Skip to main content
SpringerLink
Log in

Biologische Grundlagen der Strahlentherapie

  • Chapter
Strahlentherapie

  • 26 Accesses

Zusammenfassung

Das grundsätzliche Ziel jeder Strahlentherapie maligner Geschwülste ist es, eine maximale Zerstörung des Tumors bei möglichst geringer Schädigung der normalen Gewebe zu erreichen, wobei eine „Gratwanderung“ zwischen beiden Effekten der ionisierenden Strahlung häufig unumgänglich ist. Dieses Prinzip wurde erstmals im Jahre 1936 von Holthusen dargestellt (Abb. 101).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Alper, T., Fowler, J.F., Morgan, R.L., Vonberg, D.D., Ellis, F., Oliver, R.: The characterization of the “Type C” survival curve. Brit. J. Radiol. 35, 722–723 (1962).

    Google Scholar 

  • Alper, T.: Cell Death and Its Modification: The Roles of Primary Lesions in Membranes and DNA. In: Biophysical Aspects of Radiation Quality, pp. 171–183. Wien: International Atomic Energy Agency 1971.

    Google Scholar 

  • Altman, K I., Gerber, G.B., Okada, S.: Radiation Biochemistry. New York—London: Academic Press 1970.

    Google Scholar 

  • Bacq, Z.M.: Chemical Protection against Ionizing Radiation. Springfield (Ill.): C.C. Thomas 1965.

    Google Scholar 

  • Barendsen, G.W.: Cellular responses determining the effectiveness of fast neutrons relative to X-rays for effects on experimentel tumours. Europ. J. Cancer 7, 181–190 (1971).

    CAS  Google Scholar 

  • Barendsen, G.W.: Quantitative biophysical aspects of responses of tumours and normal tissues to ionizing radiations. In: Current Topics of Radiat. Research Quarterly, Vol. Vol. 9 (ed. M. Ebert, A. Howard), pp. 101–108. Amsterdam: North-Holland 1973.

    Google Scholar 

  • Barendsen, G.W., Broerse, J.J.: Experimental radiotherapy of a rat rhabdomyosarcoma with 15 MeV neutrons and 300 kV X-rays. Europ. J. Cancer 6, 89–109 (1970).

    CAS  Google Scholar 

  • Barendsen, G.W., Walter, H.M.D., Fowler, J.F., Bewley, D.K.: Effects of different ionizing radiations on human cells in tissue culture. III. Experiments with cyclotron-accelerated alpha-particles and deuterons. Radiat. Res. 18, 106–119 (1963).

    PubMed  CAS  Google Scholar 

  • Barranco, S.C., Romsdahl, M.M., Humphrey, R.M.: The radiation response of human malignant melanoma cells grown in vitro. Cancer Res. 31, 830–833 (1971).

    PubMed  CAS  Google Scholar 

  • Berry, R.J.: Celluläre Faktoren der Strahlenempfindlichkeit. In: Präoperative Tumorbestrahlung (Hrsg. O. Hug), S. 1–11. München: Urban & Schwarzenberg 1971.

    Google Scholar 

  • Berry, R.J., Wiernik, G., Patterson, J.S., Hopewell, J.W.: Excess late subcutaneous fibrosis after irradiation of pig skin, consequent upon the application of the NSD formula. Brit., J. Radiol. 47, 277–281 (1974).

    CAS  Google Scholar 

  • Betz, E.H.: Morphologische Veränderungen des lymphatischen Systems nach Bestrahlung In: Die Strahlenwirkung auf das Lymphsystem (Hrsg. K.H. Kärcher, C. Streffer), S. 29–36. Berlin-Heidelberg-New York: Springer 1974.

    Google Scholar 

  • Bewley, D.K.: Fast Neutron Beams for Therapy. Curr. Topic in Radiat. Research. Vol. 6, pp. 249–292. Amsterdam: North-Holland 1970.

    Google Scholar 

  • Bosiljanoff, P., Porschen, W., Piepenbring, W., Mühlensiepen, H., Feinendegen, L.E.: In-vivo-Untersuchungen über die relative Strahlenempfindlichkeit hypoxischer Zellen. Strahlentherapie (im Druck).

    Google Scholar 

  • Braun, H.: Beiträge zur Histologie und Zytologie des bestrahlten Thymus. III. Mitteilung: Die Wirkung subletaler Dosen. Strahlentherapie 126, 236–246 (1965).

    PubMed  CAS  Google Scholar 

  • Braun, H., Heuck, F., Ladner, H.-A., Messerschmidt, O., Musshoff, K., Streffer, C.: Strahlenempfindlichkeit von Organen und Organsystemen der Säugetiere und des Menschen. Stuttgart: Thieme 1973.

    Google Scholar 

  • van den Brenk, H.A.S.: Oxygen Effect in Radiation Therapy. In: Current Topics in Radiation Research (ed. M. Ebert, A. Howard), vol. 5, pp. 197–254. Amsterdam: North-Holland 1969.

    Google Scholar 

  • van den Brenk, H.A.S., Kerr, R.C., Richter, W., Papworth, M.D.: Enhancement of radiosensitivity of skin of patients by high pressure oxygen. Brit. J. Radiol. 38, 857–864 (1966).

    Google Scholar 

  • Broerse, J.J., Barendsen, G.W., Freriks, G., van Putten, L.M.: RBE values of 15 MeV neutrons for effects on normal tissues. Europ. J. Cancer 7, 171–177 (1971).

    CAS  Google Scholar 

  • Broerse, J.J., Barendsen, G.W., van Kersen, G.R.: Survival of cultured human cells after irradiation with fast neutrons of different energies in hypoxic and oxygenated conditions. Int. J. Radiat. Biol. 13, 559–572 (1967).

    Google Scholar 

  • Catterall, M., Rogers, C., Thomlinson, R.H., Field, S.B.: An investigation into the clinical effects of fast neutrons. Brit. J. Radiol. 44, 603–611 (1971).

    PubMed  CAS  Google Scholar 

  • Chapman, J.D., Dugle, D.L., Reuvers, A.P., Gillespie, C.J., Borsa, J.: Chemical radiosen-sitization studies with mammalian cells growing in vitro. In: Radiation Research (eds. O.F. Nygaard, H.J. Adler, W.K. Sinclair), pp. 752–760. New York-San Francisco-London: Academic Press 1975.

    Google Scholar 

  • Chapman, J.D., Reuvers, A.P., Borsa, J., Henderson, J.S., Migliore, R.D.: Nitrohetero-cyclic drugs as selective radiosensitizers of hypoxic mammalian cells. Cancer Chemotherapy Reports, Part 1, 58, 559–570 (1974).

    CAS  Google Scholar 

  • Churchill-Davidson, J., Foster, A., Wiernik, G., Collins, C.D., Pizey, N.C.D., Skeggs, D.B. L., Purser, P.R.: The place of oxygen in radiotherapy. Brit. J. Radiol. 39, 321–331 (1966).

    PubMed  CAS  Google Scholar 

  • Cleaver, J.E.: Thymidine Metabolism and Cell Kinetics. In: North-Holland Research Monographs; Frontiers of Biology 6 (ed. A. Neuberger, EX. Tatum). Amsterdam: North-Holland 1967.

    Google Scholar 

  • Cleaver, J.E.: DNA repair and radiation sensitivity in human (xeroderma pigmentosum) cells. Int. J. Radiat. Biol. 18, 557–565 (1970).

    CAS  Google Scholar 

  • Cleaver, J.E.: Repair-processes for Photochemical Damage in Mammalian Cells. In: Adv. in Radiat. Biology, Vol. 4 (ed. J.T. Lett, H. Adler, M. Zelle), pp. 1–75. New York-London: Academic Press 1974.

    Google Scholar 

  • Cohen, A., Cohen, L.: Radiobiology of the C3H mouse mammary carcinoma: The effect of body dose on the radiocurability of the tumour treated in situ. Brit. J. Cancer 7, 452–455 (1953).

    PubMed  CAS  Google Scholar 

  • Denekamp, J.: Cellular proliferation kinetics of animal tumours. Cancer Res. 30, 393–400 (1970).

    PubMed  CAS  Google Scholar 

  • Denekamp, J.: Changes in the rate of proliferation in normal tissues after irradiation. In: Radiation Research (eds. O.F. Nygaard, H.J. Adler, W.K. Sinclair), pp. 810–825. New York-San Francisco-London: Academic Press 1975.

    Google Scholar 

  • Denekamp, J., Thomlinson, R.H.: The cell proliferation kinetics of four experimental tumours after acute X-irradiation. Cancer Res. 31, 1279–1284 (1971).

    PubMed  CAS  Google Scholar 

  • Dertinger, H., Jung, H.: Molekulare Strahlenbiologie. Heidelberger Taschenbücher 57/ 58, Berlin-Heidelberg-New York: Springer 1969.

    Google Scholar 

  • Dische, S.: The hyperbaric oxygen chamber in the radiotherapy of carcinoma of the bladder. Brit. J. Radiol. 46, 13–17 (1973).

    PubMed  CAS  Google Scholar 

  • Dische, S.: The hyperbaric oxygen chamber in the radiotherapy of carcinoma of the uterine cervix. Brit. J. Radiol. 47, 99–107 (1974).

    PubMed  CAS  Google Scholar 

  • Dittrich, W., Göhde, W.: Impulsfluorometrie bei Einzelzellen in Suspension. Z. Naturforsch. 24b, 360–361 (1969).

    Google Scholar 

  • Dutreix, J., Wambersie, A., Bounik, C.: Cellular recovery in human skin reactions: Application to dose fraction, number overall time relationship in radiotherapy. Europ. J. Cancer 9, 159–167 (1973).

    CAS  Google Scholar 

  • Edenberg, H.J., Hanawalt, Ph.C: The timecourse of DNA repair replication in ultraviolet-irradiated HeLa cells. Biochim. biophys. Acta (Amst.) 324, 206–217 (1973).

