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Immune Mechanisms in Injury to Glomeruli and Tubulo-Interstitial Tissue

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Urinary System

Abstract

At the beginning of this century the idea took form that human glomerular diseases were caused by immunologic mechanisms. Since that time many attempts have been made to induce glomerular diseases and elucidate the pathogenetic mechanisms involved. The study of these experimental models has given an insight into the pathophysiology and underlying immunologic mechanisms of renal disease and glomerular disease in particular.

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References

  • Allison MEM, Wilson CB, Gottschalk CW (1974) Pathophysiology of experimental glomerulonephritis in rats. J Clin Invest 53: 1402–1423

    Article  PubMed  CAS  Google Scholar 

  • Andres GA, McCluskey RT (1975) Tubular and interstitial renal disease due to immunologic mechanisms. Kidney Int 7: 271–289

    Article  PubMed  CAS  Google Scholar 

  • Andres GA, Morgan C, Hsu KC, Rifkind RA, Seegal BC (1962) Electron microscopic studies of experimental nephritis with ferritin-conjugated antibody. The basement membranes and cisternae of visceral epithelial cells in nephritic rat glomeruli. J Exp Med 115: 929–936

    Article  PubMed  CAS  Google Scholar 

  • Arakawa M, Kimmelstiel P (1970) The glomerulonephritis of acute serum sickness: a study using light and electron microscopy. Am J Clin Pathol 54: 60–70

    PubMed  CAS  Google Scholar 

  • Arhelger RB, Gronvall JA, Can OB Jr, Brunson JG (1963) Electron microscopic localization of nephrotoxic serum in rabbit glomeruli with ferritin-conjugated antibody. Lab Invest 12: 33–37

    PubMed  CAS  Google Scholar 

  • Arisz L, Noble B, Milgrom M, Brentjens JR, Andres GA (1979) Experimental chronic serum sickness in rats. A model of immune complex glomerulonephritis and systemic immune complex deposition. Int Arch Allergy Appl Immunol 60: 80–88

    Article  PubMed  CAS  Google Scholar 

  • Assmann KJM, Tangelder MM, Lange WPJ, Tadema TM, Koene RAP (1983) Membranous glomerulonephritis in the mouse. Kidney Int 24: 303–312

    Article  PubMed  CAS  Google Scholar 

  • Avasthi PS, Avasthi P, Tokuda S, Anderson RE, Williams RC Jr (1971) Experimental glomerulonephritis in the mouse: I. The model. Clin Exp Immunol 9: 667–676

    PubMed  CAS  Google Scholar 

  • Barabas AZ, Lannigan R (1974) Induction of an autologous immune complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney tubular antibody: II. Early glomerular lesions. Br J Exp Pathol 55: 282–290

    PubMed  CAS  Google Scholar 

  • Barabas AZ, Boyd N, Cornish J, Lannigan R (1982) Progressive passive Heymann nephritis in the rat. Lab Invest 47: 400–405

    PubMed  CAS  Google Scholar 

  • Bariety J, Druet P, Laliberte F, Sapin C (1971) Glomerulonephritis with rand ßIC-globulin deposits induced in rats by mercuric chloride. Am J Pathol 65: 293–302

    PubMed  CAS  Google Scholar 

  • Battifora HA, Markowitz AS (1969) Nephrotoxic nephritis in monkeys. Sequential light, immunofluorescence and electron microscopic studies. Am J Pathol 55: 267–281

    PubMed  CAS  Google Scholar 

  • Belton B, Belair MF, Kuhn J, Druet P, Bariety J (1982) Trapping of circulating proteins in immune deposits of Heymann nephritis. Lab Invest 46: 306–312

    Google Scholar 

  • Bolton WK, Sturgill BC (1978) Bovine serum albumin chronic serum sickness nephropathy in rats. Br J Exp Pathol 59: 167–177

    PubMed  CAS  Google Scholar 

  • Bolton WK, Tucker FL, Sturgill BC (1980) Experimental autoimmune glomerulonephritis in chickens. J Clin Lab Immunol 3: 179–184

    PubMed  CAS  Google Scholar 

  • Bolton WK, Tucker FL, Sturgill BC (1984) New avian model of experimental glomerulonephritis consistent with mediation by cellular immunity. Nonhumorally mediated glomerulonephritis in chickens. J Clin Invest 73: 1263–1276

    Article  PubMed  CAS  Google Scholar 

  • Border WA, Adler SG, Wang H, Kamil ES, Ward HJ, Cohen H (1983) The pathologic and therapeutic implications of electrical charge in immune complex glomerulonephritis. In: Lambert PP, Bergmann P, Beauwens R (eds) The pathogenicity of cationic proteins. Raven, New York

    Google Scholar 

  • Brentjens JR, O’Connell DW, Pawlowski IB, Andres GA (1974) Extraglomerular lesions associated with deposition of circulating antigen-antibody complexes in kidneys of rabbits with chronic serum sickness. Clin Immunol Immunopathol 3: 112–126

