Abstract
The kidneys of male mice of susceptible strains exposed to toxic concentrations of chloroform (HCC13) are acutely swollen and pale with a granular appearance. Often, in survivors, the kidneys have white capsular mottling and cortical streaks due to calcification of necrotic tubules (Deringer et al. 1953). Kidneys are enlarged somewhat, as confirmed by increased renal weight in chloroform-treated male mice (Ahmadizadeh et al. 1984).
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References
Ahmadizadeh M, Kuo CH, Hook JB (1981) Nephrotoxicity and hepatotoxicity of chloroform in mice: effect of deuterium substitution. J Toxicol Environ Health 8: 105–111
Ahmadizadeh M, Echt R, Kuo CH, Hook JB (1984) Sex and strain differences in mouse kidney: Bowman’s capsule morphology and susceptibility to chloroform. Toxicol Lett 20: 161–171
Branchflower RV, Nunn DS, Highet RJ, Smith JH, Hook JB, Pohl LR (1984) Nephrotoxicity of chloroform: metabolism to phosgene by the mouse kidney. Toxicol Appl Pharmacol 72: 159–168
Christensen LR, Wolff GL, Matanic B, Bond E, Wright E (1963) Accidental chloroform poisoning of BALB/ cAmNlcr mice. Z Versuchstierkd 2: 135–140
Clemens TL, Hill RN, Bullock LP, Johnson WD, Sultatos LG, Vesell ES (1979) Chloroform toxicity in the mouse: role of genetic factors and steroids. Toxicol Appl Pharmacol 48: 117–130
Culliford D, Hewitt HB (1957) The influence of sex hormone status on the susceptibility of mice to chloroform-induced necrosis of the renal tubules. J Endocrinol 14: 381–393
Deringer MK, Dunn TB, Heston WE (1953) Results of exposure of strain C3H mice to chloroform. Proc Soc Exp Biol Med 83: 474–479
Eschenbrenner AB, Miller E (1945) Sex differences in kidney morphology and chloroform necrosis. Science 102: 302–303
Hepler OE, Simonds JP (1945) Experimental nephropathies. Calcification and phosphatase in the kidneys of dogs poisoned with mercury bichloride, potassium dichromate and uranyl nitrate. Arch Pathol 40: 37–43
Hewitt HB (1956) Renal necrosis in mice after accidental exposure to chloroform. Br J Exp Pathol 37: 32–39
Hill RN (1977) Differential toxicity of chloroform in the mouse. Ann NY Acad Sci 298: 170–176
Hill RN, Clemens TL, Liu DK, Vesell ES, Johnson WD (1975) Genetic control of chloroform toxicity in mice. Science 190: 159–161
Ilett KF, Reid WD, Sipes IG, Krishna G (1973) Chloroform toxicity in mice: correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules. Exp Mol Pathol 19: 215–229
Jacobsen L, Andersen EK, Thorborg JV (1964) Accidental chloroform nephrosis in mice. Acta Pathol Microbiol Scand 61: 503–513
Klaassen CD, Plaa GL (1966) Relative effects of various chlorinated hydrocarbons on liver and kidney function in mice. Toxicol Appl Pharmacol 9: 139–151
Kluwe WM, Hook JB (1981) Potentiation of acute chloroform nephrotoxicity by the glutathione depletor diethyl maleate and protection by the microsomal enzyme inhibitor piperonyl butoxide. Toxicol Appl Pharmacol 59: 457–466
Krüs S, Zaleska-Rutczynska Z (1970) Morphological counterparts of the genetically determined resistance of mice to chloroform poisoning. Experientia 26: 101–102
Krüs S, Starzynski S, Zaleska-Rutczynska Z, NaciazekWieniawska A (1974) The role of testosterone in developing chloroform-induced renal tubular necrosis in mice. Nephron 12: 275–280
Smith JH, Maita K, Sleight SD, Hook JB (1983) Mechanism of chloroform nephrotoxicity. I. Time course of chloroform toxicity in male and female mice. Toxicol Appl Pharmacol 70: 467–479
Smith JH, Maita K, Sleight SD, Hook JB (1984) Effect of sex hormone status on chloroform nephrotoxicity and renal mixed function oxidases in mice. Toxicology 30: 305–316
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© 1986 Springer-Verlag Berlin Heidelberg
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Carlton, W.W., Engelhardt, J.A. (1986). Chloroform Nephrosis, Male Mouse. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96956-0_23
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DOI: https://doi.org/10.1007/978-3-642-96956-0_23
Publisher Name: Springer, Berlin, Heidelberg
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