Atrophy, Exocrine Pancreas, Rat

  • Gary A. Boorman
  • Scot L. Eustis
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Naturally occurring atrophy of the exocrine pancreas in the rat was described by Kendrey and Roe (1969) as having a macroscopic granular appearance. In experimentally induced progressive atrophy the pancreas appeared fatty in rats after 6 weeks on a copper-deficient diet (Smith et al. 1982).


Pancreatic microcystic transformation pancreatic degeneration pancreatic involution 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Anderson N, Low D (1965) Juvenile atrophy of the canine pancreas. Anim Hosp 1:101–109Google Scholar
  2. Andrew W (1944) Senile changes in the pancreas of Wistar Institute rats and of man with special regard to the similarity of locale and cavity formation. Am J Anat 74: 97–126CrossRefGoogle Scholar
  3. Angiolelli RF, Rio GJ (1972) Infectious pancreatic necrosis virus-induced pancreatic lesions in Swiss albino mice: electron microscopy. Am J Vet Res 33:1513–1520PubMedGoogle Scholar
  4. Anver MR, Cohen BJ (1979) Lesions associated with aging. In: Baker HJ, Lindsey JR, Weisbroth SH (eds) The laboratory rat, vol I. Biology and diseases. Academic, New York, pp 377–399Google Scholar
  5. Anver MR, Cohen BJ, Lattuada CP, Foster SJ (1982) Age-associated lesions in barrier-reared male Sprague-Dawley rats: a comparison between Hap: (SD) and Crl: COBS[R]CD[R](SD) stocks. Exp Aging Res 8: 3–24PubMedCrossRefGoogle Scholar
  6. Attwood HD, Woolley PA (1980) Pancreatic pathology in dasyurid marsupials. J Wildl Dis 16: 245–249PubMedGoogle Scholar
  7. Berg BN (1967) Longevity studies in rats. II. Pathology of ageing rats. In: Cotchin E, Roe FJC (eds) Pathology of laboratory rats and mice. Blackwell Scientific, Oxford, chap 23Google Scholar
  8. Boorman G A, Hollander CF (1973) Spontaneous lesions in the female WAG/Rij (Wistar) rat. J Gerontol 28: 152–159PubMedGoogle Scholar
  9. Burek JD (1978) Pathology of aging rats. CRC, Boca Raton FLGoogle Scholar
  10. Churg A, Richter WR (1971) Early changes in the exocrine pancreas of the dog and rat after ligation of the pancreatic duct. Am J Pathol 63: 521–546PubMedGoogle Scholar
  11. Craighead JE (1966) Pathogenicity of the M and E variants of the encephalomyocarditis (EMC) virus. II. Lesions of the pancreas, parotid and lacrimal glands. Am J Pathol 48:375–386PubMedGoogle Scholar
  12. Eppig J J, Leiter EH (1977) Exocrine pancreatic insufficiency syndrome in CBA/J mice. I. Ultrastructural study. Am J Pathol 86:17–30PubMedGoogle Scholar
  13. Fell BF, King TP, Davies NT (1982) Pancreatic atrophy in copper-deficient rats: histochemical and ultrastructural evidence of a selective effect on acinar cells. Histochem J 14:665–680PubMedCrossRefGoogle Scholar
  14. Gorelkin L, Jahrling PB (1974) Pancreatic involvement by Venezuelan equine encephalomyelitis virus in the hamster. Am J Pathol 75: 349–362PubMedGoogle Scholar
  15. Hashimoto A, Kita I, Okada K, Fujimoto Y (1979) Juvenile acinar atrophy of the pancreas of a dog. Vet Pathol 16:74–80PubMedGoogle Scholar
  16. Herman L, Fitzgerald PJ (1962) The degenerative changes in pancreatic acinar cells caused by DL-ethionine. J Cell Biol 12:277–296PubMedCrossRefGoogle Scholar
  17. Hill FWG, Osborne AD, Kidder DE (1971) Pancreatic degenerative atrophy in dogs. J Comp Pathol 81: 321–330PubMedCrossRefGoogle Scholar
  18. Hultquist GT, Jonsson LE (1965) Ligation of the pancreatic duct in rats. Acta Soc Med Uppsala 70: 82–88Google Scholar
  19. Kendrey G, Roe FJC (1969) Histopathological changes in the pancreas of laboratory rats. Lab Anim 3:207–220CrossRefGoogle Scholar
  20. Koo SI, Turk DE (1977) Effect of zinc deficiency on the ultrastructure of the pancreatic acinar cell and intestinal epithelium in the rat. J Nutr 107: 896–908PubMedGoogle Scholar
  21. Lansdown ABG (1974) Exocrine pancreatic insufficiency: a comparison of the clinical findings with the epi/epi mutation and Coxsackie virus B infection in mice. J Hered65:378Google Scholar
