Advertisement

Sialodacryoadenitis (SDA) Infection, Rat

  • Robert O. Jacoby
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

Lesions develop during the 1st week after infection and occur primarily in the submaxillary and parotid salivary glands, which are located on the anteroventral and anterolateral aspects of the neck, respectively (Fig. 175). The glands are unilaterally or bilaterally enlarged ans pale yellow to white in contrast to their normal tan color (Fig. 176). Periglandular connective tissue is often edematous and, together with glandular enlargement, may cause grossly visible cervical swelling in the living rat. The parotid salivary gland of the rat is lobulated and sometimes difficult to delineate from surrounding adipose tissue when inflammatory edema is severe. The cervical lymph nodes may also be enlarged and edematous. They are frequently congested, especially early in infection, and occasionally flecked with red spots. Gross lesions of the oropharynx and tubular portions of the gastrointestinal tract have not been reported.

Synonyms

Rat Coronavirus infection 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ashe WK (1969) Properties of the rat submaxillary gland virus hemagglutinin and antihemagglutinin and their incidence in apparently healthy gnotobiotic and conventional rats. J Gen Virol 4:1–7PubMedCrossRefGoogle Scholar
  2. Barthold SW (1985) Research complications and state of knowledge of rodent coronaviruses. In: Hamm TA (ed) Complications of viral and mycoplasmal infections in rodents to toxicological research and testing, Hemisphere, Washington DC (in press)Google Scholar
  3. Bhatt PN, Jacoby RO (1977) Experimental infection of adult axenic rats with Parker’s rat Coronavirus. Arch Virol 54: 345–352PubMedCrossRefGoogle Scholar
  4. Bhatt PN, Jacoby RO (1985) Some epizootiological observations of natural and experimental sialodacryoadenitis infection in rats. Lab Anim Sci (in press)Google Scholar
  5. Bhatt PN, Percy DH, Jonas AM (1972) Characterization of the virus of sialodacryoadenitis of rats: a member of the Coronavirus group. J Infect Dis 126:123–130PubMedCrossRefGoogle Scholar
  6. Bhatt PN, Jacoby RO, Jonas AM (1977) Respiratory infection in mice with sialodacryoadenitis virus, a Coronavirus of rats. Infect Immun 18: 823–827PubMedGoogle Scholar
  7. Greene EC (1959) Anatomy of the rat. Transactions of American Philosophical Society, vol 27. Hafner, New York, p 93Google Scholar
  8. Jacoby RO, Bhatt PN, Jonas AM (1975) The pathogenesis of sialodacryoadenitis in gnotobiotic rats. Vet Pathol 12: 196–209PubMedGoogle Scholar
  9. Jacoby RO, Bhatt PN, Jonas AM (1979) Viral disease. In: Baker H, Lindsey JR, Weisbroth SH (eds) The laboratory rat, vol 1, Biology and diseases. Academic, New York, chap 11Google Scholar
  10. Jonas AM, Craft J, Black CL, Bhatt PN, Hilding D (1969) Sialodacryoadenitis in the rat. A light and electron microscopic study. Arch Pathol 88: 613–622PubMedGoogle Scholar
  11. Lai Y-L, Jacoby RO, Bhatt PN, Jonas AM (1976) Keratoconjunctivitis associated with sialodacryoadenitis in rats. Invest Ophthalmol 15: 538–541PubMedGoogle Scholar
  12. Lyon HW, Christian JJ, Miller CW (1959) Cytomegalic inclusion disease of lacrimal glands in male laboratory rats. Proc Soc Exp Biol Med 101:164–166PubMedGoogle Scholar
  13. Parker JC, Cross SS, Rowe WP (1970) Rat Coronavirus (RCV): a prevalent, naturally occurring pneumotropic virus of rats. Arch Virusforsch 31: 293–302PubMedCrossRefGoogle Scholar
  14. Peters RL, Collins MJ Jr (1981) Use of mouse hepatitis virus antigen in an enzyme-linked immunosorbent assay for rat coronaviruses. Lab Anim Sci 31:472–475PubMedGoogle Scholar
  15. Smith AL (1983) An immunofluorescence test for detection of serum antibody to rodent coronaviruses. Lab Anim Sci 33:157–160PubMedGoogle Scholar
  16. Taguchi F, Yamada A, Fujiwara K (1979) Asymptomatic infection of mouse hepatitis virus in the rat. Arch Virol 59:275–279PubMedCrossRefGoogle Scholar
  17. Utsumi K, Ishikawa T, Maeda T, Shimizu S, Tatsumi H, Fujiwara K (1980) Infectious sialodacryoadenitis and rat breeding. Lab Anim 14: 303–307PubMedCrossRefGoogle Scholar
  18. Vickers RA, Gorlin RJ (1977) Face, lips, teeth, mouth, jaws, salivary glands and neck. In: Anderson WAD, Kissane JM (eds) Pathology, 7th ed, vol 2. Mosby, St. Louis, chap 29Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Robert O. Jacoby

There are no affiliations available

Personalised recommendations