Abstract
Osteogenic sarcoma is a tumour formed by the proliferation of sarcomatous cells giving rise to osteoid or bony tissue (figs. 25–28). This definition excludes any sarcomatous tumour accompanied by the formation of benign reactive osteoid or osseous tissue.
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References
Ackerman AJ (1948) Multiple osteogenic sarcoma. Am J Roentgenol 60: 623–632.
Ahuja SC, Villacin AB, Smith G, Bullough PG, Huvos AG, Marcove R (1977) Juxtacortical (parosteal) osteogenic sarcoma, histological grading and prognosis. J Bone Joint Surg 59A: 632–647
Amstutz HC (1969) Multiple osteogenic sarcoma metastatic or multicentric? Report of two cases and review of literature. Cancer 24: 923–931
Anani AP, Costa J, Remagen W (1987) L’échappement métastatique dans la moelle osseuse (skip métastase) de l’ostéosarcome. Ann Pathol 7: 193–197
Anderson RB, McAlister JA, Wrenn RN (1989) Intracortical osteosarcoma of tibia. Skeletal Radiol 18: 627–630
Araki N, Uchida A, Kimura T, Yoshikawa H, Aoki Y, Ueda T, Takai S, Miki T, Ono K (1991) Involvement of the retino-blastoma gene in primary osteosarcomas and other bone and soft-tissue tumors. Clin Orthop 270: 271–277
Ayala AG, Rojy Raymond AK, Jaffe N, Chawla S, Carrasco H, Link M, Jimenez J, Edeiken J, Wallace S, Murray JA, Benjamin R (1989) Small cell osteosarcoma. A clinicopathologic study of 27 cases. Cancer 64: 2162–2173
Ballance WA, Mendelsohn G, Carter JR, Abdul-Karim FW, Jacobs G, Makley JT (1988) Osteogenic sarcoma malignant fibrous histiocytoma subtype. Cancer 62: 763–771
Baro PR, Bastart FM, Bartrina JR, Mateo JM, Vidal MTR (1989) Osteosarcoma of calcaneus with Rothmund-Thompson syndrome. Case report. Skeletal Radioll 8:136–139
Benedikt RA, Kransdorf MJ, Jelinek JS, Moser RP (1992) Osteosarcomatosis in a skeletal immature girl. Skeletal Radiol 21: 187–189
Bentzen SM, Poulsen HS Kaae S, Myhre-Jensen O, Johansen H, Mouridsen HT, Daugaard S, Arnoldi C (1988) Prognostic factors in osteosarcomas. Cancer 62: 194–202
Bertoni F, Boriani S, Laus M, Campanacci M (1982) Periosteal chondrosarcoma and periosteal osteosarcoma: two distinct entities. J Bone Joint Surg 64B: 370–376
Bertoni F, Unni KK, McLeod RA, Dahlin DC (1985) Osteosarcoma resembling osteoblastoma. Cancer 55: 416–426
Catanese J, Dutcher JP Dorfman HD, André DF, Wiemil PH (1988) Mediastinal osteosarcoma with extension to lungs in a patient treated for Hodgkin’s disease. Cancer 62: 2252–2257
Charig MJ, Golding SJ, Lindsell DRM (1990) Osteosarcoma: an unusual thoracic metastasis. Br J Radiol April: 304–306
Dahlin DC, Unni KK (1977) Osteosarcoma of bone and its important recognizable varieties. Am J Surg Path 1: 61–72
Dahlin DC, Unni KK, (1986) General aspects and data on 8,542 cases; 4th edn, Charles Thomas, Springfield, pp. 269–307
De Santos LA, Edeiken B (1982) Purely Iytic osteosarcoma. Skeletal Radiol 9:1–7
De Santos LA, Edeiken BS, (1985) Subtle early osteosarcoma. Skeletal Radiol 13: 44–48
Dickersin GR, Rosenberg AE (1991) The ultrastructure of small cell osteosarcoma with a review of the light microscopy and differential diagnosis. Hum Pathol 22: 267–275
Dubousset J, Missenard G, Kalifa CH (1991) Management of osteogenic sarcoma in children and adolescents. Clin Ortop 270: 52–59
Dun D, Dehner P (1977) Metastatic osteosarcoma to lung. A clinicopathologic study of surgical and resections. Cancer 40: 3054–3064
Dwinnell LA, Dahlin DC, Ghormley RK (1954) Parosteal (juxtacortical) osteogenic sarcoma. J Bone Joint Surg 36A: 732–744
Enneking WF, Kagan A (1975) “Skip” metastases in osteosarcoma. Cancer 36: 2192–2205
