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Nebenschilddrüsen und Vitamin-D- Stoffwechsel

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Endokrinologie des Kindes- und Jugendalters

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Zusammenfassung

Die Nebenschilddrüsen hat als erster wahrscheinslich Owen 1850 bei der Sektion eines Rhinozeros im Londoner Zoo beschrieben [1]. Danach haben Remak [2], Virchow [3] und Sandström [4] 1880 über die Nebenschilddrüsen publiziert, letzterer beschrieb sie bei zahlreichen Spezies von Säugetieren und beim Menschen. Der Name Nebenschilddrüsen wurde wahrscheinhch erstmals von Vassale u. Generale [5] gebraucht. Der Zusammenhang zwischen Nebenschilddrüsenfunktion und Tetanie wurde von Wölfer 1879 [6] und von Weiss 1880 [7] erkannt und von Vassale u. Generale 1896 weiter belegt [8]. Der Zusammenhang zwischen Nebenschilddrüsenfunktion und der von v. Reckhnghausen beschriebenen Knochenveränderung wurde 1903 von Ashkenazy in Königsberg vermutet [9] und führte zu dem langen wissenschafthchen Streit zwischen Erdheim [10] und Mandl [11]. Erdheim vermutete eine Nebenschilddrüsenüberfunktion sekundär zu den Knochenveränderungen, während Mandl eine Überfunktion der Nebenschilddrüsen als Ursache für die Knochenerkrankung verantworthch machte, womit ihm das Verdienst der korrekten Erstbeschreibung der ossären Symptomatik bei Hyperparathyreoidismus zukommt.

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Literatur

  1. Owen R (1852) On the anatomy of the Indian rhinoceros. Trans Zool Soc London 4/31:Art 111

    Google Scholar 

  2. Remak R (1851, 1858) Untersuchungen über die Entwicklung des Wirbeltieres. Berhn, Reimer 25:194 und Berlin, 191

    Google Scholar 

  3. Virchow R (1863–1867) In: Die krankhaften Geschwülste, Bd 3. Berlin, Hirschwald, S 13

    Google Scholar 

  4. Sandström J (1880) Om en ny körtel hos mennisken och artskilhga däggdjur (in schwedisch). Upsala Laekarefoeren Föerh 15:441

    Google Scholar 

  5. Vassale G, Generale F (1896) SugH effetti dell’ estirpazione delle ghandole para tiroidee. Riv PatolNerv Ment 1:95

    Google Scholar 

  6. Wölfer A (1880) Über die Entwicklung und den Bau der Schilddrüse mit Rücksicht auf die Entwicklung der Kröpfe. Berlin

    Google Scholar 

  7. Weiss N (1880) Über Tetanie. Volksmann Samml Khn Vortr Inn Med 7: Serie 189 1696

    Google Scholar 

  8. Vassale G, Generale F (1896) Sugli effetti dell’ estirpazione delle ghiandole paratiroidee. Riv PatolNerv Ment 1:95

    Google Scholar 

  9. Askanazy M (1903) Über Ostitis deformans ohne osteoides Gewebe. Arb Pathol Anat Inst Tuebingen 4:398–442

    Google Scholar 

  10. Erdheim J (1907) Über Epithelkörperchenbefunde bei Osteomalazie. Beitr. Akad Wiss Wien Math Naturwiss Kl Abt III 116:311

    Google Scholar 

  11. Mandl J (1925) Therapeutischer Versuch bei einem Fall von Osteitis fibrosa generalisata mittels Exstirpation eines Epithelkörperchentumors. Zentralbl Chir 53:260–264

    Google Scholar 

  12. Hanson AM (1923) An aUmentary study of the parathyroid glands of cattle. Mil Surg 52:280–284

    Google Scholar 

  13. Collip JB, Clarke EP, Scott JW (1925) The effect of a parathyroid hormone on normal animals. J Biol Chem 63:439

    CAS  Google Scholar 

  14. McLean FC, Hasting AB (1935) Clinical estimation and significance of calcium ion concentrations in the blood, Am J Med Sei 189:601

    Article  Google Scholar 

  15. Martin E, Bourdillon J (1940) Un cas de tétanie idiopathique chronique. Rev Med Suisse Romande 60:1166–77

    Google Scholar 

  16. Albright F, Burnett CH, Smith PH, Parson W (1942) Pseudohypoparathyroidism, an example of seabright-bantam syndrome. Endocrinology 30:922

    CAS  Google Scholar 

  17. Rasmussen H, Sze Y, Young R (1964) Further studies on the isolation and characterization of parathyroid polypeptides. J Biol Chem 239:2852–2857

    PubMed  CAS  Google Scholar 

  18. Potts JT Jr, Aurbach GD, Sherwood LM (1966) Parathyroid hormone: Chemical properties and structural requirements for biological and immunological activity. Recent Prog Horm Res 22:101–132

    CAS  Google Scholar 

  19. Keutmann HT, Sauer MM, Boehnert M, Hendry GN, O’Riordan JLH (1978) Application of biosynthetic labelling to structural analysis of human parathyroid hormone. US Endocrine Society, 60 Annual Meeting, Miami (Poster Session 477)

    Google Scholar 

  20. Berson SA, Yalow RS, Aurbach GD, Potts JT Jr (1963) Immunoassay of bovine and human parathyroid hormone. Proc Natl Acad Sei USA 49:613–617

    Article  CAS  Google Scholar 

  21. Chase LR, Aurbach GD (1967) Parathyroid function and the renal excretion of 3’,5’- adenylic acid. Proc Natl Acad Sei USA 58:518

    Article  CAS  Google Scholar 

  22. Curtis GM (1930) The blood supply of the human parathyroids. Surg Gynecol Obstet 51:805

    Google Scholar 

  23. Altenähr E (1971) Electron microscopical evidence for innervafion of chief cells in human parathyroid gland. Experientia 27:1077

    Article  PubMed  Google Scholar 

  24. Castleman B, Mallory TB (1935) The pathology of the parathyroid gland in hyperparathyroidism. A study of 25 cases. Am J Pathol 11:1

    PubMed  CAS  Google Scholar 

  25. Rother P (1969) Uber Vorkommen und Funktion der oxyphilen Welsschen Zellen in Glandulae parathyreoidea. Z Mikrosk Anat Forsch 79:553

    Google Scholar 

  26. Christie AC (1967) The parathyroid oxyphil cells. J Clin Pathol 20:591

    Article  CAS  Google Scholar 

  27. Thiele J, Ries P, Georgii A (1975) Spezielle und funktionelle Pathomorphologie der Epithelkörperchen in einem unausgewählten Obduktionsgut. Virchows Arch [Pathol Anat] 376:195–208

    Article  Google Scholar 

  28. Paloyan E, Lawrence AM, Straus FH (1973) Hyperparathyroidism. Grune & Stratton, New York London

    Google Scholar 

  29. Habener JF, Kemper BW, Rieh A, Potts JT Jr (1977) Biosynthesis of parathyroid hormone. Recent Prog Horm Res 33:249–308

    Google Scholar 

  30. Habener JF, Kemper BW, Rich A, Potts JT Jr (1977) Biosynthesis of parathyroid hormone. Recent Prog Horm Res 33:249–308

    Google Scholar 

  31. MacGregor RR, Hamilton JW, Cohn DV (1975) The by-pass of tissue hormone stores during the secretion of newly synthesized parathyroid hormone. Endocrinology 97:178–188

    Article  PubMed  CAS  Google Scholar 

  32. Möhr H, Hesch RD, Mcintosh CHS, Jüppner H (1980) Parathyroid hormone fragments in secretory granules of human parathyroid adenomas. Eur J Clin Invest 10:317–323

    Article  PubMed  Google Scholar 

  33. Möhr H, Hesch RD (1980) Different handhng of parathyrin by basal- lateral and brush- border membranesofthebovinekidneycortex, BiochemJ188:649–655D’Amour P, Segre GV, Roth SI (1979) Analysis of parathyroid hormone and its fragments in rat tissues: Chemical identification and microscopical locahzation, J Chn Invest 63:89–98

    Google Scholar 

  34. Bialasiewicz AA, Jüppner H, Diehl V, Hesch RD (1979) Binding of parathyroid hormone to surface receptors of cultured B-lymphocytes, Biochem Biophys Acta 584:467–478

    Article  PubMed  CAS  Google Scholar 

  35. Hesch RD, Hehrmann R (1979) Der primäre Hyperparathyreoidismus. Verh Dtsch Ges Inn Med 85:288–299

    Google Scholar 

  36. Rasmussen H (1974) Parathyroid hormone, calcitonin and the calciferols. In: Wilhams RH (ed) Textbook of endocrinology. Saunders, Philadelphia, pp 660–773

    Google Scholar 

  37. Moore EW (1970) Ionized calcium in normal serum, uhrafiltrates and whole blood determined by ion exchange electrodes, J Chn Invest 49:318–323

