Sialodacryoadenitis (SDA) Infection, Rat

  • Robert O. Jacoby
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Lesions develop during the 1st week after infection and occur primarily in the submaxillary and parotid salivary glands, which are located on the anteroventral and anterolateral aspects of the neck, respectively (Fig. 175). The glands are unilaterally or bilaterally enlarged ans pale yellow to white in contrast to their normal tan color (Fig. 176). Periglandular connective tissue is often edematous and, together with glandular enlargement, may cause grossly visible cervical swelling in the living rat. The parotid salivary gland of the rat is lobulated and sometimes difficult to delineate from surrounding adipose tissue when inflammatory edema is severe. The cervical lymph nodes may also be enlarged and edematous. They are frequently congested, especially early in infection, and occasionally flecked with red spots. Gross lesions of the oropharynx and tubular portions of the gastrointestinal tract have not been reported.


Rat Coronavirus infection 


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© Springer-Verlag Berlin Heidelberg 1985

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  • Robert O. Jacoby

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