Enneking WF, Kagan A (1978) Transepiphyseal extension of osteosarcoma: incidence, mechanism and implications. Cancer 41: 1526–1537
Fahey M, Spanier SS, Vander Griend RA (1992) Osteosarcoma of the pelvis. A clinical and histopathological study of twenty-five patients. J Bone Joint Surg 74A: 320–330
Feugeas O, Guriec N, Babin-Boilletot A, Marcellin L, Simon P, Babin S, Thyss A, Hofman P, Terrier P, Kalifa C, BrunatMentigny M, Patricot L-M, Oberling F (1996) Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma. J Clin Oncol 14: 467–472
Finkel MP, Biskis BO, Farell C (1967) Pathogenic effects of extracts of human osteosarcomas in hamsters and mice. Arch Path 84: 425–428
Finkel MP, Biskis BO, Jinkins PB (1966) Virus induction of osteosarcomas in mice. Science 151: 698–701
Fitzgerald RH, Dablin DC, Sim FH (1973) Multiple metachronous osteogenic sarcoma. J Bone Joint Surg 55A: 595–605
Forest M, Abelanet R, Daudet-Monsac M (1981) L’étude morphologique d’une tumeur osseuse. Notions pratiques macroscopiques, radiographiques et cytologiques. Ann Pathol 1: 86–89
Garbe LR, Monges GM, Paregrin EM, Payan HL (1981) Ultrastructural study of osteosarcoma. Hum Pathol 12: 891–896
Gherlinzoni F, Antoci B, Canale V (1983) Multicentric osteosarcomata (osteosarcomatosis). Skeletal Radiol 10: 281–285
Glasser DB, Lane JM, Huvos AG, Marcove RC, Rosen G (1992) Survival, prognosis and therapeutic response in osteogenic sarcoma. Cancer 69: 698–708
Goodman MA, McMaster JH, Drash AL, Diamond PE, Kappakas GS, Scranton PE (1978) Metabolic and endocrine alterations in osteosarcoma patients. Cancer 42: 603–610
Guy EP, Hourtoule FG, Loisillier F (1956) Ostéosarcomes ossifiants muticentriques des os. Bull Cancer (Paris) 43: 258–265
Hadjipavlou A, Lander P, Srolovitz H, Enker P (1992) Malignant transformation in Paget disease of bone. Cancer 70: 2802–2808
Haibach H, Farrel C, Dittrich F (1985) Neoplasms arising in Paget’s disease of bone: a study of 82 cases. Am J Clin Pathol 83: 594–600
Hall RB, Robinson LH, Malawar MM, Dunham WK (1985) Periosteal osteosarcoma. Cancer 55: 165–171
Hansen MF (1991) Molecular considerations in osteosarcoma. Clin Orthop 270: 237–246
Haye C (1981) A propos de la survenue d’un ostéosarcome primitif chez une enfant traitée pour tumeur de la rétine. Bull Soc Ophtal Fr I: 99–100
Healy JH, Buss D (1991) Radiation and pagetic osteogenic sarcoma. Clin Orthop 270: 120–127
Hopper KD, Haseman DB, Moser RP, Sweet DE, Madewell DE (1990) Osteosarcomatosis (case report). Skeletal Radiol 19: 535–537
Hopper KD, Moser RP, Haseman DB. Sweet DE. Madewell JF, Kransdorf MJ (1990) Osteosarcomatosis. Radio 1175: 233–239
Huvos AG (1986) Osteogenic sarcoma of bones and soft tissues in older persons. A clinicopathologic analysis of 117 patients older than 6o years. Cancer 57: 1447–1449
Huvos AG, Butler A, Bretsky SS (1983) Osteogenic sarcoma associated with Paget’s disease of bone. A clinicopathology study of 65 patients. Cancer 52: 1489–1495
Huvos AG, Butler A, Bretsky SS (1985) Osteogenic sarcoma in pregnant women, pronostic, therapeutic implications, and literature review. Cancer 56: 2326–2331
Huvos AG, Rosen G, Bretsky SS, Butler A (1982) Telangiectatic osteogenic sarcoma: a clinicopathologic study of 124 patients. Cancer 49: 1679–1689
Huvos AG, Rosen G, Marcove RC (1977) Primary osteogenic sarcoma. Pathologic aspects in 20 patients after treatment with chemotherapy en bloc resection, and prosthetic bone replacement. Arch Path Lab Med l01: 14–18