    Article  CAS  Google Scholar 

  38. Bronner F (1964) Dynamics in function of calcium. In: Comar LC, Bronner F (eds) Mineral metabolism, vol 2, part A. Academic Press, London New York, pp 342–447

    Google Scholar 

  39. Massry SG, Goldstein DA (1979) The search for uremic toxin (s) „X,“ „X“ = PTH. Clin Nephrol 11:181–189

    PubMed  CAS  Google Scholar 

  40. Jüppner H, Möhr H, Hesch RD (1980) Antibodies and peptides blocking the parathyroid hormone receptor and the hormone dependent adenylate cyclase of renal plasma membranes. Sixth Int Congr of Endocrinology, Melbourne, abstracts. No. 268 p 343

    Google Scholar 

  41. Pritchard JJ (1956) The biochemistry and physiology of bone. Academic Press, London New York, pp 179–211

    Google Scholar 

  42. Peck WA (1978) The specialization of bone cells. In: Copp DN, Talmage RV (eds) Endocrinology of calcium metabohsm. Academic Press, London New York, pp 237–240

    Google Scholar 

  43. Herrmann-Erbe MPM, Gaillard PJ, Hekkelman JV (1978) Regulation of the response of embryonic bone to PTH and PTH fragments. A morphologic and biochemical study. In: Copp DN, Talmage RV (eds) Endocrinology of calcium metabohsm. Academic Press, London New York, pp 253–269

    Google Scholar 

  44. Jüppner H, Sräer J, Ardaillou R, Ebel H, Ruf M, Möhr H (1978) PTH receptors at different sites along the nephron. Acta Endocrinol [Suppl 215] (Copenh) 87:105–106

    Google Scholar 

  45. Nordin B, Peacock M (1969) The role of the kidney in regulation of plasma calcium. Lancet 11:1280–1283

    Article  Google Scholar 

  46. Munson PL (1955) Studies on the role of the parathyroid in calcium and phosphorus metabohsm. Ann NY Acad Sei 60:776–795

    Article  CAS  Google Scholar 

  47. Chase LR, Melson GL, Aurbach GD (1969) Pseudohypoparathyreoidism: Defective excretion of 3’,5’-AMP in response to parathyroid hormone. J Clin Invest 48:1832

    Article  PubMed  CAS  Google Scholar 

  48. Aurbach GD, Potts J (1964) The parathyroids. Adv Metab Disord 1:45–93

    CAS  Google Scholar 

  49. Coleman EN (1965) Infantile hypercalcemia and cardiovascular lesions: Evidence, hypothesis and speculation. Arch Dis Child 40:535–540

    Article  PubMed  CAS  Google Scholar 

  50. Glimcher MK, Krane SM (1968) Organization and structure of bone and mechanism of calcification. In: Gould BS, Ramachandran GN (eds) Treatise of collagen, part B. Academic Press, London New York, pp 68–241

    Google Scholar 

  51. Fleisch H, Russel RGG (1970) Pyrophosphate, polyphosphate and calcium homeostasis. In: Rasmussen H (ed) The international encyclopedia of pharmacology and therapeutics. Pergamon, London

    Google Scholar 

  52. Fleisch H, Bonjour JP, Morgan DB, Reynolds JJ, Schenk R, Smith R, Russel GG (1971) Diphosphorates. In: Taylor SW (ed) Endocrinology. Heinemann, London, p 430

    Google Scholar 

  53. Neumann VF (1970) TTie membrane regulation of ion fluxes in the skeleton. Fed Proc 29:1846

    Google Scholar 

  54. Wasserman RH, Corradino RA, Taylor AN, Morisey RL (1971) Intestinal calcium absorption vitamin D, adaption and the calcium-binding protein. In: Nichols G, Wasserman RH (eds) Cellular mechanisms for calcium transfer and homeostasis. Academic Press, London New York, p 294

    Google Scholar 

  55. Howard JE (1968) Reflections on calcium habits in man. Can Med Assoc J 99:41–48

    PubMed  CAS  Google Scholar 

  56. Neer R, Berman M, Fisher L, Rosenberg LE (1967) Multicompartment analysis of calcium kinetics in normal adult males. J Clin Invest 46:1364–1379

    Article  PubMed  CAS  Google Scholar 

  57. Potts JD, Deftos LJ (1974) Parthyroid hormone, calcitonin, vitamin D, bone and bone minimal metabohsm. In: Bondy PK, Rosenberg LE (eds) Duncan’s disease of metabohsm. Sounders, Philadelphia, p 1277Haussler MR, McCain TA (1977) Basic and chnical concepts related to vitamin D metabohsm and action. N Engl J Med 297:974–983