    Article  PubMed  CAS  Google Scholar 

  • Brentjens JR, Noble B, Andres GA (1982) Immunologically mediated lesions of kidney tubules and interstitium in laboratory animals and in man. Springer Semin Immunopathol 5: 357–378

    Article  PubMed  CAS  Google Scholar 

  • Cameron JS (1979) Pathogenesis and treatment of membranous nephropathy. Kidney Int 15: 88–103

    Article  PubMed  CAS  Google Scholar 

  • Capron M, Bascou C, Vial M, Grossetete J, Hinglais N, Girard JF, Druet P (1982) Effects of decomplementation on mercuric chloride-induced glomerulonephritis in Brown-Norway rats. Clin Exp Immunol 49: 611–617

    PubMed  CAS  Google Scholar 

  • Cochrane CG, Unanue ER, Dixon FJ (1965) A role of polymorphonuclear leukocytes and complement in nephrotoxic nephritis. J Exp Med 122: 99–116

    Article  PubMed  CAS  Google Scholar 

  • Couser WG, Salant DJ (1980) In situ immune complex for- mation and glomerular injury. Kidney Int 17: 1–13

    Article  PubMed  CAS  Google Scholar 

  • Couser WG, Salant DJ (1982) Immunopathogenesis of glomerular capillary wall injury in nephrotic states. In: Brenner BM, Stein JH (eds) Nephrotic syndrome. Churchill Livingstone, New York

    Google Scholar 

  • Couser WG, Stilmant M, Lewis EJ (1973) Experimental glomerulonephritis in the guinea pig: I. Glomerular lesions associated with antiglomerular basement membrane antibody deposits. Lab Invest 29: 236–243

    PubMed  CAS  Google Scholar 

  • Couser WG, Stilmant MM, Darby C (1976) Autologous immune complex nephropathy: I. Sequential study of immune complex deposition, ultrastructural changes, proteinuria, and alterations in glomerular sialoprotein. Lab Invest 34: 23–30

    PubMed  CAS  Google Scholar 

  • Couser WG, Stilmant MM, Jermanovich NB (1977) Complement-independent nephrotoxic nephritis in the guinea pig. Kidney Int 11: 170–180

    Article  PubMed  CAS  Google Scholar 

  • Couser WG, Steinmuller DR, Stilmant MM, Salant DJ, Lowenstein LM (1978) Experimental glomerulonephritis in the isolated perfused rat kidney. J Clin Invest 62: 1275–1287

    Article  PubMed  CAS  Google Scholar 

  • Dixon FJ (1962) Tissue injury produced by antigen-antibody complexes. In: Graber P, Miescher P (eds) Mechanism of cell and tissue damage produced by immune reactions. In: Second International Symposium on Immunopathology. Schwabe, Basel, p 71

    Google Scholar 

  • Dixon FJ, Vazquez JJ, Weigle WO, Cochrane CG (1958) Pathogenesis of serum sickness. Arch Pathol 65: 18–28

    CAS  Google Scholar 

  • Dixon FJ, Feldman JD, Vazquez JJ (1961) Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J Exp Med 113: 899–920

    Article  PubMed  CAS  Google Scholar 

  • Donker AJ, Venuto RC, Vladutiu AO, Brentjens JR, Andres GA (1984) Effects of prolonged administration of D-penicillamine or captopril in various strains of rats. Clin Immunol Immunopathol 30: 142–155

    Article  PubMed  CAS  Google Scholar 

  • Druet E, Sapin C, Günther E, Feingold N, Druet P (1977) Mercuric chloride-induced anti-glomerular basement membrane antibodies in the rat: genetic control. Eur J Immunol 7: 348–351

    Article  PubMed  CAS  Google Scholar 

  • Druet P, Ayed K, Bariety J, Bernandin JF, Druet E, Girard JF, Hinglais N, Sapin C (1978) Glomerulonéphrite immunes experimentales indrites par le bichlorure de mercure chez le rat. In: Hamburger J, Crosnier J, Funck N, Erentano L (eds) Actualités néphrologiques de l’Hôpital Necker, Paris. Flammarion, Paris, pp 245–264

    Google Scholar 

  • Druet E, Sapin C, Fournie G, Mandet C, Günther E, Druet P (1982) Genetic control of susceptibility to mercury-induced immune nephritis in various strains of rat. Clin Immunol Immunopathol 25: 203–212

    Article  PubMed  CAS  Google Scholar 

  • Edgington TS, Glassock RJ (1967) Isolation and pathogenetic role of the nephritogenic antigen in experimental allergic glomerulonephritis induced with renal tubular antigen (EAG-TA). Fed Proc 26: 573 (abstract)

    Google Scholar 

  • Edgington TS, Glassock RI, Dixon FJ (1967) Autologous immune-complex pathogenesis of experimental allergic glomerulonephritis. Science 155: 1432–1434

    Article  PubMed  CAS  Google Scholar 

  • Emancipator SN, Gallo GR, Lamm ME (1983) Experimental IgA nephropathy induced by oral immunization. J Exp Med 157: 572–582

    Article  PubMed  CAS  Google Scholar 

  • Feenstra K, Lee RVD, Greben HA, Arends A, Hoedemaeker Pi (1975) Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens: I. The natural history: a histologic and immunohistologic study at the light microscopic and the ultra-structural level. Lab Invest 32: 235–242

    PubMed  CAS  Google Scholar 

  • Feldman JD (1958) Electron microscopy of serum sickness nephritis. J Exp Med 108: 957–962

    Article  PubMed  CAS  Google Scholar 

  • Fennell RH Jr, Pardo VM (1967) Experimental glomerulonephritis in rats. Lab Invest 17: 481–488

    PubMed  Google Scholar 

  • Fish AJ, Michael AF, Vernier RL, Good RA (1966) Acute serum sickness nephritis in the rabbit. An immune deposit disease. Am J Pathol 49: 997–1022

    PubMed  CAS  Google Scholar 

  • Fish AJ, Carmody KM, Michael AF (1979) Spatial orientation and distribution of antigens within human glomerular basement membrane. J Lab Clin Med 94: 447–457

    PubMed  CAS  Google Scholar 

  • Fleuren GJ (1976) Studies on pathogenesis and treatment of experimental immune complex glomerulonephritis. Roos and Roos, Arnhem

    Google Scholar 

  • Fleuren GJ, Hoedemaeker PJ (1981) Experimental anti-basement membrane renal disease: a linear glomerular and tubular immunofluorescence pattern caused by antibodies directed against endothelial antigens. In: Zurukzoglu W, Papadimitriou M, Pyrpassopoulos M, Sion M, Zamboulis C (eds) 8th Int Congr Nephrology, Athens, June 1981. Karger, Basel

    Google Scholar 

  • Fleuren GJ, Hoedemaeker PJ (1982) Localisation en microscopie immuno-éléctronique des antigènes impliqués dans la fixation linéaire le long des membranes basales dans un modèle homologue chez le rat. Nephrologie 3: 93 (abstract)

    Google Scholar 

  • Fleuren GJ, Hoedemaeker PJ, de Vries L, Nieuwenhuis P (1982) Réaction greffe contre hôte chez le rat: développement d’anticorps anti-rein. Nephrologie 3: 93 (abstract)

    Google Scholar 

  • Fleuren GJ, Hoedemaeker PJ, de Vries L, Nieuwenhuis P (1983) Graft-versus-host reaction in rats: development of anti-kidney antibodies and glomerulonephritis. Nieren-und Hochdruck Krankheiten 12: 361

    Google Scholar 

  • Fleuren GJ, Warnaar SO, Hoedemaeker PJ (1984) Glomerulonephritis induced by heterologous antibodies against GP-70. In: Robinson RR (ed) Nephrology: Proc 9th Int Congr Nephrol, Los Angeles. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Germuth FG Jr (1953) A comparative histologic and immunologic study in rabbits of induced hypersensitivity of the serum sickness type. J Exp Med 97: 257–282

    Article  PubMed  Google Scholar 

  • Germuth FG Jr, Rodriguez E (1973) Immunopathology of the renal glomerulus. Little Brown, Boston

    Google Scholar 

  • Germuth FG Jr, Senterfit LB, Pollack AD (1967a) Immune complex disease: I. Experimental acute and chronic glomerulonephritis. Johns Hopkins Med J 120: 225–251

    PubMed  Google Scholar 

  • Germuth FG Jr, Kelemen WA, Pollack AD (1967b) Immune complex disease: II. The role of circulatory dynamics and glomerular filtration in the development of experimental glomerulonephritis. Johns Hopkins Med J 120: 252–261

    PubMed  Google Scholar 

  • Glassock RJ, Edgington TS, Watson JI, Dixon FJ (1968) Autologous immune complex nephritis induced with renal tubular antigen: II. The pathogenetic mechanism. J Exp Med 127: 573–588

    Article  PubMed  CAS  Google Scholar 

  • Gleichmann E, Pals ST, Rolink AG, Radaszkiewicz T, Gleichmann H (1984) Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases. Immunol Today 5: 324–332

    Article  Google Scholar 

  • Golbus SM, Wilson CB (1979) Experimental glomerulonephritis induced by in situ formation of immune complexes in glomerular capillary wall. Kidney Int 16: 148–157

    Article  PubMed  CAS  Google Scholar 

  • Grupe WE, Kaplan MH (1967) A proximal tubular antigen in the pathogenesis of autoimmune nephrosis. Fed Proc 26: 573 (abstract)

    Google Scholar 

  • Haakenstad AO, Striker GE, Mannik M (1983) Removal of glomerular immune complex deposits by excess antigen in chronic mouse model of immune complex disease. Lab Invest 48: 323–331

    PubMed  CAS  Google Scholar 

  • Hall CL, Colvin RB, Carey K, McCluskey RT (1977) Passive transfer of autoimmune disease with isologous IgG1 and IgG2 antibodies to the tubular basement membrane in strain XIII guinea pigs. Loss of self-tolerance induced by autoantibodies. J Exp Med 146: 1246–1260

    Article  PubMed  CAS  Google Scholar 

  • Harmon WE, Grupe WE, Parkman R (1980) Control of autologous immune complex nephritis: I. Suppression of the disease in the presence of T cell sensitization. J Immunol 124: 1034–103 8

    Google Scholar 

  • Heymann W, Lund HZ (1951) Nephrotic syndrome in rats. Pediatrics 7: 691–706

    PubMed  CAS  Google Scholar 

  • Heymann W, Hackel DB, Harwood S, Wilson SG, Hunter JL (1959) Production of nephrotic syndrome in rats by Freund’s adjuvant and rat kidney suspensions. Proc Soc Exp Biol Med 100: 660–664

    PubMed  CAS  Google Scholar 

  • Heymann W, Hunter JLP, Hackel DB (1962a) Experimental auto-immune nephrosis in rats: III. J Immunol 88: 135–141

    PubMed  CAS  Google Scholar 

  • Heymann W, Hunter JL, Hackel DB, Cuppage F (1962b) Transfer of experimental auto-immune nephrosis in rats. Proc Soc Exp Biol Med 111: 568–573

    PubMed  CAS  Google Scholar 

  • Hinglais N, Druet P, Grossetete J, Sapin C, Bariety J (1979) Ultrastructural study of nephritis induced in Brown-Norway rats by mercuric chloride. Lab Invest 41: 150–159

    PubMed  CAS  Google Scholar 

  • Hirsch F, Couderc J, Sapin C, Fournie G, Druet P (1982) Polyclonal effect of HgC12 in the rat, its possible role in an experimental autoimmune disease. Eur J Immunol 12: 620–625

    Article  PubMed  CAS  Google Scholar 

  • Hoedemaeker PJ (1972) Een vorm van experimentele glomerulonefritis in de rat. Ned Tijdschr Geneeskd 116: 1802 (abstract)

    Google Scholar 

  • Hoedemaeker PJ, Feenstra K, Nijkeuter A, Arends A (1972) Ultrastructural localization of heterologous nephrotoxic antibody in the glomerular basement membrane of the rat. Lab Invest 26: 610–613

    PubMed  CAS  Google Scholar 

  • Hoedemaeker PJ, Fleuren GJ, Weening JJ (1984) Etiologic factors in immunologically mediated glomerulonephritis. In: Robinson RR (ed) Nephrology: Proc 9th Int Congr Nephrol, Los Angeles. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Hoyer JR (1980) Tubulointerstitial immune complex nephritis in rats immunized with Tamm-Horsfall protein. Kidney Int 17: 284–292

    Article  PubMed  CAS  Google Scholar 

  • Huang CC, Chang SC, Lin YC, Chen KH, Hsu IK (1963) Nephrotoxic serum renal disease in the Taiwan monkey. J Lab Clin Med 62: 201–215

    PubMed  CAS  Google Scholar 

  • Huang F, Kalant N (1968) Isolation and characterization of antigenic components of rat glomerular basement membrane. Can J Biochem 46: 1523–1532

    PubMed  CAS  Google Scholar 

  • Hyman LR, Colvin RB, Steinberg AD (1976a) Immunopathogenesis of autoimmune tubulointerstitial nephritis: I. Demonstration of differential susceptibility in strain II and strain XIII guinea pigs. J Immunol 116: 327–335

    PubMed  CAS  Google Scholar 

  • Hyman LR, Steinberg AD, Colvin RB, Bernard EF (1976b) Immunopathogenesis of autoimmune tubulointerstitial nephritis: II. Role of an immune response gene linked to the major histocompatibility complex. J Immunol 117: 1894–1897

    PubMed  CAS  Google Scholar 

  • Izui S, McConahey PJ, Theofilopoulos AN, Dixon FJ (1979) Association of circulating retroviral gp70-antigp70 immune complexes with murine systemic lupus erythematosus. J Exp Med 149: 1099–1116

    Article  PubMed  CAS  Google Scholar 

  • Kay CF (1940) The mechanism by which experimental nephritis is produced in rabbits injected with nephrotoxic duck serum. J Exp Med 72: 559–572

    Article  PubMed  CAS  Google Scholar 

  • Kay CF (1942) The mechanism of a form of glomerulonephritis: nephrotoxic nephritis in rabbits. Am J Med Sci 204: 483–490

    Google Scholar 

  • Kelley VE, Winkelstein A, Izui S, Dixon FJ (1981) Prostaglandin E1 inhibits T-cell proliferation and renal disease in MRL/1 mice. Clin Immunol Immunopathol 21: 190–213

    Article  PubMed  CAS  Google Scholar 

  • Kerjaschki D, Farquhar MG (1982) The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci USA 79: 5557–5561

    Article  PubMed  CAS  Google Scholar 

  • Kerjaschki D, Farquhar MG (1983) Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats. J Exp Med 157: 667–686

    Article  PubMed  CAS  Google Scholar 

  • Kher KK (1983) Tolerance to autologous immune complex nephritis: evidence for suppression of “B” cell response. Kidney Int 23: 185 (abstract)

    Google Scholar 

  • Kirtland HH III, Mohler DN, Horowitz DA (1980) Methyldopa inhibition of suppressor-lymphocyte function. A proposed cause of autoimmune hemolytic anemia. N Engl J Med 302: 825–832

    Article  PubMed  CAS  Google Scholar 

  • Klassen J, McCluskey RT, Milgrom F (1971) Nonglomerular renal disease produced in rabbits by immunization with homologous kidney. Am J Pathol 63: 333–358

    PubMed  CAS  Google Scholar 

  • Kondo Y, Shigematsu H (1972) Cellular aspects of rabbit Masugi nephritis: I. Cell kinetics in recoverable glomerulonephritis. Virchows Arch [Cell Pathol] 10: 40–50

    CAS  Google Scholar 

  • Krakower CA, Greenspon SA (1951) Localization of the nephrotoxic antigen within the isolated renal glomerulus. Arch Pathol 51: 629–639

    CAS  Google Scholar 

  • Lehman DH, Wilson CB (1976) Role of sensitized cells in antitubular basement membrane interstitial nephritis. Int Arch Allergy Appl Immunol 51: 168–174

    Article  PubMed  CAS  Google Scholar 

  • Lehman DH, Marquardt H, Wilson CB, Dixon FJ (1974a) Specificity of autoantibodies to tubular and glomerular basement membranes induced in guinea pigs. J Immunol 112: 241–248

    PubMed  CAS  Google Scholar 

  • Lehman DH, Wilson CB, Dixon FJ (1974b) Interstitial nephritis in rats immunized with heterologous tubular basement membrane. Kidney Int 5: 187–195

    Article  PubMed  CAS  Google Scholar 

  • Lerner RA, Dixon FJ (1968) The induction of acute glomerulonephritis in rabbits with soluble antigens isolated from normal homologous and autologous urine. J Immunol 100: 1277–1287

    PubMed  CAS  Google Scholar 

  • Lewis RM, Armstrong MYK, Andre-Schwartz J, Muftuoglu A, Beldotti L, Schwartz RS (1968) Chronic allogenic disease: I. Development of glomerulonephritis. J Exp Med 128: 653–679

    Article  Google Scholar 

  • Lindberg LH, Rosenberg LT (1968) Nephrotoxic serum nephritis in mice with a genetic deficiency in complement. J Immunol 100: 34–38

    PubMed  CAS  Google Scholar 

  • Lindemann W (1900) Sur le mode d’action de certains poisons rénaux. Ann Inst Pasteur 14: 49–59

    CAS  Google Scholar 

  • Litwin A, Bash JA, Adams LE, Donovan RJ, Hess EV (1979) Immunoregulation of Heymann’s nephritis: I. Induction of suppressor cells. J Immunol 122: 1029–1034

    PubMed  CAS  Google Scholar 

  • Lockwood CM, Mason DW, Bowman C (1983) Suppressor cell function in mercuric chloride-induced autoimmune nephritis in the Brown-Norway rat. Kidney Int 24: 406 (abstract)

    Google Scholar 

  • Madaio MP, Salant DJ, Cohen AJ, Adler S, Couser WG (1983) Comparative study of in situ immune deposit formation in active and passive Heymann nephritis. Kidney Int 23: 498–505

    Article  PubMed  CAS  Google Scholar 

  • Mannik M, Striker GE (1980) Removal of glomerular deposits of immune complexes in mice by administration of excess antigen. Lab Invest 42: 483–489

    PubMed  CAS  Google Scholar 

  • Masugi M (1933) Ober das Wesen der spezifischen Veränderungen der Niere and der Leber durch das Nephrotoxin bzw. das Hepatotoxin. Beitr Pathol Anat Allg Pathol 91: 82–112

    Google Scholar 

  • Masugi M, Sato Y (1934) Über die allergische Gewebsreaktion der Niere. Zugleich ein experimenteller Beitrag zur Pathogenese der diffusen Glomerulonephritis and der Periarteritis Nodosa. Virchows Arch [Pathol Anat] 293: 615–664

    Article  Google Scholar 

  • Mauer SM, Sutherland DER, Howard RJ, Fish AJ, Najarian JS, Michael AF (1973) The glomerular mesangium: III. Acute immune mesangial injury: a new model of glomerulonephritis. J Exp Med 137: 553–570

    Article  PubMed  CAS  Google Scholar 

  • Mendrick DL, Noble B, Brentjens JR, Andres GA (1980) Antibody mediated injury to proximal tubules in Heymann nephritis. Kidney Int 18: 328–343

    Article  PubMed  CAS  Google Scholar 

  • Mendrick DL, Rennke HG, Cotran RS, Springer TA, Abbas AK (1983) Methods in laboratory investigation. Monoclonal antibodies against rat glomerular antigens: production and specificity. Lab Invest 49: 107–117

    PubMed  CAS  Google Scholar 

  • Miettinen A, Linder E (1976) Membrane antigens shared by renal proximal tubules and other epithelia associated with absorption and excretion. Clin Exp Immunol 23: 568–577

    PubMed  CAS  Google Scholar 

  • Miettinen A, Törnroth T, Tikkanen I, Virtanen I, Linder E (1980) Heymann nephritis induced by kidney brush border glycoproteins. Lab Invest 43: 547–555

    PubMed  CAS  Google Scholar 

  • Morrison WI, Wright NB (1977) Viruses associated with renal disease of man and animals. Prog Med Virol 23: 22–55

    PubMed  CAS  Google Scholar 

  • Nagasawa T, Shibata S (1970) Application of the antibody against soluble GBM substance to the immunofluorescence staining of kidney sections. Jpn J Exp Med 40: 23–32

    PubMed  CAS  Google Scholar 

  • Naruse T, Fukasawa T, Hirokawa N, Oike S, Miyakawa Y (1976) The pathogenesis of experimental membranous glomerulonephritis induced with homologous nephritogenic tubular antigen. J Exp Med 144: 1347–1362

    Article  PubMed  CAS  Google Scholar 

  • Neale TJ, Woodroffe AJ, Wilson CB (1984) Spontaneous glomerulonephritis in rabbits: role of a glomerular capillary antigen. Kidney Int 26: 701–711

    Article  PubMed  CAS  Google Scholar 

  • Noble B, Olson KA, Milgrom M, Albini B (1980) Tissue deposition of immune complexes in mice receiving daily injections of bovine serum albumin. Clin Exp Immunol 42: 255–262

    PubMed  CAS  Google Scholar 

  • Oite T, Batsford SR, Mihatsch MJ, Takamiya H, Vogt A (1982) Quantitative studies of in situ immune complex glomerulonephritis in the rat induced by planted, cat-ionized antigen. J Exp Med 155: 460–474

    Article  PubMed  CAS  Google Scholar 

  • Oldstone MBA, Dixon FJ (1971) Immune complex disease in chronic viral infections. J Exp Med 134: 32s - 40s

    PubMed  CAS  Google Scholar 

  • Polak L, Barnes JM, Turk JL (1968) The genetic control of contact sensitization to inorganic metal compounds in guinea-pigs. Immunology 14: 707–711

    PubMed  CAS  Google Scholar 

  • Robertson DM, More RH (1961) Structure of glomerular axial region in normal and nephritic rabbits. Arch Pathol 72: 331–342

    Google Scholar 

  • Rolink AG, Gleichmann H, Gleichmann E (1983) Diseases caused by reactions of T lymphocytes to incompatible structures of the major histocompatibility complex: VII. Immune-complex glomerulonephritis. J Immunol 130: 209–215

    PubMed  CAS  Google Scholar 

  • Roman-Franco AA, Turiello M, Albini B, Ossi E, Milgrom F, Andres GA (1978) Anti-basement membrane antibodies and antigen-antibody complexes in rabbits injected with mercuric chloride. Clin Immunol Immunopathol 9: 464–481

    Article  PubMed  CAS  Google Scholar 

  • Rothbard S, Watson RF (1969) Comparison of reactions of antibodies to rat collagen and to rat kidney in the basement membranes of rat renal glomeruli. J Exp Med 129: 1145–1161

    Article  PubMed  CAS  Google Scholar 

  • Roubinian JR, Papoian R, Talal N (1977) Effects of neonatal thymectomy and splenectomy on survival and regulation of autoantibody formation in NZB/NZW F1 mice. J Immunol 118: 1524–1529

    PubMed  CAS  Google Scholar 

  • Salant DJ, Belok S, Madaio MP, Couser WG (1980) A new role for complement in experimental membranous nephropathy in rats. J Clin Invest 66: 1339–1350

    Article  PubMed  CAS  Google Scholar 

  • Sanchez-Crespo M, Alonso F, Barat A, Egido J (1982) Rat serum sickness: possible role of inflammatory mediators allowing deposition of immune complexes in the glomerular basement membrane. Clin Exp Immunol 49: 631–638

    PubMed  CAS  Google Scholar 

  • Sapin C, Druet E, Druet P (1977) Induction of anti-glomerular basement membrane antibodies in the Brown-Norway rat by mercuric chloride. Clin Exp Immunol 28: 173–179

    PubMed  CAS  Google Scholar 

  • Sapin C, Druet P, Mandet C (1980) Induction of susceptibility to HgC12 immune glomerulonephritis in the Lewis rat by immunocompetent cells from susceptible F1 hybrids. Eur J Immunol 10: 371–374

    Article  PubMed  CAS  Google Scholar 

  • Schneeberger EE, Grupe WE (1976) The ultrastructure of the glomerular slit diaphragm in autologous immune complex nephritis. Lab Invest 34: 298–305

    PubMed  CAS  Google Scholar 

  • Senterfit LB, Germuth FG Jr (1969) Significance of mesangial localization of immune complexes in rabbits developing arteritis in the absence of glomerulonephritis (GLN). Fed Proc 28: 421 (abstract)

    Google Scholar 

  • Shibata S, Nagasawa T, Naruse T, Miyakawa Y (1967) Glomerulonephritis induced in rats by antiserum against a glycoprotein rat kidney–a new experimental model of glomerulonephritis. Jpn J Exp Med 37: 337–353

    PubMed  CAS  Google Scholar 

  • Shibata S, Miyakawa Y, Naruse T, Nagasawa T, Takuma T (1969) A glycoprotein that induces nephrotoxic antibody: its isolation and purification from rat glomerular basement membrane. J Immunol 102: 593–601

    PubMed  CAS  Google Scholar 

  • Shibata S, Nagasawa T, Miyakawa Y, Naruse T (1971) Nephritogenic glycoprotein: I. Proliferative glomerulonephritis induced in rats by a single injection of the soluble glycoprotein isolated from homologous glomerular basement membrane. J Immunol 106: 1284–1294

    PubMed  CAS  Google Scholar 

  • Shigematsu H (1970) Glomerular events during the initial phase of rat Masugi nephritis. Virchows Arch [Cell Pathol] 5: 187–200

    CAS  Google Scholar 

  • Shigematsu H, Kobayashi Y (1972) Pulmonary involvements in the initial phase of rat Masugi nephritis. Virchows Arch [Cell Pathol] 11: 111–123

    CAS  Google Scholar 

  • Shigematsu H, Kobayashi Y (1976) Accelerated serum sickness in the rabbit: II. Glomerular ultra-structural lesions in transient proliferative and progressive disorganizing glomerulonephritis. Virchows Arch [Pathol Anat] 369: 269–282

    Article  CAS  Google Scholar 

  • Solomon DH, Gardello JW, Fauger H, Dethier FM, Ferrebee JW (1949) Nephrotoxic nephritis in rats: evidence for the glomerular origin of the kidney antigen. J Exp Med 90: 267–272

    Article  PubMed  CAS  Google Scholar 

  • Steblay RW (1962) Glomerulonephritis induced in sheep by injections of heterologous glomerular basement membrane and Freund’s complete adjuvant. J Exp Med 116: 253–272

    Article  PubMed  CAS  Google Scholar 

  • Steblay RW (1963) Glomerulonephritis induced in monkeys by injections of heterologous glomerular basement membrane and Freund’s adjuvant. Nature 197: 1173–1176

    Article  PubMed  CAS  Google Scholar 

  • Steblay RW (1967) Studies on autoimmune nephritis in sheep and rats: IV. The relative efficacy of heterologous, homologous and autologous glomerular basement membrane (GBM) in inducing nephritis. Fed Proc 26: 531 (abstract)

    Google Scholar 

  • Steblay RW, Rudofsky U (1966) Studies on autoimmune nephritis in rats: I. Nephritis induced in rats by injections of human glomerular basement membrane (HGBM) and Freund’s adjuvant (FA). Clin Res 14: 449 (abstract)

    Google Scholar 

  • Steblay RW, Rudofsky U (1971) Renal tubular disease and autoantibodies against tubular basement membrane induced in guinea pigs. J Immunol 107: 589–594

    PubMed  CAS  Google Scholar 

  • Steinberg AD, Huston DP, Taurog JD, Cowdery JS, Raveché ES (1981) The cellular and genetic basis of murine lupus. Immunol Rev 55: 121–154

    Article  PubMed  CAS  Google Scholar 

  • Stuffers-Heiman M, Gunther E, van Es LA (1979) Induction of autoimmunity to antigens of the glomerular basement membrane in inbred Brown-Norway rats. Immunology 36: 759–767

    PubMed  CAS  Google Scholar 

  • Sugisaki T, Yoshida T, McCluskey RT, Andres GA, Klassen J (1980) Autoimmune cell-mediated tubulointerstitial nephritis induced in Lewis rats by renal antigens. Clin Immunol Immunopathol 15: 33–43

    Article  PubMed  CAS  Google Scholar 

  • Sugisaki T, Kano K, Andres G, Milgrom F (1982) Antibodies to tubular basement membrane elicited by stimulation with allogeneic kidney. Kidney Int 21: 557–564

    Article  PubMed  CAS  Google Scholar 

  • Theofilopoulos AN, Dixon FJ (1980) Immune complexes in human diseases. A review. Am J Pathol 100: 529–594

    CAS  Google Scholar 

  • Unanue R, Dixon J (1965) Experimental glomerulonephritis: V. Studies on the interaction of nephrotoxic antibodies with tissues of the rat. J Exp Med 121: 697–714