  22. Leiter EH, Cunliffe-Beamer T (1977) Exocrine pancreatic insufficiency syndrome in CBA/J mice. Pathological and genetic analysis. Gastroenterology 73: 260–266PubMedGoogle Scholar
  23. Leong ASY, Slavotinek AH, Deakin EJ, Nance SH, Elmslie RG (1982) The pathology of experimental chronic fibrosing pancreatitis — light microscopic and ultrastructural observations. Pathology 14: 363–368PubMedCrossRefGoogle Scholar
  24. Lombardi B, Estes LW, Longnecker DS (1975) Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by DL-ethionine fed with a choline-deficient diet. Am J Pathol 79:465–480PubMedGoogle Scholar
  25. Mann JR, Slater DN, Boyle P, Mangnall Y, Fox M (1979) The effects of steroids and glucagon on the morphological changes in the duct-ligated pancreas of the rat. Br J Exp Pathol 60: 423–433PubMedGoogle Scholar
  26. Muller HB (1970) Der Einfluss kupferarmer Kost auf das Pankreas. Virchows Arch (Pathol Anat) 350: 353–367CrossRefGoogle Scholar
  27. Nevalainen TJ, Janigan DT (1974) Degeneration of mouse pancreatic acinar cells during fasting. Virchows Arch (Cell Pathol) 15:107–118Google Scholar
  28. Papp M, Fodor I, Varga G, Folly G (1982) Pancreatic edema: its effect on the function and morphology of the pancreas in dogs and rats. Mt Sinai J Med (NY) 49: 456–464Google Scholar
  29. Pappenheimer AM, Kunz LJ, Richardson S (1951) Passage of Coxsackie virus (Connecticut-5 strain) in adult mice with production of pancreatic disease. J Exp Med 94: 45–64PubMedCrossRefGoogle Scholar
  30. Pfister K, Rossi GL, Freudiger U, Bigler B (1980) Morphological studies in dogs with chronic pancreatic insufficiency. Virchows Arch (Pathol Anat) 386:91–105CrossRefGoogle Scholar
  31. Pivetta OH, Green EL (1973) Exocrine pancreatic insufficiency: a new recessive mutation in mice. J Hered 64: 301–302PubMedGoogle Scholar
  32. Pound AW, Walker NI (1981) Involution of the pancreas after ligation of the pancreatic ducts. I. A histological study. Br J Exp Pathol 62: 547–558PubMedGoogle Scholar
  33. Prentice DE, James RW, Wadsworth PF (1980) Pancreatic atrophy in young Beagle dogs. Vet Pathol 17:575–580PubMedCrossRefGoogle Scholar
  34. Rimaila-Parnanen E, Westermarck E (1982) Pancreatic degenerative atrophy and chronic pancreatitis in dogs. A comparative study of 60 cases. Acta Vet Scand 23: 400–406PubMedGoogle Scholar
  35. Scheuhammer AM (1983) Chronic manganese exposure in rats: histological changes in the pancreas. J Toxicol Environ Health 12: 353–360PubMedCrossRefGoogle Scholar
  36. Scheuhammer AM, Cherian MG (1983) The influence of manganese on the distribution of essential trace elements. II. The tissue distribution of manganese, magnesium, zinc, iron and copper in rats after chronic manganese exposure. J Toxicol Environ Health 12: 361–370PubMedCrossRefGoogle Scholar
  37. Smith PA, Sunter JP, Case RM (1982) Progressive atrophy of pancreatic acinar tissue in rats fed a copper-deficient diet supplemented with D-penicillamine or triethylene tetramine: morphological and physiological studies. Digestion 23: 16–30PubMedCrossRefGoogle Scholar
  38. Szabo T, Greenstein AJ, Geller SA, Dreiling DA (1978) Pancreatic atrophy in the canine: an entity of exocrine-endocrine dissociation. Mt Sinai J Med (NY) 45: 503–508Google Scholar
  39. The TL, Maxwell WL, Thirumalai C (1980) Light microscopic and ultrastructural changes of the exocrine pancreas in the magnesium deficient rats. Exp Pathol (Jena) 18:245–253Google Scholar
  40. Walker NI, Pound AW (1983) An autoradiographic study of the cell proliferation during involution of the rat pancreas. J Pathol 139:407–418PubMedCrossRefGoogle Scholar
  41. Westermarck E (1980) The hereditary nature of canine pancreatic degenerative atrophy in the German shepherd dog. Acta Vet Scand 21: 389–394PubMedGoogle Scholar
  42. White DC, Sutherland DE, Najarian JS (1981) Endocrine function and histology of the canine pancreas after exocrine ablation by ductal injection of silicone rubber adhesive. J Surg Res 31: 371–374PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Gary A. Boorman
  • Scot L. Eustis

There are no affiliations available

Personalised recommendations