Abstract
The accumulation of a wide range of potentially toxic substances of differing molecular size and physical properties suggests that at present a specific approach to artificial liver support for the treatment of fulminant hepatic failure (FHF) is not possible. Our approach, therefore, has been the development of broad-spectrum adsorbents for use in whole-blood haemoperfusion. Charcoal haemoperfusion and polyacrylonitrile haemodialysis will remove water-soluble substances, but the removal of protein-bound substances has been limited by the lack of a sufficiently blood-compatible adsorbent.
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References
Bloch P, Delorme ML, Rapin JR, Granger A, Boschat M, Opolon P (1978) Reversible modifications of neurotransmitters of the brain in experimental acute hepatic coma. Surg Gynecol Obstet 146: 551–558
Chang TMS (1974) Platelet-surface interactions: Effect of albumin coating or heparin complexing on thrombogenic surfaces. Can J Physiol Pharmacol 52:275–285
Dunlop EH, Hughes RD, Williams R (1978) Physico-chemical aspects of the removal of protein bound substances by charcoal and adsorbents of potential value in systems of artificial liver support, Part 1: Equilibrium properties. Med Biol Eng Comput 16:343–349
Gimson AES, Langley PG, Hughes RD, Canalese J, Mellon PJ, Williams R, Woods HF, Weston MJ (1980) Prostacyclin to prevent platelet activation during charcoal haemoperfusion in fulminant hepatic failure. Lancet 1:173–175
Hughes RD, Ton HY, Langley PG, Silk DBA, Williams R (1978) The use of an in vitro haemoperfusion circuit to evaluate the blood compatibility of albumin-coated Amberlite XAD-7 resin. Int J Artif Organs 3:129–134
Hughes RD, Ton HY, Williams R (1979a) Adsorption studies on albumin coated Amberlite XAD-7 for haemoperfusion in acute liver failure. Proc Eur Soc Artif Organs 6:297–300
Hughes RD, Ton HY, Langley PG, Davies M, Hanid MA, Mellon P, Silk DBA, Williams R (1979b) Albumin-coated Amberlite XAD-7 resin for haemoperfusion in acute liver failure, Part II: In vivo evaluation. Artif Organs 3:23–26
Hughes RD, Lane DA, Cella G, Kakkar W, Langley PG , Williams R (1980) Platelet function during haemoperfusion in acute liver failure. Int J Artif Organs 3:30–34
Packham MA, Evans G, Glynn MF, Mustard JF (1969) The effect of plasma proteins on the interaction of platelets with foreign surfaces. J Lab Clin Med 73:686–697
Rubin MH, Weston MJ, Bullock G, Roberts J, Langley PG, White YS, Williams R (1977) Abnormal platelet function and ultrastructure in fulminant hepatic failure. Q J Med 46:339–352
Ton HY, Hughes RD, Silk DBA, Williams R (1979a) Albumin-coated Amberlite XAD-7 resin for hemoperfusion in acute liver failure, Part 1: Adsorption studies. Artif Organs 3:20–22
Ton HY, Hughes RD, Silk DBA,Williams R (1979b) Adsorption of human serum albumin to Amberlite XAD-7 resin. J Biomed Mater Res 13:407–422
Weston MJ, Gazzard BG, Buxton BH, Winch J, Machado AL, Flax H, Williams R (1974) Effects of haemoperfusion through charcoal or XAD-2 resin on an animal model of fulminant hepatic failure. Gut 15:482–486
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© 1981 Springer-Verlag Berlin Heidelberg
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Hughes, R.D., Williams, R. (1981). Development of a Blood-Compatible Resin for Artificial Liver Support. In: Brunner, G., Schmidt, F.W. (eds) Artificial Liver Support. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96629-3_13
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DOI: https://doi.org/10.1007/978-3-642-96629-3_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-96631-6
Online ISBN: 978-3-642-96629-3
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