Huvos AG, Woodard HQ, Cahan WG, Higinbotham NL, Steward FW, Butler A, Bretsky SS (1985) Postradiation osteogenic sarcoma of bone and soft tissues. A clinicopathologic study of 66 patients. Cancer 55: 1244–1255
Jeffree GM, Price CHG, Sissons HA (1975) The metastatic spread of osteosarcoma. Br J Cancer 32: 87–107
Kevin Raymond A (1992) Osteosarcoma: perspectives. Am J Surg Pathol 16: 193–194
Knudson AG, Meadows AT, Nichols WN (1976) Chromosomal deletion and retinoblastoma. N Engl J Med 295:1120–1123
Kozlowski K, Scougall JS, Oates RK (1980) Osteosarcoma in a boy with Rothmund-Thomson syndrome. Pediatr Radiol 10: 42–45
Kramer K, Hicks DG, Palis J, Rosier RN, Oppenheimer J, Fallon MD, Cohen HJ (1993) Epithelioid osteosarcoma of bone immunocytochemical evidence suggesting divergent epithelial and mesenchymal differenciation in a primary osseous neoplasm. Cancer 71: 2977–2982
Kurt AM, Unni KK, Mcleod RA, Pritchard DJ (1990) Lowgrade intraosseous osteosarcoma. Cancer 65: 1418–1428
Kyriakos M (1980) Intracortical osteosarcoma. Cancer 46: 2525–2533
Lacassagne A, Gricourouff G (1966) Effets cancérigènes des rayonnements ionisants. Radiobiologie appliquée. Gauthier-Villars, Paris, pp 584–646
Lee WR, Laurie J, Townsend AL (1975) Fine structure of a radiation-induced osteogenic sarcoma. Cancer 76: 1414–1425
Lichtenstein L (1955) Tumors of periosteal origin. Cancer 8: 1060–1069
Mahoney JP, Spanier SS, Morris JL (1979) Multifocal osteosarcoma. A case report with review of the literature. Cancer 44: 1897–1907
Malawer MM, Dunham WK (1983) Skip metastases in osteosarcoma: recent experience. J Bone Onc 22: 236–245
Mankin HJ, Gebhardt MC, Springfield DS, Litwat GJ, Kusazaki K, Rosenberg AE (1991) Flow cytometric studies of human osteosarcoma. Clin Orthop 270: 169–180
Matsuno T, Unni KK, McLeod RA, Dahlin DC (1976) Telangiectatic osteogenic sarcoma. Cancer 38: 2538–2547
Mazabraud A, Perdereau B, Contesso G (1992) Réflexions sur la validation de la classification des formes les plus fréquentes des sarcomes ostéogènes par des méthodes fonctionnelles isotopiques. Bull Cancer 79: 759–765
Mazabraud A, Perdereau B, Gongora R (1986) Classification of osteosarcoma by 85Sr scintimetry. Arch Orthop Scan 57: 74–77
McCarthy EF, Tolo VT, Dorfman HD (1987) Multicentric, metachronous, low-grade, sclerosing osteogenic sarcoma. Case report. Skeletal Radiol 16: 592–596
McMaster JH (1977) Carbohydrate metabolism in osteosarcoma. Int Orthop 1: 19–21
Meadows AT, Strong LC, Lif P (1980) Bone sarcoma as a second malignant neoplasm in children. Influence of radiation and genetic predisposition. Cancer 46: 2603–2606
Merle d’Aubigné R, Thomine JM (1970) A propos de 9 cas de sarcomes juxtacorticaux. Mém Acad Chir 96: 4549
Mervak TR, Unni KK, Pritchard DJ, McLeod RA (1991) Telangiectatic osteosarcoma. Clin Orthop 270: 135–139
Mirra JM, Bullough PG, Marcove RC, Jacobs B, Huvos AG (1974) Malignant fibrous histiocytoma and osteosarcoma in association with bone infarcts. Report of four cases, two in caisson workers. J Bone Joint Surg 56A: 932–940
Mirra JM, Dodd L, Johnston W, Frost DB, Barton D (1991) Primary intracortical osteosarcoma of femur, sclerosing variant, grade Ito 2 anaplasia. Skeletal Radiol 20: 613–616
Mirra JM, Kameda N, Rosen G, Eckardt J (1988) Primary osteosarcoma of toe phalanx: first documented case. Review of osteosarcoma of short tubular bones. Am J Surg Pathol 12: 300–307
Newton WA, Meadows AT, Shimada HS, Bunin GR, Vawter GF (1991) Bone sarcomas as second malignant neoplasms following childhood cancer. Cancer 67: 193–201
Naka T, Fukuda T, Shinohara N, Iwamoto Y, Sugioka Y, Tsuneyoshi M (1995) Osteosarcoma versus malignant fibrous histiocytoma of bone in patients older than 4o years. Cancer 76: 972–984
Noguera R, Navarro S, Triche TJ (1990) Translocation (11; 22) in small cell osteosarcoma. Cancer Genet Cytogenet 45:121–124
Norton KI, Hermann G, Abdelwahab IF, Kein MJ, Granometter LM, Rabinowitz JG (1991) Epiphyseal involvement in osteosarcoma. Radiology 180: 813–816
Olson PL, Prewitt L, Griffiths HJ, Cherkna B (1991) Multifocal osteosarcoma. Skeletal Radiol 20: 624–627
Paltiel HJ, Wilkinson RH, Kozakewich HPW (1988) Osteosarcoma of the distal femoral epiphysis. Skeletal Radiol 17: 527–530
Pappo A, Schneider NR, Sanders JM, Buchanan GR (1991) secondary myelodysplastic syndrome complicating therapy for osteogenic sarcoma. Cancer 68: 1373–1375
Parham DM, Pratt CB, Parvey LS, Webber BL, Champion J (1985) Chidhood multifocal osteosarcoma clinicopathologic and radiologic correlates. Cancer 55: 2653–2658
Patel DV, Hammer RA, Levin B, Fisher MA (1984) Primary osteogenic sarcoma of the spine. Skeletal Radiol 12: 276–279
Perdereau B. Mazabraud A, Gongora R (1993) Contribution de la scintigraphie dynamique à l’aide de 99Tc-MDP à la classification nosologique des sarcomes ostéogènes anaplasiques. J Med Nucl Biophys 17: 212–217
Pignatti G, Bacci G, Picci P, Dallari D, Bertoni F, Bacchini P, Capanna R (1991) Telangiectatic osteosarcoma of the extremities. Results in 17 patients treated with neoadjuvant chemotherapy. Clin Orthop 270: 99–106
Pintado SO, Lane J, Huvos AG (1989) Parosteal osteogenic sarcoma of bone with coexistent low and high-grade sarcomatous components. Hum Pathol 20: 488–491
Porter DE, Holden ST, Cohen BB, Wallace MR, Reid R (1992) A significant proportion of patients with osteosarcoma may belong to Li-Fraumeni cancer families. J Bone Joint Surg 74B: 883–892
Price CHG (1961) Osteogenic sarcoma. An analysis of survival and its relationship to histological grading and structure. J Bone Joint Surg. 43B: 300–313
Price CHG (1966) The prognosis of osteosarcoma. An analytical study. Br J Radiol 39: 181–188
Price CHG, Zhuber K, Salzer-Kuntschik M, Salzer M, Willert HG, Immenkamp M, Groh P, Matejorsky Z, Key’ W (1975) Osteosarcoma in children a study of 125 cases. J Bone Joint Surg 57B: 341–345
Raymond AK (1991) Surface osteosarcoma. Clin Orthop 270: 140–148
Rebaud P, David L, Plauchu H, Chatelain P, Moulin G, François R (1985) Observation familiale de syndrome de RothmundThonson. Pediatrie 4o: 487–489
Reddick RL, Michelitch H, Levine AM, Triche TJ (1980) Osteogenic sarcoma. A study of the ultrastructure. Cancer 45: 64–71
Remagen W, Jani L, Luthi A, Schuman L (1981) Atypical (dedifferentiated) chondrosarcoma or osteosarcoma with preponderant chondrobastic differentiation? J Cancer Res Clin Oncol l01: 177–182
Resnik CS, Aisner SC, Young JWR, Levine A (1993) Osteosarcoma arising in bone infarction. Case report. Skeletal Radiol 22: 58–61
Rosen G, Caparos B, Huvos AG, Kosloff C, Nirenberg A, Cacavio A, Marcove RC, Lane JM, MeRta B, Urban C (1982) Pre-operative chemotherapy for osteogenic sarcoma: selection of post-operative chemotherapy. Cancer 49: 1221–1230
Schajowicz F, McCuire MH, Araujo ES, Muscolo DL, Giletis S (1988) Osteosarcomas arising on the surfaces of long bones. J Bone Joint Surg 70A: 555–564
Schlienger P, Calle R, Haye C, Vilcoq P (1985) Sarcomes osseux et tumeurs malignes de la rétine. Bull Cancer (Paris) 72: 16–24
Scholz RB, Kabish H, Weber B, Röser K, Delling G, Winkler K (1992) Studies of the RBi gene and p53 gene in human osteosarcoma. Pediatr Hematol Oncol 9: 125–137
Seeger LL, Gold RH, Chandnani VP (1991) Diagnostic imaging of osteosarcoma. Clin Orthop 270: 254–263