    Google Scholar 

  58. DeLuca HF, Schnoes HK (1976) Metabohsm and mechanism of action of vitamin D. Annu Rev Biochem 45:631–666

    Article  PubMed  CAS  Google Scholar 

  59. Fraser DR, Kodicek E (1970) Unique biosynthesis by kidney of a biologically active vitamin D metabohte. Nature 228:764–766

    Article  PubMed  CAS  Google Scholar 

  60. Norman SW, Henry H (1974) 1.25-Dihydroxycholecalciferol - A hormonally active form of vitamin D3. Recent Prog Horm Res 30:431–480

    Google Scholar 

  61. Pike JW, Tovernd S, Boass A (1977) Circulating 1-alpha,25-(OH)2-D during physiological states of calcium stress. In: Norman AW, Schaefer K, Coburn JN (eds) Vitamin D: Biochemical, chemical and chnical aspects related to calcium metabohsm. de Gruyter, pp 187–189

    Google Scholar 

  62. Hesch RD (1979) Diagnostische und therapeutische Empfehlungen für die renale Osteopathie. In: Hesch RD, Hehrmann R (Hrsg) Renale Osteopathie. Thieme, Stuttgart, S 113–119

    Google Scholar 

  63. David L, Anast CS (1974) Calcium metabohsm in newborn infants, J Chn Invest 54:287–296

    Article  CAS  Google Scholar 

  64. Tsang RC, Chen IW, Friedman MA, Chen IW (1973) Neonatal parathyroid function: Role of gestational age and postnatal age. J Pediatr 83:728–738

    Google Scholar 

  65. Schedewie HK, Odell WD, Fischer DA, Krutzik SR, Dodge M, Cousins L, Fisher WP (1979) Parathormon and perinatal calcium homeostasis. Pediatr Res 13:1–6

    Article  PubMed  CAS  Google Scholar 

  66. Fanconi A (1975) Hypokalzamie beim Neugeborenen. Paediatr Fortbildungskurse Prax 41:184

    Google Scholar 

  67. Saville P, Kretchmer N (1960) Neonatal tetany, a report of 125 cases and review of the hterature. Biol Neonate 2:1

    Article  CAS  Google Scholar 

  68. Wolf H, Hesch RD (1975) Calcitonin in the newborn and influence of vitamin D3. In: Stembera ZK, Polacek K, Sabata V (eds) Perinatal medicine. Thieme, Stuttgart, Avice- num, Czechoslovak Medical Press Prague, pp 300–302

    Google Scholar 

  69. Tsang RC, Light IJ, Sutherland JM, Kleinmann LI (1973) Possible factors in neonatal hypocalcemia of prematurity. J Pediatr 82:423–429

    Article  PubMed  CAS  Google Scholar 

  70. Tsang RC, Kleinman LI, Sutherland JM, Light IJ (1972) Hypocalcemie in enfants of diabetic mothers. J Pediatr 80:384–395

    Article  PubMed  CAS  Google Scholar 

  71. Wagner G, Transbol I, Melchior JC (1964) Hyperparathyroidismus and pregnancy. Acta Endocrinol (Copenh) 47:549–564

    CAS  Google Scholar 

  72. Blizzard RM, Chee D, Davis W (1966) The incidence of parathyroid and other antibodies in the sere of patients with idiopathic hypoparathyroidism. Chn Exp Immunol 1:11

    Google Scholar 

  73. DiGeorge AM, Dacon C, Lischner HW, Arey JB (1966) Congenital absence of the thymus and its immunologic consequences. Concurrence with congenital hypoparathyroidism, Abstract Amer Ped Soc.

    Google Scholar 

  74. Brown DP, Tsang RC, Chen IW (1976) Oral calcium supplementation in premature and asphyxiated neonates. J Pediatr 89:973–977

    Article  PubMed  CAS  Google Scholar 

  75. Fanconi A (1976) Störungen des Calcium- und Phosphatstoffwechsels, In: Harnack G A von (Hrsg) Therapie der Krankheiten des Kindesalters. Springer, Berhn Heidelberg New York, S 102

    Google Scholar 

  76. Salle BL, David L, Chopard JP, Grafmeyer DC, Renand H (1975) Prevention of early neonatal hypocalcemia in low birth weight infants with continuous calcium infusions. Pediatr Res 11:1180–1185

