Interstitial Nephritis, Mouse
In acute interstitial nephritis, the kidney is enlarged and pale. If the disease is focal in distribution, the lesions may be seen as white or gray foci in the cortex. In the acute phase, a lesion near the capsular surface of the kidney may be elevated; in focal chronic interstitial nephritis the lesions are usually depressed. In diffuse chronic interstitial nephritis the kidneys are reduced in size and the surface is granular or nodular; the capsule is often adherent to the underlying renal parenchyma. If diffusely fibrotic, the kidney cuts with increased resistance. The cut surface may have a white zone at the corticomedullary junction. In some cases, cortical or medullary cysts may be present.
SynonymsAcute interstitial nephritis chronic interstitial nephritis tubulo-interstitial nephritis acute or chronic inflammation of the interstitium
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