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31P Magnetic resonance spectroscopy and its application to autism and brain development

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Neuroimaging in child neuropsychiatric disorders

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Abstract

Magnetic resonance spectroscopy (MRS) is a powerful non invasive technique for investigating the molecular metabolic underpinning of brain disorders which involve abnormalities in the development, remodeling, or turnover of neuronal membranes. MRS of the naturally-occurring phosphorus isotope (31P)is ideally suited to the study of such disorders, because of its capacity for directly measuring brain membrane production and degradation, and the bio-energetics that support normal neuronal function. MRS furthermore relies on naturally occurring isotopes and the same nuclear magnetic resonance principles as magnetic resonance imaging (MRI),making repeated studies and studies of children both possible and safe.

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Authors
  1. N. J. Minshew
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  2. J. W. Pettegrew
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© 1998 Springer-Verlag Berlin Heidelberg

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Minshew, N.J., Pettegrew, J.W. (1998). 31P Magnetic resonance spectroscopy and its application to autism and brain development. In: Neuroimaging in child neuropsychiatric disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95848-9_17

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  • DOI: https://doi.org/10.1007/978-3-642-95848-9_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-95850-2

  • Online ISBN: 978-3-642-95848-9

  • eBook Packages: Springer Book Archive

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