    Article  PubMed  CAS  Google Scholar 

  • Unanue ER, Dixon FJ, Feldman JD (1967) Experimental allergic glomerulonephritis induced in the rabbit with homologous renal antigens. J Exp Med 125: 163–176

    Article  PubMed  CAS  Google Scholar 

  • van Damme BJC, Fleuren GJ, Bakker WW, Vernier RL, Hoedemaeker PJ (1978) Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens: V. Fixed glomerular antigens in the pathogenesis of heterologous immune complex glomerulonephritis. Lab Invest 38: 502–510

    PubMed  Google Scholar 

  • van Es LA, Blok APR, Schoenfield L, Glassock RJ (1977) Chronic nephritis induced by antibodies reacting with glomerular-bound immune complexes. Kidney Int 11: 106–115

    Article  PubMed  Google Scholar 

  • van Liew JB, Brentjens JR, Noble B (1983) Relationship of kidney function to immunopathology in chronic serum sickness of rats. Kidney Int 24: 160–169

    Article  PubMed  Google Scholar 

  • van Rappard-van der Veen FM, Rolink AG, Gleichmann E (1982) Diseases caused by reactions of T lymphocytes towards incompatible structures of the major histocompatibility complex: VI. Autoantibodies characteristic of systemic lupus erythematosus induced by abnormal T-B cell cooperation across I-E. J Exp Med 155: 1555–1560

    Google Scholar 

  • van Zwieten MJ, Bhan AK, McCluskey RT, Collins AB (1976) Studies on the pathogenesis of experimental anti-tubular basement membrane nephritis in the guinea pig. Am J Pathol 83: 531–546

    PubMed  Google Scholar 

  • van Zwieten MJ, Leber PD, Bhan AK, McCluskey RT (1977) Experimental cell-mediated interstitial nephritis induced with exogenous antigens. J Immunol 118: 589–593

    PubMed  Google Scholar 

  • Vogt A, Batsford SR (1983) Interaction of cationic antigens with GBM: pathogenic implications. In: Lambert PP, Bergmann P, Beauwens R (eds) The pathogenicity of cationic proteins. Raven, New York

    Google Scholar 

  • Vogt A, Bockhorn H, Kozima K, Sasaki M (1968) Electron microscopic localization of the nephrotoxic antibody in the glomeruli of the rat after intravenous application of purified nephritogenic antibody-ferritin conjugates. J Exp Med 127: 867–878

    Article  PubMed  CAS  Google Scholar 

  • Vogt A, Schmidt HU, Takamiya H, Batsford S (1980) `In situ’ immune complex nephritis and basic proteins. Proc Eur Dial Transplant Assoc 17: 613–620

    PubMed  CAS  Google Scholar 

  • Weening JJ (1984) Autoimmune reactions and glomerulonephritis caused by heavy metals and other toxins. In: Hayes AW, Schnell RC, Miya TS (eds) Developments in the science and practice of toxicology. Elsevier, New York, pp 211–218

    Google Scholar 

  • Weening JJ, Fleuren GJ, Hoedemaeker PJ (1978) Demonstration of antinuclear antibodies in mercuric chloride-induced glomerulopathy in the rat. Lab Invest 39: 405–411

    PubMed  CAS  Google Scholar 

  • Weening JJ, Grond J, van der Top D, Hoedemaeker PJ (1980) Identification of the nuclear antigen involved in mercury-induced glomerulopathy in the rat. Invest Cell Pathol 3: 129–134

    PubMed  CAS  Google Scholar 

  • Weening JJ, Hoedemaeker PJ, Bakker WW (1981) Immunoregulation and anti-nuclear antibodies in mercury-induced glomerulopathy in the rat. Clin Exp Immunol 45: 64–71

    PubMed  CAS  Google Scholar 

  • Willoughby WF, Dixon FJ (1970) Experimental hemorrhagic pneumonitis produced by heterologous anti-lung antibody. J Immunol 104: 28–37

    PubMed  CAS  Google Scholar 

  • Wilson CB, Dixon FJ (1970) Antigen quantitation in experimental immune complex glomerulonephritis: I. Acute serum sickness. J Immunol 105: 279–290

    PubMed  CAS  Google Scholar 

  • Wilson CB, Gushwa LC, Peterson OW, Tucker BJ, Blantz RC (1981) Glomerular immune injury in the rat: effect of antagonists of histamine activity. Kidney Int 20: 628–635

    Article  PubMed  CAS  Google Scholar 

  • Zanetti M, Druet P (1980) Passive Heymann’s nephritis as a model of immune glomerulonephritis mediated by antibodies to immunoglobulins. Clin Exp Immunol 41: 189–195

    PubMed  CAS  Google Scholar 

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Hoedemaeker, P.J., Fleuren, G.J., Weening, J.J. (1986). Immune Mechanisms in Injury to Glomeruli and Tubulo-Interstitial Tissue. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96956-0_14

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