    Article  Google Scholar 

  77. Peden V (1960) True idiopathic hypoparathyroidism as a sex hnked recessive trait. Am J Hum Genet 12:323

    PubMed  CAS  Google Scholar 

  78. Pronsky D, Kiamco RT, Waldstein S (1968) Famihal idiopathic hypoparathyroidism. J Clin Endocrinol Metab 18:61

    Article  Google Scholar 

  79. Spinner MW, Blizzard RM, Childs B (1968) Chnical and genetic heterogeneity in idiopathic Addison’s disease and hypoparathyroidism. J Clin Endocrinol Metab 28:795

    Article  PubMed  CAS  Google Scholar 

  80. Dummermuth G (1965) Elektroencephalographie im Kindesalter. Thieme, Stuttgart

    Google Scholar 

  81. Antebi L, Bouchard R, Guedeney J, Perles C, Weiss J (1966) Cardiomegaly due to hypocalcemia. Pediatrics 38:909–999

    Google Scholar 

  82. Aryenpur I, Farhondi A, Zangeneh F (1974) Congestive heart failure secondary to idiopathic hypoparathyroidism. Am J Dis Child 127:738–739

    Google Scholar 

  83. Courvoisier B, Berthoud E, Zahn DG, Grandjean A (1959) Donnés actuelles sur la physiologique clinique des parathyreoides. Helv Med Acta [Suppl] 38:26

    Google Scholar 

  84. Marshall RW (1976) Calcium fractions in plasma. In: Nordin BEC (ed) Metabolism. Churchill Livingstone, Edinburgh London New York

    Google Scholar 

  85. Kooh SW, Fraser D, DeLuca HF, Holick MF, Belsey RE, Clark MI, Murray TM (1975) Treatment of hypoparathyroidism and pseudohypoparathyroidism with metabohtes of vitamin D: Evidence for impaired conversion of 25-hydroxyvitamin D to 1,25-dihydroxy- vitamin D. N Engl J Med 293:840–844

    Article  PubMed  CAS  Google Scholar 

  86. Kind HP, Handysides A, Kooh SW, Eraser D (1977) Vitamin D therapy in hypoparathyroidism and pseudo-hypoparathyroidism: Weight-related dosages for initiation of therapy and manitenance therapy. J Pediatr 91:1006–1010

    Google Scholar 

  87. Chesney RW, Horowitz SD, Kream BE, Eisman JA, Hong R, DeLuca HF (1977) Failure of conventional doses of la-25 dihydroxycholecalciferol to correct hypocalcemia in a girl with idiopathic hypoparathyroidism. N Engl J Med 297:1272–1275

    Article  PubMed  CAS  Google Scholar 

  88. Fanconi A (1969) Hypoparathyreoidismus im Kindesalter. Erg Inn Med Kinderheilkd 28:54–119

    CAS  Google Scholar 

  89. Asherov J, Weinberger A, Pinkhas J (1977) Lack of response to vitamine D therapy in a patient with hypoparathyroidism under anticonvulsant drugs. Helv Paediatr Acta 32:369–373

    PubMed  CAS  Google Scholar 

  90. Drezner M, Neelon FA, Lebowitz HE (1973) Pseudohypoparathyreoidismus type II. A possible defect in the reception of the cAMP signal. N Engl J Med 1056–1060

    Google Scholar 

  91. Stömag W, Fischer JA (1975) Pseudohypoparathyroidism. Disappearance of the resistance to parathyroid extract during treatment with vitamin D. Am J Med 59:140–144

    Google Scholar 

  92. Mannix HJ (1975) Primary hyperparathyroidism in children. Am J Surg 129:528–531

    Article  PubMed  Google Scholar 

  93. Goldbloom RB, GilHs DA, Prasad M (1972) Hereditary parathyroid hyperplasie: A surgical emergency of early infancy. Pediatrics 49:514–522

    Google Scholar 

  94. Spiegel AM, Harrison HE, Marx SJ (1977) Neonatal primary hyperparathyroidism with autosomal dominant inheritance. J Pediatr 90:269–272

    Article  PubMed  CAS  Google Scholar 

  95. Freyschmidt J, Hehrmann R (1978) Primärer Hyperparathyreoidismus als Differential- diagnose von schweren Skelettdestruktionen. Roentgenblaetter 31:495–502

    CAS  Google Scholar 

  96. Rhone DP (1975) Primary neonatal hyperparathyroidism. Report of a case and reviews of the literature. Am J Clin Pathol 64:488–499

    PubMed  CAS  Google Scholar 

  97. Cushworth DC, Dent CE, Scriver CR (1972) Primary hyperparathyroidism and hyperaminoaciduria. Clin Chim Acta 41:355–361

