Pathobiochemie der Alkoholabhängigkeit

  • H. Rommelspacher
  • L. G. Schmidt
  • M. Otto
Conference paper
Part of the Suchtproblematik book series (SUCHT)

Zusammenfassung

Eine ganze Reihe von biochemischen Veränderungen bei Alkoholkranken ist bekannt. Für die meisten Befunde ist nicht ausreichend belegt, ob sie Ausdruck der Disposition, der Intoxikation, von Residualeffekten im Sinne von Krankheitsmarkern (Folge der Manifestation der Erkrankung) oder der Folgen der toxischen Wirkung von Alkohol und seines Metaboliten Acetaldehyd sind. Trotz dieser Schwierigkeiten soll anhand von Arbeitshypothesen versucht werden, über einige Befunde zu berichten und durch Aufzeigen von Querverbindungen zu anderen Forschungsgebieten das Verständnis für die biochemischen Grundlagen der Alkoholkrankheit zu vertiefen.

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Literatur

  1. Allen JRF, Holmstedt BR (1980) The simple alkaloids. Phytochemistry 19:1573–1582CrossRefGoogle Scholar
  2. Amit Z, Sutherland EA, Gill K, Ogren SO (1984) Zimelidine: a review of its effects on ethanol consumption. Neurosci Biobehav Rev 8:35–54PubMedCrossRefGoogle Scholar
  3. Beaman CM, Hunter GA, Dunn LL, Reid LD (1984) Opioids, benzodiazepines and intake of ethanol. Alcohol 1:39–42PubMedCrossRefGoogle Scholar
  4. Bosin TR, Faull KF (1988) Harman in alcoholic beverages: pharmacological and toxicological implications. Alcohol CHn Exp Res 12:679–682CrossRefGoogle Scholar
  5. Davis VE, Walsh MJ, Yamanaka Y (1970) Augmentation of alkaloid formation from dopamine by alcohol and acetaldehyde in vitro. J Pharmacol Exp Ther 174:401–412PubMedGoogle Scholar
  6. Fuchs V, Coper H, Rommelspacher H (1987) The effects of ethanol and haloperidol on dopamine receptor (Dj) density. Neuropharmacology 26:1231–1233Google Scholar
  7. Geller I, Seifter J (1960) The effects of meprobamate, barbiturates, D-amphetamine and promazine on experimentally induced conflict in the rat. Psychopharmacologia (Berlin) 1:482–492Google Scholar
  8. Greenberg DA, Cooper EC, Gordon A, Diamond I (1984) Ethanol and the y-aminobutyric acid-benzodiazepine receptor complex. J Neurochem 42:1063–1068CrossRefGoogle Scholar
  9. Helander A, Tottmar O (1987) Effects of ethanol, acetaldehyde and disulfiram on the metabolism of biogenic aldehydes in isolated human blood cells and platelets. Biochem Pharmacol 36:3981–3985PubMedCrossRefGoogle Scholar
  10. Hoffman PL, Rabe CS, Moses F, Tabakoff B (1989) N-Methyl-D-aspartate receptors and ethanol: Inhibition of calcium flux and cyclic GMP production. J Neurochem 52:1937–1940Google Scholar
  11. Hunt WA (1983) Ethanol and the central nervous system. In: Tabakoff B, Sutker PB, Randall CL (eds) Medical and social aspects of alcohol abuse. Plenum, New York, pp 133–163Google Scholar
  12. Hunter GA, Beaman CM, Dunn LL, Reid LD (1984) Selected opioids, ethanol and intake of ethanol. Alcohol 43–46Google Scholar
  13. Koob GF, Mendelson WB, Schäfer J, Wall TL, Britton KT, Bloom FE (1989) Picrotoxin receptor ligand blocks anti-punishment effects of alcohol. Alcohol 5:437–443CrossRefGoogle Scholar
