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Is Juvenile Myoclonic Epilepsy Polygenic?

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Genetics of the Epilepsies

Abstract

It has been suggested [3, 6] that juvenile myoclonic epilepsy (JME) may follow a polygenic threshold pattern of inheritance — specifically, with a differential sex effect, in that females are more often affected than males. However, as described below, we have examined 78 families with JME from Berlin and 27 from Los Angeles and have found no evidence to support the polygenic hypothesis for pure JME, either with or without differential thresholds for the two sexes. We could reach no conclusion when we included other epilepsies or EEG abnormalities in our definition of the trait.

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References

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Author information

Author notes

  1. S. E. Hodge

    Present address: NY State Psychiatric Institute Columbia University, 722 W. 168th Street, Box 14, New York, NY, 10032, USA

  2. D. A. Greenberg

    Present address: Department of Psychiatry, Mt. Sinai medical Center, 1 Gustave Levy Place, New York, NY, 10029, USA

Authors and Affiliations

  1. Department of Biomathematics and Psychiatry, UCLA School of Medicine, USA

    S. E. Hodge

  2. Southwest Regional VA Epilepsy Center, Neurology Service, Wadsworth VA Medical Center, Los Angeles, USA

    D. A. Greenberg

  3. Neurologische Abteilung, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19, Germany

    M. Durner & D. Janz

  4. Reed Neurological Research Center, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA, 90024, USA

    A. V. Delgado-Escueta

Authors
  1. S. E. Hodge
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  2. D. A. Greenberg
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  3. M. Durner
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  4. A. V. Delgado-Escueta
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  5. D. Janz
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Editor information

Editors and Affiliations

  1. Neurologische Abteilung, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19, Germany

    Gertrud Beck-Mannagetta M.D. (Assistant Professor of Neurology) & Dieter Janz M.D. (Professor of Neurology) (Assistant Professor of Neurology) &  (Professor of Neurology)

  2. Dight Laboratories, University of Minnesota, 400 Church Street S.E., 55455, Minneapolis, MN, USA

    V. Elving Anderson M.D. (Professor of Genetics and Cell Biology) (Professor of Genetics and Cell Biology)

  3. Abteilung für Neuropädiatrie, Universität Kiel, Schwanenweg 20, D-2300, Kiel, Germany

    Hermann Doose M.D. (Professor of Pediatrics) (Professor of Pediatrics)

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© 1989 Springer-Verlag Berlin Heidelberg

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Hodge, S.E., Greenberg, D.A., Durner, M., Delgado-Escueta, A.V., Janz, D. (1989). Is Juvenile Myoclonic Epilepsy Polygenic?. In: Beck-Mannagetta, G., Anderson, V.E., Doose, H., Janz, D. (eds) Genetics of the Epilepsies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95553-2_9

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  • DOI: https://doi.org/10.1007/978-3-642-95553-2_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-95555-6

  • Online ISBN: 978-3-642-95553-2

  • eBook Packages: Springer Book Archive

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