Abstract
Tumors arise in many organs, particularly parotid salivary glands, following inoculation of neonatal mice. Submaxillary and sublingual salivary glands, as well as lacrimal glands and accessory mucous and serous glands of the head and neck are also affected. Salivary tumors are bilateral or unilateral, multilobular, usually well circumscribed, and up to 5 cm in diamter. Small tumors are soft, tan to gray, and bulge on cut surface. Larger tumors can have pseudocystic, mucoid centers and hemorrhage and occasionally ulcerate the overlying skin. Other common tumor sites are renal cortex, thymus, mammary gland, skin, subcutis, bone, mesothelium, adrenal, and less commonly, elsewhere. Liver, lung, and pancreas are frequant sites for metastases (Dawe 1979; Stewart 1960). Prior to tumor development, pups are runted with thymic atrophy. Small nodules on the costochondral and costovertebral junctions are often seen (Buffet and Levinthal 1962).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Allison AC (1980) Immune responses to polyoma virus and polyoma virus-induced tumors. In: Klein G (ed) Viral oncology. Raven, New York, pp 481–487
Buffet RF, Levinthal JD (1962) Polyoma virus infection in mice. Arch Pathol 74: 513–526
Dawe CJ (1972) Epithelial-mesenchymal interactions in relation to the genesis of polyoma virus-induced tumours of mouse salivary gland. In: Tarin D (ed) Tissue interactions in carcinogenesis. Academic, New York, chap 10
Dawe CJ (1979) Tumours of the salivary and lachrymal glands, nasal fossa and maxillary sinuses. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol II. Tumours of the mouse. IARC Sci Publ no 23, Lyon, pp 91–133
Dubensky TW, Villarreal LP (1984) The primary site of replication alters the eventual site of persistent infection by Polyomavirus in mice. J Virol 50: 541–546
Dubensky TW, Murphy FA, Villarreal LP (1984) Detection of DNA and RNA virus genomes in organ systems of whole mice: patterns of mouse organ infection by Polyomavirus. J Virol 50: 779–783
Howatson AF, McCulloch EA, Almeida JD, Siminovich L, Axelrad AA, Ham AW (1960) Studies in vitro, in vivo, and by electron microscope of a virus recovered from a C3H mouse mammary tumor: relationship to polyoma virus. JNCI 24:1131–1151
Howley PM (1980) Molecular biology of SV40 and the human polyomaviruses BK and JC. In: Klein G (ed) Viral oncology. Raven, New York, pp 489–550
Imamura M (1968) Electron microscopic study of polyoma-induced salivary gland tumors, with special reference to cell-virus interactions. JNCI 41:1265–1283
McCance DJ, Mims CA (1977) Transplacental tramsission of polyoma virus in mice. Infect Immun 18:196–202
McCance DJ, Mims CA (1979) Reactivation of Polyomavirus in kidneys of persistently infected mice during pregnancy. Infect Immun 25: 998–1002
McCance DJ, Sebesteny A, Griffin BE, Balkwill F, Tilly R, Gregson NA (1983) A paralytic disease in nude mice associated with polyoma virus infection. J Gen Virol 64: 57–67
Rowe WP (1961) The epidemiology of mouse polyoma virus infection. Bacteriol Rev 25:18–31
Sebesteny A, Tilly R, Balkwill F, Trevan D (1980) Demyelination and wasting associated with Polyomavirus infection in nude (nu/nu) mice. Lab Anim 14: 337–345
Stanton MF, Stewart SE, Eddy BE, Blackwell RH (1959) Oncogenic effect of tissue-culture preparations of Polyomavirus on fetal mice. JNCI 23:1441–1475
Stewart SE (1960) The polyoma virus. Adv Virus Res 7: 61–90
Vandeputte M, Eyssen H, Sobis H, De Somer P (1974) Induction of polyoma tumors in athymic nude mice. Int J Cancer 14:445–450
Ward JM, Lock A, Collins MJ Jr, Gonda MA, Reynolds CW (1984) Papovaviral sialadenitis in athymic nude rats. Lab Anim 18: 84–89
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Barthold, S.W. (1985). Polyoma Virus Infection, Salivary Glands, Mouse. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Digestive System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96910-2_35
Download citation
DOI: https://doi.org/10.1007/978-3-642-96910-2_35
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-96912-6
Online ISBN: 978-3-642-96910-2
eBook Packages: Springer Book Archive