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Ewing’s sarcoma, neuroepithelioma and Askin’s tumour

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Pathology of bone tumours

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Abstract

In 1921, Ewing distinguished among round-cell sarcomas a tumour of particularly grave prognosis which he regarded as an endothelioma of bone. Over the decades, discussions on the histiogenesis of this tumour have not provided an unequivocal answer to its origin, and the term “Ewing’s sarcoma” without reference to the origin of the cell, has been generally accepted.

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References

  • Ambros IM, Ambros PF, Strehl S, Kovar H, Gadner H, SalzerKuntschik M (1991) MIC2 is a specific marker for Ewing’s sarcoma and peripheral primitive neuroectodermal tumors: evidence for a common histogenesis of Ewing’s sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. Cancer 67: 1886–1893

    Article  PubMed  CAS  Google Scholar 

  • Angervall L, Enzinger FM (1975) Extraskeletal neoplasm resembling Ewing’s sarcoma. Cancer 36: 240–251

    Article  PubMed  CAS  Google Scholar 

  • Askin FB, Rosai J, Sibley RK, Dehmer LP, McAlister HW (1979) Malignant small cell tumor of the thoracopulmonary region in childhood. A distinctive clinicopathologic entity of uncertain histogenesis. Cancer 43: 2438–2451

    CAS  Google Scholar 

  • Aurias A (1988) Données cytogénétiques dans les sarcomes des os et des tissus mous. Bull Cancer 75: 423–429

    PubMed  CAS  Google Scholar 

  • Aurias A, Rimbaud C, Buffe d, Zucker IM, Mazabraud A (1984) Translocation involving chromosome 22 in Ewing’s sarcoma. A cytogenetic study of four fresh tumors. Cancer Genet Cyto 12: 21–25

    Article  CAS  Google Scholar 

  • Aurias A, Rimbaut C, Buffe D, Dubousset J, Mazabraud A (1983) Translocation du chromosome 22 dans le sarcome d’Ewing. CR Acad Sc Paris 296: 1105–1107

    CAS  Google Scholar 

  • Aurias A, Rimbaut C, Buffe D, Dubousset J, Mazabraud A (1983) Chromosomal translocation in Ewing’s sarcoma. N Engl J Med 309, 8: 496–498

    Google Scholar 

  • Bator SM, Bauer TW, Marks KE, Norris DG (1986) Periosteal Ewing’s sarcoma. Cancer 58: 1781–1784

    Article  PubMed  CAS  Google Scholar 

  • Becroft DMO, Pearson A, Shaw RL, Zwi LG (1984) Chomosomal translocation in extraskeletal Ewing’s tumor. Lancet 8399, 2: 400

    Article  Google Scholar 

  • Bolen JW, Thorning D (1980) Peripheral neuroepithelioma: a light and electron microscopic study. Cancer 46: 2456–2462

    Article  PubMed  CAS  Google Scholar 

  • Bouziani A, Ben Rejeb A, Mazabraud A, Jagueux M, Orcel L (1987) Le sarcome Ewing. Etude rétrospective de 1o8 cas avec revue de la littérature. Arch Inst Pasteur Tunis 64, 3: 327–340

    PubMed  CAS  Google Scholar 

  • Carey PJ, Malcom AJ, Pearson ADJ, Kemshead TK, Reid MM (1988) Immunocytochemical detection of tumors of neuroectodermal origin. J Clin Pathol 41: 586–589

    Article  PubMed  CAS  Google Scholar 

  • Carter RL, Al-Sam SZ, Corbett RP, Clinton S (1990) A comparative study of immunohistochemical staining for neuronspecific enolase, protein gene product 9.5 and S100 protein in neuroblastoma, Ewing’s sarcoma and other round cell tumours in children. Histopathology 16: 461–467

    Google Scholar 

  • Cavazzana AO, Miser JS, Jefferson J, Triche TJ (1987) Experimental evidence for a neural origin of Ewing’s sarcoma of bone. Am J Pathol 127: 507–518

    PubMed  CAS  Google Scholar 

  • Chadarevian JP, Vekemans M, Seemayer T (1984) Reciprocal translocation in small-cell sarcomas (letter). N Engl J Med 311: 1702

    PubMed  Google Scholar 

  • Dehmer LP (1993) Primitive neuroectodermal tumors and Ewing’s sarcomas. Am J Surg Pathol 16: 192–193