    Article  Google Scholar 

  98. Bricker NS (1972) On the pathogenesis of the uremic state: An exposition of the „tradeoff“ hypothesis. N Engl J Med 286:1093–1098

    Article  PubMed  CAS  Google Scholar 

  99. Swenson RS, Weisinger JL, Ruggeri JL, Reaven GM (1975) Evidence that parathyroid hormone is not required for phosphate homeostasis in renal failure. Metabohsm 24:199–204

    Article  CAS  Google Scholar 

  100. Tröhler U, Bonjour JP, Fleisch H (1976) Inorganic phosphate homeostasis Renal adaption to the dietary intake in intake and thyroparathyroidectomised rats. J Clin Invest 57:264–274

    Article  PubMed  Google Scholar 

  101. Steele TH, Underwood JL (1978) Renal response to phosphorus deprivation in the isolated rat kidney. Kidney Int 13:124–129

    Article  PubMed  CAS  Google Scholar 

  102. Llach F, Massry SG, Singer FR, Kurokawa K, Kaye JH, Coburn JW (1975) Skeletal resistance to endogenous parathyroid hormone in patients with early renal failure. A possible cause of secondary hyperparathyroidism. J Clin Endocrinol Metab 41:339–345

    Article  PubMed  CAS  Google Scholar 

  103. Lihenfeldt-Toal H von, Hesch RD, Hüfner M, Mcintosh C (1974) Excretion of cyclic 3’,5’-adenosine monophosphate in renal insufficiency and primary hyperparathyroidism after stimulation with parathyroid hormone. Horm Metab Res 6:314–318

    Article  Google Scholar 

  104. Jüppner H, Bialasiewicz AA, Hesch RD (1978) Autoantibodies to parathyroid hormone receptors. Lancet II: 1222–1224

    Article  Google Scholar 

  105. Jüppner H, Hesch RD (1980) Inhibition of the parathyroid hormone dependent adenylate cyclase by receptor antibodies and low molecular peptides. Acta Endocrinol (Copenh) [Sppl] 124/94:122–123

    Google Scholar 

  106. Massry SG (1980) Parathyroid hormone and the uremic manifestations. Contrib Nephrol 20:84–91

    PubMed  CAS  Google Scholar 

  107. Delling G, Lühmann H (1979) Morphologie und Histomorphometrie der renalen Osteopathie. In: Hesch RD, Hehrmann R (Hrsg) Renale Osteopathie. Thieme, Stuttgart, S 22–45

    Google Scholar 

  108. Brickman AS, Jowsey J, Sherrad DJ et al. (1975) In: Norman AW, Schaefer K, Grigoleit HG, Herrath D von, Rith E (eds) Vitamin D and problems related to uremic bone disease. De Gruyter, Berlin, pp 241–247

    Google Scholar 

  109. Deluca HF (1978) Vitamin D metabohsm and function. Arch Intern Med 138:836–845

    Article  PubMed  CAS  Google Scholar 

  110. Norman AW, Schaefer K, Coburn JW, Deluca AF, Eraser D, Grigoleit HG, Herrath D von (1977) Vitamin D. Biochemical, chemical and chnical aspects related to calcium metabohsm. De Gruyter, Berhn New York

    Google Scholar 

  111. Eraser DR (1980) Regulation of the metabolism of vitamin D. Physiol Rev 60:551

    Google Scholar 

  112. Hesch RD, Henning HV, Gerlach W, Scheler F (1971) Früherkennung von Störungen der intestinalen Calciumabsorption bei Niereninsuffizienz. Khn Wochenschr 49:115

    Article  CAS  Google Scholar 

  113. Freyschmidt J (1979). In: Hesch RD, Hehrmann R (Hrsg) Renale Osteopathie. Thieme, Stuttgart, p 116

    Google Scholar 

  114. Moh H, Schmid F (1978) Radiologische Grundzüge der atypischen Rachitisformen. Z Kinderheilkd 80:469–483

    Google Scholar 

  115. World Health Organisation (1970) Vitamin D prophylaxe. Requirements of ascorbic acid, vitamin D, etc. Tech Rep Ser 452

    Google Scholar 

  116. Eraser D, Koch SW, Scriver CR (1978) Vitamin-D resistent rickets. In: Copp DN, Talmage RV (eds) Endocrinology of calcium metabohsm. Excerpta Medica, Amsterdam Oxford, pp 6–15

