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The influence of neuropeptides and methylphenidate on evoked potentials in autistic and hyperkinetic children

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Neuroimaging in child neuropsychiatric disorders
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Abstract

Neuropsychological studies suggest evidence that autistic and attention deficit disordered (ADHD) children suffer from attention and information processing deficits (Kootz et al., 1981; Prior, 1987; Corkum and Siegel, 1995). Autistic and ADHD children show deficits in particular on dichotic listening tasks, continuous performance tasks and so-called “frontal tasks” (Pennington and Ozonoff, 1996).

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References

  • Bailey K, Perros P, Price G (1993) ERP changes after a single dose of methylphenidate on a visual continuous performance task. Biol Psychol 37: 45

    Article  Google Scholar 

  • Berman S, Friedman D (1995) The development of selective attention as reflected by event-related brain potentials. J Exp Child Psychol 59: 1–31

    Article  PubMed  CAS  Google Scholar 

  • Born J, Kern W, Pietrowsky R, Sittig W, Fehm HL (1989) Fragments of ACTH affect electrophysiological signs of controlled processing in humans. Psychopharmacology 99: 439–444

    Article  PubMed  CAS  Google Scholar 

  • Buitelaar JK, Van Engeland H, De Kogel FH, De Vries H, Van Hooff J, Van Ree JM (1992) The adrenocorticotropic hormone (4-9) analog ORG-2766 benefits autistic children: report on a second controlled clinical trial. J Am Acad Child Adolesc Psychiat 31: 1149–1156

    Article  CAS  Google Scholar 

  • Buitelaar JK, Van Engeland H, Van Ree JM, De Wied D (1990) Behavioral effects of ORG-2766, a synthetic analog of the adrenocorticotropic hormone (4-9) analog, in 14 outpatient autistic children. J Autism Dev Disord 20: 467–478

    Article  PubMed  CAS  Google Scholar 

  • Coons HW, Klorman R, Borgstedt AD (1987) Effects of methylphenidate on adolescents with a childhood history of attention deficit disorder. II. Information processing. J Am Acad Child Adolesc Psychiat 26: 368–374

    Article  CAS  Google Scholar 

  • Corkum PV, Siegel LS (1993) Is the continuous performance task a valuable research tool for use with children with Attention Deficit Hyperactivity Disorder? J Child Psychol Psychiat 34: 1217–1239

    Article  PubMed  CAS  Google Scholar 

  • Courchesne E, Lincoln A J, Kilman BA, Galambos R (1985) Event-related brain correlates of the processing of novel visual and auditory information processing in autism. J Autism Dev Disord 15: 55–76

    Article  PubMed  CAS  Google Scholar 

  • Courchesne E, Kilman BA, Galambos R, Lincoln AJ (1984) Autism: processing of novel auditory information assessed by event-related potentials. Electroencephalogr Clin Neurophysiol 59: 238–248

    Article  PubMed  CAS  Google Scholar 

  • Courchesne E, Lincoln AJ, Yeung-Courchesne R, Elmasian R, Grillon C (1989) Pathophysiologic findings in non-retarded autism and receptive developmental disorder. J Autism Dev Disord 19: 1–17

    Article  PubMed  CAS  Google Scholar 

  • Courchesne E (1978) Neurophysiological correlates of cognitive development: changes in long-latency event-related potentials from childhood to adulthood. Electroencephalogr Clin Neurophysiol 45: 468–482

    Article  PubMed  CAS  Google Scholar 

  • Dawson G, Finley C, Phillips S, Galpert L, Lewy A (1988) Reduced P3 amplitude of the event-related brain potential: its relationship to language ability in autism. J Autism Dev Disord 18: 493–504

    Article  PubMed  CAS  Google Scholar 

  • Donchin E (1981) Psychophysiology 18: 493–513

    Article  PubMed  CAS  Google Scholar 

  • Fitzpatrick PA, Klorman R, Brumaghim JT, Borgstedt AD (1992) Effects of sustained release and standard preparations of methylphenidate on attention deficit disorder. J Am Acad Child Adolesc Psychiat 31: 226–234

    Article  CAS  Google Scholar 

  • Frank Y (1993) Visual event related potentials after methylphenidate and sodium valproate in children with attention deficit hyperactivity disorder. Clin Electroencephalogr 24: 19–23

    PubMed  Google Scholar 

  • Halliday R, Rosenthal JH, Naylor H, Callaway E (1976) Averaged evoked potential predictors of clinical improvement in hyperactive children treated with methylphenidate: An initial study and replication. Psychophysiology 13: 429–440

    Article  PubMed  CAS  Google Scholar 

  • Hillyard SA, Hink RF, Schwent VL, Picton TW (1973) Electrical signs of selective attention in the human brain. Science 182: 177–180

    Article  PubMed  CAS  Google Scholar 

  • Holcomb PJ, Ackerman PT, Dykman RA (1986) Auditory event-related potentials in attention and reading disabled boys. Int J Psychophysiol 3: 263–273

    Article  PubMed  CAS  Google Scholar 

  • Holcomb PJ, Ackerman PT, Dykman RA (1985) Cognitive event-related brain potentials in children with attention and reading deficits. Psychophysiology 22: 656–667

    Article  PubMed  CAS  Google Scholar 

  • Jonkman LM, Kemner C, Verbaten MN, Koelega HS, Camfferman G, Van der Gaag R, Buitelaar JK, Van Engeland H (1997) Effects of methylphenidate on event-related potentials and performance of attention deficit hyperactivity disorder children in auditory and visual selective attention tasks. Biol Psychiat 41: 690–702

    Article  PubMed  CAS  Google Scholar 

  • Kemner C, Verbaten MN, Cuperus J, Camfferman G, Slangen JL, Van Engeland H (1994) Visual and somatosensory event-related brain potentials in autistic children and three different control groups. Electroencephalogr Clin Neurophysiol 92: 225–237

    Article  PubMed  CAS  Google Scholar 

  • Kemner C, Verbaten MN, Cuperus JM, Camfferman G, Van Engeland H (1995) Auditory event-related brain potentials in autistic children and three different control groups. Biol Psychiat 38: 150–165

    Article  PubMed  CAS  Google Scholar 

  • Kemner C, Verbaten MN, Koelega HS, Buitelaar JK, van der Gaag RJ, Camfferman G, van Engeland H (1996) Event-related brain potentials in children with attention deficit and hyperactivity disorder (ADDH): effects of stimulus deviancy and task relevance in the visual and auditory modality. Biol Psychiat

    Google Scholar 

  • Kenemans JL, Verbaten MN, Melis CJ, Slangen JL (1992) Visual stimulus change and the orienting reaction: event-related potential evidence for a two stage process. Biol Psychol 33: 97–114

    Article  PubMed  CAS  Google Scholar 

  • Klorman R, Salzman LF, Pass HL, Borgstedt AD, Dainer KB (1979): Effect of methylphenidate on hyperactive children’s evoked responses during passive and active attention. Psychophysiology 16: 23–29

    Article  PubMed  CAS  Google Scholar 

  • Klorman R, Salzman LF, Bauer LO, Coons HW, Borgstedt AD, Halpern WI (1983) Effects of two doses of methylphenidate on cross situational and borderline hyperactive children’s evoked potential. Electroencephalogr Clin Neurophysiol 56: 169–185

    Article  PubMed  CAS  Google Scholar 

  • Klorman R, Brumaghim JT, Salzman LF, Strauss J, Borgstedt AD, McBride MC, Loeb S (1990) Effects of methylphenidate on processing negatives in patients with attention deficit hyperactivity disorder. Psycholphysio-logy 27: 328–337

    CAS  Google Scholar 

  • Klorman R, Brumaghim JT, Fitzpatrick PA, Borgstedt AD, Strauss J (1994) Clinical and cognitive effects of methylphenidate on children with attention deficit disorder as a function of aggresion oppositionality and age. J Abn Psychol 103: 206–221

    Article  CAS  Google Scholar 

  • Lincoln AJ, Courchesne E, Harms L, Allen M (1993) Contextual probability evaluation in autistic, receptive developmental disorder and control children: event-related potential evidence. J Autism Dev Disord 23: 37–58

    Article  PubMed  CAS  Google Scholar 

  • Loiselle D, Stamm JS, Maitinsky S, Whipple SC (1980) Evoked potential and behavioral signs of attentive dysfunctions in hyperactive boys. Psychophysiology 17:193–201

    Article  PubMed  CAS  Google Scholar 

  • Michael RL, Klorman R, Salzman F, Borgstedt AD, Dainer KB (1981) Normalizing effects of methylphenidate on hyperactive children’s vigilance performance and evoked potentials. Psychophysiology 18: 663–677

    Article  Google Scholar 

  • Michael RL, Klorman R, Salzman F, Borgstedt AD, Dainer KB (1981) Normalizing effects of methylphenidate on hyperactive children’s vigilance performance and evoked potentials. Psychophysiology 18: 663–677

    Article  Google Scholar 

  • Näätänen R (1990) The role of attention in auditory information processing as revealed by event-related potentials and other brain measures of cognitive functioning. Behav Brain Sci 13: 201–288

    Article  Google Scholar 

  • Novak GP, Solanto M, Abikoff H (1995) Spatial orienting and focused attention in attention deficit hyperactivity disorder. Psychophysiology 32: 546–559

    Article  PubMed  CAS  Google Scholar 

  • Oades RD, Walker MK, Geffe LB, Stern LM (1988) Event-related potentials in autistic and healthy children on an auditory choice reaction time test. Int J Psychophysiol 6: 25–37

    Article  PubMed  CAS  Google Scholar 

  • Pennington BF, Ozonoff S (1996) Executive functions and developmental psychopathology. J Child Psychol Psy-chiat 1: 51–87

    Article  Google Scholar 

  • Polich J, Kok A (1995) Cognitive and biological determinants of P300: an integrative review. Biol Psychol 41: 103–146

    Article  PubMed  CAS  Google Scholar 

  • Prior MR (1987) Biological and neuropsychological approaches to childhood autism. British J Psychiat 150: 8–17

    Article  CAS  Google Scholar 

  • Pritchard WS, Raz N, August GJ (1987) Visual augmenting/ reducing and P30o in autistic children. J Autism Dev Disord 17: 231–242

    Article  PubMed  CAS  Google Scholar 

  • Robaey P, Breton F, Dugas M, Renault B (1992) An event-related potential study of controlled and automatic processes in 6-8 year old boys with attention deficit hyperactivity disorder. Electroencephalogr Clin Neuro-physiol 82: 330–340

    Article  CAS  Google Scholar 

  • Satterfield JH, Schell AM, Nicholas TW, Satterfield BT, Freese TH (1990) Ontogeny of selective attention effects on event-related potentials in attention deficit hyperactivity disorder and normal boys. Biol Psychiat 28: 879–903

    Article  PubMed  CAS  Google Scholar 

  • Satterfield JH, Schell AM, Nicholas T, Backs RW (1988) Topographic study of auditory event-related potentials in normal boys and boys with attention deficit disorder with hyperactivity. Psychophysiology 25: 591–606

    Article  PubMed  CAS  Google Scholar 

  • Syrigou-Papavasiiiou A, Lycaki H, LeWitt PA, Verma NP, Spivak D, Chayasirisobhon S (1988) Dose response effects of chronic methylphenidate administration on late event-related potentials in attention deficit disorder. Clin Electroencephalogr 19: 129–133

    Google Scholar 

  • Taylor MJ (1988) Developmental changes in ERPs to visual language stimuli. Biol Psychol 26: 321–338

    Article  PubMed  CAS  Google Scholar 

  • Taylor MJ, Voros JG, Logan WJ, Malone MA (1993) Changes in event-related potentials with stimulant medication in children with attention deficit hyperactivity disorder. Biol Psychol 36: 139–156

    Article  PubMed  CAS  Google Scholar 

  • Verbaten MN, Roelofs JW, Sjouw W, Slangen JL (1986) Different effects of uncertainty and complexity on single trial visual ERPs and the SCR-OR in non signal conditions. Psychophysiology 23: 254–262

    Article  PubMed  CAS  Google Scholar 

  • Verbaten MN, Roelofs JW, Van Engeland H, Kenemans JL, Slangen JL (1991) Abnormal visual event-related potentials of autistic children. J Autism Dev Disord 21: 449–470

    Article  PubMed  CAS  Google Scholar 

  • Verbaten MN, Kemner C, Buitelaar JK, Van Ree JM, Van Beijsterveld CEM, Van Engeland H (1996) Effects of ORG-2766 on brain event-related potentials of autistic children. Psychiat Res 63: 33–45

    Article  CAS  Google Scholar 

  • Verbaten MN, Overtoom CCE, Koelega HS, Swaab-Barne-veld H, Van der Gaag RJ, Buitelaar JK, Van Engeland H (1994) Methylphenidate influences both early and late ERP waves of ADHD children in a continuous performance test. J Abn Child Psychol 22: 1–18

    Article  Google Scholar 

  • Wickens C, Kramer A, Vanasse L, Donchin E (1983) Performance of concurrent tasks: A psychophysiological analysis of the reciprocity of information processing resources. Science 221: 1080–1082

    Article  PubMed  CAS  Google Scholar 

  • Winsberg BG, Javitt DC, Shanahan Silipo G, Doneshka MD (1993) Mismatch negativity in hyperactive children: effects of methylphenidate. Psychopharmacol Bull 29: 229–233

    PubMed  CAS  Google Scholar 

  • Wolterink G, Van Ree JM (1989) Opioid systems in the amygdala can serve as substrate for the behavioral effects of the ACTH 4-9 analog ORG-2766. Neuropeptides 14: 129–136

    Article  PubMed  CAS  Google Scholar 

  • Zambelli AJ, Stamm JS, Maitinsky S, Loiselle DL (1977) Auditory evoked potentials and selective attention in formerly hyperactive adolescent boys. Am J Psychiat 134: 742–747

    PubMed  CAS  Google Scholar 

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© 1998 Springer-Verlag Berlin Heidelberg

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Van Engeland, H., Verbaten, M.N., Jonkman, L., Kemner, C. (1998). The influence of neuropeptides and methylphenidate on evoked potentials in autistic and hyperkinetic children. In: Neuroimaging in child neuropsychiatric disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95848-9_20

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  • DOI: https://doi.org/10.1007/978-3-642-95848-9_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-95850-2

  • Online ISBN: 978-3-642-95848-9

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