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Antimikrobielle Chemotherapie

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Zusammenfassung

Obwohl seh dem 17. Jahrhundert verschiedene Stoffe bei der Behandlung von Infektionskrankheiten angewandt wurden (z.B. Chinin gegen Malaria und Emetin gegen Amöbenruhr), beginnt die Chemotherapie als Wissenschaft erst mit Paul Ehrlich. Er formulierte als erster das Prinzip der selektiven Toxicität. Er erkannte die spezifischen chemischen Beziehungen zwischen Parasit und therapeutisch wirksamem Mittel. Er untersuchte die Entwicklung der Resistenz gegen die Chemotherapeutica bei den Parasiten und die Rolle der kombinierten Therapie, die der Resistenzbildung entgegenwirkt. Ehrlichs Experimente im ersten Jahrzehnt des 20. Jahrhunderts führten zu den Arsphenaminen, dem ersten größeren Erfolg einer planmäßig betriebenen Chemotherapie.

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Authors and Affiliations

  1. Department of Microbiology, University of California School of Medicine, San Francisco, USA

    Ernest Jawetz Ph. D. M. D. (Professor of Microbiology and Chairman, Professor of Medicine, Lecturer in Pediatries)

  2. Baylor University College of Medicine, Houston, Texas, USA

    Joseph L. Melnick Ph. D. (Professor of Virology and Epidemiology)

  3. Department of Microbiology, Yale University School of Medicine, New Haven, USA

    Edward A. Adelberg Ph. D. (Professor of Microbiology and Chairman)

Authors
  1. Ernest Jawetz Ph. D. M. D.
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  2. Joseph L. Melnick Ph. D.
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  3. Edward A. Adelberg Ph. D.
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© 1977 Springer-Verlag Berlin · Heidelberg

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Jawetz, E., Melnick, J.L., Adelberg, E.A. (1977). Antimikrobielle Chemotherapie. In: Medizinische Mikrobiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96397-1_10

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  • DOI: https://doi.org/10.1007/978-3-642-96397-1_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-08162-3

  • Online ISBN: 978-3-642-96397-1

  • eBook Packages: Springer Book Archive

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