What is dilated cardiomyopathy?
Cardiomyopathies are diseases of the myocardium with cardiac dysfunction not due to specific causes such as hypertension, congenital, valvular, coronary, arterial, or pericardial abnormalities. According to the definition of the WHO, primary cardiomyopathies are classified as dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, and arrhythmogenic right ventricular cardiomyopathy (18). Dilated cardiomyopathy is the most common cause of chronic heart failure. The involved pathogenetic mechanisms, the incidence and exact time course of the disease are yet unknown. It may be idiopathic or familial/genetic although specific causes such as a viral and/or (auto)immune involvement of the heart have been recognized as a possible cause of the disease.
KeywordsDilate Cardiomyopathy Endomyocardial Biopsy Viral Myocarditis Viral Persistence Acute Myocarditis
Unable to display preview. Download preview PDF.
- 9.Kühl U, Noutsias M, Seeberg B, Schannwell M, Welp LB, Schultheiß H-P Strauer BE Chronic inflammation in the myocardium of patients with clinically suspected dilated cardiomyopathy. J Heart Failure (January 1994), 231–245Google Scholar
- 10.Kühl U, Schultheiß H-P, Strauer BE (1994) Methylprednisolone in chronic myocarditis. Postgrad. Med. J. 70; S35-S42Google Scholar
- 15.Mason JW, O’Connel JB, Herskowitz A (1994) and the Myocarditis Treatment Trial Investigators. A clinical trial of immunosuppressive therapy for myocarditis. N Engl J Med; 321: 1061–1068Google Scholar
- 18.Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on The Definition and Classification of Cardiomyopathies. Circulation 1996; 93: 841–842Google Scholar
- 23.Steenbergen C, Kolbeck PC, Wolfe JA, Anthony RM, Sanfilippo FP, Jennings RB (1986) Detection of lymphocytes in endomyocardium using immunohistochemical techniques. Relevance to evaluation of endomyocardial biopsies in suspected cases of lymphocytic myocarditis. J Appl Cardiol; 1:63–73Google Scholar