    Article  Google Scholar 

  • Delattre O, AzambuJa JC, Aurias A, Zucman J, Peter M, Zhang F, Hors-Cayla MC, Rouleau G, THomas G (1991) Mapping of human chromosome 22 with a panel of somatic cell hybrids. Genomics 9: 721–727

    Article  PubMed  CAS  Google Scholar 

  • Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, Kovar H, Joubert I, Dejong P, Rouleau G, Rouleua G, Aurias A, Thomas G (1992) Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumors. Nature 359: 162–165

    Article  PubMed  CAS  Google Scholar 

  • Delattre O, Zucman J, Melot T, Sastre X, Zucker JM, Lenoir G, Ambros P, Sheer D, Turc-Carel C, Triche T, Aurias A, Thomas G (1994) The Ewing family of tumours: a subgroup of small round cell tumours defined by specific chimeric transcripts. New Engl J Med 331: 294–299

    Article  PubMed  CAS  Google Scholar 

  • Desmaze C, Zucman J, Delattre O, Thomas G, Aurias A (1992) Unicolor and bicolor in situ hybridization in the diagnosis of peripheral neuroepithelioma and related tumors. Genes Chromosomes Cancer 5: 1–5

    Article  Google Scholar 

  • Dickman PS, Triche TJ (1986) Extraosseous Ewing’s sarcoma versus primitive rhadomyosarcoma. Diagnostic criteria and clinical correlation. Hum Pathol 17: 881–893

    Article  PubMed  CAS  Google Scholar 

  • Ehara S, Kattapuram SV, Egglin TK (1991) Ewing sarcoma. Radiographic pattern of healing and bony complications in patients with long-term survival. Cancer 68: 1531–1535

    Article  PubMed  CAS  Google Scholar 

  • Ewing J (1921) Diffuse endothelioma of bone. Proc New York. Path Soc 21: 17–24

    Google Scholar 

  • Fellinger EJ, Garin-Chesa P, Glasser DB, Huvos AG, Rettig WG (1992) Comparison of cell surface antigen HBA71 (p3o/32MIC2), neuron-specific enolase, and vimentin in the immunohistochemical analysis of Ewing’s sarcoma of bone. Am J Surg Pathol 16: 746–755

    Article  PubMed  CAS  Google Scholar 

  • Frouge C, Vanel D, Coffre C, Couanet D, Contesso G, Sarrazin D (1988) The role of magnetic resonance imaging in the evaluation of Ewing’s sarcoma. A report of 27 cases. Skeletal Radiol 17: 387–392

    Article  PubMed  CAS  Google Scholar 

  • Garand R, Nomballais F, Lemevel A, Mouraud E, Lemevel B (1981) Leucémie aiguë myéloblastique après sarcome d’Ewing: complication iatrogène? Bull Cancer (Paris) 68: 25–31

    CAS  Google Scholar 

  • Gonzalez Crussi F, Wolfson SL, Migusi K, Nakajima T (1984) Peripheral neuroectodermal tumor (neuroepithelioma) of the chest wall. Cancer 54: 2519–2527

    Article  Google Scholar 

  • Haas OA, Chott A, Ladenstein R, Gardner H (1987) Poorly differentiated, neuron-specific enolase positive round cell tumor with two translocations t(11; 22) and t(21; 22). Cancer 6o: 2219–2223

    Article  Google Scholar 

  • Haimoto H, Tkahashi Y, Koshikawa T, Nagura H, Kato K (1985) Immuno-histochemical localization of enolase in normal human tissues other than nervous and neuroendocrine tissues. Lab Invest 52: 257–263

    PubMed  CAS  Google Scholar 

  • Hartman KR, Triche TJ, Kinsella TJ, Miser JS (1991) Prognostic value of histopathology in Ewing’s sarcoma. Long-term follow-up of distal extremity primary tumors. Cancer 67: 163–171

    Article  PubMed  CAS  Google Scholar 

  • Isayama T, Iwasaki H, Kikuchi M, Yoh S, Tkagishi N (1990) Neuroectodermal tumor of bone. Evidence for neural differentiation in a cultured cell line. Cancer 65: 1771–1781

