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Current Concepts and Treatment of Histiocytosis X (Langerhans’ Cell Histiocytosis)

  • M. E. Nesbit
Part of the UICC International Union Against Cancer book series (1360)

Abstract

Histiocytosis is a general term used to indicate certain pathological disorders of the reticuloendothelial system [1]. Cells of this system have been classified as the mononuclear phagocytic system (MPS) because of their common origin and function [2]. They constitute an important defence system in the body against infections and foreign particulate matter, as well as being an important cellular component of the afferent limb of the immune response. The cells probably all originate from the pro-monocyte in the bone marrow and give rise to two different cell lineages. One line includes the peripheral monocyte which, in turn, gives rise to the tissue macrophage (histiocyte), while the other line includes the cells referred to as the dentritic cell population. This latter cell line is intimately involved with the thymus-dependent regions of the body and important in antigen processing, and the cells are powerful stimulators of mixed leukocyte reactions [3].

Keywords

Eosinophilic Granuloma Bony Lesion Afferent Limb Sinus Histiocytosis Birbeck Granule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1986

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  • M. E. Nesbit

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