    Google Scholar 

  117. Eraser D, Koch SW, Scriver CR (1967) Hyperparathyroidism as the cause of hyperaminoaciduria and phosphaturia in human vitamin D deficiency. Pediatr Res 1:425–435

    Article  Google Scholar 

  118. Krohn HP, Brodehl J, Offner G, Liappis N, Weber HP (1974) Uber die Veränderung der Nierenfunktion bei der Vitamin D Mangel-Rachitis. Monatsschr Kinderheilkd 121:327–328

    Google Scholar 

  119. Sitrin M, Meredith S, Rosenberg IH (1979) Vitamin D deficiency and bone disease in gastrointestinal disorders. Arch Intern Med 138:886–888

    Article  Google Scholar 

  120. Prader A, Illig R, Heierh F (1961) Eine besondere Form der primären Vitamin D resistenten Rachitis mit Hypokalzämie und autosomal dominantem Erbgang: Die hereditäre Pseudomangelrachitis. Helv Paediatr Acta 16:452

    Google Scholar 

  121. Fräser D, Kooh SW, Kind HP, Holick MF, Tanaka Y, DeLuca HF (1973) Pathogenesis of hereditary vitamin D dependent rickets. An inborn error of vitamin D metabohsm involving defective conversion of 25-hydroxyvitamin D to 1 alpha 25 dihydroxyvitamin D. N Engl J Med 289:817

    Article  PubMed  Google Scholar 

  122. Fanconi G, Girardet P (1951) Famihärer persistierender Phosphatdiabetes mit Vitamin D resistenter Rachitis, Helv Paediatr Acta 7:14–41

    Google Scholar 

  123. Krohn HP, Brandis M, Brodehl J, Offner G (1976) Vhamin D resistente Rachitis: Ergebnis einer zwölfmonatigen kombinierten Therapie mit Vitamin D und Phosphat. Monatsschr Kinderheilkd 124:417–418

    Google Scholar 

  124. Winters RW, Graham JB, Wilhams TF, McFalls VW, Burnett CH (1958) A genetic study of famihal hypophosphatemia and vitamin D resistant rickets with a review of the hterature. Medicine (Baltimore) 37:97

    Article  CAS  Google Scholar 

  125. Krohn HP (1980) Die famihäre Hypophosphatämie mit Vitamin D resistenter Rachitis. Habihtationsschrift, Universität, Hannover

    Google Scholar 

  126. McMair S, Stickler GB (1969) Growth in famihal hypophosphatemic vitamin D resistant rickets. N Engl J Med 281:511–516

    Article  Google Scholar 

  127. Scriver CR, Reade TM, DeLuca HF, Hamstra AJ (1978) Serum 1,25 dihydroxy-vitamin- D levels in normal subjects and in patients with hereditary rickets or bone disease. N Engl J Med 299:976–979

    Article  PubMed  CAS  Google Scholar 

  128. Krohn HP, Brandis M, Brodehl J, Offner G (1974) Tubulärer Phosphattransport bei der Vitamin D resistenten Rachitis. Monatsschr Kinderheilkd 122:583–585

    PubMed  CAS  Google Scholar 

  129. Krohn HP, Brandis M, Brodehl J, Offermann G (1976) The effect of hyperparathyroidism on tubular reabsorption of amino acids in vitamin D resistant rickets. Pediatr Res 10:875

    Article  Google Scholar 

  130. Glorieux FH, Scriver CR, Reade TM, Goldman A, Roseborough A (1972) Use of phosphate and vitamin D to prevent dwarfism and rickets in x-linked hypophosphatemia. N Engl J Med 287:481–487

    Article  PubMed  CAS  Google Scholar 

  131. Hesch RD, Hehrmann R (1979) Renale Osteopathie. Thieme, Stuttgart

    Google Scholar 

  132. Brodehl J (1978) The Fanconi Syndrome, In: Edelman CM Jr (ed) Pediatric Kidney disease. Little Brown, Boston, pp 955–986

    Google Scholar 

  133. Compston JE, Thompson RPH (1977) Intestinal absorption of 25-hydroxyvitamin D and osteomalacia in primary bihary cirrhosis. Lancet II: 721–724

    Article  Google Scholar 

  134. Wagonfeld JP, Nemchausky BA, Boh M (1976) Copmarison of vitamin D and 25 hydroxy vitamin D in the therapy of primary bihary cirrhosis. Lancet 11:391–394

    Article  Google Scholar 

  135. Hahn TJ, Birge SJ, Scharp CR, Avioh LV (1972) Phénobarbital induced alterations in vitamin D metabolism. J Clin Invest 91:741

