Abstract
Kidneys are bilaterally and symmetrically enlarged three- to fivefold (Fig. 239) after 4–8 weeks of diphenylthiazole feeding 1.03% in pelletized rat chow (Carone et al. 1974). Enlargement is most prominent in outer medulla and consists of dilated tubules arranged radially (Fig. 239). Renal microdissection reveals saccular and fusiform dilations of all collecting tubules in the outer medulla, with occasional distention of cortical collecting and distal tubules. Following drug withdrawal, gross renal changes return to normal in 4–8 weeks (Kanwar and Carone 1984).
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References
Carone FA, Rowland RG, Perlman SG, Ganote CR (1974) The pathogenesis of drug-induced renal cystic disease. Kidney Int 5: 411–421
Carone FA, Stolarczyk J, Krumlovsky FA, Perlman SG, Roberts TH, Rowland RG (1975) The nature of a drug-induced renal concentrating defect in rats. Lab Invest 31: 658–664
Casey HW, Ayers KM, Robinson FR (1978) The urinary system. In Benirschke K, Garner FN, Jones TC (eds) Pathology of laboratory animals, vol I. Springer, Berlin, Heidelberg, New York, Chap 3, pp 115–173
Dousa TP, Rowland RG, Carone FA (1973) Renal medullary adenylate cyclase in drug-induced nephrogenic diabetes insipidus. Proc Soc Exp Biol Med 142: 720–722
Grantham JJ (1983) Polycystic kidney disease: a predominance of giant nephrons. Am J Physiol 244: F3–F10
Iverson WO, Fetterman GH, Jacobson ER, Olsen JH, Senior DF, Schobert EE (1982) Polycystic kidney and liver disease in springbok: I. Morphology of the lesions. Kidney Int 22: 146–155
Kanwar YS, Carone FA (1984) Reversible changes of tubular cell and basement membrane in drug-induced renal cystic disease. Kidney Int 25: 35–43
Mandell J, Koch WK, Nidess R, Preminger GM, McFarland E (1983) Congenital polycystic kidney disease. Am J Pathol 113: 112–114
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© 1986 Springer-Verlag Berlin Heidelberg
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Carone, F.A. (1986). Diphenylthiazole-Induced Renal Cystic Disease, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96956-0_30
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DOI: https://doi.org/10.1007/978-3-642-96956-0_30
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