  14. Liljequist S, Engel JA (1984) Reversal of the anti-conflict action of valproate by various GABA and benzodiazepine antagonists. Life Sci 34:2525–2533PubMedCrossRefGoogle Scholar
  15. Lister RG, Eckardt M, Weingartner H (1987) Ethanol intoxication and memory. Recent developments and new directions. In: Galanter M (ed) Recent developments in alcoholism, vol 5. Plenum Press, New York, p 111–125Google Scholar
  16. MacKerell AD, Blater EE, Pietruszko R (1986) Human aldehyde dehydrogenase: Kinetic identification of the isozyme for which biogenic aldehydes and acetaldehyde compete. Alcohol Clin Exp Res 10:266–270Google Scholar
  17. Melchior CL, Tabakoff B (1986) The effect of 5,7-dihydroxytryptamine treatment on the response to ethanol in mice. Pharmacol Biochem Behav 24:955–961PubMedCrossRefGoogle Scholar
  18. Murphy JM, BcBride WJ, Lumeng L, Li TK (1987) Contents of monoamines in forebrain regions of alcohol-preferring (P) and non-preferring (NP) lines in rats. Pharmacol Biochem Behav 26:389–392Google Scholar
  19. Myers RD, Véale WL (1972) The determinants of alcohol preference in animals. In: Kissin B, Begleiter H (eds) Biology of alcoholism, vol II. Plenum Press, New York, pp 131–168Google Scholar
  20. Naranjo C (1979) Psychotropic properties of the harmala alkaloids. In: Efron DH, Holmstedt B, Kline NS (eds). Ethnopharmacologic search for psychoactive drugs. Raven Press, New York, pp 385–391Google Scholar
  21. Otto M, Rommelspacher H, Schmidt LG (1990) Neurobiologische Befunde beiGoogle Scholar
  22. Opioidabhängigen. In diesem Band Pawhk M, Rommelspacher H (1988) Demonstration of a distinct class of high-affinity binding sites for [3H]norharman ([3H])0-carbohne) in the rat brain. Eur J Pharmacol 147:163–171Google Scholar
  23. Pawhk M, Kaulen P, Baumgarten HG, Rommelspacher H (1990) Quantitative autoradiography of [3H]norharman ([3H])ö-carbohne) binding sites in the rat brain. J Chem Neuroanat 3:19–24Google Scholar
  24. Reid LD, Hunter GA (1984) Morphine and naloxone modulate intake of ethanol. Alcohol 1:33–37PubMedCrossRefGoogle Scholar
  25. Rommelspacher H, Nanz C, Borbe HO, Fehske KJ, MüUer WE (1980) Methylyö-carboline (harmane), a potent endogenous inhibitor of benzodiazepine receptor binding. Naunyn-Schmiedeberg’s Arch Pharmacol 314:97–100CrossRefGoogle Scholar
  26. Rommelspacher H (1981) The β-carbolines (Harmanes) — a new class of endogenous compounds. Their relevance for the pathogenesis and treatment of psychiatric and neurological diseases. Pharmacopsychiatria 14:117–125PubMedCrossRefGoogle Scholar
  27. Rommelspacher H, Nanz C, Borbe HO, Fehske KJ, Müller WE, Wollert U (1981) Benzodiazepine antagonism by harmane and other)Ö-carbohnes in vitro and in vivo. Eur J Pharmacol 70:409–416PubMedCrossRefGoogle Scholar
  28. Rommelspacher H, Barbey M, Strauss S, Greiner B, Fähndrich E (1982) Is there a correlation between the concentration of yff-carbolines and their pharmacodynamic effects? In: Bloom F, Barchas J, Sandler M, Usdin E (Hrsg) Prog Chn Biol Res, vol 90, pp 41–55Google Scholar
  29. Rommelspacher H, Büchau C, Weiss J (1987) Harman induces preference for ethanol in rats: is the effect specific for ethanol? Pharmacol Biochem Behav 26:749–755PubMedCrossRefGoogle Scholar