    CAS  Google Scholar 

  • Eichhorn, H.-J.: Klinische Erfahrungen mit Neutronentherapie. In: Gemeinsamer Kongreß der Deutschen und der Österreichischen Röntgengeseilschaft (Hrsg. A. Breit, K.-H. Kärcher), S. 356. Stuttgart: Thieme 1974.

    Google Scholar 

  • Elkind, M.M.: Damage and Repair Processes Relative to Neutron (and Charged Particle) Irradiation. In: Current Topics in Radiation Research Quarterly (ed. M. Ebert, A. Howard), Vol. 7, pp. 1–44. Amsterdam: North-Holland 1970/71.

    Google Scholar 

  • Elkind, M.M., Kano, E.: Radiation-induced age-response changes in Chinese Hamster cells. Evidence for a new form of damage and its repair. Int. J. Radiat. Biol. 19, 547–560 (1971).

    CAS  Google Scholar 

  • Elkind, M.M., Sinclair, W.K.: Recovery of X-irradiated Mammalian Cells. In: Current Topics in Radiation Research (ed. M. Ebert, A. Howard), Vol. 1, pp. 165–220. Amsterdam: North-Holland 1965.

    Google Scholar 

  • Elkind, M.M., Sutton, H.: Radiation response of mammalian cells grown in culture. I. Repair of X-ray damage in surviving Chinese Hamster cells. Radiat. Res. 13, 556–593 (1960).

    PubMed  CAS  Google Scholar 

  • Elkind, M.M., Sutton-Gilbert, H., Moses, W.B., Kamper, C: Sublethal and lethal radiation damage. Nature (Lond.) 214, 1088–1092 (1967).

    CAS  Google Scholar 

  • Elkind, M.M., Whitmore, G.F.: The Radiobiology of Cultured Mammalian Cells. New York: Gordon & Breach 1967.

    Google Scholar 

  • Ellis, F.: Nominal standard dose and the ret. Brit. J. Radiol. 44, 101–108 (1971).

    PubMed  CAS  Google Scholar 

  • Erikson, R.L., Szybalski, W.: Molecular radiobiology of human cell lines. III. Radiation-sensitizing properties of 5-iododeoxyuridine. Cancer Res. 23, 122–130 (1963).

    CAS  Google Scholar 

  • Evans, R.G., Bagshaw, M.A., Gordon, L.F., Kurkjian, St.D., Hahn, G.M.: Modification of recovery from potentially lethal X-ray damage in plateau phase Chinese Hamster cells. Radiat. Res. 59, 597–605 (1974).

    PubMed  CAS  Google Scholar 

  • Fabrikant, J.I.: Radiation Effects on Rapidly and Slowly Proliferating Cell Renewal Systems. In: Frontier of Radiation Therapy and Oncology (ed. J.M. Vaeth), Vol. 6, pp. 57–58. Basel-München-Paris-London-New York-Sydney: Karger 1972.

    Google Scholar 

  • Field, S.B., Hornsey, Sh.: RBE values for cyclotron neutron effects on normal tissues and tumours as a function of dose and dose fractionation. Europ. J. Cancer 7, 161–169 (1971).

    CAS  Google Scholar 

  • Fowler, J.F.: The estimation of total dose for different numbers of fractions in radiotherapy. Brit. J. Radiol. 38, 365–368 (1965).

    PubMed  CAS  Google Scholar 

  • Fowler, J.F.: Radiation Biology as Applied to Radiotherapy. In: Current Topics in Radiation Research (ed. M. Ebert, A. Howard), Vol. 7, pp. 303–364. Amsterdam: North-Holland 1968.

    Google Scholar 

  • Fowler, J.F.: Fundamental aspects of LET in Radiobiology. In: Radiation Research (eds. O.F. Nygaard, H.J. Adler, W.K. Sinclair), pp. 1040–1052. New York — San Francisco — London: Academic Press 1975.

    Google Scholar 

  • Fowler, J.F., Denekamp, J., Page, A.L., Begg, A.C., Field, S.B., Butler, K.: Fractionation with X-rays and neutrons in mice: Response of skin and C3H mammary tumours. Brit. J. Radiol. 45, 237–249 (1972).

    PubMed  CAS  Google Scholar 

  • Froese, G.: Division delay in HeLa cells and Chinese Hamster cells. A time lapse study. Int. J. Radiat. Biol. 10, 353–367 (1966).

    CAS  Google Scholar 

  • Gray, L.H.: Radiobiologic basis of oxygen as a modifying factor in radiation therapy. Amer. J. Roentgenol. 85, 803–815 (1961).

    PubMed  CAS  Google Scholar 

  • Hagen, U.: Molekulare Mechnaismen bei der Reparatur von Strahlenschäden in Lymphocyten. In: Die Strahlenwirkung auf das Lymphsystem (Hrsg. K.H. Kärcher, C. Streffer), S. 23–28. Berlin — Heidelberg — New York: Springer 1974.

    Google Scholar 

  • Hahn, G.M., Bagshaw, M.A.: Serum concentration. Effects on cycle and X-ray sensitivity of mammalian cells. Science 151, 459–461 (1966).

    PubMed  CAS  Google Scholar 

  • Hahn, G.M., Little, J.B.: Plateau-Phase Cultures of Mammalian Cells: An in vitro Model for Human Cancer. In: Current Topics in Radiation Research Quarterly (ed. M. Ebert, A. Howard), Vol. 8, pp. 39–83. Amsterdam: North-Holland 1972.

    Google Scholar 

  • Hahn, G.M., Stewart, J.R., Yang, S.-J., Parker, V.: Chinese Hamster cell monolayer cultures. I. Changes in cell dynamics and modifications of the cell cycle with the period of growth. Exp. Cell Res. 49, 285–292 (1968).

    PubMed  CAS  Google Scholar 

  • Harbers, E., Chadhuri, N.K., Heidelberger, C.: Studies on fluorinated pyrimidines. VIII. Further biochemical and metabolic investigations. J. biol. Chem. 234, 1255–1262 (1958).

    Google Scholar 

  • Harrison, J., Myers, M., Wiley, A., Vermund, H.: Management of Wilms Tumor with particular emphasis on combination treatment with radiation, actinomycin D and vincristine. Int. J. Radiat. Oncol. Biol. Phys. 1, 227–234 (1976).

    PubMed  CAS  Google Scholar 

  • Heidelberger, C., Chaudhuri, N.K., Danneberg, P., Mooren, D., Griesbach, L., Duschins-ki, R., Schmitz, R.J., Pleven, E., Scheiner, J.: Fluorinated pyrimidines, a new class of tumorinhibitory compounds. Nature (Lond.) 179, 663–666 (1957).

    CAS  Google Scholar 

  • Hermens, A.F., Barendsen, G.W.: Changes of cell proliferation kinetics in a rat rhabdomyosarcoma before and after X-irradiation. Europ. J. Cancer 5, 173–189 (1969).

    CAS  Google Scholar 

  • Hermens, A.F.: Variations in the Cell Kinetics and the Growth Rate in an Experimental Tumour during Natural Growth and after Irradiation. Rijswijk: Publication of the Radiobiological Institute, TNO 1973.

    Google Scholar 

  • Hewitt, H.B., Wilson, C.W.: The effect of tissue oxygen tension on the radiosensitivity of leukaemia cells irradiated in situ in the livers of leukaemic mice. Brit. J. Cancer 13, 675–684 (1959).

    PubMed  CAS  Google Scholar 

  • Holthusen, H.: Beiträge zur Biologie der Strahlenwirkung. Untersuchungen an Askarideneinern. Pflügers Arch. ges. Physiol. 187, 1–24 (1921).

    Google Scholar 

  • Holthusen, H.: Erfahrungen über die Verträglichkeitsgrenze für Röntgenstrahlen und deren Nutzanwendung zur Verhütung von Schäden. Strahlentherapie 57, 254–269 (1936).

    Google Scholar 

  • Hornsey, Sh.: The effect of hypoxia on the sensitivity of the epithelial cells of the jejunum. Int. J. Radiat. Biol. 18, 539–546 (1970).

    CAS  Google Scholar 

  • Hornsey, Sh.: Sensitization of hypoxic cells in vivo with triacetonamin-N-oxyl (TAN). Int. J. Radiat. Biol. 22, 91–94 (1972).

    CAS  Google Scholar 

  • Hoshino, T., Nagai, M., Sato, F., Sano, K.: Bromouridine (BUdR) as a Radiosensitizing Agent of Malignant Brain Tumours. In: Radiation Protection and Sensitization (ed. H.L. Moroson, M. Quintiliani), pp. 491–497. London: Taylor & Francis 1970.

    Google Scholar 

  • Howard, A., Pelc, S.R.: Synthesis of DNA in normal and irradiated cells and its relation to chromosome breakage. Heredity 6, 261–273 (1953).

    CAS  Google Scholar 

  • Howes, A.: An estimation of changes in the proportions and absolute numbers of hypoxic cells after irradiation of transplanted C3H mouse mammary tumor. Brit. J. Radiol. 42, 441–447 (1969).

    PubMed  CAS  Google Scholar 

  • Howlett, J.F., Thomlinson, R.H., Alper, T.: A marked dependence of the comparative effectiveness of neutrons on tumour line, and its implications for clinical trials. Brit. J. Radiol. 48, 40–47 (1975).

    PubMed  CAS  Google Scholar 

  • Hug, O.: Medizinische Strahlenkunde. Berlin-Heidelberg-New York: Springer 1974.

    Google Scholar 

  • Hussey, D.H., Fletcher, G.H., Cadero, J.B.: A preliminary report of the MDAH-Tamvec neutron therapy pilot study. In: Radiation Research (eds. O.F. Nygaard, H.J. Adler, W.K. Sinclair), pp. 1106–1117. New York-San Francisco-London: Academic Press 1975.

    Google Scholar 

  • Jüngling, O., Langendorff, H.: Über die Wirkung zeitlich verteilter Dosen auf den Kernteilungsablauf von Vivia faba equina. Strahlentherapie 44, 771–782 (1932).

    Google Scholar 

  • Kaplan, H.S.: Radiosensitization by the Halogenated Pyrimidine Analogues: Laboratory and Clinical Investigations. In: Radiation Protection and Sensitization (ed. H.L. Moroson, M. Quintiliani), pp. 35–42. London: Taylor & Francis 1970.

    Google Scholar 

  • Kellerer, A.M.: Die Wirkung kleiner Strahlendosen. In: Die Strahlenwirkung auf das Lymphsystem (Hrsg. K.H. Kärcher, C. Streffer), S. 1–12. Berlin — Heidelberg — New York: Springer 1974.

    Google Scholar 

  • Kellerer, A.M., Hug, O.: Theory of Dose-effect Relations. In: Handbuch der medizinischen Radiologie (Hrsg. O. Olsson, F. Strnad, H. Vieten, A. Zuppinger), Bd.II/3, S. 1–42. Berlin-Heidelberg-New York: Springer 1972.

    Google Scholar 

  • Kim, J.H., Evans, T.C.: Effects of X-irradiation on the mitotic cycle of Ehrlich ascites tumor cells. Radiat. Res. 21, 129–143 (1964).

    PubMed  CAS  Google Scholar 

  • Kirk, J., Gray, W.M., Watson, E.R.: Cumulative radiation effect. Part V: Time gaps in treatment regimes. Clin. Radiol. 26, 159–176 (1975).

    Google Scholar 

  • Kriss, J.P., Maruyama, U., Tung, L.A., Bond, S.B., Revesz, L.: The fate of 5-bromode-oxyuridine, 5-bromodeoxycytidine, and 5-iododeoxycytidine in man. Cancer Res. 23, 260–268 (1963).

    PubMed  CAS  Google Scholar 

  • Krönig, S., Friedrich, W.: Physikalische und biologische Grundlagen der Strahlentherapie. Sonderband Strahlentherapie 1918.

    Google Scholar 

  • Lajtha, L.G.: Radiation effects on steady-state cell populations. Radiat. Res. 33, 659–669 (1968).

    PubMed  CAS  Google Scholar 

  • Lajtha, L.G., Oliver, R., Kumatori, T., Ellis, F.: On the mechanism of radiation effects on DNA-synthesis. Radiat. Res. 8, 1–16 (1958).

    PubMed  CAS  Google Scholar 

  • Lamerton, L.F.: Cell proliferation and the differential response of normal and malignant tissues. Brit. J. Radiol. 45, 161–170 (1972).

    PubMed  CAS  Google Scholar 

  • Langendorff, H.: Zum cyclischen AMP—Mechanismus bei der Wirkung von Strahlen-schutzsubstanzen. Naturwissenschaften 57, 455 (1970).

    PubMed  CAS  Google Scholar 

  • Leith, J.T., Lewinsky, B.S., Schilling, W.A.: Modification of mouse skin to X-irradiation by bleomycin treatment. Radiat. Res. 61, 100–109 (1975).

    PubMed  CAS  Google Scholar 

  • Lesher, S., Frey, R.J.M., Sacher, A.: Effects of chronic 7-irradiation on the generation cycle of the mouse duodenum. Exp. Cell Res. 25, 398–404 (1961).

    PubMed  CAS  Google Scholar 

  • Linden, W.A., Zywitz, F., Landen, H., Wendt, C.: Synchronisation des Teilungszyklus von L-Zellen in der G2 -Phase durch fraktionierte Röntgenstrahlung und Daunomy-cin. Strahlentherapie 146, 216–225 (1973).

    PubMed  CAS  Google Scholar 

  • Littbrand, B., Revesz, L.: The effect of oxygen on cellular survival and recovery after radiation. Brit. J. Radiol. 42, 914–924 (1969).

    PubMed  CAS  Google Scholar 

  • Little, J.B.: Irradiation of primary human amnion cell cultures: Effects on DNA-synthesis and progression through the cell cycle. Radiat. Res. 44, 674–699 (1970).

    PubMed  CAS  Google Scholar 

  • Little, J.B.: Repair of potentially-lethal radiation damage in mammalian cells: enhancement by conditioned medium from stationary cultures. Int. J. Radiat. Biol. 20, 87–92(1971).

    CAS  Google Scholar 

  • Lomakina, L.J., Zhilina, M.V., Sagdeeva, L.G.: The action of 5-fluoro-2’-deoxyuridine and aminopterin on the mitotic cycle events in the culture of Chinese Hamster cells. Cytology 9, 1155–1159 (1967).

    CAS  Google Scholar 

  • Malaise, E., Chavandra, N., Tubiana, M.: The relationship between growth labelling index and histological type of human solid tumours. Europ. J. Cancer 9, 305–312 (1973).

    CAS  Google Scholar 

  • Malaise, E.P., Charbit, A., Chavandra, N., Combes, P.F., Douchez, J., Tubiana, M.: Change in volume of irradiated human metastases. Investigation of sublethal damage and tumour repopulation. Brit. J. Cancer 26, 43–52 (1972).

    PubMed  CAS  Google Scholar 

  • Melching, H.-J., Streffer, C.: Zur Beeinflussung der Strahlenempfindlichkeit von Säugetieren durch chemische Substanzen. In: Fortschritte der Arzneimittelforschung (Hrsg. E. Jucker), Bd. 9, S. 11–128. Basel — Stutgart: Birkhäuser 1966.

    Google Scholar 

  • Michael, B.D., Adams, G.E., Hewitt, H.B., Jones, W.G.B., Watts, M.E.: A post-effect of oxygen in irradiated bacteria: Asub-milli-second fast mixing study. Radiat. Res. 54, 239–251 (1973).

    PubMed  CAS  Google Scholar 

  • Mohler, W.C., Elkind, M.M.: Radiation response of mammalian cells grown in culture. III. Modification of X-rays survival of Chinese Hamster cells by 5-bromodeoxyuri-dine. Exp. Cell Res. 30, 481–491 (1963).

    CAS  Google Scholar 

  • Nitze, H.R., Ganzer, U., Vosteen, K.H.: Die Strahlenbehandlung maligner Tumoren nach Synchronisation des Zellteilungsrhythmus. Erfahrungen nach zweijähriger klinischer Anwendung. Strahlentherapie 143, 329–337 (1972).

    PubMed  CAS  Google Scholar 

  • Olive, P.L., Inch, W.R., Sutherland, R.M.: The effect of triacetonamin-N-oxyl on oxygenation and radiocurability of mouse mammary carcinoma. Radiat. Res. 52, 618 – 626 (1972).

    PubMed  CAS  Google Scholar 

  • Painter, R.B., Cleaver, J.E.: Repair replication, unscheduled DNA synthesis and the repair of mammalian DNA. Radiat. Res. 37, 451–466 (1969).

    PubMed  CAS  Google Scholar 

  • Parker, L., Skarsgard, L.D., Emmerson, P.T.: Sensitization of anoxic mammalian cells to X-rays by triacetoneamine N-oxyl. Survival and toxicity studies. Radiat. Res. 38, 493–500 (1969).

    PubMed  CAS  Google Scholar 

  • Phillips, R.A., Tolmach, L.J.: Repair of potentially lethal damage in X-irradiated HeLa cells. Radiat. Res. 29, 413–432 (1966).

    PubMed  CAS  Google Scholar 

  • Porschen, W., Feinendegen, L.E.: Biologische In-vivo-Dosimetrie von 15 MeV-Neutro-nen bei normalen und Tumorzellen-Zellmarkierung mit Jod-125-Desoxyuridin. Strahlentherapie 145, 27–38 (1973).

    PubMed  CAS  Google Scholar 

  • Powers, W.E., Tolmach, L.J.: A multicomponent X-ray survival curve for mouse lymphosarcoma cells irradiated in vivo. Nature (Lond.) 197, 710–711 (1963).

    CAS  Google Scholar 

  • Puck, T.T., Marcus, P.J.: Action of X-rays on mammalian cells. J. exp. Med. 103, 653–660 (1956).

    PubMed  CAS  Google Scholar 

  • Puck, T.T., Steffen, J.: Life cycle analysis of mammalian cells. I. A method for localizing metabolic events within the life cycle, and its application to the action of colce-mide and sublethal doses of X-irradiation. Biophys. J. 3, 379–397 (1963).

    PubMed  CAS  Google Scholar 

  • Rauth, A.M., Kaufman, K., Thomson, J.E.: In vivo testing of hypoxic cell radiosensi-tizers. In: Radiation Research (eds. O.F. Nygaard, H.J. Adler, W.K. Sinclair), pp. 761 – 772. New York-San Francisco-London: Academic Press 1975.

    Google Scholar 

  • Reddy, S.B., Erbe, W., Linden, W.A., Landen, H., Baigent, C.: Die Dauer der Phasen im Cellcyclus von L-929-Zellen. Vergleich von impulsphotometrischen und autoradiographischen Messungen. Biophysik 10, 45–50 (1973).

    PubMed  CAS  Google Scholar 

  • Regaud, C.: Distribution chronologique rationnelle d’un traitement de cancer épithélial par les radiations. C.R. Soc. Biol. (Paris) 86, 1085–1088 (1922).

    Google Scholar 

  • Reinhold, H.S., Jovanovic, D., Keyeux, A., Maisin, JR., Dunjic, A.: The Influence of Radiation on Blood Vessels and Circulation. In: Current Topics in Radiation Research Quarterly, Vol. 10 (ed. M. Ebert, A. Howard), pp. 1–198. Amsterdam: North-Holland 1974.

    Google Scholar 

  • Rogers, C.: The middle atlantic neutron therapy trial. In: Radiation Research (eds. O.F. Nygaard, HJ. Adler, W.K. Sinclair), pp. 1092–1105. New York-San Francisco-London: Academic Press 1975.

    Google Scholar 

  • Scherer, E., Stender, H.-St.: Strahlenpathologie der Zelle. Stuttgart: Thieme 1963.

    Google Scholar 

  • Shirakawa, S., Luce, J.K., Tannock, J.F., Frei, J.E.: Cell proliferation in human melanoma. J. clin. Invest. 49, 1188–1199 (1970).

    PubMed  CAS  Google Scholar 

  • Sinclair, W.K.: Cyclic-X-rays responses in mammalian cells in vitro. Radiat. Res. 33, 620–643 (1968).

    PubMed  CAS  Google Scholar 

  • Steel, G.G.: Cell loss from experimental tumours. Cell Tissue Kinet. 1, 193–207 (1968).

    Google Scholar 

  • Stellwagen, R.H., Tomkins, G.M.: Preferential inhibition by 5-bromodeoxyuridine of the hepatoma cell cultures. J. molec. Biol. 56, 167–182 (1971).

    PubMed  CAS  Google Scholar 

  • Strandqvist, M.: Studien über die kumulative Wirkung der Röntgenstrahlen bei Fraktionierung. Acta Radiol. (Stockh.) Suppl. 55, (1944).

    Google Scholar 

  • Streffer, C.: Strahlen-Biochemie. Heidelberger Taschenbücher 59/60. Berlin-Heidelberg — New York: Springer 1969.

    Google Scholar 

  • Streffer, C.: DNA-synthesis in the spleen of mice after whole-body X-irradiation and its modification by 5-hydroxytryptamine and NADH. Int. J. Radiat. Biol. 25, 425–435 (1974).

    CAS  Google Scholar 

  • Streffer, C., Beisel, P.: Radiation effects on NAD- and DNA-metabolism in mouse spleen. FEBS Letters 44, 127–130 (1974).

    PubMed  CAS  Google Scholar 

  • Streffer, C., Flügel, M.: Der Strahlenschutzeffekt des 5-Hydroxytryptamins und 5-Methoxytryptamins in Kombination mit einer kurzzeitigen Hypoxie. Strahlentherapie 146, 444–449 (1973).

    PubMed  CAS  Google Scholar 

  • Streffer, C., Schafferus, S.: The induction of liver enzymes by Cortisol after combined treatment of mice with X-irradiation and inhibitors of protein synthesis. Int. J. Radiat. Biol. 20, 301–313 (1971).

    CAS  Google Scholar 

  • Streffer, C., Schweiger, K.: Zur biochemischen Wirkung einiger strahlensensibilisieren-der Substanzen. Strahlentherapie 143, 244–254 (1972).

    PubMed  CAS  Google Scholar 

  • Streffer, C., Schriever, H.: Wirkung von 5-BUdR auf die strahlenbedingte Hemmung der DNA-Synthese in der Milz von Mäusen (unveröffentlichte Ergebnisse).

    Google Scholar 

  • Suit, H.D.: Radiation Biology: A Basis for Radiotherapy. In: Textbook of Radiotherapy (ed. G.H. Fletcher), 2nd edition, pp. 75–121. Philadelphia: Lea Febiger 1973.

    Google Scholar 

  • Suit, H.D., Gallager, H.S.: Intact tumor cells in irradiated tissue. Arch. Path. 78, 648–651 (1964).

    PubMed  CAS  Google Scholar 

  • Suit, H.D., Hewitt, R., Urano, M.: Effect of radiation-sentitizing agents in radiation therapy of mouse mammary carcinoma. Radiology 94, 189–195 (1970).

    PubMed  CAS  Google Scholar 

  • Suit, H.D., Maeda, M.: Hyperbaric oxygen and radiobiology of C3H mouse mammary carcinoma. Amer. J. Roentgenol. 96, 177–192 (1966).

    PubMed  CAS  Google Scholar 

  • Suit, H.D., Maeda, M.: Hyperbaric oxygen and radiobiology of C3H mouse mammary carcinoma. J. nat. Cancer Inst. 39, 639–650 (1967).

    PubMed  CAS  Google Scholar 

  • Szybalski, W.: Molecular events resulting in radiation injury, repair and sensitization of DNA. Radiat. Res. Suppl. 7, 147–159 (1967).

    PubMed  CAS  Google Scholar 

  • Tannock, J.F.: Oxygen diffusion and distribution of cellular radiosensitivity in tumor J. nat. Cancer Inst. (im Druck), (zit. nach Suit, 1973).

    Google Scholar 

  • Terasima, T., Tolmach, L.J.: Variation in several responses of HeLa cells to X-irradiation during the division cycle. Biophys. J. 3, 11–33 (1963).

    PubMed  CAS  Google Scholar 

  • Thomlinson, R.H.: Changes in Oxygenation in Tumours in Relation to Irradiation. In: Frontiers of Radiation Therapy and Oncology (ed. J.M. Vaeth), Vol. 3, pp. 109–121. Basel-München—Paris—London-New York—Sydney: Karger 1968.

    Google Scholar 

  • Thomlinson, R.H.: The oxygen effect and radiotherapy with fast neutrons. Europ. J. Cancer 7, 139–144 (1971).

    CAS  Google Scholar 

  • Thomlinson, R.H., Craddock, E.A.: The gross response of an experimental tumour to single doses of X-rays. Brit. J. Cancer 21, 108–136 (1967).

    PubMed  CAS  Google Scholar 

  • Thomlinson, R.H., Gray, L.H.: The histological structure of some human lung cancers and possible implications for radiotherapy. Brit. J. Cancer 9, 539–549 (1955).

    PubMed  CAS  Google Scholar 

  • Thompson, L.H., Suit, H.D.: Proliferation kinetics of X-irradiated mouse L-cells studies with time-lapse photography. Int. J. Radiat. Biol. 15, 347–362 (1969).

    CAS  Google Scholar 

  • Till, J.E., McCulloch, E.A.: A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat. Res. 14, 213–222 (1961).

    PubMed  CAS  Google Scholar 

  • Town, Ch.D., Smith, K.C., Kaplan, H.S.: Repair of X-ray damage to bacterial DNA. Curr. Topics in Radiat. Res. Quarterly 8, 351–399 (1973).

    CAS  Google Scholar 

  • Trott, K.-R.: Strahlenwirkung auf die Vermehrung von Säugetierzellen. In: Handbuch der medizinischen Radiologie (Hrsg. L. Diethelm, F. Heuck, O. Olsson, K. Ranniger, F. Strnad, H. Vieten, A. Zuppinger), Bd.II/3, S. 43–125. Berlin—Heidelberg—New York: Springer 1972.

    Google Scholar 

  • Trott, K.-R.: Strahlenbiologische Grundlagen der Strahlentherapie unter besonderer Berücksichtigung der Therapie mit Korpuskularstrahlen. Strahlentherapie 148, 451–462 (1974).

    PubMed  CAS  Google Scholar 

  • Tubiana, M.: The kinetics of tumor cell proliferation and radiotherapy. Brit. J. Radiol. 44, 325–347 (1971).

    PubMed  CAS  Google Scholar 

  • Tubiana, M.: Clinical Data and Radiobiological Bases for Radiotherapy. In: Current Topics of Radiation Research Quarterly (ed. M. Ebert, A. Howard), Vol. 9, pp. 109–118. Amsterdam: North-Holland 1973.

    Google Scholar 

  • Wacker, A., Trebst, A., Jacherts, D., Weygandt, F.: Über den Einbau von 5-Bromuracil-(2–14C) in die Desoxyribonucleinsäure verschiedener Bakterien. Z. Naturforsch. 9b, 616–617 (1954).

    CAS  Google Scholar 

  • Walters, R.A., Petersen, D.F.: Radiosensitivity of mammalian cells. I. Timing and dosedependence of radiation-induced division delay. Biophys. J. 8, 1475–1486 (1968).

    PubMed  CAS  Google Scholar 

  • Wharam, M.D., Phillips, Th.L., Kane, L., Utley, J.F.: Response of murine solid tumor to in vivo combined chemotherapy and irradiation. Radiology 109, 451–455 (1973).

    PubMed  CAS  Google Scholar 

  • Wideröe, R. : Various Examples from Cellular Kinetics Showing how Radiation Quality Can Be Analysed and Calculated by the Two-Component Theory of Radiation. In: Biophysical Aspects of Radiation Quality, pp. 311–329. Wien: International Atomic Energy Agency 1971.

    Google Scholar 

  • Wideröe, R.: Problems and trends in radiotherapeutic treatment of deep-seated tumors. Radiol. clin. 44, 112–141 (1975).

    Google Scholar 

  • Winston, B.M., Ellis, F., Hall, E.J.: The Oxford NSD calculator for clinical use. Clin. Radiol. 20, 8–11 (1969).

    PubMed  CAS  Google Scholar 

  • Withers, H.R.: Lethal and sublethal cellular injury in multifraction irradiation. Europ. J.Cancer 11, 581–583 (1975a).

    CAS  Google Scholar 

  • Withers, H.R.: Response of the jejunum to neutrons. Cancer (1975b, in press).

    Google Scholar 

  • Zamenhof, S., Griboff, G.: Incorporation of halogenated pyrimidines into the deoxyribonucleic acids of bacterium E. coli and its bacteriophages. Nature (Lond.) 174, 306–307 (1954).

    CAS  Google Scholar 

  • Zimmer, K.G., Müller, A.: New Light on Radiation Biology from Electron Spin Resonance Studies. In; Current Topics in Radiation Research (ed. M. Ebert, A. Howard), Vol. 1, pp. 1–48. Amsterdam: North-Holland 1965.

    Google Scholar 

Download references

Authors
  1. C. Streffer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Radiologisches Zentrum, Strahlen- und Poliklinik, Universitätsklinikum Essen, Hufelandstr. 55, 4300, Essen, Deutschland

    Eberhard Scherer

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Streffer, C. (1976). Biologische Grundlagen der Strahlentherapie. In: Scherer, E. (eds) Strahlentherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96346-9_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-96346-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-07772-5

  • Online ISBN: 978-3-642-96346-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation