Hemangiosarcoma, Liver, Rat

  • James A. Popp
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


The gross appearance is variable. Lesions may be barely visible or up to 1 cm in diameter. They frequently bulge above the surface of the liver capsule, but are sometimes deeply embedded in the liver parenchyma and not visible on the capsular surface. The lesion usually lacks a capsule and has poorly defined borders. Perhaps the greatest variability occurs in the color, usually red, reddish-brown, or black with a mottled appearance, and in the consistency of the lesion. The more cellular and less vascular areas may be white to light tan. Hemangiosarcomas typically are soft and pliable and ooze blood or blood-tinged fluid when sectioned. Cysts are common due either to greatly dilated vascular spaces or to areas of necrosis which subsequently fill with blood. Rupture of cysts or friable vascular walls results in hemoperi-toneum or hemothorax from metastatic lesions in over 75% of rats dying of hemangiosarcoma (Ward et al. 1975).


Angiosarcoma malignant hemangioendothelioma 


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© Springer-Verlag Berlin Heidelberg 1985

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  • James A. Popp

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