  30. Rommelspacher H (1988) Pathobiochemie der Alkoholkrankheit. Dtsch Ärztebl 85:19–21Google Scholar
  31. Rommelspacher H, Strauss S, May T (1988) Demonstration of a distinct class of high-affinity receptors for [3H])ff-carbolines in man and rat. Soc Neurosci Abstr 143:10Google Scholar
  32. Rommelspacher H, Wolffgramm J, Widjaja S (1989) Effects of despiramine on rat behavior are prevented by concomitant treatment with ethanol. Pharmacol Biochem Behav 32:533–542PubMedCrossRefGoogle Scholar
  33. Rommelspacher H, Damm H, Lutter S, Schmidt LG, Otto M, Sachs-Ericsson N, Schmidt G (1990) Harman (l-methyl-)0-carbohne) in blood plasma and erythrocytes of nonalcohohcs foUowing ethanol loading. Alcohol 7:21–31CrossRefGoogle Scholar
  34. Samson HH, Tollvier GA, Peffer AO, Sadeghi KG, Mills FG (1987) Oral ethanol reinforcement in the rat: effect of the partial inverse benzodiazepine agonist RO 15–4513. Pharmacol Biochem Behav 27:517–519PubMedCrossRefGoogle Scholar
  35. Schmidt LG, Otto M, Sachs-Ericsson N, Kreutzberg K, Platz W, Rommelspacher H (1990) Untersuchung biologischer Marker des Alkohohsmus. In diesem BandGoogle Scholar
  36. Schuckit MA (1986) Genetic and clinical impUcations of alcohoHsm and affective disorders. Am J Psychiat 143:140–147PubMedGoogle Scholar
  37. Seizinger BR, Höllt V, Herz A (1984) Effects of chronic ethanol treatment on the in vitro biosynthesis of pro-opiomelanocortin and its posttranslational processing to β-endorphine in the intermediate lobe of the rat pituitary. J Neurochem 43:607–613PubMedCrossRefGoogle Scholar
  38. Suzdak PD, Schwartz RD, Skolnik P, Paul SMU (1986) Ethanol stimulates y-aminobutyric acid receptor-mediated chloride transport in rat brain synapto- neurosomes. Proc Nad Acad Sci USA 83:4071–4075CrossRefGoogle Scholar
  39. Svensson L, Engel J, Härd E (1989) Effects of the 5-HT receptor agonist, 8-OH-DPAT, on ethanol preference in the rat. Alcohol 6:17–21PubMedCrossRefGoogle Scholar
  40. Susilo R, Rommelspacher H (1987) Formation of a)ö-carboline (1,2,3,4-tetrahy-dro-l-methyl-)ff-carboline-l-carboxylic acid) following intracerebroventricu- lar injection of tryptamine and pyruvic acid. Naunyn-Schmiedeberg’s Arch Pharmacol 335:70–75CrossRefGoogle Scholar
  41. Tabakoff B, Ritzmann RF (1977) The effects of 6-hydroxydopamine on tolerance to and dependence on ethanol. J Pharmacol Exp Ther 203:319–331PubMedGoogle Scholar
  42. Takada R, Saito K, Matsumura H, Inoki R (1989) Effect of ethanol on hippo-campal GABA receptors in the rat brain. Alcohol 6:115–119PubMedCrossRefGoogle Scholar
  43. Ticku MK, Burch T (1980) Alterations in aminobutyric acid receptor sensitivity following acute and chronic ethanol treatments. J Neurochem 34:417–423PubMedCrossRefGoogle Scholar
  44. Waldmeier PL (1983) Neurobiochemische Wirkungen antidepressiver Substanzen. In: Langer G, Heimann H (Hrsg) Psychopharmaka, Grundlagen und Therapie. Springer, Wien, pp 65–78Google Scholar
  45. Winokur G (1983) AlcohoHsm and depression. Subst Alcohol Actions Misuse 4:111–119PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • H. Rommelspacher
  • L. G. Schmidt
  • M. Otto

There are no affiliations available

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