Abstract
Polyploidy cannot be observed grossly.
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References
Alfert M, Geschwind II (1958) The development of poly-somaty in the rat liver. Exp Cell Res 15: 230–232
Andrew W, Brown HM, Johnson JB (1943) Senile changes in the liver of mouse and man, with special reference to the similarity of the nuclear alterations. Am J Anat 72: 199–221
Carr RD, Smith MJ, Keil PG (1960) The liver in the aging process. Histology. Arch Pathol 70:15–18
De Leeuw-Israel FR, van Bezooijen CFA, Hollander CF (1972) Ploidy as a possible explanation for the variation in liver function during the life span of the rat. Z Al-ternsforsch 26: 29–33
Enesco HE, Samborsky J (1983) Liver polyploidy: influence of age and of dietary restriction. Exp Gerontol 18: 79–87
Engelmann GL, Richardson A, Katz A, Fierer JA (1981) Age-related changes in isolated rat hepatocytes. Comparison of size, morphology, binucleation, and protein content. Mech Ageing Dev 16: 385–395
Epstein CJ (1967) Cell size, nuclear content, and the development of polyploidy in the mammalian liver. Proc Natl Acad Sci USA 57: 327–334
Gahan PB, Middleton J (1982) Hepatocyte euploidization is a typical mammalian physiological specialization. Comp Biochem Physiol 71A: 345–348
Harrison MF (1953) Percentage of binucleate cells in the livers of adult rats. Nature 171: 611
Hollander CF, Thung PJ (1966) Relations between regenerative growth and ageing in the mouse liver. In: Lindop PJ, Sacher GA (eds) Proc Colloquium on Radiation and Ageing. Taylor and Francis, London, pp 3–14
James J, Tas J, Bosch KS, de Meere AIP, Schuyt HC (1979) Growth patterns of rat hepatocytes during postnatal development. Eur J Cell Biol 19: 222–226
Meinders-Groeneveld J (1969) Enige Kwantitatieve Aspecten der Polyploidie. Een experimentel onderzoek bij ratten. Doctoral dissertation, University of Amsterdam
Nadal C, Zajdela F (1966) Polyploidie somatique dans le foie de rat. I. Le role des cellules binuclees dans la genese des cellules polyploides. Exp Cell Res 42: 99–116
Shima A, Sugahara T (1976) Age-dependent ploidy class changes in mouse hepatocyte nuclei as revealed by Feul-gen-DNA cytofluorometry. Exp Gerontol 11: 193–203
Swartz FJ (1956) The development in the human liver of multiple desoxyribose nucleic acid (DNA) classes and their relationships to the age of the individual. Chromo-soma (Berl) 8: 53–72
Van Bezooijen CFA (1984) Influence of age-related changes in rodent liver morphology and physiology on drug metabolism. A review. Mech Ageing Dev 25:1–22
Van Bezooijen CFA, de Leeuw-Israel FR, Hollander CF (1973) On the role of hepatic cell ploidy in changes in liver function with age and following partial hepatectomy. Mech Ageing Dev 1: 351–356
Van Bezooijen CFA, Van Noord MJ, Knook DL (1974) The viability of parenchymal liver cells isolated from young and old rats. Mech Ageing Dev 3:107–119
Van Bezooijen CFA, Bukvic S J, Sleyster E Ch, Knook DL (1984) Bromsulfophthalein storage capacity of rat hepatocytes separated into ploidy classes by centrifugal elut-riation. In: van Bezooijen CFA (ed) Proc Eurage Workshop on Pharmacological, Morphological and Physiological Aspects of Liver Aging. EURAGE, Rijswijk pp 115–120
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© 1985 Springer-Verlag Berlin Heidelberg
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van Zwieten, M.J., Hollander, C.F. (1985). Polyploidy, Liver, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Digestive System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96910-2_13
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DOI: https://doi.org/10.1007/978-3-642-96910-2_13
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