    Article  PubMed  CAS  Google Scholar 

  • Jaffe R, Santamaria M, Yunis EJ, Agastini RM, Medina J, Goodman H (1984) The neurocctodermal tumor of bone. Am J Surg Pathol 8: 885–898

    Article  PubMed  CAS  Google Scholar 

  • Jeon IS, Davis JN, Braun BS, Sublett JE, Roussel MF, Denny CT, Shapiro DN (1995) A variant Ewing’s sarcoma translocation (7; 22) fuses the EWS gene to the ETS gene ETVi. Oncogene 1o: 1229–1234

    Google Scholar 

  • Jürgens H, Bier V, Harms D, Beck G, Brandeis W, Etsptiler G, Gardner H, Schmidt D, Treuner J, Willder K, Gôbel V (1988) Malignant peripheral neuroectodermal tumors. A retrospective analysis of 42 patients. Cancer 61: 349–357

    Article  PubMed  Google Scholar 

  • Kahn HJ, Thorner PS (1989) Monoclonal antibody MB2: a potential marker for Ewing’s sarcoma and primitive neuroectodermal tumor. Pediatric Pathol 9: 153–162

    Article  CAS  Google Scholar 

  • Kontozoglou T, Krakauer K, Qilzilbash AH (1986) Ewing’s sarcoma cytologic features in fine needle aspirates in two cases. Acta Cytol 3o: 513–518

    Google Scholar 

  • Kovar H, Dworzak M, Strehl S, Schnell E, Ambros IM, Ambros PF, Gardner H (1990) Over expression of the pseudoautosomal gene M1C2 in Ewing’s sarcoma and peripheral primitive ectodermal tumor. Oncogene 5: 1067–1070

    PubMed  CAS  Google Scholar 

  • Ladanyi M, Heinemann FS, Huvos AG, Rao PH, Chen Q, Jhanwar SC (1990) Neural differentiation in small round cell tumors of bone and soft tissue with the translocation t(11; 22)(q24; q12): an immunohistochemical study of n cases. Hum Pathol 21: 1245–1251

    Article  Google Scholar 

  • Lagerkvist B, Ivemark B, Sylven B (1969) Malignant neuroepithelioma in childhood. A report of three cases. Acta Chir Scand 135: 641–645

    PubMed  CAS  Google Scholar 

  • Lee CS, Southey MC, Slater H, Auldist AW, Chow CW, Venter DJ (1995) Primary cutaneous Ewing’s sarcoma peripheral primitive neuroectodermal tumors in childhood. A molecular, cytogenetic and immunohistochemical study. Diagn Mol Pathol 4: 174–181

    Article  PubMed  CAS  Google Scholar 

  • Leroy JP, Volant A, Mazabraud A (1984) Les sarcomes d’origine nerveuse. Sem Hôp Paris 6o, 29: 2081–2086

    Google Scholar 

  • Linnoila RI, Tsokos M, Triche TJ, Marangos PJ, Chandra RS (1986) Evidence for neural origin and PAS-positive variants of the malignant small cell tumor of thoracopulmonary region ( Askin tumor ). Am J Surg Pathol 10: 124–133

    Article  PubMed  CAS  Google Scholar 

  • Lipinski M, Braham K, Caillaud JM, Carlu C, Tursz T (1983) HNK-I antibody detects and antigen expressed on neuroectodermal cells. J Exp Med 158: 1775–1780

    Article  PubMed  CAS  Google Scholar 

  • Lipinski M, Braham K, Philip I, Wiels J, Philip T, Dellagi K, Goridis C, Lenoir GM, Tursz T (1986) Phenotypic characterization of Ewing sarcoma cell lines with monoclonal antibodies. J Cell Biochem 31: 289–296

    Article  PubMed  CAS  Google Scholar 

  • Lipinski M, Braham K, Philip I, Wiels J, Philip T, Goridis C, Lenoir GM, Tursz T (1987) Neuroectodermal-associated antigens on Ewing’s sarcoma cell lines. Cancer Res 47: 183–187

    PubMed  CAS  Google Scholar 

  • Lipinski M, Tursz T (1982) Tumeur d’Ewing: origine neuro-ectodermique? Analyse à l’aide d’anticorps monoclonaux. Research 42: 706–711

    Google Scholar 

  • Lipinski M, Turzs T (1988) Apports de l’immunologie et de la biologie moléculaire. Bull Cancer 75: 417–421

