Skip to main content

Chloroform Nephrosis, Male Mouse

  • Chapter
Urinary System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

The kidneys of male mice of susceptible strains exposed to toxic concentrations of chloroform (HCC13) are acutely swollen and pale with a granular appearance. Often, in survivors, the kidneys have white capsular mottling and cortical streaks due to calcification of necrotic tubules (Deringer et al. 1953). Kidneys are enlarged somewhat, as confirmed by increased renal weight in chloroform-treated male mice (Ahmadizadeh et al. 1984).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ahmadizadeh M, Kuo CH, Hook JB (1981) Nephrotoxicity and hepatotoxicity of chloroform in mice: effect of deuterium substitution. J Toxicol Environ Health 8: 105–111

    Article  PubMed  CAS  Google Scholar 

  • Ahmadizadeh M, Echt R, Kuo CH, Hook JB (1984) Sex and strain differences in mouse kidney: Bowman’s capsule morphology and susceptibility to chloroform. Toxicol Lett 20: 161–171

    Article  PubMed  CAS  Google Scholar 

  • Branchflower RV, Nunn DS, Highet RJ, Smith JH, Hook JB, Pohl LR (1984) Nephrotoxicity of chloroform: metabolism to phosgene by the mouse kidney. Toxicol Appl Pharmacol 72: 159–168

    Article  PubMed  CAS  Google Scholar 

  • Christensen LR, Wolff GL, Matanic B, Bond E, Wright E (1963) Accidental chloroform poisoning of BALB/ cAmNlcr mice. Z Versuchstierkd 2: 135–140

    Google Scholar 

  • Clemens TL, Hill RN, Bullock LP, Johnson WD, Sultatos LG, Vesell ES (1979) Chloroform toxicity in the mouse: role of genetic factors and steroids. Toxicol Appl Pharmacol 48: 117–130

    Article  PubMed  CAS  Google Scholar 

  • Culliford D, Hewitt HB (1957) The influence of sex hormone status on the susceptibility of mice to chloroform-induced necrosis of the renal tubules. J Endocrinol 14: 381–393

    Article  PubMed  CAS  Google Scholar 

  • Deringer MK, Dunn TB, Heston WE (1953) Results of exposure of strain C3H mice to chloroform. Proc Soc Exp Biol Med 83: 474–479

    PubMed  CAS  Google Scholar 

  • Eschenbrenner AB, Miller E (1945) Sex differences in kidney morphology and chloroform necrosis. Science 102: 302–303

    Article  PubMed  CAS  Google Scholar 

  • Hepler OE, Simonds JP (1945) Experimental nephropathies. Calcification and phosphatase in the kidneys of dogs poisoned with mercury bichloride, potassium dichromate and uranyl nitrate. Arch Pathol 40: 37–43

    CAS  Google Scholar 

  • Hewitt HB (1956) Renal necrosis in mice after accidental exposure to chloroform. Br J Exp Pathol 37: 32–39

    PubMed  CAS  Google Scholar 

  • Hill RN (1977) Differential toxicity of chloroform in the mouse. Ann NY Acad Sci 298: 170–176

    Article  CAS  Google Scholar 

  • Hill RN, Clemens TL, Liu DK, Vesell ES, Johnson WD (1975) Genetic control of chloroform toxicity in mice. Science 190: 159–161

    Article  PubMed  CAS  Google Scholar 

  • Ilett KF, Reid WD, Sipes IG, Krishna G (1973) Chloroform toxicity in mice: correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules. Exp Mol Pathol 19: 215–229

    Article  PubMed  CAS  Google Scholar 

  • Jacobsen L, Andersen EK, Thorborg JV (1964) Accidental chloroform nephrosis in mice. Acta Pathol Microbiol Scand 61: 503–513

    PubMed  CAS  Google Scholar 

  • Klaassen CD, Plaa GL (1966) Relative effects of various chlorinated hydrocarbons on liver and kidney function in mice. Toxicol Appl Pharmacol 9: 139–151

    Article  PubMed  CAS  Google Scholar 

  • Kluwe WM, Hook JB (1981) Potentiation of acute chloroform nephrotoxicity by the glutathione depletor diethyl maleate and protection by the microsomal enzyme inhibitor piperonyl butoxide. Toxicol Appl Pharmacol 59: 457–466

    Article  PubMed  CAS  Google Scholar 

  • Krüs S, Zaleska-Rutczynska Z (1970) Morphological counterparts of the genetically determined resistance of mice to chloroform poisoning. Experientia 26: 101–102

    Article  PubMed  Google Scholar 

  • Krüs S, Starzynski S, Zaleska-Rutczynska Z, NaciazekWieniawska A (1974) The role of testosterone in developing chloroform-induced renal tubular necrosis in mice. Nephron 12: 275–280

    Article  PubMed  Google Scholar 

  • Smith JH, Maita K, Sleight SD, Hook JB (1983) Mechanism of chloroform nephrotoxicity. I. Time course of chloroform toxicity in male and female mice. Toxicol Appl Pharmacol 70: 467–479

    Article  PubMed  CAS  Google Scholar 

  • Smith JH, Maita K, Sleight SD, Hook JB (1984) Effect of sex hormone status on chloroform nephrotoxicity and renal mixed function oxidases in mice. Toxicology 30: 305–316

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Carlton, W.W., Engelhardt, J.A. (1986). Chloroform Nephrosis, Male Mouse. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96956-0_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-96956-0_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-96958-4

  • Online ISBN: 978-3-642-96956-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics