Skip to main content
SpringerLink
Log in
Book cover

Urinary System pp 112–139Cite as

Renal Cell Adenoma and Carcinoma, Rat

  • Chapter

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

Renal cell adenomas and carcinomas are epithelial tumors which are predominately localized in the cortex. They are usually well demarcated from the surrounding tissue and have a firm consistency. Large tumors of this type, which may reach a diameter of several centimeters, are readily visible to the naked eye as grayish-white or grayish-yellow masses projecting from the cortex. Frequently the tumors contain red spots due to hemorrhage. Cystic tumors or tumor components may appear as translucent vesicles at the surface of the kidney.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Apitz K (1944) Die Geschwülste und GewebsmiBbildungen der Nierenrinde: III. Die Adenome. Virchows Arch 311: 328–359

    Google Scholar 

  • Arison RN, Feudale EL (1967) Induction of renal tumour by streptozotocin in rats. Nature 214: 1254–1255

    Article  PubMed  CAS  Google Scholar 

  • Bannasch P, Schacht U (1968) Nitrosamin-induzierte tubuläre Glykogenspeicherung und Geschwulstbildung in der Rattenniere. Virchows Arch [B] 1: 95–97

    Google Scholar 

  • Bannasch P, Schacht U, Storch E (1974) Morphogenese und Mikromorphologie epithelialer Nierentumoren bei Nitrosomorpholin-vergifteten Ratten: I. Induktion und Histologie der Tumoren. Z Krebsforsch 81: 311–331

    Google Scholar 

  • Bannasch P, Krech R, Zerban H ( 1978 a) Morphogenese und Mikromorphologie epithelialer Nierentumoren bei Nitrosomorpholin-vergifteten Ratten: II. Tubuläre Glykogenose und die Genese von klar oder acidophilzelligen Tumoren. Z Krebsforsch 92: 63–86

    Google Scholar 

  • Bannasch P, Krech R, Zerban H (1978b) Morphogenese und Mikromorphologie epithelialer Nierentumoren bei Nitrosomorpholin-vergifteten Ratten: III. Onkocytentubuli und Onkocytome. Z Krebsforsch 92: 87–104

    Google Scholar 

  • Bannasch P, Mayer D, Krech R (1979) Neoplastische und präneoplastische Veränderungen bei Ratten nach einmaliger oraler Applikation von N-Nitrosomorpholin. J Cancer Res Clin Oncol 94: 233–248

    Article  PubMed  CAS  Google Scholar 

  • Bannasch P, Krech R, Zerban H (1980) Morphogenese und Mikromorphologie epithelialer Nierentumoren bei Nitrosomorpholin-vergifteten Ratten: IV. Tubuläre Läsionen und basophile Tumoren. J Cancer Res Clin Oncol 98: 243–265

    Google Scholar 

  • Bannasch P, Hacker HJ, Tsuda H, Zerban H (1986) Aberrant regulation of carbohydrate metabolism and metamorphosis during renal carcinogenesis. Adv Enzyme Regul (to be published)

    Google Scholar 

  • Bell ET (1950) Renal diseases, 2nd edn. Lea and Febiger, Philadelphia, p 435

    Google Scholar 

  • Bennington JL, Beckwith JB (1975) Tumors of the kidney, renal pelvis, and ureter. Atlas of tumor pathology, 2nd series, fascicle 12. Armed Forces Institute of Pathology, Washington, DC

    Google Scholar 

  • Berdjis CC (1963) Kidney tumours and irradiation pathogenesis of kidney tumours in irradiated rats. Oncologia 16: 312–324

    Article  CAS  Google Scholar 

  • Butler WH, Greenblatt M, Lijinsky W (1969) Carcinogenesis in rats by aflatoxins B1, G1, and B2. Cancer Res 29: 2206–2211

    PubMed  CAS  Google Scholar 

  • Dees JH, Reuber MD, Trump BF (1976) Adenocarcinoma of the kidney: I. Ultrastructure or renal adenocarcinomas induced by rats by N-(4’fluoro-4-biphenylyl)acetamide. JNCI 57: 779–794

    PubMed  CAS  Google Scholar 

  • Eker R, Mossige J, Johannessen JV, Aars H (1981) Hereditary renal adenomas and adenocarcinomas in rats. Diagn Histopathol 4: 99–110

    PubMed  CAS  Google Scholar 

  • Ertürk E, Cohen SM, Bryan GT (1970) Induction, histogenesis, and isotransplantability of renal tumors induced by formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide in rats. Cancer Res 30: 2098–2106