    PubMed  CAS  Google Scholar 

  • Llombart-Bosch A, Lacombe JT, Olaya AP, Contesso G (1989) Peripheral neuroectodermal sarcoma of soft tissue (peripheral neuroepithelioma): a pathologic study of ten cases with differential diagnosis regarding other small, round-cell sarcomas. Hum Pathol 20: 273–280

    Article  PubMed  CAS  Google Scholar 

  • Llombart-Bosch A, Lacombe MJ, Contesso G, Peydro-Olaya A (1987) Small round blue cell sarcoma of bone mimicking atypical Ewing’s sarcoma with neuroectodermal features. An analysis of five cases with immunohistochemical and electron microscopical support. Cancer 60: 1570–1582

    Article  PubMed  CAS  Google Scholar 

  • Lloreta J, Tusquets I, Prieto V, Serrano S, Prat J (1990) Primary neuroectodermal tumor of bone. Report of a case in an adult. Surg Pathol 3: 325–331

    Google Scholar 

  • Mark A, Israel MA, Thiele C, Whang-Peng J, Koa-Shan CS, Triche TJ, Miser J (1985) Peripheral neuroepithelioma: genetic analysis of tumor derived cell lines. Advances in neuroblastoma research, pp. 161–170

    Google Scholar 

  • Moll R, Lee I, Gould VE, Berndt R, Franke WW (1987) Immunocytochemical analysis of Ewing’s tumors patterns of expression of intermediate filaments and desmosomal proteins indicate cell type heterogeneity and pluripotential differentiation. Am J Pathol 127: 288–304

    PubMed  CAS  Google Scholar 

  • Nesbitt KA, Vidone RA (1976) Primitive neuroectodermal tumor (neuroblastome) arising in sciatic nerve of a child. Cancer 37: 1562–1570

    Article  PubMed  CAS  Google Scholar 

  • Oberling CH (1928) Le réticulo-sarcome et le réticuloendothélio-sarcome de la moelle osseuse (sarcomes d’Ewing). Bull Cancer 17: 259–296

    Google Scholar 

  • Oberling CH, Raileaou C (1932) Nouvelles recherches sur les réticulosarcomes de la moelle osseuse (sarcomes d’Ewing). Bull Cancer 21: 333–345

    Google Scholar 

  • Pagès A (1981) Pathologie de la crête neurale. Ann Pathol 1: 109–119

    PubMed  Google Scholar 

  • Parham DM, Thompson E, Fletcher B, Meyer WH (1991) Metastatic small cell tumor of bone with true rosettes and glial fibrillary acidic protein positivity. Am J Clin Pathol 95: 166–171

    PubMed  CAS  Google Scholar 

  • Perlman EJ, Dickman PS, Askin FB, Grier HE, Miser JS, Link MP (1994) Ewing sarcoma-routine diagnostic utilisation of MlC2 analysis: A pediatric oncology group-/ Childrens cancer group intergroup study. Hum Pathol 25: 304–307

    Article  PubMed  CAS  Google Scholar 

  • Perlman EJ, Lumadue JA, Hawkins AL, Cohen K, Colombani P, Griffin CA (1995) Primary cutaneous neuroendocrine tumors. Diagnostic use of cytogenetic and M1C2 analysis. Cancer Genet Cytogenet 82: 30–34

    Article  PubMed  CAS  Google Scholar 

  • Rettig WJ, Garin-Chesa P, Huvos AG (1992) Ewing’s sarcoma: new approaches to histogenesis and molecular plasticity. Editorial Lab Invest 66: 133–137

    CAS  Google Scholar 

  • Reynolds CP, Smith RG, Frenkel EP (1981) The diagnostic dilemma of the “small round cell neoplasm” catecholamine fluorescence and tissue culture morphology as markers for neuroblastoma. Cancer 48: 2088–2094

    Article  PubMed  CAS  Google Scholar 

  • Rimbaud C, Mazabraud A, Aurias A, Thiery JP, Buffe D (1983) Ewing’s sarcoma graft on nude rat. Typing of cytological and cytogenetic characteristics. nth meeting of the Int Soc Onco-developmental Biol, Stockholm

    Google Scholar 

  • Roessner A, Jürgens H (1993) Round cell tumors of bone. Path Res Pract 189: 1111–1136

    Article  Google Scholar 

  • Rouleau GA, Merel P, Lutchman M, Sanson M, Zucman J, Marineau C, Hoang-Xuant K, Demczuk S, Desmaze C, Plougastel B, Pulst S, Lenoir G, Bijlsma E, Fashold R, Dumanski J, deJong P, Parry D, Eldrige R, Aurias A, Delattre O, Thomas G (1993) Alteration in a new gene encoding a putative membrane-organizing causes neuro-fibromatosis type 2. Nature 363: 515–521

    Article  PubMed  CAS  Google Scholar 

  • Rousselin B, Vanel D, Lacombe MJT, Istria BJM, Spielman M, Masselot J (1989) Clinical and radiologic analysis of 13 cases of primary neuroectodermal tumors of bone. Skeletal Radiol 18: 115–120

    Article  PubMed  CAS  Google Scholar 

  • Rud NP, Reiman HM, Pritchard DJ, Frassica FJ, Smithson WA (1989) Extraosseous Ewing’s sarcoma. A study of 42 cases. Cancer 64: 1548–1553

    Article  PubMed  CAS  Google Scholar 

  • Schajowicz F (1959) Ewing’s sarcoma and reticulum cell sarcoma of bone, with special reference to the histochemical demonstration of glycogen as an aid to differential diagnosis. J Bone Joint Surg 41A: 349–356

    PubMed  Google Scholar 

  • Siegal GP, Oliver WR, Reinus WR, Gilula LA, Foulkes MA, Kissane JM, Askin FB (1987) Primary Ewing’s sarcoma 206 involving the bones of the head and neck. For the intergroup Ewing’s sarcoma study. Cancer 60: 2829–2840

    Article  PubMed  CAS  Google Scholar 

  • Stéfani (de) E, Carzoglio J, Deneo Pellegrini H, Olivera L, Cendan M, Kasdorf H (1984) Ewing’s sarcoma: value of tumor necrosis as a predictive factor. Bull Cancer (Paris) 71: 16–21

    Google Scholar 

  • Steiner GC, Matano S, Present D (1995) Ewing sarcoma of humerus with epithelial differentiation. Skeletal Radiol 24: 379–382

    Article  PubMed  CAS  Google Scholar 

  • Stephenson CF, Bridge JH, Sandberg AA (1992) Cytogenetic and pathologic aspects of Ewing’s sarcoma and neuroectodermal tumors. Hum Pathol 23: 1270–1277

    Article  PubMed  CAS  Google Scholar 

  • Stout AP (1918) A tumor of the ulnar nerve. Proc NY Pathol Soc 18: 2–12

    Google Scholar 

  • Stratton B, Askin FB, Kissane JM (1982) Intramyofiber skeletal muscle invasion in Ewing’s sarcoma of bone. Clinicopathologic observation from the intergroup Ewing’s sarcoma study. Am J Pediatr Hematol Oncol 4: 231

    PubMed  CAS  Google Scholar 

  • Tayton KJJ (1980) Ewing’s sarcoma at the site of a metal plate. Cancer 45: 413–415

    Article  PubMed  CAS  Google Scholar 

  • Thomas G (1992) Identification des gènes impliqués dans la translocation t(11;-22) caractéristique du sarcome d’Ewing. Médecine-Sciences 8: 994–995

    Google Scholar 

  • Triche TJ (1988) Diagnosis of small round cell tumors of childhood. Bull Cancer 75: 297–310

    PubMed  CAS  Google Scholar 

  • Triche TJ, Askin FB (1983) Neuroblastoma and the differential diagnosis of small-, round-, blue-cell tumors. Hum Pathol 14: 569–595

    Article  PubMed  CAS  Google Scholar 

  • Turc-Carel C, Aurias A, Mugneret F, Lizard S, Sidaner I, Volk C, Thiery JP, Olschwzan S, Philip I, Berger MP, Philip T, Lenoir GM, Mazabraud A (1988) Chromosomes in Ewing’s sarcoma. An evaluation of 85 cases and remarkable consistency of t(11;-22)(q24;-q12). Cancer Genet Cytogenet 32: 229–238

    Article  PubMed  CAS  Google Scholar 

  • Turc-Carel C, Philip I, Berger MP, Philip T, Lenoir GM (1983) Chromosomal translocation in Ewing’s sarcoma. N Engl J Med 309: 497–498

