison M. Bendele
  • William W. Carlton

There are no affiliations available

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