Abstract
The immunosuppressed child with cancer is constantly at risk for infectious disease. The extent of susceptibility is dependent upon the integrity of the various components of the immune system and the virulence and number of microbes to which the individual is exposed. The type and stage of the malignancy, extent of anticancer and antimicrobial therapy, frequency of exposure to infectious agents, duration of hospitalization and nutritional status of the host determine the risk for infection.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Hughes WT, Tufenkeji H, Bartley DL (1983) The immune compromised host. Pediatr Clin North Am 30: 103
Lowy FD, Hammer SM (1983) Staphylococcus epidermidis infections. Ann Intern Med 99: 834
Friedman LE, Brown AE, Miller DR, Armstrong D (1984) Staphylococcus epidermidis septicemia in children with leukemia and lymphoma. Am J Dis Child 136: 715
Young LS, Armstrong D, Belevin A, Lieberman P (1971) Nocardia asteroides infection complicating neoplastic disease. Am J Med 50: 356
Hughes WT (1984) Pneumocystis carinii pneu-monitis. Chest 85: 810
Henson D, Siegel SE, Fuccillo DA, Matthew E, Levine AS (1972) Cytomegalovirus infections during acute childhood leukemia. J Infect Dis 126: 469
Spector SA, Rua JA, Spector DH, McMillan R (1984) Detection of human cytomegalovirus in clinical specimen by DNA-DNA hybridization. J Infect Dis 150: 121
Feldman S, Hughes WT, Daniel CB (1975) Varicella in children with cancer: seventy-seven cases. Pediatrics 56: 388
Feldman S, Hughes WT, Kim HY (1973) Herpes zoster in children with cancer. Am J Dis Child 126: 178
Whitley R, Hilty M, Haynes R et al (1981) Vidarabine (vira-A) therapy of chickenpox in immunosuppressed children (abstract 868). Twenty- first international conference on antimicrobial agents and chemotherapy, Chicago, November, 1981
Prober CG, Kirk LE, Keeney RE (1982) Acyclovir therapy of chickenpox in immunosuppressed children — a collaborative study. J Pediatr 101: 622
Hughes WT (1982) Systemic candidiasis: a study of 109 fatal cases. Pediatr Infect Dis 1: 11
Bartley DL, Hughes WT, Parvey LS, Parham D (1982) Computed tomography of hepatic and splenic fungal abscesses in leukemic children. Pediatr Infect Dis 1: 317
Hughes WT, Kuhn S, Chandhary S et al (1977) Successful chemoprophylaxis for Pneumocystis carinii pneumonitis. N Engl J Med 279: 1419
Hughes WT, Feldman SF, Gigliotti F, Shenep J, Sixbey J (1985) Prevention of infectious complications in acute lymphocytic leukemia. Semin Oncol 12: 180
Young LS (1982) Prophylactic granulocytes in the neutropenic host. Ann Intern Med 96: 240
Walsh TJ, Schimpff SC (1983) Prevention of infection among patients with cancer. Eur J Cancer Clin Oncol 19: 1333
Valdiviesa M, Cabanillas F, Keating M, Barkley HT, Murphy WK, Burgess MA, Frazier H, Chen T, Bodey GP (1984) Effects of intensive induction chemotherapy for extensive — disease small cell bronchogenic carcinoma in protected environment — prophylactic antibiotic units. Am J Med 76: 405
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Hughes, W.T. (1986). Infections in Children with Malignant Disease. In: Voûte, P.A., Barrett, A., Bloom, H.J.G., Lemerle, J., Neidhardt, M.K. (eds) Cancer in Children. UICC International Union Against Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96889-1_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-96889-1_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-15342-9
Online ISBN: 978-3-642-96889-1
eBook Packages: Springer Book Archive