Shrikhande SS, Rao RS (1977) Histopathological study of regional Iymph nodes in osteosarcoma. J Surg Oncol 9: 371–377
Siegel RD, Ryan LM, Antman KH (1989) Osteosarcoma in adults. One institution’s experience. Clin Orthop 240: 261–269
Sim FH, Kurt AM, McLeod RA, Unni KK (1990) Low-grade central osteosarcoma. Skeletal Radiol 19: 457–460
Sim FH, Unni KK, Beabout JW, Dahlin DC (1979) Osteosarcoma with small cells simulating Ewing’s tumor. J Bone Joint Surg 61A: 207–215
Sim FH, De Vries EMG, Miser JS, Unnik K (1992) Osteoblastic osteosarcoma (grade 4) with Rothmund-Thomson syndrome (case report). Skeletal Radio’ 21: 543–545
Thorpe WP, Reilly IJ, Rosenberg SA (1979) Prognostic significance of alkaline phosphatase measurements in patients with osteogenic sarcoma receiving chemotherapy. Cancer 43: 2178–2181
Tillotson C, Rosenberg A, Gebhardt M, Rosenthal DI (1988) Postradiation multicentric osteosarcoma. Cancer 62: 67–71
Tomeno B, Languepin A (1982) Sarcome juxtacortical. Rev Prat (Paris) 32: 3515–3520
Tsuneyoshi M, Dorfman HD (1987) Epiphyseal osteosarcoma: distinguishing features from clear cell chondrosarcoma, chondroblastoma and epiphyseal enchondroma. Hum Pathol 18: 644–651
Unni KK, Dahlin DC, Beabout JW, Ivins JC (1976) Parosteal osteogenic sarcoma. Cancer 37: 2466–2475
Unni KK, Dahlin DC, McLeod RA, Pritchard DJ (1977) Intraosseous well-differentiated osteosarcoma. Cancer 40: 1337–1347
Valenty M (1989) Facteurs pronostiques de l’ostéosarcome à propos d’une série de 130 malades traités à l’institut Gustave-Roussy entre 1981 et 1988. Mémoire (diplôme d’études approfondies, statistique et santé) Université Paris Sud (UFR Kremlin Bicêtre)
Valenty M, Bendjaballah F, Vanel D, Terrier PH, Henry-Amar M (1990) Facteurs pronostiques de l’ostéosarcome. Bull Cancer (Paris) 77: 545 (summary)
Van Der Heul RO, Von Ronnen JR (1967) Juxtacortical osteosarcoma. Diagnosis, differential diagnosis, treatment and an analysis of eighty cases. J Bone Joint Surg 49A: 415–439
Van Rijssel TG (1980) Classification and prognosis of osteosarcoma. In: Therapeutic progress in ovarian cancer,testicular cancer and the sarcomas. AT Van Oosterom edn
Varela-Duran J, Dehner LP (1980) Postirradiation osteosarcoma in childhood a clinicopathologic study of three cases and review of the literature. Am J Pediatr Hematol Oncol 2: 263–271
Vigorita VJ, Ghelman B, Jones JK, Marcove RC (1984) Intracortical osteosarcoma. Am J Surg Pathol 8: 65–71
Wiklund TA, Blomvist CP, Raty J, Elomaa J, Rissanen P, Miettinen M (1991) Postirradiation sarcoma. Analysis of a nationwide cancer registry material. Cancer 68: 524–531
Wold LE, Unni KK, Beabout JW, Pritchard DJ (1984) Highgrade surface osteosarcomas. Am J Surg Pathol 8: 181–186
Wold LE, Unni KK, Beabout JW, Sim FM, Dablin DC (1984) Dedifferentiated parosteal osteosarcoma. J Bone Joint Surg 66A: 53–59
Yamaguchi H, Nojima T, Matsuno T, Sasaki T, Isu K, Ubayama Y, Yamawaki S, Gotoh M (1988) The alteration in the pattern of pulmonary metastasis with adjuvant chemotherapy in osteosarcoma. International Orthopaedics (SICOT) 12: 305–308
Yamaguchi H, Ioguchida G, Yamamuro I, Koloura Y, Iakada N, Kawaguchi N, Kanekoy Y, Nakamura Y, Sasaki MS, Ishizaki K (1992) Allelotype analysis in osteosarcomas: Frequent allele loss on 3q,13q,17 p and 18 q. Cancer Res 52: 2419–2423
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Mazabraud, A. (1998). Osteogenic sarcoma. In: Pathology of bone tumours. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95839-7_11
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