    PubMed  Google Scholar 

  • Grawitz P (1883) Die sogenannten Lipome der Niere. Virchows Arch 93: 39–63

    Article  Google Scholar 

  • Gray JE, von Zwieten MJ, Hollander CF (1982) Early light microscopic changes of chronic progressive nephrosis in several strains of aging laboratory rats. J Gerontol 37: 142–150

    PubMed  CAS  Google Scholar 

  • Gusek W (1975) Die Ultrastruktur Cycasin-induzierter Nierenadenome. Virchows Arch [A] 365: 221–237

    Article  CAS  Google Scholar 

  • Gusek W, Mestwerdt W (1969) Cycasin-induzierte Nierentumoren bei der Wistarratte unter besonderer Berücksichtigung der Adenome. Beitr Path Anat 139: 199–218

    CAS  Google Scholar 

  • Hagen S (1977) Zur Zellproliferation der Rattenniere unter N-Nitrosomorpholin in verschiedenen Konzentrationen. Autoradiographische Untersuchungen mit 3HThymidin. Inaugural dissertation, Wurzburg University

    Google Scholar 

  • Hard GC (1976) Tumors of the kidney, renal pelvis and ureter. In: Turusov VS (ed) Tumours of the rat, part 2. IARC, Lyons, pp 73–101 (Pathology of tumours in laboratory animals, vol 1 )

    Google Scholar 

  • Hard GC (1985) Identification of high-frequency model for renal carcinoma by the induction of renal tumors in the mouse with a single dose of streptozotocin. Cancer Res 45: 703–708

    PubMed  CAS  Google Scholar 

  • Hard GC, Butler WH (1971 a) Ultrastructural aspects of renal adenocarcinoma induced in the rat by dimethylnitrosamine. Cancer Res 31: 336–372

    Google Scholar 

  • Hard GC, Butler WH (1971 b) Morphogenesis of epithelial neoplasms induced in the rat kidney by dimethylnitrosamine. Cancer Res 31: 1496–1505

    Google Scholar 

  • Heatfield BM, Hinton DE, Trump BF (1976) Adenocarcinoma of the kidney: II. Enzyme histochemistry of renal adenocarcinomas induced in rats by N-(4’-fluoro-4biphenyl)acetamide. JNCI 57: 795–808

    PubMed  CAS  Google Scholar 

  • Hiasa Y, Kitahori Y, Konishi N, Enoki N, Shimoyama T, Miyashiro A (1984 a) Trisodium nitrilotriacetate mono-hydrate: promoting effects on the development of renal tubular cell tumors in rats treated with N-ethyl-Nhydroxy-ethylnitrosamine. JNCI 72: 483–489

    Google Scholar 

  • Hiasa Y, Lin JC, Konishi N, Kitahori Y, Enoki N, Shimoyama T (1948 b) Histopathological and biochemical analyses of transplantable renal adenocarcinoma in rats induced by N-ethyl-N-hydroxyethylnitrosamine. Cancer Res 44: 1664–1670

    Google Scholar 

  • Hirose M, Imaida K, Ito H, Hayashi M, Ishihara Y, Ito N (1981) Effects of chloroform and dimethylnitrosamine on renal carcinogenesis in unilaterally nephrectomized rats fed formic acid 2-[4-(5-nitro-2-furyl)-2-[thiazolyl]hydrazide. Carcinogenesis 2: 703–708

    Article  PubMed  CAS  Google Scholar 

  • Hoch-Ligeti C, Stutzman E, Arvin JM (1968) Cellular composition during tumor induction in rats by cycad husk, JNCI 41: 605–614

    PubMed  CAS  Google Scholar 

  • Horton L, Fox C, Corrin B, Sönksen PH (1977) Streptozotocin-induced renal tumors in rats. Br J Cancer 36: 692–699

    Article  PubMed  CAS  Google Scholar 

  • Hruban Z, Mochizuki Y, Morris HP, Slesers A (1973) Ultrastructure of Morris renal tumors. JNCI 50: 1487 1495

    Google Scholar 

  • Ito N (1973) Experimental studies on tumors of the urinary system of rats induced by chemical carcinogens. Acta Path Jpn 23: 87–109

    CAS  Google Scholar 

  • Ito N, Johno I, Marugami M, Konishi Y, Hiasa Y (1966) Histopathological and autoradiographic studies on kidney tumors induced bei N-nitrosodimethylamine in rat. Gann 57: 595–604

    PubMed  CAS  Google Scholar 

  • Jasmin G, Riopelle JL (1968) Renal adenomas induced by dimethylnitrosamine. Enzyme histochemistry in the rat. Arch Pathol 85: 298–305

    Google Scholar 

  • Kirkman H (1959) Estrogen-induced tumors of the kidney of the Syrian hamster. Natl Cancer Inst Mongr 1: 1–139

