Histochemical Characteristics of Foci Induced by Diethylnitrosamine, Liver, Mouse

  • Stan D. Vesselinovitch
  • Hans J. Hacker
  • Peter Bannasch
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


The process of hepatocarcinogenesis has been studied extensively in rats with the objective of identifying progenitors of the sequentially emerging cell populations (Bannasch et al. 1980; Emmelot and Scherer 1980; Färber 1980; Pitot and Sirica 1980; Williams 1980). Studies, much more limited in scope, have been carried out in mice (Becker and Sell 1979; Becker et al. 1977; Butler and Hempsall 1978; Jalanko and Ruoslahti 1979; Lipsky et al. 1981; Moore et al. 1981; Vesse-linovitch 1980; Vesselinovitch et al. 1979, 1982, 1984; Vesselinovitch and Mihailovich 1983 a, b). The objective of the present study was to investigate the enzyme histochemical pattern of the focal lesions identified as basophilic foci in hematoxylin and eosin stained sections within the first 24 weeks of treatment with diethylnitrosamine (DEN). The study focused on the enzymes and metabolic products related to carbohydrates.


Focal Lesion Glycogen Phosphorylase B6C3F1 Mouse Focal Cell Histochemical Characteristic 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Stan D. Vesselinovitch
  • Hans J. Hacker
  • Peter Bannasch

There are no affiliations available

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