Rat Parvovirus Infection, Liver

  • Robert O. Jacoby
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Gross lesions are rare in naturally infected rats and only cursory descriptions are available in published reports. Acute parvovirus infection can cause hepatic necrosis. Affected livers have been portrayed as soft and pale and may contain gray-white foci (necrosis) or red foci (hyperemia and hemorrhage) (Ruffolo et al. 1966). Similar changes have been reported by Coleman and coworkers (Coleman et al. 1983), who also found ascites and yellow discoloration of the liver due to icterus. The foregoing changes should be expected primarily in suckling rats. However, mechanical or toxic injury to the livers of infected adult rats may be expressed by gross evidence of virus-induced necrosis (Mkrgolis et al. 1968; Ruffolo et al. 1966). Mild lesions, resulting in nonfatal acute hepatic necrosis, should resolve uneventfully without residual lesions. If necrosis is severe, the liver may become firm or variably nodular.


Rat virus infection Kilham rat virus infection H-l virus infection 


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© Springer-Verlag Berlin Heidelberg 1985

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  • Robert O. Jacoby

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