    Google Scholar 

  • Turc-Carel C, Philip I, Berger MP, Philip T, Lenoir GM (1984) Chromosome study of Ewing’s sarcoma (ES) cell lines: consistency of a reciprocal translocation t(11;-22)(g24;-q12). Cancer Genet Cytogenet 12: 1–19

    Article  PubMed  CAS  Google Scholar 

  • Urano F, Umezawa A, Hong W, Kikuchi H, Hata J (1996) A novel chimera gene between EWS and EiAF, encoding the adenovirus EiA enhancer-binding protein, in extaosseus Ewing’s sarcoma. Biochem Biophys Res Commun 219: 608–612

    Article  PubMed  CAS  Google Scholar 

  • Vecchio G, Cavazzana AO, Triche TJ, Ron D, Reynolds CP, Eva A (1989) Expression of the dbl proto-oncogene in Ewing’s sarcomas. Oncogene 4: 897–900

    PubMed  CAS  Google Scholar 

  • Voog R, Couderc P, Barrie J (1964) Sarcome d’Ewing costal révélé par un hémothorax spontané. J Fr Med Chir Thor 18: 449–456

    CAS  Google Scholar 

  • Wang-Peng J, Triche TJ, Knutsen T, Miser J, Kao-Shan S, Tsai S, Israel MA (1986) Cytogenetic characterization of selected small round cell tumor of childhood. Cancer 21: 185–208

    Google Scholar 

  • Whang-Peng J, Triche TJ, Knutsen T, Miser J, Douglass EC, Israel MA (1984) Chromosome translocation in peripheral neuroepithelioma. N Engl J Med 311: 584–585

    Article  PubMed  CAS  Google Scholar 

  • Wilkins RM, Pritchard DJ, Burget EO, Unni KK (1986) Ewing’s sarcoma of bone. Experience with 140 patients. Cancer 58: 2551–2555

    Article  PubMed  CAS  Google Scholar 

  • Zucman J, Delattre O, Desmaze C, Plougastel B, Joubert I, Melot T, Peter M, Dejang P, Rouleau G, Aurias A, Thomas G (1992) Cloning and characterization of the Ewing’s sarcoma and peripheral neuroepthelioma t(11;-22) translocation breakpoints. Genes Chromosomes and Cancer 5: 271–277

    Article  CAS  Google Scholar 

  • Zucker JM, Michon J, Mazabraud A, Quintana E, Bataini JP (1983) Sarcome d’Ewing. Rev Prat 33: 1169–1183

    PubMed  CAS  Google Scholar 

  • Zucman G, Delattre O, Desmaze C, Epstein AL, Stenman G, Speleman F, Fletchers CDM, Aurias A, Thomas G (1993) EWS and ATF-I gene fusion induced by t(12;-22) translocation in malignant melanoma of soft parts. Nature Genetics 4: 341–345

    Article  PubMed  CAS  Google Scholar 

  • Zucman J, Delattre O, Desmaze C, Plougastel B, Joubert I, Melot T, Peter M, Dejang P, Rouleau G, Aurias A, Thomas G (1992) Cloning and characterization of the Ewing’s sarcoma and peripheral neuroepthelioma t(11;-22) translocation breakpoints. Genes Chromosomes and Cancer 5: 271–277

    Article  PubMed  CAS  Google Scholar 

  • Zucman J, Melot T, Desmaze C, Ghysdael J, Plougastel B, Peter M, Zucker JM, Triche T, Sheer D, Turc-Carel C, Ambros P, Combaret V, Lenoir G, Aurias A, Thomas G, Delattre O (1993) Combinatorial generation of variable fusion proteins in peripheral primitive neuroectodermal tumors. EMBO 12: 4481–4487

    CAS  Google Scholar 

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  1. Institut Curie, Paris Centre de Pathologie, 20, avenue de la Gare, 91570, Bièvres, France

    André Mazabraud MD (Former Head of Department of Pathological Anatomy)

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© 1998 Springer-Verlag Berlin Heidelberg

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Mazabraud, A. (1998). Ewing’s sarcoma, neuroepithelioma and Askin’s tumour. In: Pathology of bone tumours. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95839-7_18

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  • DOI: https://doi.org/10.1007/978-3-642-95839-7_18

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