    Article  Google Scholar 

  136. Schäfer U, Flury WH, Herrath D von, Kraft D, Schweingruber R (1972) Vitamin- D-Stoffwechsel und Antiepileptika. Schweiz Med Wochenschr 102:785

    Google Scholar 

  137. Brooks M, Bell NH, Love L etal. (1978) Vitamin-D-dependent rickets type II. N Engl J Med 298:996–999

    Article  PubMed  CAS  Google Scholar 

  138. Salassa RM, Jowey J, Arnaud CD (1970) Hypophosphatemic osteomalecia associated with „nonendocrine“ tumors. N Engl J Med 283:65

    Article  PubMed  CAS  Google Scholar 

  139. Royer P, Habib R, Mathieu H (1967) Nephrologie im Kindesalter. Thieme, Stuttgart, S 218

    Google Scholar 

  140. Palsan S, Garabedian M, Sorgniard R, Hohck MF, DeLuca HF (1975) 1,25 dihydroxyvi- tamin D3 and 1 a-hydroxyvitamin D3 in children. Pediatr Res 9:586–593

    Google Scholar 

  141. Chesney BW, Mazess RP, Rose P, Hamstra AJ, DeLuca HF (1980) Supranormal 25-hydroxyvitamin D and subnormal 1–25 dihydroxyvitamin D. Am J Dis Child 134:140–143

    PubMed  CAS  Google Scholar 

  142. Stickler GB, Beabout JW, Riggs BL (1970) Chnical experience with 41 typical famihal hypophosphatemic patients and 2 atypical nonfamihal cases. Mayo Chn Proc 45:197

    CAS  Google Scholar 

  143. Moncrieff MW, Chance GW (1969) Nephrotoxic-effect of vitamin D therapy in vitamin D infractory rickets. Arch Dis Child 44:571–579

    Article  PubMed  CAS  Google Scholar 

  144. Panier L, Kooh SW, Conen PF, Gibson AAM, Eraser D (1968) Renal function and histology after long-term vitamin D therapy of vitamin D infractory rickets. J Pediatr 73:833–844

    Article  Google Scholar 

  145. Walton RJ, Bijvoet OLM (1975) Nomogram for derivation of renal threshold phosphate concentration. Lancet 11:309–310

    Article  Google Scholar 

  146. Hesch RD (1978) Arbeitsgruppe Parathormon. Endokrinol Inf 3:109

    Google Scholar 

  147. Hesch RD, Offermann G, Wood G, Ziegler R (1980) Expertengruppe Parathormon und Calcitonin. Endokrinol 3:85–88

    Google Scholar 

  148. Lihenfeld-Toal H von, Hüfner M, Hesch RD, Mcintosh C (1974) The excretion of cAMP in renal insufficiency and primary hyperparathyroidism after stimulation with parathyroid hormone. Horm Metab Res 6:314–318

    Article  Google Scholar 

  149. McDonald KM (1972) Responsiveness of bone to parathyroid extract in sibhngs with pseudohypoparathyroidism. Metabolism 21:521–531

    Article  PubMed  CAS  Google Scholar 

  150. Kaiser W, Ponsold W (1959) Über eine Möglichkeit zur Diagnose der relativen Neben- schilddrüseninsuffizienz durch Infusion von Äthylendiamintetraazetat (ÄDTA). Khn Wochenschr 37:1183–1185

    Article  CAS  Google Scholar 

  151. Parfitt AM (1967) Delayed recognition of postoperative hypoparathyroidism. Med J Aust 1:702–708

    PubMed  CAS  Google Scholar 

  152. Hesch RD, Hehrmann R, Jüppner H (1978) Biokybernetische Aspekte der Parathormonsekretion unter Berücksichtigung des Vitamin-D Stoffwechsels. In: Oeff K, Schmidt HAE (Hrsg) Nuklearmedizin, Bd I.Medico, Berlin,S210–222

    Google Scholar 

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Authors
  1. R.-D. Hesch
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  2. H.-P. Krohn
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Editors and Affiliations

  1. Kinderklinik, Abt. f. pädiatrische Endokrinologie, Universitätsklinikum der Gesamthochschule Essen, Hufelandstraße 55, 4300, Essen, Deutschland

    H. Stolecke

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Hesch, RD., Krohn, HP. (1982). Nebenschilddrüsen und Vitamin-D- Stoffwechsel. In: Stolecke, H. (eds) Endokrinologie des Kindes- und Jugendalters. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96694-1_7

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  • DOI: https://doi.org/10.1007/978-3-642-96694-1_7

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