    CAS  Google Scholar 

  • Krech R, Bannasch P (1979) Mucopolysaccharidose interstitieller Zellen während der Genese epithelialer Nierentumoren. Verh Dtsch Ges Path 63: 393–397

    CAS  Google Scholar 

  • Laqueur GL, Mickelsen O, Whiting MG, Kurland LT (1963) Carcinogenic properties of nuts from cycas circinalis L. indigenous to Guam. JNCI 31: 919–951

    PubMed  CAS  Google Scholar 

  • Llombart-Bosch A, Peydro A (1975) Morphological, histochemical and ultrastructural observations of diethylstilbestrol-induced kidney tumors in the Syrian golden hamster. Eur J Cancer 11: 403–412

    PubMed  CAS  Google Scholar 

  • Lombard LS, Rice JM, Vesselinovitch SD (1974) Renal tumors in mice: light microscopic observations of epithelial tumors induced by ethylnitrosourea. JNCI 53: 1677–1685

    PubMed  CAS  Google Scholar 

  • Magee PN, Barnes JM (1962) Induction of kidney tumours in the rat with dimethylnitrosamine ( N-nitrosodimethylamine ). J Pathol Bacteriol 84: 19–31

    Google Scholar 

  • Maldague P (1966) Radiocancérisation expérimentale du rein par les rayons X chez le rat: I. Les radiocancers du rein. Pathol Europ 1: 321–409

    CAS  Google Scholar 

  • Mao P, Molnar JJ (1967) The fine structure and histochemistry of lead-induced renal tumors in rats. Am J Pathol 50: 571–603

    PubMed  CAS  Google Scholar 

  • Matthews JJ, Walpole AL (1958) Tumours of the liver and kidney induced in Wistar rats with 4’-fluoro-4-aminodiphenyl. Br J Cancer 12: 234–241

    Article  PubMed  CAS  Google Scholar 

  • McGiven AR, Ireton HJ (1972) Renal epithelial dysplasia and neoplasia in rats given dimethylnitrosamine. J Pathol 108: 187–190

    Article  PubMed  CAS  Google Scholar 

  • Meister P, Rabes H (1973) Nierentumoren durch Diäthylnitrosamin nach partieller Leberresektion: Morphologie und Wachstumsverhalten. Z Krebsforsch 80: 169–178

    Google Scholar 

  • Merkow LP, Epstein SM, Slifkin M, Pardo M (1973) The ultrastructure of renal neoplasms induced by aflatoxin B1. Cancer Res 33: 1608–1614

    PubMed  CAS  Google Scholar 

  • Morris HP, Velat CA, Wagner BP (1957) Carcinogenicity of some ingested acetylated mono-and diaminobiphenyl compounds in the rat. JNCI 18: 101–115

    PubMed  CAS  Google Scholar 

  • Mostofi FK, Davis CJ (1984) Pathology of tumors of the kidney. In: Javadpour N (ed) Cancer of the kidney. Thieme, Stuttgart, pp 15–31

    Google Scholar 

  • Oberling CH, Riviere M, Haguenau F (1959) Ultrastructure des épithéliomas à cellules du rein (hypernéphromes ou tumeurs de Grawitz) et son implication pour l’histogénése de ces tumeurs. Bull Assoc Fr Cancer 46: 356–381

    CAS  Google Scholar 

  • Ohmori T, Hiasa Y, Murata Y, Williams GM (1982) Gamma glutamyl transpeptidase activity in carcinogen-induced epithelial lesions of the rat kidney. Gann 73: 543–548

    PubMed  CAS  Google Scholar 

  • Pielsticker K, Wieser O, Mohr U, Wrba H (1967) Diaplazentär-induzierte Nierentumoren bei der Ratte. Z Krebsforsch 69: 345–350

    Article  PubMed  CAS  Google Scholar 

  • Rakieten N, Gordon BS, Cooney DA, Davis RD, Schein PS (1968) Renal tumorigenic action of streptozotocin (NSC-85998) in rats. Cancer Chemother Rep 52: 563–567

    PubMed  CAS  Google Scholar 

  • Reznik G, Ward JM, Hardisty JF, Russfield A (1979) Renal carcinogenic and nephrotoxic effects-of the flame re-Angioma, Angiosarcoma, Kidney, Syrian Hamster 139 tardant tris(2,3-dibromoprophyl)phosphate in F344 rats and (C57 BL/6NxC3H/HeN)F1 mice. JNCI 63: 205–212

    PubMed  CAS  Google Scholar 

  • Riopelle JL, Jasmin G (1963) Discussion sur la nature des tumeurs rénales induites chez le rat par le diméthylnitrosamine. Rev Can Biol 22: 365–381

    PubMed  CAS  Google Scholar 

  • Rosen VJ Jr, Castanera TJ, Kimmeldorf DJ, Jones DC (1961) Renal neoplasms in the irradiated and nonirradiated Sprague-Dawley rat. Am J Pathol 38: 359–369

    PubMed  CAS  Google Scholar 

  • Seljelid R, Ericsson LE (1965) Electron microscopic observations on specializations of the cell surface in renal clear cell carcinoma. Lab Invest 4: 435–447

    Google Scholar 

  • Shirai T, Ohshima M, Masuda A, Tamano S, Ito N (1984) Promotion of 2-(ethylnitrosamino)ethanol-induced renal carcinogenesis in rats by nephrotoxic compounds: positive responses with folic acid, basic lead acetate, and N-(3,5-dichlorophenyl)succinimide but not with 2,3-dibromo-1-propanol phosphate. JNCI 72: 477–482

    PubMed  CAS  Google Scholar 

  • Squire RA, Goodman GD, Valerio MG, Frederickson T, Strandberg JD, Levitt MH, Lingeman CH, Harshbarger JC, Dawe CJ (1978) Tumors. In: Benirschke K, Garner FM, Jones TC (eds) Pathology of laboratory animals, vol II. Springer, Berlin Heidelberg New York, pp 1051–1283

    Google Scholar 

  • Sugihara R, Sugihara S Jr (1976) Electron microscopic observations on the morphogenesis of renal carcinoma induced in rat kidney by dimethylnitrosamine and N-(3,5-dichlorophenyl)succinimide. Cancer Res 36: 533–550

    PubMed  CAS  Google Scholar 

  • Tannenbaum M (1971) Ultrastructural pathology of human renal cell tumors. Pathol Annu 6: 249–277

    PubMed  CAS  Google Scholar 

  • Tanner DC, Lipsky M (1984) Effect of lead acetate on N-(4’-fluoro-4-biphenyl)acetamide-induced renal carcinogenesis in the rat. Carcinogenesis 5: 1109–1113

    Article  PubMed  CAS  Google Scholar 

  • Terracini B, Campobasso O (1979) Tumours of the kidney, renal pelvis and ureter. In: Turusov VS (ed) Tumours of the mouse. IARC, Lyons, pp 289–295 (Pathology of tumours in laboratory animals, vol 2 )

    Google Scholar 

  • Thoenes W, Störkel ST, Rumpelt H-J (1985) Human chromophobic cell renal carcinoma. Virchows Arch [Cell Pathol] 48: 207–217

    Article  CAS  Google Scholar 

  • Thomas C, Schmähl D (1964) Zur Morphologie der Nie- rentumoren bei der Ratte. Z. Krebsforsch 66: 125–137

    PubMed  CAS  Google Scholar 

  • van Esch GJ, van Genderen H, Vink HH (1962) The induction of renal tumors by feeding of basic lead acetate to rats. Br J Cancer 16: 289–297

    Article  PubMed  Google Scholar 

  • Weber G (1980) Enzymic programs in human renal adenocarcinomas. In: Sufrin G, Beckley SA (eds) Renal adenocarcinomas. UICC, Geneva, pp 45–50

    Google Scholar 

  • Wegner G, Stutz E, Büchner F (1961) Tumoren und Mißbildungen bei Wistar-Ratten in der ersten Generation nach Ganzbestrahlung des Muttertieres mit 270 r am 18. Graviditätstag. Beitr Path Anat 124: 396–414

    Google Scholar 

  • Zak FG, Holzner JH, Singer EJ, Popper H (1960) Renal and pulmonary tumors in rats fed dimethylnitrosamine. Cancer Res 20: 96–99

    PubMed  CAS  Google Scholar 

  • Zollinger HU (1953) Durch chronische Bleivergiftung erzeugte Nierenadenome und -carcinome bei Ratten und ihre Beziehung zu den entsprechenden Neubildungen des Menschen. Virchows Arch 323: 694–710

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Peter Bannasch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Heide Zerban
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, 01772, Southborough, MA, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology, Emeritus) & Ronald Duncan Hunt D.V.M. (Professor of Comparative Pathology) (Professor of Comparative Pathology, Emeritus) &  (Professor of Comparative Pathology)

  2. Institut für Experimentelle Pathologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, 3000, Hannover 61, Federal Republic of Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Bannasch, P., Zerban, H. (1986). Renal Cell Adenoma and Carcinoma, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96956-0_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-96956-0_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-96958-4

  • Online ISBN: 978-3-642-96956-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation